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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Thrombomodulin

thrombomodulin
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, Plasminogen, CAN, AGE, von Willebrand factor
Papers using thrombomodulin antibodies
Thrombin-activatable fibrinolysis inhibitor and its relation with inflammation in rheumatoid arthritis
Supplier
An Seong Soo A. et al., In The Korean Journal of Hematology, 2008
... -arginine chloromethyl ketone (PPACK), thrombin and thrombomodulin were obtained from American Diagnostica Inc ...
Anticoagulant therapy for idiopathic pulmonary fibrosis
Supplier
Nukiwa Toshihiro et al., In Pulmonary Medicine, 2004
... Shino-test), the same antibody used for ELISA, RAGE (MAB5328, 1 : 50, CHEMICON International, Inc., Temecula, CA), thrombomodulin (TM1009, 1 : 100, DAKO Company Ltd., Glostrup, Denmark), ...
Papers on thrombomodulin
Microfluidic perfusion culture chip providing different strengths of shear stress for analysis of vascular endothelial function.
New
Kanamori et al., Tsukuba, Japan. In J Biosci Bioeng, 30 Sep 2014
Compared with conditions of no shear stress, endothelial nitric oxide synthase mRNA expression increased by 50% and thrombomodulin mRNA expression increased by 8-fold under a shear stress of 9.5 dyn/cm(2).
Procoagulant imbalance in patients with non-alcoholic fatty liver disease.
New
Fargion et al., Milano, Italy. In J Hepatol, Jul 2014
METHODS: Plasma was evaluated for levels of pro- and anti-coagulants, and for thrombin-generation assessed as endogenous-thrombin-potential (ETP) with and without thrombomodulin or Protac® as protein C activators.
Women with unexplained recurrent pregnancy loss do not have evidence of an underlying prothrombotic state: experience with calibrated automated thrombography and rotational thromboelastometry.
New
Arya et al., London, United Kingdom. In Thromb Res, May 2014
The use of low tissue factor (1 pM) to better reflect physiological conditions and assay modification to better assess the protein C pathway (5 pM in the presence of thrombomodulin) provided no additional discrimination.
Thrombomodulin alfa treatment in patients with acute promyelocytic leukemia and disseminated intravascular coagulation: a retrospective analysis of an open-label, multicenter, post-marketing surveillance study cohort.
New
Sakata et al., Nagoya, Japan. In Thromb Res, May 2014
Studies regarding the safety and efficacy of thrombomodulin alfa (TM-α; recombinant human soluble thrombomodulin) in patients with APL and DIC are limited.
Poor prognosis of hypocoagulability assessed by thrombin generation assay in disseminated intravascular coagulation.
New
Kim et al., Seoul, South Korea. In Blood Coagul Fibrinolysis, Apr 2014
The thrombin generation assay was performed on the calibrated automated thrombogram using tissue factor with or without the addition of thrombomodulin, showing three parameters: lag time, endogenous thrombin potential (ETP), and peak thrombin.
The failure of biologics in sepsis: where do we stand?
Review
New
Giamarellos-Bourboulis, Athens, Greece. In Int J Antimicrob Agents, Jun 2013
These comprise intravenous clarithromycin, haemoperfusion through a polymyxin B-embedded fibre device (PMX-B), recombinant thrombomodulin (rTM) and intravenous immunoglobulin preparations enriched in IgM and IgA (IgMA).
Insights into thrombin activatable fibrinolysis inhibitor function and regulation.
Review
New
Gils et al., Vancouver, Canada. In J Thromb Haemost, Jun 2013
TAFI can be activated by thrombin alone, but the rate of activation is accelerated when in complex with thrombomodulin.
Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS).
Review
New
Scientific and Standardization Committee on DIC of the International Society on Thrombosis and Haemostasis (ISTH) et al., Sapporo, Japan. In J Thromb Haemost, May 2013
Coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS) occurs as a result of increased activation of the thrombomodulin and protein C pathways, leading to the suppression of coagulation and activation of fibrinolysis.
[Noninvasive analysis of retinal microstructure and function: challenges and a promising future].
Review
New
Yoshida, Asahikawa, Japan. In Nihon Ganka Gakkai Zasshi, Mar 2013
In in vitro studies, we examined the effects of laminar shear stress on gene expression in human retinal microvascular endothelial cells (HRMECs) and found that long-term exposure to physiologic shear stress in the retinal arterioles upregulated eNOS and thrombomodulin mRNA expression and down-regulated ET-1 mRNA expression in the HRMECs.
[Mechanism and risk factors of cardiogenic thromboembolism in patients with atrial fibrillation].
Review
Otsuka, In Nihon Rinsho, 2013
In the experimental model, rapid atrial pacing acutely downregulated the gene expression of thrombomodulin(TM) and tissue factor pathway inhibitor (TFPI) in the atrial endocardium.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration.
GeneRIF
Wu et al., Tainan City, Taiwan. In Faseb J, 2012
TM interacts with ezrin. TM cytoplasmic domain directly interacts with the N-terminal domain of ezrin
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Impact
Hauer-Jensen et al., Cincinnati, United States. In Nat Med, 2012
Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-induced mortality.
Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
GeneRIF
Wu et al., Tainan City, Taiwan. In J Immunol, 2012
we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response.
Mechanisms coupling thrombomodulin to tumor dissemination.
GeneRIF
Palumbo et al., Haifa, Israel. In Thromb Res, 2012
Mechanisms coupling thrombomodulin to tumor dissemination
Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
GeneRIF
Satomi et al., Sendai, Japan. In Transplant Proc, 2012
results suggest that thrombomodulin may improve the viability of liver grafts from non-heart-beating donors.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Impact
GeneRIF
Conway et al., Leuven, Belgium. In N Engl J Med, 2009
Mutations that impair the function of thrombomodulin occur in about 5% of patients with atypical hemolytic-uremic syndrome
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Impact
GeneRIF
Nawroth et al., Heidelberg, Germany. In Nat Med, 2007
Thrombomodulin-dependent activated protein C formation mediates cytoprotection in diabetic nephropathy by inhibiting glomerular apoptosis.
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.
Impact
Psaty et al., Seattle, United States. In Jama, 2007
Five of these confirm previously reported associations (fibrinogen genes and protein C), 2 were inconsistent with earlier reports (thrombomodulin and plasminogen activator inhibitor 1), and 15 were new discoveries.
The thrombomodulin-protein C system is essential for the maintenance of pregnancy.
Impact
GeneRIF
Weiler et al., Milwaukee, United States. In Nat Med, 2003
These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta, which is essential for the maintenance of pregnancy.
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