Anticoagulant therapy for idiopathic pulmonary fibrosis
In Pulmonary Medicine, 2004
... Shino-test), the same antibody used for ELISA, RAGE (MAB5328, 1 : 50, CHEMICON International, Inc., Temecula, CA), thrombomodulin (TM1009, 1 : 100, DAKO Company Ltd., Glostrup, Denmark), ...
Why ser and not thr brokers catalysis in the trypsin fold.
Saint Louis, United States. In Biochemistry, 24 Mar 2015
The S195T mutation abrogates the Na(+)-dependent enhancement of catalytic activity in thrombin, activated protein C, and factor Xa and significantly weakens the physiologically important allosteric effects of thrombomodulin on thrombin and of cofactor Va on factor Xa. The evolutionary selection of Ser over Thr in trypsin-like proteases was therefore driven by the need for high catalytic activity and efficient allosteric regulation.
[Hypercoagulable state in patients with multiple myeloma].
China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Jan 2015
OBJECTIVE: This study was to detect the plasma thrombomodulin (TM), D-dimer and fibrinogen in patients with multiple myeloma (MM) and to analyze their relationship with morbid state, and also to investigate the relationship of the expression of coagulation factor with the ratio of myeloma cells.
Coagulation abnormalities in sepsis.
Taipei, Taiwan. In Acta Anaesthesiol Taiwan, Jan 2015
However, these subgroup analyses of activated protein C, antithrombin, and thrombomodulin trials show that overt coagulation activation is strongly associated with the best therapeutic effect of the inhibitor.
Traumatic coagulopathy--part 1: Pathophysiology and diagnosis.
Auburn, United States. In J Vet Emerg Crit Care (san Antonio), 2014
Excessive activation of the thrombin-thrombomodulin activated Protein C pathway, catecholamine-induced endothelial damage as well as disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype are all hypotheses that have been proposed in attempts to explain the functional mechanism of ATC.