Flow cytometry in the study of cell death.more suppliers
In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
Genomic analysis of smoothened inhibitor resistance in Basal cell carcinoma.
San Francisco, United States. In Cancer Cell, 09 Apr 2015
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2.
Interactions between hormones and epilepsy.
Oslo, Norway. In Seizure, 23 Mar 2015
Progesterone and its main metabolite 5α-pregnan-3α-ol-20-one (3α-5α-THP) act mainly to enhance postsynaptic GABA-ergic activity, while androgens enhance GABA-activated currents.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Genome-wide (over)view on the actions of vitamin D.
Kuopio, Finland. In Front Physiol, 2013
Chromatin immunoprecipitation sequencing (ChIP-seq) in GM10855 and GM10861 lymphoblastoid cells, undifferentiated and lipopolysaccharide-differentiated THP-1 monocytes, LS180 colorectal cancer cells and LX2 hepatic stellate cells revealed between 1000 and 13,000 VDR-specific genomic binding sites.
TRPV5: a Ca(2+) channel for the fine-tuning of Ca(2+) reabsorption.
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Beijing, China. In Handb Exp Pharmacol, 2013
This role is further optimized by the modulation of TRPV5 trafficking and activity via its binding partners; co-expressed proteins; tubular factors such as calbindin-D28k, calmodulin, klotho, uromodulin, and plasmin; extracellular and intracellular factors such as proton, Mg(2+), Ca(2+), and phosphatidylinositol-4,5-bisphosphate; and fluid flow.