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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Microtubule associated serine/threonine kinase-like

THC2, MASTL
This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010] (from NCBI)
Top mentioned proteins: PCNA, CDC2, ACID, thrombopoietin, Aurora
Papers on THC2
Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.
New
Beltinger et al., Ulm, Germany. In Cancer Lett, Mar 2016
Simulated activation of the serine/threonine protein kinase Greatwall (GWL, encoded by MASTL) that attenuates the pivotal AURKA inhibitor PP2A, predicted stabilization of AURKA.
Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening.
New
Greco et al., Milano, Italy. In Oncotarget, Nov 2015
Further analysis of three selected hit genes, namely Cyclin D1, MASTL and COPZ1, showed that they represent common vulnerabilities for thyroid tumor cells, as their inhibition reduced the viability of several thyroid tumor cell lines, regardless the histotype or oncogenic lesion.
Singlet ground state actinide chemistry with geminals.
New
Ayers et al., Hamilton, Canada. In Phys Chem Chem Phys, Jul 2015
Our study of the ground state spectroscopic constants (bond lengths and vibrational frequencies) and potential energy curves of actinide oxides (UO2(2+) and ThO2) as well as the energetic stability of ThC2 isomers reveals that vOO-AP1roG describes the electronic structure of heavy-element compounds accurately, at mean-field computational cost.
Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC.
New
Brakenhoff et al., Amsterdam, Netherlands. In Mol Cancer Ther, Jun 2015
Validation experiments showed that knockdown of expression of Forkhead box M1 (FOXM1) or microtubule-associated serine/threonine kinase-like (MASTL) indeed causes radiosensitization in a panel of NSCLC cells.
Distribution and predominance of genotype 3 in hepatitis C virus carriers in the province of kahramanmaras, Turkey.
New
Senol et al., Kahramanmaraş, Turkey. In Hepat Mon, Apr 2015
Urine samples from the patients were tested for amphetamine with an Amphetamines II (AMPS2) kit, cocaine was tested with a Cocaine II (COC2) kit, opiates were tested with an Opiates II (OPI2) kit, and cannabinoids were tested with a Cannabinoids II (THC2) kit in Roche/Hitachi Cobas c501 device.
MASTL promotes cyclin B1 destruction by enforcing Cdc20-independent binding of cyclin B1 to the APC/C.
Wolthuis et al., Amsterdam, Netherlands. In Biol Open, 2014
Here, we show that MASTL is essential for cyclin B1 recruitment to the mitotic APC/C and that this occurs entirely independently of Cdc20.
Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation.
Raslova et al., In J Clin Invest, 2014
Point mutations in the 5' UTR of ankyrin repeat domain 26 (ANKRD26) are associated with familial thrombocytopenia 2 (THC2) and a predisposition to leukemia.
ENSA expression correlates with attenuated tumor propagation in liver cancer.
Hsiao et al., Taiwan. In Biochem Biophys Res Commun, 2014
ENSA also interacts with microtubule-associated serine/threonine-protein kinase-like (MASTL) to regulate the cell cycle.
Structure induced Yb valence changes in the solid solution Yb(x)Ca(1-x)C2.
Ruschewitz et al., Köln, Germany. In Inorg Chem, 2013
Compounds with x ≥ 0.75 crystallize in the tetragonal CaC2 type structure (I4/mmm, Z = 2) and obey Vegard's law; for x ≤ 0.75 the monoclinic ThC2 type structure (C2/c, Z = 4) is found, which coexists with the monoclinic CaC2-III type structure (C2/m, Z = 4) for x ≤ 0.25.
[Mild bleeding diathesis in a 62-year-old woman with hereditary thrombocytopenia].
Najm et al., Worms, Germany. In Internist (berl), 2013
Due to the positive family history and normal thrombocyte morphology ANKRD26-associated thrombocytopenia 2 (THC2) was suspected.
Efavirenz interference in urine screening immunoassays for tetrahydrocannabinol.
Laurens et al., Pretoria, South Africa. In Ann Clin Biochem, 2012
METHODS: Random urine samples from 30 patients on EFV therapy were analysed for THC metabolites by two near-testing devices (THC One Step Marijuana and Rapid Response(®) Drugs of Abuse Test Strips) and two automated immunoassays (Roche Diagnostics Cannabinoids II and Beckman Coulter SYNCHRON(®) Systems THC2).
Theoretical study of the structure and bonding in ThC2 and UC2.
Konings et al., Karlsruhe, Germany. In J Phys Chem A, 2012
The electronic structure and various molecular properties of the actinide (An) dicarbides ThC(2) and UC(2) were investigated by relativistic quantum chemical calculations.
Monoclonal antibodies against Xenopus greatwall kinase.
Peng et al., Lincoln, United States. In Hybridoma (larchmt), 2011
Finally, we demonstrated the usefulness of the MAb against human Gwl/MASTL.
Thrombocytopenias due to gray platelet syndrome or THC2 mutations.
Review
GeneRIF
Johnson et al., Denver, United States. In Semin Thromb Hemost, 2011
Studies indicate that mutations in three different genes within the THC2 locus have been associated with congenital thrombocytopenia, including a mutation in MASTL.
Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families.
Savoia et al., Pavia, Italy. In Blood, 2011
Until recently, thrombocytopenia 2 (THC2) was considered an exceedingly rare form of autosomal dominant thrombocytopenia and only 2 families were known.
Characterization of the mechanisms controlling Greatwall activity.
GeneRIF
Castro et al., Montpellier, France. In Mol Cell Biol, 2011
results identify Gwl as a member of the AGC family of kinases that appears to be regulated by unique mechanisms and that differs from the other members of this family
MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis.
GeneRIF
Wolthuis et al., Amsterdam, Netherlands. In Cell Cycle, 2010
MASTL enhances cyclin B1-Cdk1-dependent mitotic phosphorylation events, directing mitotic entry, anaphase and cytokinesis in human cells.
In vivo inactivation of MASTL kinase results in thrombocytopenia.
GeneRIF
Drachman et al., Seattle, United States. In Exp Hematol, 2009
transient knockdown of MASTL correlates with a decrease in the expression of c-mpl and GpIIb, and reduction of circulating thrombocytes
FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10.
GeneRIF
Drachman et al., Seattle, United States. In Hum Hered, 2002
A paper that narrows the identity of the gene for autosomal dominant thrombocytopenia (THC2) to FLJ14813. The mutation is present in all affected people across three generations while is absent in unaffected family members & 94 random blood donors.
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