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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Oct 2014.

Thrombomodulin

thrombomodulin
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, Plasminogen, CAN, AGE, von Willebrand factor
Papers using thrombomodulin antibodies
Thrombin-activatable fibrinolysis inhibitor and its relation with inflammation in rheumatoid arthritis
Supplier
An Seong Soo A. et al., In The Korean Journal of Hematology, 2008
... -arginine chloromethyl ketone (PPACK), thrombin and thrombomodulin were obtained from American Diagnostica Inc ...
Anticoagulant therapy for idiopathic pulmonary fibrosis
Supplier
Nukiwa Toshihiro et al., In Pulmonary Medicine, 2004
... Shino-test), the same antibody used for ELISA, RAGE (MAB5328, 1 : 50, CHEMICON International, Inc., Temecula, CA), thrombomodulin (TM1009, 1 : 100, DAKO Company Ltd., Glostrup, Denmark), ...
Papers on thrombomodulin
Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.
New
Impact
Luft et al., Berlin, Germany. In J Clin Oncol, 20 Nov 2014
Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and endothelial thrombomodulin (THBD) plays a role in this process.
Chemical sympathectomy attenuates inflammation, glycocalyx shedding and coagulation disorders in rats with acute traumatic coagulopathy.
New
Li et al., Nanjing, China. In Blood Coagul Fibrinolysis, 16 Nov 2014
Serum catecholamine, soluble thrombomodulin and syndecan-1 were also effectively inhibited by sympathectomy.
Alterations in the Coagulation System of Active Smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study.
New
Kleber et al., Mannheim, Germany. In Adv Exp Med Biol, 10 Nov 2014
They displayed significantly higher values for fibrinogen, soluble fibrinogen, factor XIII, and tissue factor pathway inhibitor; whereas FVII, FVIII, FXII, von Willebrand factor (vWF), and thrombomodulin were decreased.
Prominent protein Z-induced thrombin inhibition in cirrhosis: A new functional assay for hypercoagulability assessment.
New
Kim et al., Seoul, South Korea. In J Gastroenterol Hepatol, 10 Nov 2014
Thrombin generation assays (TGA) were performed with and without thrombomodulin (TM) or PZ, and the ratios were calculated by dividing TGA values with TM or PZ by values without TM or PZ.
Coagulation phenotypes in septic shock as evaluated by calibrated automated thrombography.
New
Vieillard-Baron et al., France. In Shock, 24 Oct 2014
Thrombin generation was studied in plasma from patients presenting septic shock at diagnosis and 6 hours after a conventional therapeutic management using calibrated automated thrombography with or without thrombomodulin (TM) addition.
Expression of thrombomodulin, calretinin, cytokeratin 5/6, D2-40 and WT-1 in a series of primary carcinomas of the lung: an immunohistochemical study in comparison with epithelioid pleural mesothelioma.
New
Messerini et al., In Tumori, 30 Sep 2014
The most widely used mesothelioma markers are thrombomodulin, calretinin, cytokeratin 5/6, D2-40 and WT-1.
Coagulopathy in malaria.
Review
New
Angchaisuksiri, Bangkok, Thailand. In Thromb Res, Jan 2014
Elevated plasma levels of von Willebrand factor (vWF) and vWF propeptide, thrombomodulin, endothelial microparticles have been reported in P. falciparum-infected patients.
Traumatic coagulopathy--part 1: Pathophysiology and diagnosis.
Review
New
Martin et al., Auburn, United States. In J Vet Emerg Crit Care (san Antonio), Jan 2014
Excessive activation of the thrombin-thrombomodulin activated Protein C pathway, catecholamine-induced endothelial damage as well as disseminated intravascular coagulation (DIC) with a fibrinolytic phenotype are all hypotheses that have been proposed in attempts to explain the functional mechanism of ATC.
New insights into modulation of thrombin formation.
Review
New
ten Cate et al., Maastricht, Netherlands. In Curr Atheroscler Rep, Nov 2013
This protective effect is mediated in part through generation of anticoagulant enzymes, including activated protein C, formed on the action of thrombin on the endothelial receptor thrombomodulin.
Insights into thrombin activatable fibrinolysis inhibitor function and regulation.
Review
New
Gils et al., Vancouver, Canada. In J Thromb Haemost, Jun 2013
TAFI can be activated by thrombin alone, but the rate of activation is accelerated when in complex with thrombomodulin.
[Morphological and molecular bases of cardiac development].
Review
Burdan et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2012
Their expression is regulated by various molecules, including transcription (XIN, GATA, MEF, Tbx5, Baf60c, PECAM, tie-2, MEF2) and growth (VEGF, FGF, PDGF) factors, as well as proteins (i.e., dickkopf-1, cerberus, cytotactin, fibrillin, nodal, thrombomodulin, Wnt, bone morphometric ones - BMP2, BMP 4, BMP5, BMP7) and other substances, such as retinoid and folic acid.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration.
GeneRIF
Wu et al., Tainan City, Taiwan. In Faseb J, 2012
TM interacts with ezrin. TM cytoplasmic domain directly interacts with the N-terminal domain of ezrin
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Impact
Hauer-Jensen et al., Cincinnati, United States. In Nat Med, 2012
Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-induced mortality.
Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
GeneRIF
Wu et al., Tainan City, Taiwan. In J Immunol, 2012
we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response.
Mechanisms coupling thrombomodulin to tumor dissemination.
GeneRIF
Palumbo et al., Haifa, Israel. In Thromb Res, 2012
Mechanisms coupling thrombomodulin to tumor dissemination
Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
GeneRIF
Satomi et al., Sendai, Japan. In Transplant Proc, 2012
results suggest that thrombomodulin may improve the viability of liver grafts from non-heart-beating donors.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Impact
GeneRIF
Conway et al., Leuven, Belgium. In N Engl J Med, 2009
Mutations that impair the function of thrombomodulin occur in about 5% of patients with atypical hemolytic-uremic syndrome
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Impact
GeneRIF
Nawroth et al., Heidelberg, Germany. In Nat Med, 2007
Thrombomodulin-dependent activated protein C formation mediates cytoprotection in diabetic nephropathy by inhibiting glomerular apoptosis.
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.
Impact
Psaty et al., Seattle, United States. In Jama, 2007
Five of these confirm previously reported associations (fibrinogen genes and protein C), 2 were inconsistent with earlier reports (thrombomodulin and plasminogen activator inhibitor 1), and 15 were new discoveries.
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