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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Jul 2015.

Uromodulin

THP, Gli2, Tamm-Horsfall glycoprotein, uromodulin, THP1
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Interleukin-6, HAD, ACID
Papers using THP antibodies
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
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Jagannath Chinnaswamy et al., In Frontiers in Microbiology, 2008
... Human THP-1 monocytoid cell line (TIB#3456, ATCC, MD, USA) was maintained at 37°C and 5% CO2 in HEPES buffered RPMI-1640 (Sigma Aldrich, St Louis, MO, USA) ...
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
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Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... 2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, Uscn), and very low-density lipoprotein (VLDL, E1847r, EIAab) were used for the ...
Rationale for the use of mitoxantrone in multiple sclerosis
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Christopherson Kent W. et al., In Advances in Hematology, 2003
... AML cell lines, HL-60 and THP-1, were obtained from ATCC (Manassas, VA) and cultured in RPMI 1640 medium (with phenol red) (Thermo Scientific Hyclone, Logan, UT) supplemented ...
Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis
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Villaggio Barbara et al., In Arthritis Research & Therapy, 1999
... After that time samples of THP-1 cells were also treated with an apoptosis inducer [25], staurosporine (17 nM; Sigma Aldrich), for 24 hours ...
Flow cytometry in the study of cell death.
Supplier
Av-Gay Yossef et al., In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
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Papers on THP
Uromodulin: from monogenic to multifactorial diseases.
Review
New
Ghiggeri et al., Brescia, Italy. In Nephrol Dial Transplant, 31 Aug 2015
The exact role uromodulin (UMOD) plays in renal physiology remains enigmatic.
Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.
New
Agerberth et al., Huddinge, Sweden. In Autophagy, 28 Aug 2015
In addition, activation of LC3-II in primary macrophages and THP-1 cells was not detected.
Proteomics reveals a role for attachment in monocyte differentiation into efficient pro-inflammatory macrophages.
New
Zubarev et al., In J Proteome Res, 28 Aug 2015
Label-free proteomics of a model of human monocytes (THP-1 cell line) revealed that the cells remaining in suspension upon LPS treatment were activated by cytokines and primed for rapid responsiveness to pathogens.
A new pharmacological effect of levornidazole: inhibition of NLRP3 inflammasome activation.
New
Xu et al., Nanjing, China. In Biochem Pharmacol, 23 Aug 2015
The NLRP3 inflammasome could be activated by lipopolysaccharide (LPS) plus ATP or monosodium urate (MSU) in PMA-pretreated THP-1 macrophages.
Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses.
New
Yarchoan et al., Bethesda, United States. In Plos Pathog, 31 Jul 2015
The C-terminal peptide of LANA also inhibited interleukin-1beta (IL-1β) production from lipopolysaccharide-treated THP-1 cells by more than 50%.
Role of GLI2 in hypopituitarism phenotype.
Review
New
Jorge et al., São Paulo, Brazil. In J Mol Endocrinol, 30 Jun 2015
GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway.
Interactions between hormones and epilepsy.
Review
New
Svalheim et al., Oslo, Norway. In Seizure, May 2015
Progesterone and its main metabolite 5α-pregnan-3α-ol-20-one (3α-5α-THP) act mainly to enhance postsynaptic GABA-ergic activity, while androgens enhance GABA-activated currents.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Finally, we show that both classes of SMO variants respond to aPKC-ι/λ or GLI2 inhibitors that operate downstream of SMO, setting the stage for the clinical use of GLI antagonists.
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
New
Impact
de Sauvage et al., San Francisco, United States. In Cancer Cell, Apr 2015
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2.
Comparative Proteomics of Activated THP-1 Cells Infected with Mycobacterium tuberculosis Identifies Putative Clearance Biomarkers for Tuberculosis Treatment.
New
Faksri et al., Khon Kaen, Thailand. In Plos One, Dec 2014
Intracellular and secreted proteomes from activated THP-1 cells infected with the Mtb H37Rv strain (MOI = 1) and treated with isoniazid and rifampicin for 1 day (infection stage) and 5 days (clearance stage) were analyzed.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
New
Impact
Yang et al., Houston, United States. In Cell, Dec 2014
This mechanism activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Beyond tissue injury-damage-associated molecular patterns, toll-like receptors, and inflammasomes also drive regeneration and fibrosis.
Review
New
Schaefer et al., München, Germany. In J Am Soc Nephrol, Jul 2014
Kidney-specific DAMPs include crystals and uromodulin released by renal tubular damage.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
New
Impact
Cho et al., Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
New
Impact
ICGC PedBrain Tumor Project et al., Heidelberg, Germany. In Cancer Cell, Apr 2014
Children >3 years old harbored an excess of downstream MYCN and GLI2 amplifications and frequent TP53 mutations, often in the germline, all of which were rare in infants and adults.
Genome-wide (over)view on the actions of vitamin D.
Review
Carlberg, Kuopio, Finland. In Front Physiol, 2013
Chromatin immunoprecipitation sequencing (ChIP-seq) in GM10855 and GM10861 lymphoblastoid cells, undifferentiated and lipopolysaccharide-differentiated THP-1 monocytes, LS180 colorectal cancer cells and LX2 hepatic stellate cells revealed between 1000 and 13,000 VDR-specific genomic binding sites.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
GeneRIF
Wang et al., Jinan, China. In J Biol Chem, 2012
SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5.
The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies.
GeneRIF
Danilewicz et al., Łódź, Poland. In Pol J Pathol, 2012
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group
Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.
GeneRIF
Fox et al., Baltimore, United States. In Plos One, 2011
association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants in UMOD gene
More papers using THP antibodies
Decreased Tamm-Horsfall protein in lithiasic patients
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Gam Lay-Harn et al., In International Journal of Biological Sciences, 1996
... The primary antibody was a polyclonal anti-THP antibody (Biomedical Technologies Inc, USA) raised ...
The hemolytic syndrome in subacute bacterial endocarditis
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Kachlany Scott C. et al., In Toxins, 1978
... HL-60, THP-1, and K562 cells were maintained in RPMI 1640 medium with 10% fetal bovine serum (Life Technologies, Carlsbad, CA) at 37 ...
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