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Thyroid hormone receptor, beta

THRB, GRTH, Thr1, thyroid hormone receptor beta1, PRTH
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, TRbeta
Papers on THRB
Ioxynil and Tetrabromobisphenol A Suppress Thyroid-Hormone-Induced Activation of Transcriptional Elongation Mediated by Histone Modifications and RNA Polymerase II Phosphorylation.
Yamauchi et al., Shizuoka, Japan. In Toxicol Sci, 30 Apr 2014
To elucidate molecular mechanisms by which the phenolic herbicide ioxynil (IOX) and the brominated flame retardant tetrabromobisphenol A (TBBPA) exert thyroid hormone (TH) disrupting activity, we investigated the effects of the chemicals on the histone and RNA polymerase II (RNAPII) modifications in Xenopus laevis XL58-TRE-Luc cells in direct TH-response genes encoding TH receptor β (Thrb) and TH-induced basic leucine zipper protein (Thibz) using chromatin immunoprecipitation assays.
Thyroid signaling in immune organs and cells of the teleost fish rainbow trout (Oncorhynchus mykiss).
Navas et al., Madrid, Spain. In Fish Shellfish Immunol, 20 Apr 2014
We demonstrate that immune organs (head kidney and spleen) and isolated leukocytes (from head kidney and peripheral blood) of the rainbow trout (Oncorhynchus mykiss) express both thyroid receptor α (THRA) and β (THRB).
3,5-di-iodothyronine stimulates tilapia growth through an alternate isoform of thyroid hormone receptor β1.
Orozco et al., Mexico. In J Mol Endocrinol, 28 Feb 2014
Recent studies in our laboratory have shown that in some teleosts, 3,5-di-iodothyronine (T2 or 3,5-T2) is as bioactive as 3,5,3'-tri-iodothyronine (T3) and that its effects are in part mediated by a TRβ1 (THRB) isoform that contains a 9-amino acid insert in its ligand-binding domain (long TRβ1 (L-TRβ1)), whereas T3 binds preferentially to a short TRβ1 (S-TRβ1) isoform that lacks this insert.
The thyroid hormone receptor β induces DNA damage and premature senescence.
Aranda et al., Madrid, Spain. In J Cell Biol, 06 Feb 2014
In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid mice.
Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility.
Singh et al., Benares, India. In Andrologia, Nov 2013
UNLABELLED: Gonadotrophin-regulated testicular RNA helicase (GRTH) plays an important role in RNA functions including nuclear transcription, pre-mRNA splicing and it regulates the translation of specific genes required for the progression of spermatogenesis.
Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha.
Chatterjee et al., Cambridge, United Kingdom. In Biochim Biophys Acta, Jul 2013
BACKGROUND: Thyroid hormone acts via receptor subtypes (TRα1, TRβ1, TRβ2) with differing tissue distributions, encoded by distinct genes (THRA, THRB).
Thyroid hormone receptors and cancer.
Cheng et al., Bethesda, United States. In Biochim Biophys Acta, Jul 2013
The THRA and THRB genes encode several TR isoforms that express in a tissue- and development-dependent manner.
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Kleene, Boston, United States. In Reproduction, Jul 2013
As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood.
Thyroid hormone resistance: a novel mutation in thyroid hormone receptor beta (THRB) gene - case report.
Kandemir et al., Ankara, Turkey. In Turk J Pediatr, May 2013
It is usually caused by mutations in the thyroid hormone receptor beta (THRB) gene.
Genome-wide and candidate gene association studies of placental abruption.
Williams et al., Boston, United States. In Int J Mol Epidemiol Genet, 2012
CAMK2B, NR1H3, PPARG, PRKCA, and THRB) and OP (e.g., COX5A, and NDUF family of genes) were associated with PA risk (P-value <0.05).
Thyroid hormone receptors in health and disease.
Fliers et al., Amsterdam, Netherlands. In Minerva Endocrinol, 2012
Mutations in both the THRA and THRB gene have been described, each inducing a characteristic phenotype clearly showing the selective effect of an excess or shortage of thyroid hormone in specific TRα and TRβ regulated organs.
A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation.
Wilkinson et al., Sheffield, United Kingdom. In Plos One, 2012
TR-α expression both potentiated and sensitized the -238A response to LPS or a titanium particulate stimulus, whilst siRNA knockdown of either THRA or THRB impaired transcriptional activation for the -238A variant only.
Long-term 3,5,3'-triiodothyroacetic acid therapy in a child with hyperthyroidism caused by thyroid hormone resistance: pharmacological study and therapeutic recommendations.
Onigata et al., Yokohama, Japan. In Thyroid, 2012
PATIENT FINDINGS: The gene encoding the thyroid hormone receptor beta (THRB) of the patient carries a P453T mutation.
Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.
Kullo et al., Rochester, United States. In Mayo Clin Proc, 2012
Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC indices. Our results provide insights into the molecular basis underlying variation in RBC traits.
Homozygous thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: three new cases and review of the literature.
Refetoff et al., Chicago, United States. In J Clin Endocrinol Metab, 2012
report of three new subjects, from two families, in whom resistance to thyroid hormone was associated with homozygous mutations in the THRB gene; report strengthens the concept that the mutated TRbeta interferes with the function of the TRalpha1 in humans
Androgen-induced activation of gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) transcription: essential role of a nonclassical androgen response element half-site.
Dufau et al., Bethesda, United States. In Mol Cell Biol, 2012
GRTH regulation by androgen in Leydig cells; molecular mechanism of androgen-regulated transcription
Liganded thyroid hormone receptor inhibits phorbol 12-O-tetradecanoate-13-acetate-induced enhancer activity via firefly luciferase cDNA.
Nakamura et al., Hamamatsu, Japan. In Plos One, 2011
Firefly luciferase cDNA sequence mediates the phorbol 12-O-tetradecanoate-13-acetate-induced transcriptional activity, which is inhibited by thyroid hormone/thyroid hormone receptor.
Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis.
Dufau et al., Bethesda, United States. In Plos One, 2011
Data show the regulatory pathways underlying GRTH action in male reproduction.
A thyroid hormone receptor that is required for the development of green cone photoreceptors.
Forrest et al., New York City, United States. In Nat Genet, 2001
Thyroid hormone receptor beta 2 (TR beta 2) is a ligand-activated transcription factor that is expressed in the outer nuclear layer of the embryonic retina.
Thyroid hormone receptor beta is essential for development of auditory function.
Curran et al., New York City, United States. In Nat Genet, 1996
We demonstrate that Tr beta-deficient (Thrb-/-) mice exhibit a permanent deficit in auditory function across a wide range of frequencies, although they show no other overt neurological defects.
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