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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Mar 2015.

Uromodulin

THP, Gli2, Tamm-Horsfall glycoprotein, uromodulin, THP1
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, HAD, ACID, Interleukin-6
Papers using THP antibodies
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
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Jagannath Chinnaswamy et al., In Frontiers in Microbiology, 2008
... Human THP-1 monocytoid cell line (TIB#3456, ATCC, MD, USA) was maintained at 37°C and 5% CO2 in HEPES buffered RPMI-1640 (Sigma Aldrich, St Louis, MO, USA) ...
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
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Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... 2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, Uscn), and very low-density lipoprotein (VLDL, E1847r, EIAab) were used for the ...
Rationale for the use of mitoxantrone in multiple sclerosis
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Christopherson Kent W. et al., In Advances in Hematology, 2003
... AML cell lines, HL-60 and THP-1, were obtained from ATCC (Manassas, VA) and cultured in RPMI 1640 medium (with phenol red) (Thermo Scientific Hyclone, Logan, UT) supplemented ...
Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis
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Villaggio Barbara et al., In Arthritis Research & Therapy, 1999
... After that time samples of THP-1 cells were also treated with an apoptosis inducer [25], staurosporine (17 nM; Sigma Aldrich), for 24 hours ...
Flow cytometry in the study of cell death.
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Av-Gay Yossef et al., In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
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Papers on THP
Smoothened variants explain the majority of drug resistance in Basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, 09 Apr 2015
Finally, we show that both classes of SMO variants respond to aPKC-ι/λ or GLI2 inhibitors that operate downstream of SMO, setting the stage for the clinical use of GLI antagonists.
Genomic analysis of smoothened inhibitor resistance in Basal cell carcinoma.
New
Impact
de Sauvage et al., San Francisco, United States. In Cancer Cell, 09 Apr 2015
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2.
Interactions between hormones and epilepsy.
Review
New
Svalheim et al., Oslo, Norway. In Seizure, 23 Mar 2015
Progesterone and its main metabolite 5α-pregnan-3α-ol-20-one (3α-5α-THP) act mainly to enhance postsynaptic GABA-ergic activity, while androgens enhance GABA-activated currents.
Orostachys japonicus Inhibits Expression of the TLR4, NOD2, iNOS, and COX-2 Genes in LPS-Stimulated Human PMA-Differentiated THP-1 Cells by Inhibiting NF-κB and MAPK Activation.
New
Kim et al., Seoul, South Korea. In Evid Based Complement Alternat Med, Dec 2014
In this report, we investigated the effects of O. japonicus extract on the expression of genes encoding pathogen-recognition receptors (TLR2, TLR4, NOD1, and NOD2) and proinflammatory factors (iNOS, COX-2, and cytokines) in LPS-stimulated PMA-differentiated THP-1 cells and the NF-κB and MAPK pathways.
GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1.
New
Munshi et al., Chicago, United States. In Sci Rep, Dec 2014
Importantly, the JQ1-resistant cells remain dependent on c-MYC that now becomes co-regulated by high levels of GLI2.
Hematopoietic cancer cell lines can support replication of sabin poliovirus type 1.
New
Bakker et al., Albania. In Biomed Res Int, Dec 2014
Sabin poliovirus type 1 was serially passaged on five human cell lines, HL60, K562, KG1, THP-1, and U937.
Virus Infections and Sudden Death in Infancy: The Role of Interferon-γ.
New
Blackwell et al., Newcastle, Australia. In Front Immunol, Dec 2014
As interferon-γ (IFN-γ) is a major response to virus infection, we examined (1) the frequency of single nucleotide polymorphism (SNP), IFNG T + 874A, in SIDS infants, their parents, and ethnic groups with different incidences of SIDS; (2) model systems with a monocytic cell line (THP-1) and human peripheral blood monocytes (PBMC) for effects of levels of IFN-γ on inflammatory responses to bacterial antigens identified in SIDS; (3) interactions between genetic and environmental factors on IFN-γ responses.
Macrophages modulate migration and invasion of human tongue squamous cell carcinoma.
New
Salo et al., Oulu, Finland. In Plos One, Dec 2014
We polarized THP-1 cells to M1 (inflammatory), M2 (TAM-like) and R848 (imidazoquinoline-treated) type Mfs.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
New
Impact
Yang et al., Houston, United States. In Cell, Dec 2014
This mechanism activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Uromodulin: from monogenic to multifactorial diseases.
Review
New
Ghiggeri et al., Brescia, Italy. In Nephrol Dial Transplant, Oct 2014
The exact role uromodulin (UMOD) plays in renal physiology remains enigmatic.
Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis.
Review
New
Schaefer et al., München, Germany. In J Am Soc Nephrol, Jul 2014
Kidney-specific DAMPs include crystals and uromodulin released by renal tubular damage.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
New
Impact
Cho et al., Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
New
Impact
ICGC PedBrain Tumor Project et al., Heidelberg, Germany. In Cancer Cell, Apr 2014
Children >3 years old harbored an excess of downstream MYCN and GLI2 amplifications and frequent TP53 mutations, often in the germline, all of which were rare in infants and adults.
Genome-wide (over)view on the actions of vitamin D.
Review
Carlberg, Kuopio, Finland. In Front Physiol, 2013
Chromatin immunoprecipitation sequencing (ChIP-seq) in GM10855 and GM10861 lymphoblastoid cells, undifferentiated and lipopolysaccharide-differentiated THP-1 monocytes, LS180 colorectal cancer cells and LX2 hepatic stellate cells revealed between 1000 and 13,000 VDR-specific genomic binding sites.
TRPV5: a Ca(2+) channel for the fine-tuning of Ca(2+) reabsorption.
Review
Peng et al., Beijing, China. In Handb Exp Pharmacol, 2013
This role is further optimized by the modulation of TRPV5 trafficking and activity via its binding partners; co-expressed proteins; tubular factors such as calbindin-D28k, calmodulin, klotho, uromodulin, and plasmin; extracellular and intracellular factors such as proton, Mg(2+), Ca(2+), and phosphatidylinositol-4,5-bisphosphate; and fluid flow.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
GeneRIF
Wang et al., Jinan, China. In J Biol Chem, 2012
SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5.
The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies.
GeneRIF
Danilewicz et al., Łódź, Poland. In Pol J Pathol, 2012
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group
Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.
GeneRIF
Fox et al., Baltimore, United States. In Plos One, 2011
association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants in UMOD gene
More papers using THP antibodies
Decreased Tamm-Horsfall protein in lithiasic patients
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Gam Lay-Harn et al., In International Journal of Biological Sciences, 1996
... The primary antibody was a polyclonal anti-THP antibody (Biomedical Technologies Inc, USA) raised ...
The hemolytic syndrome in subacute bacterial endocarditis
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Kachlany Scott C. et al., In Toxins, 1978
... HL-60, THP-1, and K562 cells were maintained in RPMI 1640 medium with 10% fetal bovine serum (Life Technologies, Carlsbad, CA) at 37 ...
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