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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Acetyl-CoA acyltransferase 1

Thio, peroxisomal 3-oxoacyl-CoA thiolase, ACAA
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, POLYMERASE
Papers on Thio
Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency.
New
Utz et al., Cambridge, United Kingdom. In J Allergy Clin Immunol, Jan 2016
OBJECTIVE: We profiled ACAAs in a diverse cohort of serum samples from patients with immunodeficiency and assessed the sensitivity and specificity of protein microarrays for ACAA identification and discovery.
[Mechanism of thioridazine plus medroxyprogesterone in the treatment of endometrial cancer].
New
Wang et al., Shanghai, China. In Zhonghua Yi Xue Za Zhi, Jun 2015
OBJECTIVE: To explore the in vitro effects of thioridazine (THIO) plus medroxyprogesterone (MPA) on the proliferation and apoptosis of endometrial cancer cell lines (Ishikawa & KLE) and examine the mechanism in the treatment of endometrial cancer.
Thio Derivatives of 2(5H)-Furanone as Inhibitors against Bacillus subtilis Biofilms.
New
Kayumov et al., Kazan', Russia. In Acta Naturae, Apr 2015
Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections.
Thio- and selenoglycosides as ligands for biomedically relevant lectins: valency-activity correlations for benzene-based dithiogalactoside clusters and first assessment for (di)selenodigalactosides.
New
Szilágyi et al., München, Germany. In Bioorg Med Chem Lett, Mar 2015
Substitution of the oxygen atom in the glycosidic linkage by a disulfide bond or by selenium makes the resulting glycoside resistant to hydrolysis.
Screening of bisphenol A, triclosan and paraben analogues as modulators of the glucocorticoid and androgen receptor activities.
New
Sollner Dolenc et al., Ljubljana, Slovenia. In Toxicol In Vitro, Feb 2015
Two new antiandrogens, 4,4'-sulfonylbis(2-methylphenol) (dBPS) and 4,4'-thiodiphenol (THIO), and two new antiglucocorticoids, bisphenol Z and its analog bis[4-(2-hydroxyethoxy)phenyl] sulfone (BHEPS) were identified.
Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain.
Jensen et al., Copenhagen, Denmark. In J Neurosci, 2015
In the present study, the orthosteric GABAA receptor (GABAAR) ligand 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol (Thio-THIP) was found to possess a highly interesting functional profile at recombinant human GABAARs and native rat GABAARs.
The Antiproliferative and Pro-apoptotic Effects of Methoxyamine on Pediatric Medulloblastoma Cell Lines Exposed to Ionizing Radiation and Chemotherapy.
Brassesco et al., Ribeirão Preto, Brazil. In Cent Nerv Syst Agents Med Chem, 2014
The DAOY (a desmoplastic cerebellar-derived MB) and ONS-76 (classical MB) cell lines were treated with MX at different concentrations, either alone or combined with various chemotherapeutic compounds: cisplatin (CDDP), temozolomide (TMZ) and thiotepa (THIO).
Profiling of cell stress protein expression in cardiac tissue of cardiosurgical patients undergoing remote ischemic preconditioning: implications for thioredoxin in cardioprotection.
Albrecht et al., Kiel, Germany. In J Transl Med, 2014
Cell stress proteome profiler arrays as well as Westernblotting and ELISA experiments for thioredoxin (Thio-1) were performed employing the respective tissue samples.
Rifampin induces hydroxyl radical formation in Mycobacterium tuberculosis.
Fattorini et al., Roma, Italy. In Antimicrob Agents Chemother, 2014
Lysate pretreatment with the O2·(-) and ·OH scavengers superoxide dismutase (SOD) and thiourea (THIO), respectively, or with the metal chelator diethylene triamine pentaacetic acid (DTPA) inhibited CP· formation, arguing in favor of a metal-catalyzed ROS response.
Thiopurines induce oxidative stress in T-lymphocytes: a proteomic approach.
Asif et al., Göttingen, Germany. In Mediators Inflamm, 2014
Three proteins (THIO, TXD17, and GSTM3) with putative functions in cellular oxidative stress responses were altered by 6-TG treatment and another protein PRDX3 was differentially phosphorylated in TPMT kd cells.
Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols.
Ozoe et al., Tottori, Japan. In Bioorg Med Chem, 2014
Several 4-substituted analogs of the partial GABAA receptor agonist 5-(4-piperidyl)-3-isothiazolol (Thio-4-PIOL) were synthesized and examined for their antagonism of insect GABA receptors expressed in Drosophila S2 cells or Xenopus oocytes.
Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1.
GeneRIF
Litonjua et al., Boston, United States. In Bmc Med Genet, 2010
Findings suggest that protective effects of endotoxin exposure on asthma may vary depending upon the presence or absence of a polymorphism in ACAA1.
Palmitoyl acyltransferases, their substrates, and novel assays to connect them (Review).
Review
Zacharias et al., Scranton, United States. In Mol Membr Biol, 2009
Thio-palmitoylation is the post-translational addition of the 16-carbon fatty acid, palmitate, to the thiol side chain of cysteine residues by a labile thioester bond.
Thiasugars: potential glycosidase inhibitors.
Review
Hashimoto et al., Yokohama, Japan. In Curr Top Med Chem, 2008
5-Thio-L-fucose, the ring sulfur analog of L-fucose, was the first thiopyran that shows a K(i) value in the micromolar range against a glycosidase.
Gateways to clinical trials.
Review
Prous et al., Barcelona, Spain. In Methods Find Exp Clin Pharmacol, 2004
This issue focuses on the following selection of drugs: Abetimus sodium, Ad5-FGF4, adeno-Interferon gamma, AE-941, AERx, alemtuzumab, alicaforsen sodium, almotriptan, alpharadin, anakinra, anatumomab mafenatox, ANG-453, anti-CTLA-4 Mab, AP-12009, aprepitant, aripiprazole, arsenic trioxide, astemizole, atlizumab, atomoxetine hydrochloride; Bevacizumab, BG-9928, BMS-188667, botulinum toxin type B, BufferGel; Caffeine, CDP-870, cetuximab, cilomilast, ciluprevir, clofarabine, continuous erythropoiesis receptor activator, CP-461; Darbepoetin alfa, deferasirox, desloratadine, desoxyepothilone B, diflomotecan, dolasetron, drotrecogin alfa (activated), duloxetine hydrochloride; ED-71, efalizumab, efaproxiral sodium, EKB-569, eletriptan, EMD-72000, enfuvirtide, erlotinib hydrochloride, escitalopram oxalate, etoricoxib; Fampridine, ferumoxytol, fondaparinux sodium; Gadofosveset sodium, gastrazole, gefitinib, gemtuzumab ozogamicin, gepirone hydrochloride glutamine; hLM609, HSPPC-96, human insulin; IDD-1, imatinib mesylate, indisulam, inhaled insulin, ixabepilone; Keratinocyte growth factor; Lapatinib, laquinimod, LDP-02, LE-SN38, levetiracetam, levosimendan, licofelone, liposomal doxorubicin, liposomal NDDP, lopinavir, lumiracoxib, LY-156735; Morphine hydrochloride, morphine-6-glucuronide, motexafin gadolinium, MS-27-275, MVA-5T4, MVA-Muc1-IL-2; Nemifitide ditriflutate, neridronic acid nitronaproxen, NSC-683864, NSC-703940, NVP-LAF-237; Oblimersen sodium, ocinaplon, oncomyc-NG, OPC-28326, ortataxel, ospemifene; Palonosetron hydrochloride, PEG-filgrastim peginterferon alfa-2(a), peginterferon alfa-2b, pegsunercept, pemetrexed disodium, pregabalin, prilocaine, pyridoxamine; RDP-58, recombinant glucagon-like peptide-1 (7-36) amide, recombinant human ApoA-I milano/phospholipid complex; SB-715992, soblidotin, sodium dichloroacetate, St. John's Wort extract; TAS-102, terfenadine, TG-1024, TG-5001, 4'-Thio-ara-C, tipranavir, topixantrone hydrochloride, trabectedin, transdermal selegiline, trimethoprim, troxacitabine, TT-232; Vatalanib succinate, vinflunine; Ximelagatran; Ziprasidone hydrochloride, Zoledronic acid monohydrate.
5-Thio-D-glucose selectively potentiates hyperthermic killing of hypoxic tumor cells.
Impact
Song et al., In Science, 1978
To investigate the mechanisms by which heat affects cancer cells, we used 5-thio-D-glucose, an inhibitor of glycolysis in HeLa S-3 cells, under aerobic and hypoxic conditions at temperatures ranging from 37 degrees to 43 degrees C. Drug alone or heat alone killed a minimum number of cells under aerobic or hypoxic conditions.
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