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proteins. Page last changed on 14 Mar 2013.
Thyroid hormone receptor, beta
THRB, GRTH, Thr1, thyroid hormone receptor beta1, PRTH
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
THRB
Lactobacillus helveticus as a tool to change proteolysis and functionality in Swiss-type cheeses.
New
Rennes, France. In J Dairy Sci, 31 Mar 2013
Among them, proteinases PrtH and PrtH2 were shown to have different cleavage specificity on pure α(s1)-casein.
Septic shock NTIS causes hypothyroidism and conditions for reduced sensitivity to thyroid hormone.
New
Lubbock, United States. In J Mol Endocrinol, 07 Feb 2013
The aim of this study was to investigate the effect of lipopolysaccharide (LPS) induced NTIS on thyroid hormone (TH) levels and TH molecular targets, as well as the relationship between septic shock NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation and TH receptor beta (THRB) gene expression at a multi-tissue level in a pig model.
Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression.
New
Bethesda, United States. In Endocrinology, Jan 2013
That a knock-in mouse harboring a dominant-negative thyroid hormone receptor (TR)-β (Thrb) mutation develops metastatic thyroid cancer strongly suggests the involvement of TRβ in carcinogenesis.
Insight into the structure-function relationship of the nonheme iron halogenases involved in the biosynthesis of 4-chlorothreonine --Thr3 from Streptomyces sp. OH-5093 and SyrB2 from Pseudomonas syringae pv. syringae B301DR.
New
Roma, Italy. In Febs J, Dec 2012
OH-5093 showed the presence of six ORFs: thr1, thr2, thr3, orf1, orf2 and thr4.
Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis function in sheep.
New
Frederiksberg, Denmark. In J Endocrinol, Dec 2012
In one or more of the target tissues, liver, cardiac muscle, and longissimus dorsi muscle, gene expressions were increased by LG-UN for TH receptors (THRA and THRB) and deiodinases but were decreased in visceral and subcutaneous adipose tissues.
Thyroid hormone receptors in health and disease.
New
Amsterdam, Netherlands. In Minerva Endocrinol, Dec 2012
Mutations in both the THRA and THRB gene have been described, each inducing a characteristic phenotype clearly showing the selective effect of an excess or shortage of thyroid hormone in specific TRα and TRβ regulated organs.
THE FIRST CASE OF ASSOCIATION BETWEEN POST PARTUM THYROIDITIS AND THYROID HORMONE RESISTANCE IN AN ITALIAN PATIENT SHOWING A NOVEL p.V283A THRB (THYROID HORMONE RECEPTOR BETA) MUTATION.
New
Roma, Italy. In Thyroid, Dec 2012
Patient findings: In this report, we describe a 30 year-old patient affected by RTH due to a novel p.V283A THRB (thyroid hormone receptor β) heterozygous mutation in exon 8 which covers the ligand binding domain, never before described in literature.
Long-term 3,5,3'-triiodothyroacetic acid therapy in a child with hyperthyroidism caused by thyroid hormone resistance: pharmacological study and therapeutic recommendations.
Review
New
Yokohama, Japan. In Thyroid, Oct 2012
METHODS: The gene encoding the thyroid hormone receptor beta (THRB) of the patient carries a P453T mutation.
Homozygous thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: three new cases and review of the literature.
Review
New
Chicago, United States. In J Clin Endocrinol Metab, Apr 2012
BACKGROUND: The most common cause of resistance to thyroid hormone (RTH) is heterozygous thyroid hormone receptor β (THRB) gene mutations.
Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options.
Review
Matsumoto, Japan. In Endocrine, 2011
Pituitary resistance to thyroid hormone (PRTH) is defined as resistance to the action of thyroid hormone that is more severe in the pituitary than at the peripheral tissue level.
THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.
Kōbe, Japan. In Int J Med Sci, 2011
In this study, we investigated whether thyroid hormone receptor beta (THRB) genetic polymorphisms can serve as a potential biomarker in patients with esophageal squamous cell carcinoma (ESCC).
MicroRNAs in thyroid cancer.
Review
Columbus, United States. In J Clin Endocrinol Metab, 2011
Our review of the literature strongly supports this notion in that a polymorphism in one microRNAs (miR-146a) predisposes to thyroid carcinoma, whereas numerous other microRNAs are involved in signaling (mainly PTEN/PI3K/AKT and T3/THRB) that is central to thyroid carcinogenesis.
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR).
GeneRIF
Bethesda, United States. In J Biol Chem, 2011
Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR).
Mutant thyroid hormone receptors (TRs) isolated from distinct cancer types display distinct target gene specificities: a unique regulatory repertoire associated with two renal clear cell carcinomas.
GeneRIF
Davis, United States. In Mol Endocrinol, 2011
TR mutations from renal clear cell carcinoma and hepatocellular carcinoma may play tissue-specific roles in carcinogenesis.
Extranuclear signaling of mutated thyroid hormone receptors in promoting metastatic spread in thyroid carcinogenesis.
Review
Bethesda, United States. In Steroids, 2011
A direct demonstration that TRβ mutants could function as oncogenes is evidenced by the spontaneous development of follicular thyroid carcinoma similar to human cancer in a knockin mouse model harboring a mutated TRβ (denoted as PV; Thrb(PV/PV) mice).
A new mutation in the thyroid hormone receptor gene of a Chinese family with resistance to thyroid hormone.
GeneRIF
Beijing, China. In Chin Med J (engl), 2011
a novel missense mutation in exon 9 of the TRbeta gene was identified in a boy with resistance to thyroid hormone, changing codon 317 from GCT to GAT, 1235C>A or A317D the same mutation was also identified in his mother
Gonadotropin-regulated testicular helicase (GRTH/DDX25): a master post-transcriptional regulator of spermatogenesis.
GeneRIF
Bethesda, United States. In Adv Exp Med Biol, 2010
studies on GRTH [proide insights into the intrinsic requirements of spermatogenesis and open new avenues for studies on regulating spermatogenesis, infertility and male contraception
An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone.
GeneRIF
Bethesda, United States. In J Transl Med, 2010
SNPs in intron control region (ICR) of THRB gene in resistance to thyroid hormone(RTH)syndrome; in index case of PRTH a common SNP in ICR stimulates overactivation of TRbeta2 promoter in pituitary cells; it is linked in cis with known R338W coding muta...
A thyroid hormone receptor that is required for the development of green cone photoreceptors.
Impact
New York City, United States. In Nat Genet, 2001
Thyroid hormone receptor beta 2 (TR beta 2) is a ligand-activated transcription factor that is expressed in the outer nuclear layer of the embryonic retina.
Thyroid hormone receptor beta is essential for development of auditory function.
Impact
New York City, United States. In Nat Genet, 1996
We demonstrate that Tr beta-deficient (Thrb-/-) mice exhibit a permanent deficit in auditory function across a wide range of frequencies, although they show no other overt neurological defects.
