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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.


THP, Gli2, Tamm-Horsfall glycoprotein, uromodulin, THP1
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Interleukin-6, HAD, ACID
Papers using THP antibodies
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
Jagannath Chinnaswamy et al., In Frontiers in Microbiology, 2008
... Human THP-1 monocytoid cell line (TIB#3456, ATCC, MD, USA) was maintained at 37°C and 5% CO2 in HEPES buffered RPMI-1640 (Sigma Aldrich, St Louis, MO, USA) ...
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... 2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, Uscn), and very low-density lipoprotein (VLDL, E1847r, EIAab) were used for the ...
Rationale for the use of mitoxantrone in multiple sclerosis
Christopherson Kent W. et al., In Advances in Hematology, 2003
... AML cell lines, HL-60 and THP-1, were obtained from ATCC (Manassas, VA) and cultured in RPMI 1640 medium (with phenol red) (Thermo Scientific Hyclone, Logan, UT) supplemented ...
Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis
Villaggio Barbara et al., In Arthritis Research & Therapy, 1999
... After that time samples of THP-1 cells were also treated with an apoptosis inducer [25], staurosporine (17 nM; Sigma Aldrich), for 24 hours ...
Flow cytometry in the study of cell death.
Av-Gay Yossef et al., In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
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Papers on THP
Interleukin-1β processing is dependent upon a calcium-mediated interaction with calmodulin.
Dearman et al., Manchester, United Kingdom. In J Biol Chem, 11 Dec 2015
Finally, using small molecule inhibitors it was demonstrated that both calcium and calmodulin were required for nigericin induced IL-1β secretion in THP-1 cells and primary human monocytes.
Bio-Inert Anodic Alumina Nanotubes for Targeting of Endoplasmic Reticulum Stress and Autophagic Signaling: A Combinatorial Nanotube-Based Drug Delivery System for Enhancing Cancer Therapy.
Evdokiou et al., In Acs Appl Mater Interfaces, 10 Dec 2015
We first show that AANTs are non-toxic and can active autophagy in different cell types including human fibroblast cells (HFF), human monocyte cells (THP-1) and human breast cancer cells (MDA-MB 231-TXSA).
Cerivastatin Represses Atherogenic Gene Expression Through the Induction of KLF2 via Isoprenoid Metabolic Pathways.
Chronos et al., In Cell Mol Biol Lett, 10 Dec 2015
In our study, human THP-1 macrophage cells were used to study the effects of various statins on the expressions of the atherosclerotic genes and Kruppel-like factor 2 (KLF2).
Cadmium affects mitotically inherited histone modification pathways in mouse embryonic stem cells.
Barile et al., United States. In Toxicol In Vitro, 09 Dec 2015
We tested the premise that Cd exerts differential toxicity in mouse embryonic stem (mES) cells by targeting total histone protein (THP) production early in stem cell development, while affecting H3K27-mono-methylation (H3K27me(1)) in latter stages of differentiation.
The vitamin D-dependent transcriptome of human monocytes.
Carlberg et al., Kuopio, Finland. In J Steroid Biochem Mol Biol, 30 Nov 2015
THP-1 cells are an established model of human monocytes, for which the at present largest set of 1,25(OH)2D3-affected genome-wide data are available.
Cost-Effectiveness of Pertuzumab in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer.
Horst et al., Stanford, United States. In J Clin Oncol, 08 Oct 2015
PURPOSE: The Clinical Evaluation of Pertuzumab and Trastuzumab (CLEOPATRA) study showed a 15.7-month survival benefit with the addition of pertuzumab to docetaxel and trastuzumab (THP) as first-line treatment for patients with human epidermal growth factor receptor 2 (HER2) -overexpressing metastatic breast cancer.
Real-time imaging of microparticles and living cells with CMOS nanocapacitor arrays.
Widdershoven et al., Enschede, Netherlands. In Nat Nanotechnol, Sep 2015
With our platform, we image the dynamic attachment and micromotion of BEAS, THP1 and MCF7 cancer cell lines in real time at submicrometre resolution in growth medium, demonstrating the potential of the platform for label/tracer-free high-throughput screening of anti-tumour drug candidates.
Uromodulin: from monogenic to multifactorial diseases.
Ghiggeri et al., Brescia, Italy. In Nephrol Dial Transplant, Aug 2015
The exact role uromodulin (UMOD) plays in renal physiology remains enigmatic.
Role of GLI2 in hypopituitarism phenotype.
Jorge et al., São Paulo, Brazil. In J Mol Endocrinol, Jun 2015
GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway.
Interactions between hormones and epilepsy.
Svalheim et al., Oslo, Norway. In Seizure, May 2015
Progesterone and its main metabolite 5α-pregnan-3α-ol-20-one (3α-5α-THP) act mainly to enhance postsynaptic GABA-ergic activity, while androgens enhance GABA-activated currents.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Finally, we show that both classes of SMO variants respond to aPKC-ι/λ or GLI2 inhibitors that operate downstream of SMO, setting the stage for the clinical use of GLI antagonists.
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
de Sauvage et al., San Francisco, United States. In Cancer Cell, Apr 2015
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2.
Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis.
Schurgers et al., Maastricht, Netherlands. In Plos One, Dec 2014
In vitro, invasion assays revealed chemoattractant properties of cell-culture medium of calcifying vascular smooth muscle cells towards THP-1 cells, which implies pro-inflammatory effect of calcium deposits.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
Yang et al., Houston, United States. In Cell, Dec 2014
This mechanism activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Potential effect and mechanism of action of topical chamomile (Matricaria chammomila L.) oil on migraine headache: A medical hypothesis.
Mohagheghzadeh et al., Shīrāz, Iran. In Med Hypotheses, Nov 2014
It probably possesses pain relief effects for migraines because of the following properties: (1) chamazulene and apigenin, which inhibit iNOS expression in activated macrophages and can lead to the prohibition of NO release and synthesis; (2) chamomile flavonoids, which have a strong inhibitory effect on endogenous prostaglandin E2 (PGE2) levels in RAW 264.7 macrophages and can play the role of selective COX-2 inhibitor; (3) chamomile polyphenols, which possess anti-inflammatory effects due to the inhibition of pro-inflammatory biomarkers in THP1 macrophages and which can reduce inflammation in neurovascular units (NVU) at the site of migraine pain; (4) chamomile, which has neuroprotective effects because of reduced NO levels; (5) sesamine in sesame oil, which possesses an anti-inflammatory effect.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
Wang et al., Jinan, China. In J Biol Chem, 2012
SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5.
The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies.
Danilewicz et al., Łódź, Poland. In Pol J Pathol, 2012
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group
Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.
Fox et al., Baltimore, United States. In Plos One, 2011
association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants in UMOD gene
More papers using THP antibodies
Decreased Tamm-Horsfall protein in lithiasic patients
Gam Lay-Harn et al., In International Journal of Biological Sciences, 1996
... The primary antibody was a polyclonal anti-THP antibody (Biomedical Technologies Inc, USA) raised ...
The hemolytic syndrome in subacute bacterial endocarditis
Kachlany Scott C. et al., In Toxins, 1978
... HL-60, THP-1, and K562 cells were maintained in RPMI 1640 medium with 10% fetal bovine serum (Life Technologies, Carlsbad, CA) at 37 ...
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