gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 03 Jul 2015.

Thrombomodulin

thrombomodulin
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Plasminogen, AGE, von Willebrand factor
Papers using thrombomodulin antibodies
Thrombin-activatable fibrinolysis inhibitor and its relation with inflammation in rheumatoid arthritis
Supplier
An Seong Soo A. et al., In The Korean Journal of Hematology, 2008
... -arginine chloromethyl ketone (PPACK), thrombin and thrombomodulin were obtained from American Diagnostica Inc ...
Anticoagulant therapy for idiopathic pulmonary fibrosis
Supplier
Nukiwa Toshihiro et al., In Pulmonary Medicine, 2004
... Shino-test), the same antibody used for ELISA, RAGE (MAB5328, 1 : 50, CHEMICON International, Inc., Temecula, CA), thrombomodulin (TM1009, 1 : 100, DAKO Company Ltd., Glostrup, Denmark), ...
Papers on thrombomodulin
Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians.
New
Li et al., Shanghai, China. In Mol Neurobiol, 02 Aug 2015
UNASSIGNED: Our meta-analysis was designed to obtain the correlation between thrombomodulin (TM) and high-sensitive C-reactive protein (hs-CRP) levels and the development of cerebral infarction (CI).
Regulation of thrombosis and vascular function by protein methionine oxidation.
Review
New
Lentz et al., Iowa City, United States. In Blood, 18 Jul 2015
Several other proteins with oxidation-sensitive methionine residues, including apolipoprotein A-I, thrombomodulin, and von Willebrand factor, may contribute to vascular disease and thrombosis.
[Vascular endothelial injury induced by anti-endothelial cell antibody in allogeneic hematopoietic stem cell transplantation].
New
Han et al., Taiwan. In Zhonghua Xue Ye Xue Za Zhi, 14 Jul 2015
When concentration of IgG was 320 and 640 μg/ml, concentrations of thrombomodulin were statistically higher in AECA positive groups [(57.50±4.50)
Coagulation abnormalities in sepsis.
Review
New
Wu et al., Taipei, Taiwan. In Acta Anaesthesiol Taiwan, Mar 2015
However, these subgroup analyses of activated protein C, antithrombin, and thrombomodulin trials show that overt coagulation activation is strongly associated with the best therapeutic effect of the inhibitor.
Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
New
Solà et al., Valencia, Venezuela. In Cochrane Database Syst Rev, Dec 2014
These trials evaluated the human activated protein C, recombinant human soluble thrombomodulin, tranexamic acid and dermatan sulphate.
Endothelial Injury Associated with Cold or Warm Blood Cardioplegia during Coronary Artery Bypass Graft Surgery.
New
Wahlers et al., Köln, Germany. In Biomed Res Int, Dec 2014
Endothelial injury was quantified by circulating endothelial cells (CECs), von Willebrand factor (vWF), and soluble thrombomodulin (sTM).
Capsaicin may have important potential for promoting vascular and metabolic health.
Review
New
O'Keefe et al., Encinitas, United States. In Open Heart, Dec 2014
The calcium influx triggered by TRPV1 activation in endothelial cells mimics the impact of shear stress in this regard, activating and increasing the expression of eNOS-but also increasing expression of cox-2, thrombomodulin, and nrf2-responsive antioxidant enzymes, while decreasing expression of proinflammatory proteins.
Protective effects of heparin on endothelial cells in sepsis.
New
Bai et al., Shenyang, China. In Int J Clin Exp Med, Dec 2014
They were intervened by heparin and the expression levels of soluble thrombomodulin (sTM) and serum activated protein C (APC) were detected by ELISA, the regulatory mechanism of heparin improving vascular endothelial cells injury induced by TNFα was detected by Western Blotting method, the methylation of histone in the gene promoter region of endothelial nitric oxide synthase (eNOS) and monocyte chemotactic protein-1 (MCP-1) were detected using chromatin immunoprecipitation method.
Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.
New
Impact
Luft et al., Berlin, Germany. In J Clin Oncol, Nov 2014
Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and endothelial thrombomodulin (THBD) plays a role in this process.
Do the observational studies using propensity score analysis agree with randomized controlled trials in the area of sepsis?
Review
New
Xu et al., Jinhua, China. In J Crit Care, Oct 2014
The interventions included activated protein C, low-dose steroid, antithrombin III, combination antibiotic therapy, fish oil supplementation, statin, etomidate for intubation, and recombinant human soluble thrombomodulin.
Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation: the view from Japan.
Review
New
Thachil et al., Tokyo, Japan. In J Thromb Haemost, Jul 2014
In this review, in addition to examining the important role of anticoagulants in the septic milieu, the clinical studies examining antithrombin, recombinant thrombomodulin and plasma-derived activated protein C are detailed.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration.
GeneRIF
Wu et al., Tainan City, Taiwan. In Faseb J, 2012
TM interacts with ezrin. TM cytoplasmic domain directly interacts with the N-terminal domain of ezrin
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Impact
Hauer-Jensen et al., Cincinnati, United States. In Nat Med, 2012
Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-induced mortality.
Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
GeneRIF
Wu et al., Tainan City, Taiwan. In J Immunol, 2012
we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response.
Mechanisms coupling thrombomodulin to tumor dissemination.
GeneRIF
Palumbo et al., Haifa, Israel. In Thromb Res, 2012
Mechanisms coupling thrombomodulin to tumor dissemination
Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
GeneRIF
Satomi et al., Sendai, Japan. In Transplant Proc, 2012
results suggest that thrombomodulin may improve the viability of liver grafts from non-heart-beating donors.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Impact
GeneRIF
Conway et al., Leuven, Belgium. In N Engl J Med, 2009
Mutations that impair the function of thrombomodulin occur in about 5% of patients with atypical hemolytic-uremic syndrome
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Impact
GeneRIF
Nawroth et al., Heidelberg, Germany. In Nat Med, 2007
Thrombomodulin-dependent activated protein C formation mediates cytoprotection in diabetic nephropathy by inhibiting glomerular apoptosis.
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.
Impact
Psaty et al., Seattle, United States. In Jama, 2007
Five of these confirm previously reported associations (fibrinogen genes and protein C), 2 were inconsistent with earlier reports (thrombomodulin and plasminogen activator inhibitor 1), and 15 were new discoveries.
share on facebooktweetadd +1mail to friends