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proteins. Page last changed on 14 Mar 2013.
Uromodulin
THP, Gli2, Tamm-Horsfall glycoprotein, uromodulin, THP1
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
THP
antibodies
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
Supplier
In Frontiers in Microbiology, 2008
... Human THP-1 monocytoid cell line (TIB#3456, ATCC, MD, USA) was maintained at 37°C and 5% CO2 in HEPES buffered RPMI-1640 (Sigma Aldrich, St Louis, MO, USA) ...
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... 2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, Uscn), and very low-density lipoprotein (VLDL, E1847r, EIAab) were used for the ...
Rationale for the use of mitoxantrone in multiple sclerosis
Supplier
In Advances in Hematology, 2003
... AML cell lines, HL-60 and THP-1, were obtained from ATCC (Manassas, VA) and cultured in RPMI 1640 medium (with phenol red) (Thermo Scientific Hyclone, Logan, UT) supplemented ...
Flow cytometry in the study of cell death.
Supplier
In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis
more suppliersSupplier
In Arthritis Research & Therapy, 1999
... After that time samples of THP-1 cells were also treated with an apoptosis inducer [25], staurosporine (17 nM; Sigma Aldrich), for 24 hours ...
Papers on
THP
Both NF-κB and c-Jun/AP-1 involved in anti-β2GPI/β2GPI-induced tissue factor expression in monocytes.
New
Zhenjiang, China. In Thromb Haemost, 07 Apr 2013
Our previous data has demonstrated that Toll-like receptor 4 (TLR4) and its signalling pathway can contribute to anti-β2-glycoprotein I/β2-glycoprotein I (anti-β2GPI/β2GPI) -induced tissue factor (TF) expression in human blood monocytes and acute monocytic leukaemia cell line THP-1.
The role of interleukin-1β in the anti-adipogenic action of macrophages on human preadipocytes.
New
Ottawa, Canada. In J Endocrinol, 05 Apr 2013
Using the THP-1 human macrophage cell line and human primary preadipocytes, our objective was to determine if IL-1β was necessary for the ability of conditioned medium from THP-1 macrophages (THP-1-MacCM) to 1) stimulate human preadipocyte inhibitor of κB kinase (IKK) β and 2) inhibit human adipocye differentiation.
Regulation of Wnt4 in chronic obstructive pulmonary disease.
New
London, United Kingdom. In Faseb J, 05 Apr 2013
In monocytic THP-1 and primary airway smooth muscle cells, Wnt4 induced inflammation and enhanced the inflammatory response to lipopolysaccharide and IL-1β but did not induce proliferation.
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
New
Impact
Stanford, United States. In Cancer Cell, 14 Feb 2013
Here, we report that itraconazole and arsenic trioxide, two agents in clinical use that inhibit Hedgehog signaling by mechanisms distinct from that of current Smoothened antagonists, retain inhibitory activity in vitro in the context of all reported resistance-conferring Smoothened mutants and GLI2 overexpression.
P2X Receptor-Dependent Erythrocyte Damage by α-Hemolysin from Escherichia coli Triggers Phagocytosis by THP-1 Cells.
New
Århus, Denmark. In Toxins (basel), Dec 2012
Cultured THP-1 cells as a model for erythrocytal phagocytosis was verified by a variety of methods, including live cell imaging.
Functional Expression of TWEAK and the Receptor Fn14 in Human Malignant Ovarian Tumors: Possible Implication for Ovarian Tumor Intervention.
New
Shanghai, China. In Plos One, Dec 2012
TWEAK promoted TNF-α production in cultured THP-1 macrophages.
Nongenomic effects of thyroid hormones on the immune system cells: New targets, old players.
Review
New
Roma, Italy. In Steroids, Aug 2012
New results demonstrate the capability of T(3) or T(4) to induce in the short time range important responses related to the immune function, such as reactive oxygen species production and cell migration in THP-1 monocytes.
GLI2 mutations as a cause of hypopituitarism.
Review
New
Boston, United States. In Pediatr Endocrinol Rev, Aug 2012
Gli2 is a transcription factor that mediates Shh signaling.
[CD20-positive peripheral T-cell lymphoma, not otherwise specified].
Review
New
In Rinsho Ketsueki, Jul 2012
This patient achieved partial remission with a treatment regimen of THP-COP excluding prednisolone, but died of pneumonia.
Uromodulin in kidney injury: an instigator, bystander, or protector?
Review
New
Saint Louis, United States. In Am J Kidney Dis, Mar 2012
Uromodulin, also known as Tamm-Horsfall protein, is a glycoprotein expressed exclusively by renal tubular cells lining the thick ascending limb of the loop of Henle.
Hyperuricemia, gout and the kidney.
Review
New
London, United Kingdom. In Curr Opin Rheumatol, Mar 2012
Familial childhood gout with progressive renal impairment attributable to mutations of the uromodulin (UMOD) gene is associated with reduced uromodulin in the proximal tubule cilia.
Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.
GeneRIF
Erlangen, Germany. In J Am Soc Nephrol, 2011
Deletion of the von Hippel-Lindau protein (Vhl), which mediates HIF degradation under normoxia, using Tamm-Horsfall protein (Thp)-driven Cre expression showed strong expression of HIF-1alpha in thick ascending limb.
Phenotype and outcome in hereditary tubulointerstitial nephritis secondary to UMOD mutations.
GeneRIF
Paris, France. In Clin J Am Soc Nephrol, 2011
Hyperuricemia disproportionate to renal function represents the hallmark of renal disease caused by UMOD mutation.
TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis.
Review
GeneRIF
France. In Cancer Res, 2011
This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-beta in cancer.[Review]
Uromodulin gene variant is associated with type 2 diabetic nephropathy.
GeneRIF
Malmö, Sweden. In J Hypertens, 2011
present study highlights that the common variant of the UMOD gene is protective against diabetic nephropathy susceptibility and also affects kidney function and blood pressure in patients with type 2 diabetes
Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner.
GeneRIF
Berlin, Germany. In J Biol Chem, 2011
a permissive role for THP in the modulation of NKCC2-dependent TAL salt reabsorptive function.
Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis.
Impact
Palo Alto, United States. In Nat Med, 2010
We also identify a molecular mechanism by which ALDH-2 inhibition reduces cocaine-seeking behavior: increases in tetrahydropapaveroline (THP) formation due to inhibition of ALDH-2 decrease cocaine-stimulated dopamine production and release in vitro and in vivo.
A critical role for alpha4betadelta GABAA receptors in shaping learning deficits at puberty in mice.
Impact
New York City, United States. In Science, 2010
However, the stress steroid THP (3alphaOH-5alpha[beta]-pregnan-20-one), which reduces tonic inhibition at puberty, facilitated learning.
Dual and opposing roles of primary cilia in medulloblastoma development.
Impact
San Francisco, United States. In Nat Med, 2009
In contrast, removal of cilia was required for medulloblastoma growth by a constitutively active glioma-associated oncogene family zinc finger-2 (GLI2), a downstream transcription factor.
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
More papers using
THP
antibodies
Impact
Yokohama, Japan. In Nat Genet, 2009
Using deep sequencing (deepCAGE), the FANTOM4 study measured the genome-wide dynamics of transcription-start-site usage in the human monocytic cell line THP-1 throughout a time course of growth arrest and differentiation.
Decreased Tamm-Horsfall protein in lithiasic patients
Supplier
In International Journal of Biological Sciences, 1996
... The primary antibody was a polyclonal anti-THP antibody (Biomedical Technologies Inc, USA) raised ...
The hemolytic syndrome in subacute bacterial endocarditis
Supplier
In Toxins, 1978
... HL-60, THP-1, and K562 cells were maintained in RPMI 1640 medium with 10% fetal bovine serum (Life Technologies, Carlsbad, CA) at 37 ...
