The thioredoxin antioxidant system.
Stockholm, Sweden. In Free Radic Biol Med, 2014
In mammalian cells, the cytosolic and mitochondrial Trx systems, in which TrxRs are high molecular weight selenoenzymes, together with the glutathione-glutaredoxin (Grx) system (NADPH, glutathione reductase, GSH, and Grx) control the cellular redox environment.
Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Chicago, United States. In Antioxid Redox Signal, 2013
Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).