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Thrombomodulin

thrombomodulin
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Plasminogen, AGE, von Willebrand factor
Papers using thrombomodulin antibodies
Thrombin-activatable fibrinolysis inhibitor and its relation with inflammation in rheumatoid arthritis
Supplier
An Seong Soo A. et al., In The Korean Journal of Hematology, 2008
... -arginine chloromethyl ketone (PPACK), thrombin and thrombomodulin were obtained from American Diagnostica Inc ...
Anticoagulant therapy for idiopathic pulmonary fibrosis
Supplier
Nukiwa Toshihiro et al., In Pulmonary Medicine, 2004
... Shino-test), the same antibody used for ELISA, RAGE (MAB5328, 1 : 50, CHEMICON International, Inc., Temecula, CA), thrombomodulin (TM1009, 1 : 100, DAKO Company Ltd., Glostrup, Denmark), ...
Papers on thrombomodulin
What's new in the pathogenesis of the coagulopathy in acute promyelocytic leukemia?'
New
Soff et al., New York City, United States. In Curr Opin Hematol, Feb 2016
Repletion of coagulation factors and platelets with blood products remains the mainstay of supportive treatment, whereas the role of recombinant soluble thrombomodulin is currently being investigated.
Peritoneal malignant mesothelioma (PMM), and primary peritoneal serous carcinoma (PPSC) and reactive mesothelial hyperplasia (RMH) of the peritoneum. Immunohistochemical and fluorescence in situ hybridisation (FISH) analyses.
New
Hiroshima et al., Tokorozawa, Japan. In J Clin Pathol, Feb 2016
METHODS: To help differentiate PMM from PPSC and RMH, we used immunohistochemistry to examine mesothelial-associated markers (calretinin, AE1/AE3, CK5/6, CAM5.2, D2-40, WT-1, HBME1, thrombomodulin), adenocarcinoma-associated markers (CEA, BerEP4, MOC31, ER (estrogen receptor), PgR, TTF-1, Claudin-4, Pax8), and malignant-related and benign-related markers (epithelial membrane antigen (EMA), desmin, GLUT-1, CD146 and IMP3), and FISH to examine for homozygous deletion of 9p21.
Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.
New
METASTROKE The Genomics and Randomized Trials Network GARNET Collaborative Research Group et al., Winston-Salem, United States. In Neurology, Jan 2016
VISP collected baseline measures of C-reactive protein (CRP), fibrinogen, creatinine, prothrombin fragments F1+2, thrombin-antithrombin complex, and thrombomodulin prior to treatment initiation.
Treatment of thrombotic microangiopathy after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin.
New
Tanimoto et al., Okayama, Japan. In Transfusion, Jan 2016
STUDY DESIGN AND METHODS: The study objective was to retrospectively analyze the outcome of patients receiving recombinant human soluble thrombomodulin (rTM), which has cytoprotective effects against calcineurin inhibitor-induced endothelial cell damage, or other therapeutics for TA-TMA from 254 consecutive HSCT recipients between 2009 to 2014 at a single institution.
Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice.
New
Uchiyama et al., Takatsuki, Japan. In J Pharmacol Sci, Dec 2015
The effect of recombinant human soluble thrombomodulin (TM-α) on acute liver failure (ALF) is unclear, and we elucidated the effect of TM-α in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced ALF in mice.
Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I.
Review
New
Lehner et al., Cambridge, United Kingdom. In Mol Immunol, Dec 2015
These include at least six α integrins, the coagulation factor thrombomodulin and the NK cell ligand CD112.
Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation.
Review
New
Robson et al., Melbourne, Australia. In Int J Surg, Nov 2015
As an example, heterotopic cardiac xenografts from donors expressing human thrombomodulin have survived for more than a year in immunosuppressed baboons, with no evidence of thrombotic microangiopathy or coagulopathy.
Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127.
Review
Abicht et al., München, Germany. In Adv Exp Med Biol, 2014
These include genetic modification of the donor animals to knock out genes responsible for xenoreactive surface epitopes and to express multiple xenoprotective molecules such as the human complement regulators CD46, 55, 59, thrombomodulin and others.
Capsaicin may have important potential for promoting vascular and metabolic health.
Review
O'Keefe et al., Encinitas, United States. In Open Heart, 2014
The calcium influx triggered by TRPV1 activation in endothelial cells mimics the impact of shear stress in this regard, activating and increasing the expression of eNOS-but also increasing expression of cox-2, thrombomodulin, and nrf2-responsive antioxidant enzymes, while decreasing expression of proinflammatory proteins.
[THE ROLE OF ENDOTHELIAL SIGNAL MOLECULES IN PATHOGENESIS OF AGE-ASSOCIATED DISEASES].
Review
Lin'kova et al., In Adv Gerontol, 2014
Regulation of the endothelium function is realized by the system of signal molecules (NO, NOS, prostacyclin, thrombomodulin, tromboxan, antithrombin, endothelins, fibronectin, Willebrand's factor et al.).
Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease.
Impact
Luft et al., Berlin, Germany. In J Clin Oncol, 2014
Although the pathophysiology of steroid refractoriness is not fully understood, evidence is accumulating that endothelial cell stress is involved, and endothelial thrombomodulin (THBD) plays a role in this process.
Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling.
GeneRIF
Yokoyama et al., Kōchi, Japan. In Arterioscler Thromb Vasc Biol, 2012
Thrombomodulin upregulates extracellular signal-regulated kinase/myeloid leukemia cell-1 signaling to protect endothelial cells from calcineurin inhibitor-induced toxicity.
Thrombomodulin is an ezrin-interacting protein that controls epithelial morphology and promotes collective cell migration.
GeneRIF
Wu et al., Tainan City, Taiwan. In Faseb J, 2012
TM interacts with ezrin. TM cytoplasmic domain directly interacts with the N-terminal domain of ezrin
Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity.
Impact
Hauer-Jensen et al., Cincinnati, United States. In Nat Med, 2012
Here we identify the thrombomodulin (Thbd)-activated protein C (aPC) pathway as a new mechanism for the mitigation of total body irradiation (TBI)-induced mortality.
Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response.
GeneRIF
Wu et al., Tainan City, Taiwan. In J Immunol, 2012
we conclude that monocytic membrane-bound thrombomodulin participates in the LPS- and gram-negative bacteria-induced inflammatory response.
Mechanisms coupling thrombomodulin to tumor dissemination.
GeneRIF
Palumbo et al., Haifa, Israel. In Thromb Res, 2012
Mechanisms coupling thrombomodulin to tumor dissemination
Recombinant human soluble thrombomodulin (ART-123) prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
GeneRIF
Satomi et al., Sendai, Japan. In Transplant Proc, 2012
results suggest that thrombomodulin may improve the viability of liver grafts from non-heart-beating donors.
Thrombomodulin mutations in atypical hemolytic-uremic syndrome.
Impact
GeneRIF
Conway et al., Leuven, Belgium. In N Engl J Med, 2009
Mutations that impair the function of thrombomodulin occur in about 5% of patients with atypical hemolytic-uremic syndrome
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Impact
GeneRIF
Nawroth et al., Heidelberg, Germany. In Nat Med, 2007
Thrombomodulin-dependent activated protein C formation mediates cytoprotection in diabetic nephropathy by inhibiting glomerular apoptosis.
Association of genetic variations with nonfatal venous thrombosis in postmenopausal women.
Impact
Psaty et al., Seattle, United States. In Jama, 2007
Five of these confirm previously reported associations (fibrinogen genes and protein C), 2 were inconsistent with earlier reports (thrombomodulin and plasminogen activator inhibitor 1), and 15 were new discoveries.
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