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Potassium channel, subfamily K, member 12

THIK-2, KCNK12, hTHIK-2
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, THIK-1, TREK-1, MSH2, OUT
Papers on THIK-2
New DNA Methylation Markers for Pancreatic Cancer: Discovery, Tissue Validation, and Pilot Testing in Pancreatic Juice.
New
Ahlquist et al., Rochester, United States. In Clin Cancer Res, Nov 2015
Pancreatic juice AUC values for CD1D, KCNK12, CLEC11A, NDRG4, IKZF1, PKRCB, and KRAS were 0.92*, 0.88, 0.85, 0.85, 0.84, 0.83, and 0.75, respectively, for pancreatic cancer compared with normal pancreas and 0.92*, 0.73, 0.76, 0.85*, 0.73, 0.77, and 0.62 for pancreatic cancer compared with chronic pancreatitis (*, P = 0.001 vs. KRAS).
Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2.
Daut et al., Marburg an der Lahn, Germany. In Pflugers Arch, 2014
THIK-2 belongs to the 'silent' channels of the two-pore-domain potassium channel family.
DNA mismatch repair MSH2 gene-based SNP associated with different populations.
Reddy et al., Mecca, Saudi Arabia. In Mol Genet Genomics, 2014
An association analysis confirmed that the KCNK12 SNP variant (rs748780) was highly associated (p value 9 × 10(-4)) with the MSH2 gene for all three samples.
Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay.
Kim et al., Seoul, South Korea. In Ann Hematol, 2014
We identified a set of genes whose expression provided prognostic indicators from whole data set (PRKCDBP, CASP10, FAM3C, KCNK12, MAN1A2, PRND, RAB1A, TMEM39B, SLC6A6, MMP12, FEM1B, C3orh37, RBP1, HK1, LOC400464, KIAA0746, and SLC25A23).
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy.
Review
Du et al., Tianjin, China. In Surg Oncol, 2013
The involved genes in the significant gains aberrations include BIRC5, CCNE2, DAB2, DDX15, EGFR, DAB2, MSH2, CDK6, HGF, ITGB4, KCNK12, LAMA3, LOXL2, MET, and PDGFRA.
Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour.
Lawson et al., Bristol, United Kingdom. In Mol Cell Neurosci, 2012
This study is the first to demonstrate expression of THIK1, THIK2 and TWIK2 mRNA in DRGs.
Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer.
Siedlecki et al., Warsaw, Poland. In Mol Carcinog, 2011
The frequency of their promoter methylation was assessed in the larger group of patients (n = 77): KCNK12 (methylated in 41% of CRC patients), GPR101 (40%), CDH2 (45%), BARX1 (56%), CNTFR (22%), SYT6 (64%), SMO (21%), EPHA5 (43%), and GSPT2 (21%).
Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells.
Silva-Santos et al., Lisbon, Portugal. In Haematologica, 2010
Within this panel, 3 genes (ULBP1, TFR2 and IFITM1) were associated with increased susceptibility to Vgamma9Vdelta2 T-cell cytotoxicity, whereas the other 7 (CLEC2D, NRP2, SELL, PKD2, KCNK12, ITGA6 and SLAMF1) were enriched in resistant tumors.
A high-density association screen of 155 ion transport genes for involvement with common migraine.
Palotie et al., Brisbane, Australia. In Hum Mol Genet, 2008
SNPs within 12 genes (KCNB2, KCNQ3, CLIC5, ATP2C2, CACNA1E, CACNB2, KCNE2, KCNK12, KCNK2, KCNS3, SCN5A and SCN9A) with promising nominal association (0.00041 < P < 0.005) in the Finnish sample were selected for replication.
Microarray comparative genomic hybridization analysis of tubular breast carcinoma shows recurrent loss of the CDH13 locus on 16q.
Werner et al., Freiburg, Germany. In Hum Pathol, 2008
In the tubular breast carcinoma samples, the highest frequencies for DNA sequence copy number losses were detected for CDH13 (in 86% of the samples) and MSH2, KCNK12 (in 52% of the samples).
Changes in expression of some two-pore domain potassium channel genes (KCNK) in selected brain regions of developing mice.
Wisden et al., Heidelberg, Germany. In Neuroscience, 2008
THIK-2 mRNA was up-regulated with TASK-1 and TASK-3 transcripts in cerebella of GABAA receptor alpha6 subunit knockout mice, possibly implying a functional association of THIK-2, TASK-1 and TASK-3.
Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts.
John et al., Basel, Switzerland. In Bmc Genomics, 2007
Select findings of our analysis revealed that the G-protein coupled receptor GPR27 is entirely contained within a frame -1 matreshka, thrombopoietin contains a matreshka which spans ~70% of its length, platelet glycoprotein IIIa (ITGB3) contains a matreshka with the predicted characteristics of a secreted peptide hormone, while the potassium channel KCNK12 contains a matreshka spanning >400 amino acids.
Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
GeneRIF
Derst et al., Berlin, Germany. In Cell Physiol Biochem, 2007
THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.
Altschuler et al., Ann Arbor, United States. In Neuroscience, 2007
TASK-1, TASK-5 and THIK-2 showed significant decreases in expression at all three times assessed.
Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus.
Altschuler et al., Ann Arbor, United States. In Hear Res, 2006
TWIK-1 and THIK-2 also showed significant decreases in expression that were maintained across all time points.
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