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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Coagulation factor III

Thromboplastin, tissue factor
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Papers using Thromboplastin antibodies
CLEC-2 activates Syk through dimerization
Heemskerk Johan W. M. et al., In Cellular and Molecular Life Sciences, 2009
... Human α-thrombin was obtained from Enzyme Research Laboratories, recombinant human tissue factor came from Dade Behring, abciximab (reopro) from Centocor; tirofiban (aggrastat) from Merck Sharp & Dohme, and ...
Upstream and downstream of mTOR
Yang Zhihong et al., In BMC Cardiovascular Disorders, 2003
... tumor necrosis factor-α (TNF-α) was purchased from R & D, France); monoclonal mouse anti-TF antibody and tissue factor activity kit were purchased from American Diagnostica Inc (Socochim, Lausanne, Switzerland); ...
Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide
Samad Fahumiya et al., In Nature medicine, 1995
... Disulfide isomerization switches tissue factor from coagulation to cell signaling ...
Papers on Thromboplastin
Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor.
Sant'Ana Dusse et al., Belo Horizonte, Brazil. In J Thromb Thrombolysis, 2012
Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor.
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.
Mackman et al., Chapel Hill, United States. In Blood, 2012
Only TF-positive cell lines activated coagulation in nude mice, and this activation was abolished by an anti-human TF Ab.
Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition.
Tanner et al., Zürich, Switzerland. In Thromb Haemost, 2012
Caffeine enhances TNF-alpha-induced endothelial TF protein expression as well as surface activity by inhibition of PI3K signalling.
Tissue factor isoforms in cancer and coagulation: may the best isoform win.
Versteeg et al., Leiden, Netherlands. In Thromb Res, 2012
In this review, we aim to present a side-by-side evaluation of normally-spliced, full length TF (flTF) and asTF with regard to coagulant function, atherosclerosis, tumor progression and malignancy-associated thrombosis.
Tissue factor proangiogenic signaling in cancer progression.
Ruf et al., Los Angeles, United States. In Thromb Res, 2012
Here we review the evidence that TF-dependent signaling is the major driver of primary tumor growth.
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