Septic shock NTIS causes hypothyroidism and conditions for reduced sensitivity to thyroid hormone.
Lubbock, United States. In J Mol Endocrinol, 07 Feb 2013
The aim of this study was to investigate the effect of lipopolysaccharide (LPS) induced NTIS on thyroid hormone (TH) levels and TH molecular targets, as well as the relationship between septic shock NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation and TH receptor beta (THRB) gene expression at a multi-tissue level in a pig model.
Thyroid hormone receptors in health and disease.
Amsterdam, Netherlands. In Minerva Endocrinol, Dec 2012
Mutations in both the THRA and THRB gene have been described, each inducing a characteristic phenotype clearly showing the selective effect of an excess or shortage of thyroid hormone in specific TRα and TRβ regulated organs.
MicroRNAs in thyroid cancer.
Columbus, United States. In J Clin Endocrinol Metab, 2011
Our review of the literature strongly supports this notion in that a polymorphism in one microRNAs (miR-146a) predisposes to thyroid carcinoma, whereas numerous other microRNAs are involved in signaling (mainly PTEN/PI3K/AKT and T3/THRB) that is central to thyroid carcinogenesis.