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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

Uromodulin

THP, Gli2, Tamm-Horsfall glycoprotein, uromodulin, THP1
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, Interleukin-6, HAD, ACID
Papers using THP antibodies
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
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Jagannath Chinnaswamy et al., In Frontiers in Microbiology, 2008
... Human THP-1 monocytoid cell line (TIB#3456, ATCC, MD, USA) was maintained at 37°C and 5% CO2 in HEPES buffered RPMI-1640 (Sigma Aldrich, St Louis, MO, USA) ...
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
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Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... 2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, Uscn), and very low-density lipoprotein (VLDL, E1847r, EIAab) were used for the ...
Rationale for the use of mitoxantrone in multiple sclerosis
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Christopherson Kent W. et al., In Advances in Hematology, 2003
... AML cell lines, HL-60 and THP-1, were obtained from ATCC (Manassas, VA) and cultured in RPMI 1640 medium (with phenol red) (Thermo Scientific Hyclone, Logan, UT) supplemented ...
Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis
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Villaggio Barbara et al., In Arthritis Research & Therapy, 1999
... After that time samples of THP-1 cells were also treated with an apoptosis inducer [25], staurosporine (17 nM; Sigma Aldrich), for 24 hours ...
Flow cytometry in the study of cell death.
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Av-Gay Yossef et al., In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
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Papers on THP
Tissue-specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans.
New
Das et al., Winston-Salem, United States. In J Clin Endocrinol Metab, Feb 2016
Abrogation of NINJ1 induction in THP1 macrophages modulated expression of genes in chemokine signaling, cell adhesion, and angiogenesis pathways.
Spatane diterpinoid from the brown algae, Stoechospermum marginatum induces apoptosis via ROS induced mitochondrial mediated caspase dependent pathway in murine B16F10 melanoma cells.
New
Janapala et al., Hyderābād, India. In Mol Carcinog, Feb 2016
Thus, in the present study, the apoptotic mechanism of a spatane diterpinoid, 5(R), 19-diacetoxy-15,18(R and S), dihydro spata-13, 16(E)-diene (DDSD) was investigated mainly in B16F10 melanoma cells because they were most susceptible to DDSD than THP1, U937, COLO205, and HL60 cells.
Notch1 Inhibition Reduces Low Shear Stress-Induced Plaque Formation.
New
Zhang et al., Jinan, China. In Int J Biochem Cell Biol, Feb 2016
Compared with USS, LSS increased inflammatory response, including IL-1β and IL-6 secretion, ICAM-1 and inducible nitric oxide synthase (iNOS) expression, and THP-1 cells adhesion.
Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.
New
Hao et al., Nanjing, China. In Sci Rep, Dec 2015
In vitro study demonstrated that Rg1 pretreatment on activated THP-1 monocytes retarded their ability to trigger CCL2 secretion from co-cultured U251 MG astrocytes.
Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System.
New
Herrup et al., Hong Kong, Hong Kong. In Plos One, Dec 2015
Individual cytokines or conditioned medium from β-amyloid-stimulated THP-1 cells that were, potent neurotoxins in normal, mixed cultures, were virtually inactive in the absence of glial cells.
The vitamin D-dependent transcriptome of human monocytes.
Review
New
Carlberg et al., Kuopio, Finland. In J Steroid Biochem Mol Biol, Nov 2015
THP-1 cells are an established model of human monocytes, for which the at present largest set of 1,25(OH)2D3-affected genome-wide data are available.
Reporter cell lines for skin sensitization testing.
Review
New
Emter et al., Dübendorf, Switzerland. In Arch Toxicol, Oct 2015
An alternative approach (THP-G8) was recently developed based on activation of the Interleukin-8 gene.
Cost-Effectiveness of Pertuzumab in Human Epidermal Growth Factor Receptor 2 -Positive Metastatic Breast Cancer.
New
Impact
Horst et al., Stanford, United States. In J Clin Oncol, Oct 2015
PURPOSE: The Clinical Evaluation of Pertuzumab and Trastuzumab (CLEOPATRA) study showed a 15.7-month survival benefit with the addition of pertuzumab to docetaxel and trastuzumab (THP) as first-line treatment for patients with human epidermal growth factor receptor 2 (HER2) -overexpressing metastatic breast cancer.
Real-time imaging of microparticles and living cells with CMOS nanocapacitor arrays.
New
Impact
Widdershoven et al., Enschede, Netherlands. In Nat Nanotechnol, Sep 2015
With our platform, we image the dynamic attachment and micromotion of BEAS, THP1 and MCF7 cancer cell lines in real time at submicrometre resolution in growth medium, demonstrating the potential of the platform for label/tracer-free high-throughput screening of anti-tumour drug candidates.
Role of GLI2 in hypopituitarism phenotype.
Review
New
Jorge et al., São Paulo, Brazil. In J Mol Endocrinol, Jun 2015
GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Finally, we show that both classes of SMO variants respond to aPKC-ι/λ or GLI2 inhibitors that operate downstream of SMO, setting the stage for the clinical use of GLI antagonists.
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
New
Impact
de Sauvage et al., San Francisco, United States. In Cancer Cell, Apr 2015
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2.
From Ancient Chinese Medicine to a Novel Approach to Treat Cocaine Addiction.
Review
Yao et al., Foster City, United States. In Cns Neurol Disord Drug Targets, 2014
The mechanism of action of ALDH2i depends on inhibiting dopamine aldehyde (DOPAL) clearance by ALDH2, enabling unmetabolized DOPAL to condense with DA to generate tetrahydropapaveroline (THP).
Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance.
Review
Athar et al., Mobile, United States. In Cancers (basel), 2014
The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and GLI3.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
Impact
Yang et al., Houston, United States. In Cell, 2014
This mechanism activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
GeneRIF
Wang et al., Jinan, China. In J Biol Chem, 2012
SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5.
The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies.
GeneRIF
Danilewicz et al., Łódź, Poland. In Pol J Pathol, 2012
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group
Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.
GeneRIF
Fox et al., Baltimore, United States. In Plos One, 2011
association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants in UMOD gene
More papers using THP antibodies
Decreased Tamm-Horsfall protein in lithiasic patients
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Gam Lay-Harn et al., In International Journal of Biological Sciences, 1996
... The primary antibody was a polyclonal anti-THP antibody (Biomedical Technologies Inc, USA) raised ...
The hemolytic syndrome in subacute bacterial endocarditis
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Kachlany Scott C. et al., In Toxins, 1978
... HL-60, THP-1, and K562 cells were maintained in RPMI 1640 medium with 10% fetal bovine serum (Life Technologies, Carlsbad, CA) at 37 ...
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