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Coagulation factor III
Thromboplastin, tissue factor
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from
Heemskerk Johan W. M. et al., In Cellular and Molecular Life Sciences, 2009
... Human α-thrombin was obtained from Enzyme Research Laboratories, recombinant human tissue factor came from Dade Behring, abciximab (reopro) from Centocor; tirofiban (aggrastat) from Merck Sharp & Dohme, and ...
Yang Zhihong et al., In BMC Cardiovascular Disorders, 2003
... tumor necrosis factor-α (TNF-α) was purchased from R & D, France); monoclonal mouse anti-TF antibody and tissue factor activity kit were purchased from American Diagnostica Inc (Socochim, Lausanne, Switzerland); ...
Versteeg et al., Leiden, Netherlands. In Thromb Res, 2012
In this review, we aim to present a side-by-side evaluation of normally-spliced, full length TF (flTF) and asTF with regard to coagulant function, atherosclerosis, tumor progression and malignancy-associated thrombosis.