Flow cytometry in the study of cell death.more suppliers
In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
Gout as a manifestation of familial juvenile hyperuricemic nephropathy.
Omaha, United States. In J Clin Rheumatol, 31 Dec 2014
We report 2 cases of familial juvenile hyperuricemic nephropathy, a rare autosomal dominant disorder characterized by uromodulin gene mutations leading to hyperuricemia secondary to profound renal uric acid underexcretion, gout, and chronic renal disease.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Cytogenetic prognostication within medulloblastoma subgroups.
Taylor, United States. In J Clin Oncol, Apr 2014
Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas.
Genome-wide (over)view on the actions of vitamin D.
Kuopio, Finland. In Front Physiol, Dec 2013
Chromatin immunoprecipitation sequencing (ChIP-seq) in GM10855 and GM10861 lymphoblastoid cells, undifferentiated and lipopolysaccharide-differentiated THP-1 monocytes, LS180 colorectal cancer cells and LX2 hepatic stellate cells revealed between 1000 and 13,000 VDR-specific genomic binding sites.
TRPV5: a Ca(2+) channel for the fine-tuning of Ca(2+) reabsorption.
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Beijing, China. In Handb Exp Pharmacol, Dec 2013
This role is further optimized by the modulation of TRPV5 trafficking and activity via its binding partners; co-expressed proteins; tubular factors such as calbindin-D28k, calmodulin, klotho, uromodulin, and plasmin; extracellular and intracellular factors such as proton, Mg(2+), Ca(2+), and phosphatidylinositol-4,5-bisphosphate; and fluid flow.