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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

Thrombomodulin

thrombomodulin
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Plasminogen, AGE, von Willebrand factor
Papers using thrombomodulin antibodies
Thrombin-activatable fibrinolysis inhibitor and its relation with inflammation in rheumatoid arthritis
Supplier
An Seong Soo A. et al., In The Korean Journal of Hematology, 2008
... -arginine chloromethyl ketone (PPACK), thrombin and thrombomodulin were obtained from American Diagnostica Inc ...
Anticoagulant therapy for idiopathic pulmonary fibrosis
Supplier
Nukiwa Toshihiro et al., In Pulmonary Medicine, 2004
... Shino-test), the same antibody used for ELISA, RAGE (MAB5328, 1 : 50, CHEMICON International, Inc., Temecula, CA), thrombomodulin (TM1009, 1 : 100, DAKO Company Ltd., Glostrup, Denmark), ...
Papers on thrombomodulin
Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens.
New
Cooper et al., Pittsburgh, United States. In Xenotransplantation, 03 May 2015
Hearts transplanted into Group A baboons (n = 4) expressed additional CD55, and those into Group B (n = 3) expressed human thrombomodulin (TBM).
Thalidomide and multiple myeloma serum synergistically induce a hemostatic imbalance in endothelial cells in vitro.
New
Su et al., Harbin, China. In Thromb Res, 18 Apr 2015
Analyses of phosphatidylserine (PS), tissue factor (TF), endothelial protein C receptor (EPCR) and thrombomodulin (TM) were performed using flow cytometry.
Coagulation abnormalities in sepsis.
Review
New
Wu et al., Taipei, Taiwan. In Acta Anaesthesiol Taiwan, Jan 2015
However, these subgroup analyses of activated protein C, antithrombin, and thrombomodulin trials show that overt coagulation activation is strongly associated with the best therapeutic effect of the inhibitor.
Thrombomodulin promotes corneal epithelial wound healing.
New
Wu et al., Tainan City, Taiwan. In Plos One, Dec 2014
PURPOSE: To determine the role of thrombomodulin (TM) in corneal epithelial wound healing, and to investigate whether recombinant TM epidermal growth factor-like domain plus serine/threonine-rich domain (rTMD23) has therapeutic potential in corneal epithelial wound healing.
Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.
New
Hauer-Jensen et al., Little Rock, United States. In Plos One, Dec 2014
Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery.
Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.
New
Impact
Luft et al., Berlin, Germany. In J Clin Oncol, Nov 2014
Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and endothelial thrombomodulin (THBD) plays a role in this process.
Do the observational studies using propensity score analysis agree with randomized controlled trials in the area of sepsis?
Review
New
Xu et al., Jinhua, China. In J Crit Care, Oct 2014
The interventions included activated protein C, low-dose steroid, antithrombin III, combination antibiotic therapy, fish oil supplementation, statin, etomidate for intubation, and recombinant human soluble thrombomodulin.
Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation: the view from Japan.
Review
New
Thachil et al., Tokyo, Japan. In J Thromb Haemost, Jul 2014
In this review, in addition to examining the important role of anticoagulants in the septic milieu, the clinical studies examining antithrombin, recombinant thrombomodulin and plasma-derived activated protein C are detailed.
The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options.
Review
New
Cooper et al., Pittsburgh, United States. In Xenotransplantation, May 2014
Further genetic manipulation of the organ-source pigs, such as pigs that express one or more coagulation-regulatory genes (e.g., thrombomodulin, endothelial protein C receptor, tissue factor pathway inhibitor, CD39), is anticipated to inhibit platelet activation and the generation of thrombus.
[Pathophysiology of atypical hemolytic uremic syndrome. Ten years of progress, from laboratory to patient].
Review
Frémeaux-Bacchi, Paris, France. In Biol Aujourdhui, 2012
Mutations in the gene of thrombomodulin and diacylglycerol kinase epsilon (DGKe) have been reported, suggesting the possibility of an alternative or more complex disease-causing mechanism than previously thought.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration.
GeneRIF
Wu et al., Tainan City, Taiwan. In Faseb J, 2012
TM interacts with ezrin. TM cytoplasmic domain directly interacts with the N-terminal domain of ezrin
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Impact
Hauer-Jensen et al., Cincinnati, United States. In Nat Med, 2012
Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-induced mortality.
Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
GeneRIF
Wu et al., Tainan City, Taiwan. In J Immunol, 2012
we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response.
Mechanisms coupling thrombomodulin to tumor dissemination.
GeneRIF
Palumbo et al., Haifa, Israel. In Thromb Res, 2012
Mechanisms coupling thrombomodulin to tumor dissemination
Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
GeneRIF
Satomi et al., Sendai, Japan. In Transplant Proc, 2012
results suggest that thrombomodulin may improve the viability of liver grafts from non-heart-beating donors.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Impact
GeneRIF
Conway et al., Leuven, Belgium. In N Engl J Med, 2009
Mutations that impair the function of thrombomodulin occur in about 5% of patients with atypical hemolytic-uremic syndrome
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Impact
GeneRIF
Nawroth et al., Heidelberg, Germany. In Nat Med, 2007
Thrombomodulin-dependent activated protein C formation mediates cytoprotection in diabetic nephropathy by inhibiting glomerular apoptosis.
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.
Impact
Psaty et al., Seattle, United States. In Jama, 2007
Five of these confirm previously reported associations (fibrinogen genes and protein C), 2 were inconsistent with earlier reports (thrombomodulin and plasminogen activator inhibitor 1), and 15 were new discoveries.
Age determination of brain contusions.
Hausmann, Erlangen, Germany. In Forensic Sci Med Pathol, 2006
Regarding the vascular response to brain injury, a significantly increased immunoreactivity could be detected in cortical contusions with a wound age of at least 3 hours for factor VIII, 1.6 days for tenascin, and 6.8 days for thrombomodulin, whereas the immunostaining for laminin and type IV collagen was regularly whereas the immunostaining for laminin and type IV collagen was regularly positive even in the vascular endothelium of ininjured brain tissue.
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