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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Gamma-aminobutyric acid

THETA, GABRQ
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: ACID, fibrillin-1, AGE, Rdl, CAN
Papers on THETA
Lessons Learned from a Cross-Model Validation between a Discrete Event Simulation Model and a Cohort State-Transition Model for Personalized Breast Cancer Treatment.
New
Siebert et al., Boston, United States. In Med Decis Making, Nov 2015
We followed the International Society for Pharmacoeconomics and Outcomes Research-Society for Medical Decision Making (ISPOR-SMDM) best practice recommendations for validation and compared modeling results of the Oncotyrol model with the state-transition model developed by the Toronto Health Economics and Technology Assessment (THETA) Collaborative.
Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus.
New
Kim et al., Seoul, South Korea. In J Neurochem, May 2015
This study uses a quantitative real-time PCR approach, in combination with in vivo chromatin immunoprecipitation, and reveals that GABAA receptor subunit, GABRA2 (α2), GABRA4 (α4), and GABRQ (θ) genes, are transcriptional targets of Egr-1.
[THE DEPENDENCE OF THE DYNAMICS IN THE BAND OF THETA ON THE TIME DELAY AND LEVEL OF CONSISTENCY IN THE PRESENTATION OF THE ACOUSTIC IMAGE OWN EEG].
New
Klimenko et al., In Ross Fiziol Zh Im I M Sechenova, Apr 2015
Dynamics of activity in the frequency band of theta waves during of procedures, listening of the acoustic image of the own EEG was investigated.
Whole exome sequencing in females with autism implicates novel and candidate genes.
Manzardo et al., Kansas City, United States. In Int J Mol Sci, 2014
Five females presented with functional variants of X-linked genes (IL1RAPL1, PIR, GABRQ, GPRASP2, SYTL4) with cadherin, protocadherin and ankyrin repeat gene families most commonly altered (e.g., CDH6, FAT2, PCDH8, CTNNA3, ANKRD11).
Cost effectiveness of personalized treatment in women with early breast cancer: the application of OncotypeDX and Adjuvant! Online to guide adjuvant chemotherapy in Austria.
Siebert et al., Austria. In Springerplus, 2014
Results were compared to a Canadian analysis conducted by the Toronto Health Economics and Technology Assessment Collaborative (THETA).
Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts.
Campbell et al., Milwaukee, United States. In Prostaglandins Other Lipid Mediat, 2013
Previously, we showed that endothelium-targeted adenoviral vector-mediated gene transfer of the human 15-lipoxygenase-1 (h15-LO-1) enhances arterial relaxation through the production of vasodilatory hydroxyepoxyeicosatrienoic acid (HEETA) and trihydroxyeicosatrienoic acid (THETA) metabolites.
Analysis of the effects of rare variants on splicing identifies alterations in GABAA receptor genes in autism spectrum disorder individuals.
Rouleau et al., Montréal, Canada. In Eur J Hum Genet, 2013
We identified truncating mutations in distinct X-linked gamma-aminobutyric acid A (GABAA) receptor subunit-encoding genes, GABRQ and GABRA3, in two different families.
Inducible endothelium-derived hyperpolarizing factor: role of the 15-lipoxygenase-EDHF pathway.
Review
Gauthier et al., Milwaukee, United States. In J Cardiovasc Pharmacol, 2013
15(S)-Hydroxy-11,12-epoxyeicosatrienoic acid (15-H-11,12-EETA) and 11(R),12(S),15(S)-trihydroxyeicosatrienoic acid (11,12,15-THETA) are endothelial metabolites of the 15-lipoxygenase (15-LO) pathway of arachidonic acid metabolism and are EDHFs.
Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response.
Reynolds et al., Nanjing, China. In Pharmacogenomics, 2013
RESULTS: The single SNPs rs1954787 (GRIK4), rs1992647 (GABRA6), rs10036156 (GABRP) and rs3810651 (GABRQ) were significantly associated with antidepressant response, as were haplotypes in GRIK4 and GABRP genes.
Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.
Lemos et al., Porto, Portugal. In Plos One, 2012
Our aims were to assess the role of common variants of gamma-aminobutyric acid A receptor (GABAAR) genes, located in the X-chromosome, in migraine susceptibility and the possible interaction between them.
GABA stimulates human hepatocellular carcinoma growth through overexpressed GABAA receptor theta subunit.
GeneRIF
Li et al., Changsha, China. In World J Gastroenterol, 2012
GABRQ plays important roles in hepatocellular carcinoma development and progression
Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ receptor polymorphisms and risk for essential tremor.
GeneRIF
Jiménez-Jiménez et al., Badajoz, Spain. In Pharmacogenet Genomics, 2011
single nucleotide polymorphisms studied in the GABRA4, GABRE, and GABRQ genes are not related to the risk for familial ET.
Gene expression profiling for guiding adjuvant chemotherapy decisions in women with early breast cancer: an evidence-based and economic analysis.
Health Quality Ontario, In Ont Health Technol Assess Ser, 2009
For each technology, an economic analysis was also completed by the Toronto Health Economics and Technology Assessment Collaborative (THETA) and is summarized within the reports.THE FOLLOWING REPORTS CAN BE PUBLICLY ACCESSED AT THE MAS WEBSITE AT: www.health.gov.on.ca/mas or at www.health.gov.on.ca/english/providers/program/mas/mas_about.htmlGENE
KRAS Testing for Anti-EGFR Therapy in Advanced Colorectal Cancer: An Evidence-Based and Economic Analysis.
Health Quality Ontario, In Ont Health Technol Assess Ser, 2009
For each technology, an economic analysis was also completed by the Toronto Health Economics and Technology Assessment Collaborative (THETA) and is summarized within the reports.THE FOLLOWING REPORTS CAN BE PUBLICLY ACCESSED AT THE MAS WEBSITE AT: www.health.gov.on.ca/mas or at www.health.gov.on.ca/english/providers/program/mas/mas_about.htmlGENE
Epidermal Growth Factor Receptor Mutation (EGFR) Testing for Prediction of Response to EGFR-Targeting Tyrosine Kinase Inhibitor (TKI) Drugs in Patients with Advanced Non-Small-Cell Lung Cancer: An Evidence-Based Analysis.
Health Quality Ontario, In Ont Health Technol Assess Ser, 2009
For each technology, an economic analysis was also completed by the Toronto Health Economics and Technology Assessment Collaborative (THETA) and is summarized within the reports.THE FOLLOWING REPORTS CAN BE PUBLICLY ACCESSED AT THE MAS WEBSITE AT: http://www.health.gov.on.ca/mas or at www.health.gov.on.ca/english/providers/program/mas/mas_about.htmlGENE
Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone.
Review
Campbell et al., Milwaukee, United States. In Am J Physiol Heart Circ Physiol, 2009
Vasoactive 15-LO metabolites derived from the vascular endothelium include 15-hydroxy-11,12-epoxyeicosatrienoic acid (15-H-11,12-HEETA) that is hydrolyzed by soluble epoxide hydrolase to 11,12,15-trihydroxyeicosatrienoic acid (11,12,15-THETA).
Investigation of gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility.
GeneRIF
Griffiths et al., Gold Coast, Australia. In Bmc Med Genet, 2007
Although GABRQ genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility
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