GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Thioredoxin
Thioredoxin, SASP
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] (from
NCBI)
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Top mentioned proteins:
ACID, CAN, HAD, V1a, Interleukin-6
Papers using
Thioredoxin
antibodies
Double blind, placebo controlled study of metronidazole as a disease modifying agent in the treatment of rheumatoid arthritis
Supplier
In Arthritis Research & Therapy, 1991
... Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1 ...
Papers on
Thioredoxin
Radiation-induced loss of salivary gland function is driven by cellular senescence and prevented by IL-6 modulation.
New
In Cancer Res, Feb 2016
We demonstrate that the loss of salivary function was closely accompanied by cellular senescence, as evidenced by a persistent DNA damage response (γH2AX, 53BP1) and the expression of senescence-associated markers (SA-βgal, p19ARF, DcR2) and secretory phenotype (SASP) factors (PAI-1, IL-6).
Metformin inhibits the pro-metastatic effect of Sorafenib in hepatocellular carcinoma by upregulating the expression of TIP30.
New
Tianjin, China. In Cancer Sci, Feb 2016
Thioredoxin, a pro-metastasis factor, is negatively regulated by TIP30 and plays an essential role during the process of HCC metastasis.
Conferring specificity in redox pathways by enzymatic thiol/disulfide exchange reactions.
Review
New
São Paulo, Brazil. In Free Radic Res, Feb 2016
Thioredoxin (Trx) proteins were the first enzymes described to accelerate thiol-disulfide exchange reactions and their high reactivity is related to the high nucleophilicity of the attacking thiol.
Upregulation of connexin43 contributes to PX-12-induced oxidative cell death.
New
Japan. In Tumour Biol, Jan 2016
UNASSIGNED: Thioredoxin (Trx) is a small redox protein that underlies aggressive tumor growth and resistance to chemotherapy.
The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen.
New
Kunming, China. In Drug Alcohol Depend, Dec 2015
Thioredoxin-1 (Trx-1) plays the roles in regulating redox and inhibiting inflammation.
DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging.
Review
New
Ancona, Italy. In Oncotarget, Dec 2015
DDR activation in senescent cells promotes acquisition of a proinflammatory secretory phenotype (SASP), which in turn elicits DDR and SASP activation in neighboring cells, thereby creating a proinflammatory environment extending at the local and eventually the systemic level.
From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes.
Review
New
Suwŏn, South Korea. In Bmb Rep, Oct 2015
The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines.
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
New
Impact
Boston, United States. In Science, Oct 2015
A striking feature of senescence is the senescence-associated secretory phenotype (SASP), a pro-inflammatory response linked to tumor promotion and aging.
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.
New
Impact
Tübingen, Germany. In Nat Cell Biol, Sep 2015
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP).
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
New
Impact
Novato, United States. In Nat Cell Biol, Aug 2015
However, as senescent cells accumulate with age, the senescence-associated secretory phenotype (SASP) can disrupt tissues and contribute to age-related pathologies, including cancer.
Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways.
Memphis, United States. In Acta Neuropathol Commun, 2014
Furthermore, IGFBP7 and CEBPB, which are transcriptional inducers of the senescence-associated secretory phenotype (SASP), were also up-regulated together with the markers of senescence and inflammation, CDKN1A (p21), CDKN2A (p16) and IL1B.
Thioredoxin from Escherichia coli as a Role Model of Molecular Recognition, Folding, Dynamics and Function.
Review
Buenos Aires, Argentina. In Protein Pept Lett, 2014
Thioredoxin (TRX) catalyzes redox reactions via the reversible oxidation of the conserved active center CGPC and it is involved in multiple biological processes, some of them linked to redox activity while others not.
Stress induced premature senescence: a new culprit in ovarian tumorigenesis?
Review
Mumbai, India. In Indian J Med Res, 2014
Besides persistent double strand (ds) DNA breaks and increased β-galactosidase activity, biological significance of telomeric attrition in conjunction with senescence associated secretory phenotype (SASP) has been highlighted in SIPS.
Senescence is a developmental mechanism that contributes to embryonic growth and patterning.
Impact
Barcelona, Spain. In Cell, 2013
Embryonic senescent cells are nonproliferative and share features with oncogene-induced senescence (OIS), including expression of p21, p15, and mediators of the senescence-associated secretory phenotype (SASP).
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Impact
Berlin, Germany. In Nature, 2013
We demonstrate that this is linked to massive proteotoxic stress, which is a consequence of the senescence-associated secretory phenotype (SASP) described previously.
TrxG and PcG proteins but not methylated histones remain associated with DNA through replication.
Impact
GeneRIF
Philadelphia, United States. In Cell, 2012
Data imply that Trx, Pc, and E(z) remain bound or rapidly rebind to nascent DNA in the absence of trimethylated histones during DNA replication in Drosophila embryos.
Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P₂ and PI(5)P.
GeneRIF
Ann Arbor, United States. In Embo J, 2012
Thus, VAC14, PI(3,5)P(2) and/or PI(5)P play a role in controlling postsynaptic function via regulation of endocytic cycling of AMPA receptors.
Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis.
GeneRIF
Paris, France. In Arterioscler Thromb Vasc Biol, 2012
The ability of Trx-1 to promote differentiation of macrophages into an alternative, anti-inflammatory phenotype may explain its protective effects in cardiovascular diseases.
Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma.
GeneRIF
Houston, United States. In Oncotarget, 2012
Trx-1 plays a key role in cell growth and survival, as well as chemoresistance, and is a potential target to overcome drug resistance in relapsed/refractory Diffuse large B-cell lymphoma.
Structural insights into interaction between mammalian methionine sulfoxide reductase B1 and thioredoxin.
GeneRIF
Trondheim, Norway. In J Biomed Biotechnol, 2011
MsrB1/Trx complex was studied in attempt to understand MsrB1 reduction mechanism. Using NMR data, molecular mechanics, protein docking & molecular dynamics simulations, found that intermediate MsrB1/Trx complex is stabilized by interprotein beta-layer.
