3,5-di-iodothyronine stimulates tilapia growth through an alternate isoform of thyroid hormone receptor β1.
Querétaro, Mexico. In J Mol Endocrinol, 28 Feb 2014
Recent studies in our laboratory have shown that in some teleosts, 3,5-di-iodothyronine (T2 or 3,5-T2) is as bioactive as 3,5,3'-tri-iodothyronine (T3) and that its effects are in part mediated by a TRβ1 (THRB) isoform that contains a 9-amino acid insert in its ligand-binding domain (long TRβ1 (L-TRβ1)), whereas T3 binds preferentially to a short TRβ1 (S-TRβ1) isoform that lacks this insert.
Thyroid hormone receptors and cancer.
Bethesda, United States. In Biochim Biophys Acta, Jul 2013
The THRA and THRB genes encode several TR isoforms that express in a tissue- and development-dependent manner.
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Boston, United States. In Reproduction, Jul 2013
As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood.
Thyroid hormone receptors in health and disease.
Amsterdam, Netherlands. In Minerva Endocrinol, 2012
Mutations in both the THRA and THRB gene have been described, each inducing a characteristic phenotype clearly showing the selective effect of an excess or shortage of thyroid hormone in specific TRα and TRβ regulated organs.