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Thyroid hormone receptor, beta

THRB, GRTH, Thr1, thyroid hormone receptor beta1, PRTH
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, TRbeta
Papers on THRB
Inhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model.
Cheng et al., Bethesda, United States. In Endocr Relat Cancer, Jan 2016
We previously demonstrated that a high fat diet (HFD) effectively induced the obese phenotype in a mouse model of thyroid cancer (Thrb(PV/PV)Pten(+/-) mice).
Successful every-other-day liothyronine therapy for severe resistance to thyroid hormone beta with a novel THRB mutation; case report.
Takeuchi et al., Ōtsu, Japan. In Bmc Endocr Disord, Dec 2015
CASE PRESENTATION: The present case study concerns an 8-year-old Japanese girl with a severe phenotype of RTH (TSH, fT3, and fT4 were 34.0 mU/L, >25.0 pg/mL and, >8.0 ng/dL, respectively), caused by a novel heterozygous frameshift mutation in exon 10 of the thyroid hormone receptor beta gene (THRB), c.1347-1357 del actcttccccc : p.E449DfsX11.
Germ Cell Nuclear Factor (GCNF/RTR) Regulates Transcription of Gonadotropin-Regulated Testicular RNA Helicase (GRTH/DDX25) in Testicular Germ Cells-The Androgen Connection.
Dufau et al., Bethesda, United States. In Mol Endocrinol, Dec 2015
Gonadotropin-regulated testicular RNA helicase (GRTH) (GRTH/DDX25), is a testis-specific protein essential for completion of spermatogenesis.
The expression of thyroid hormone receptors (THR) is regulated by the progesterone receptor system in first trimester placental tissue and in BeWo cells in vitro.
Ditsch et al., München, Germany. In Eur J Obstet Gynecol Reprod Biol, Dec 2015
On mRNA level, we also found a significantly reduced expression of THRA but no significant downregulation for THRB in placental tissue.
Iodine supplementation of the pregnant dam alters intestinal gene expression and immunoglobulin uptake in the newborn lamb.
Boland et al., Dublin, Ireland. In Animal, Dec 2015
Iodine (CaIO3) supplementation of the dam increased the relative expression (P<0.05) of the B2M, PIGR and MYC genes in the ileum of the lamb, before colostrum consumption; while the expression of THRB declined when compared with the progeny of C dams (P<0.01).
Loss of heterozygosity in thyroid hormone receptor beta in invasive breast cancer.
Wang et al., Lanzhou, China. In Tumori, Sep 2015
BACKGROUND: Loss of heterozygosity (LOH) on chromosome arm 3p, where the gene of thyroid hormone receptor beta (THRB) is located, has been reported in breast cancer.
Impaired Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism and Action
Refetoff et al., Madagascar. In Unknown Journal, Sep 2015
Its major cause, found in more than 3,000 individuals, is mutations in the TH receptor ß(THRB) gene.
The Impact of a Non-Functional Thyroid Receptor Beta upon Triiodotironine-Induced Cardiac Hypertrophy in Mice.
Ortiga-Carvalho et al., Rio de Janeiro, Brazil. In Cell Physiol Biochem, 2014
METHODS: The experiments were performed using adult male mice expressing TRβΔ337T, which contains the Δ337T mutation of the human THRB gene and impairs ligand binding.
Thyroid hormones in the central nervous system (CNS) and their effect on neoplasm formation, particularly on the development and course of glioblastoma multiforme - research hypothesis.
Nauman, Warsaw, Poland. In Endokrynol Pol, 2014
Then the evidence concerning present state of the knowledge about active transport of TH to the brain, the role of iodothyronine deiodinase type 2 and 3 in the setting concentration of T3 in the brain and GBM cells, and finally knowledge about the role of genomic (TH nuclear receptors THRA and THRB) and non-genomic modes (membrane integrin receptor αvβ3) of action of TH and its importance for GBM was outlined.
Thyroid hormone receptors and resistance to thyroid hormone disorders.
Wondisford et al., Rio de Janeiro, Brazil. In Nat Rev Endocrinol, 2014
Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes.
Clinical Consequences of Mutations in Thyroid Hormone Receptor-α1.
Peeters et al., Rotterdam, Netherlands. In Eur Thyroid J, 2014
Thyroid hormone (TH) exerts its biological activity via the TH receptors TRα1 and TRβ1/2, which are encoded by the THRA and THRB genes.
Resistance to thyroid hormone.
Szinnai et al., Izumo, Japan. In Endocr Dev, 2013
RTHβ (formerly only RTH) is caused by mutations in the thyroid hormone receptor β gene (THRB).
Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells.
Kleene, Boston, United States. In Reproduction, 2013
As a result, the mechanisms involving well-studied mRNAs (Ddx4/Mvh, Prm1, Prm2, and Sycp3) and factors (DICER1, CPEB1, DAZL, DDX4/MVH, DDX25/GRTH, translin, and ELAV1/HuR) are incompletely understood.
Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.
Kullo et al., Rochester, United States. In Mayo Clin Proc, 2012
Genes in the erythroid differentiation and cell cycle regulation pathways influence interindividual variation in RBC indices. Our results provide insights into the molecular basis underlying variation in RBC traits.
Homozygous thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: three new cases and review of the literature.
Refetoff et al., Chicago, United States. In J Clin Endocrinol Metab, 2012
report of three new subjects, from two families, in whom resistance to thyroid hormone was associated with homozygous mutations in the THRB gene; report strengthens the concept that the mutated TRbeta interferes with the function of the TRalpha1 in humans
Androgen-induced activation of gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) transcription: essential role of a nonclassical androgen response element half-site.
Dufau et al., Bethesda, United States. In Mol Cell Biol, 2012
GRTH regulation by androgen in Leydig cells; molecular mechanism of androgen-regulated transcription
Liganded thyroid hormone receptor inhibits phorbol 12-O-tetradecanoate-13-acetate-induced enhancer activity via firefly luciferase cDNA.
Nakamura et al., Hamamatsu, Japan. In Plos One, 2011
Firefly luciferase cDNA sequence mediates the phorbol 12-O-tetradecanoate-13-acetate-induced transcriptional activity, which is inhibited by thyroid hormone/thyroid hormone receptor.
Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis.
Dufau et al., Bethesda, United States. In Plos One, 2011
Data show the regulatory pathways underlying GRTH action in male reproduction.
A thyroid hormone receptor that is required for the development of green cone photoreceptors.
Forrest et al., New York City, United States. In Nat Genet, 2001
Thyroid hormone receptor beta 2 (TR beta 2) is a ligand-activated transcription factor that is expressed in the outer nuclear layer of the embryonic retina.
Thyroid hormone receptor beta is essential for development of auditory function.
Curran et al., New York City, United States. In Nat Genet, 1996
We demonstrate that Tr beta-deficient (Thrb-/-) mice exhibit a permanent deficit in auditory function across a wide range of frequencies, although they show no other overt neurological defects.
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