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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Sep 2015.

Uromodulin

THP, Gli2, Tamm-Horsfall glycoprotein, uromodulin, THP1
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, Interleukin-6, HAD, ACID
Papers using THP antibodies
Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin
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Jagannath Chinnaswamy et al., In Frontiers in Microbiology, 2008
... Human THP-1 monocytoid cell line (TIB#3456, ATCC, MD, USA) was maintained at 37°C and 5% CO2 in HEPES buffered RPMI-1640 (Sigma Aldrich, St Louis, MO, USA) ...
The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
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Kong Ling-Dong et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... 2-MG, E0260r, EIAab) and uromodulin (UMOD, E96918Ra, Uscn), and very low-density lipoprotein (VLDL, E1847r, EIAab) were used for the ...
Rationale for the use of mitoxantrone in multiple sclerosis
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Christopherson Kent W. et al., In Advances in Hematology, 2003
... AML cell lines, HL-60 and THP-1, were obtained from ATCC (Manassas, VA) and cultured in RPMI 1640 medium (with phenol red) (Thermo Scientific Hyclone, Logan, UT) supplemented ...
Estrogen and progesterone regulation of human fibroblast-like synoviocyte function in vitro: implications in rheumatoid arthritis
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Villaggio Barbara et al., In Arthritis Research & Therapy, 1999
... After that time samples of THP-1 cells were also treated with an apoptosis inducer [25], staurosporine (17 nM; Sigma Aldrich), for 24 hours ...
Flow cytometry in the study of cell death.
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Av-Gay Yossef et al., In Biological Procedures Online, 1999
... Monocytic cell line THP-1 (ATCC 202, Rockville, MA) was cultured in RPMI 1640 (Hyclone, Logan, UT) supplemented with 5% Fetal calf serum (FCS), (Hyclone, Logan, UT), and 2 mM L-glutamine (StemCell Technologies, Vancouver, BC) ...
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Papers on THP
Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease.
New
Kim et al., Seoul, South Korea. In J Immunol, 01 Oct 2015
In THP-1 cells and human blood monocytes treated with LPS, inwardly rectifying K(+) channel current (IKir,LPS) newly emerged at 1 h, peaked at 4 h (-119 ± 8.6 pA/pF), and decayed afterward (-32 ± 6.7 pA/pF at 24 h).
miR-155 is upregulated in patients with active tuberculosis and inhibits apoptosis of monocytes by targeting FOXO3.
New
Xiao et al., Xinxiang, China. In Mol Med Report, 25 Sep 2015
Finally, an over‑expression plasmid was constructed, and THP-1 cells were transfected with control miRNA, miR‑155 and the plasmid, which revealed that miR‑155 inhibited the apoptosis of THP‑1 cells.
The polyphenol PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages.
New
Ritsch et al., Beijing, China. In Atherosclerosis, 20 Sep 2015
METHODS AND RESULTS: We showed that PGG not only induced expression of SR-BI and ABCA1 in J774 and THP-1 macrophages, but was able to reverse the ox-LDL down-regulated expression of SR-BI and ABCA1 in these cells.
Real-time imaging of microparticles and living cells with CMOS nanocapacitor arrays.
New
Impact
Widdershoven et al., Enschede, Netherlands. In Nat Nanotechnol, 03 Sep 2015
With our platform, we image the dynamic attachment and micromotion of BEAS, THP1 and MCF7 cancer cell lines in real time at submicrometre resolution in growth medium, demonstrating the potential of the platform for label/tracer-free high-throughput screening of anti-tumour drug candidates.
In Vitro Infectivity Assessment by Drug Susceptibility Comparison of Recombinant Leishmania major Expressing Enhanced Green Fluorescent Protein or EGFP-Luciferase Fused Genes with Wild-Type Parasite.
New
Taheri et al., Tehrān, Iran. In Korean J Parasitol, 31 Aug 2015
To study the amastigote form, both B10R and THP-1 macrophage cell lines were infected in the stationary phase and were exposed to AmB at different time points.
Uromodulin: from monogenic to multifactorial diseases.
Review
New
Ghiggeri et al., Brescia, Italy. In Nephrol Dial Transplant, 31 Aug 2015
The exact role uromodulin (UMOD) plays in renal physiology remains enigmatic.
Role of GLI2 in hypopituitarism phenotype.
Review
New
Jorge et al., São Paulo, Brazil. In J Mol Endocrinol, Jun 2015
GLI2 is a zinc-finger transcription factor involved in the Sonic Hedgehog pathway.
Interactions between hormones and epilepsy.
Review
New
Svalheim et al., Oslo, Norway. In Seizure, May 2015
Progesterone and its main metabolite 5α-pregnan-3α-ol-20-one (3α-5α-THP) act mainly to enhance postsynaptic GABA-ergic activity, while androgens enhance GABA-activated currents.
Genomic analysis of smoothened inhibitor resistance in basal cell carcinoma.
New
Impact
de Sauvage et al., San Francisco, United States. In Cancer Cell, Apr 2015
Genomic analysis of tumor biopsies revealed that vismodegib resistance is associated with Hedgehog (Hh) pathway reactivation, predominantly through mutation of the drug target SMO and to a lesser extent through concurrent copy number changes in SUFU and GLI2.
Smoothened variants explain the majority of drug resistance in basal cell carcinoma.
New
Impact
Tang et al., Stanford, United States. In Cancer Cell, Apr 2015
Finally, we show that both classes of SMO variants respond to aPKC-ι/λ or GLI2 inhibitors that operate downstream of SMO, setting the stage for the clinical use of GLI antagonists.
Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes.
New
Tan et al., Hong Kong, Hong Kong. In Plos One, Dec 2014
METHODS: Constitutive and insulin-induced shedding of RAGE in THP-1 macrophages by ADAM10 was evaluated using an ADAM10-specific metalloproteinase inhibitor.
lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.
New
Impact
Yang et al., Houston, United States. In Cell, Dec 2014
This mechanism activates a noncanonical Hedgehog/GLI2 transcriptional program that promotes cell migration.
Potential effect and mechanism of action of topical chamomile (Matricaria chammomila L.) oil on migraine headache: A medical hypothesis.
Review
New
Mohagheghzadeh et al., Shīrāz, Iran. In Med Hypotheses, Nov 2014
It probably possesses pain relief effects for migraines because of the following properties: (1) chamazulene and apigenin, which inhibit iNOS expression in activated macrophages and can lead to the prohibition of NO release and synthesis; (2) chamomile flavonoids, which have a strong inhibitory effect on endogenous prostaglandin E2 (PGE2) levels in RAW 264.7 macrophages and can play the role of selective COX-2 inhibitor; (3) chamomile polyphenols, which possess anti-inflammatory effects due to the inhibition of pro-inflammatory biomarkers in THP1 macrophages and which can reduce inflammation in neurovascular units (NVU) at the site of migraine pain; (4) chamomile, which has neuroprotective effects because of reduced NO levels; (5) sesamine in sesame oil, which possesses an anti-inflammatory effect.
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.
New
Impact
Cho et al., Stanford, United States. In Nat Med, Jul 2014
We show that BRD4 and other BET bromodomain proteins regulate GLI transcription downstream of SMO and suppressor of fused (SUFU), and chromatin immunoprecipitation studies reveal that BRD4 directly occupies GLI1 and GLI2 promoters, with a substantial decrease in engagement of these sites after treatment with JQ1, a small-molecule inhibitor targeting BRD4.
Genome-wide (over)view on the actions of vitamin D.
Review
Carlberg, Kuopio, Finland. In Front Physiol, 2013
Chromatin immunoprecipitation sequencing (ChIP-seq) in GM10855 and GM10861 lymphoblastoid cells, undifferentiated and lipopolysaccharide-differentiated THP-1 monocytes, LS180 colorectal cancer cells and LX2 hepatic stellate cells revealed between 1000 and 13,000 VDR-specific genomic binding sites.
Limb anterior-posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3.
GeneRIF
Joyner et al., New York City, United States. In Dev Biol, 2012
Establishment of a complete range of anterior-posterior positional identities in the embryonic limb requires integration of the spatial distribution, timing, and dosage of GLI2 and GLI3 activators and repressors.
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
GeneRIF
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Small ubiquitin-like Modifier (SUMO) modification inhibits GLI2 protein transcriptional activity in vitro and in vivo.
GeneRIF
Wang et al., Jinan, China. In J Biol Chem, 2012
SUMO modification inhibits GLI2 transcriptional activity by recruiting HDAC5.
The immunoexpression of Shh, Smo and Gli2 in Helicobacter pylori positive and negative gastric biopsies.
GeneRIF
Danilewicz et al., Łódź, Poland. In Pol J Pathol, 2012
The immunoexpression of Shh, Smo and Gli2 proteins was lower in Helicobacter pylori-positive group compared to Helicobacter pylori-negative group
Association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants identified by UMOD gene region sequencing.
GeneRIF
Fox et al., Baltimore, United States. In Plos One, 2011
association of estimated glomerular filtration rate and urinary uromodulin concentrations with rare variants in UMOD gene
More papers using THP antibodies
Decreased Tamm-Horsfall protein in lithiasic patients
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Gam Lay-Harn et al., In International Journal of Biological Sciences, 1996
... The primary antibody was a polyclonal anti-THP antibody (Biomedical Technologies Inc, USA) raised ...
The hemolytic syndrome in subacute bacterial endocarditis
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Kachlany Scott C. et al., In Toxins, 1978
... HL-60, THP-1, and K562 cells were maintained in RPMI 1640 medium with 10% fetal bovine serum (Life Technologies, Carlsbad, CA) at 37 ...
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