Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
In PLoS ONE, 2002
... (Santacruz, sc-1615), Nucleolin (Santacruz, sc13057), Lamin A (Santacruz, sc-20680), MEF2C (Abcam, ab65252), HDAC4 (Cell Signaling, #2072), HAND2 (Abcam, ab56590), Tropomyosin C (Santacruz, sc73225), ...
Targeting key proximal drivers of type 2 inflammation in disease.
New York City, United States. In Nat Rev Drug Discov, Jan 2016
Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging as a unifying feature of both classically defined allergic diseases, such as asthma, and a range of other inflammatory diseases.
Effect of allergen-specific immunotherapy on CD4+ T cells.
Seattle, United States. In Curr Opin Allergy Clin Immunol, Dec 2015
Recent studies have demonstrated that AIT may restore tolerance by transiently inducing interleukin (IL)-10 producing T cells followed by selective deletion of allergen-specific TH2 cell subset.
Innate and adaptive dendritic cell responses to immunotherapy.
Bethesda, United States. In Curr Opin Allergy Clin Immunol, Dec 2015
PURPOSE OF REVIEW: In allergic disease, dendritic cells play a critical role in orchestrating immune responses to innate stimuli and promoting the formation of T helper 2 (TH2) effector versus T-regulatory cells.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Boston, United States. In J Allergy Clin Immunol, Dec 2015
Conversely, certain innate factors, namely IL-25, IL-33, and thymic stromal lymphopoietin (TSLP), are elaborated by sinus epithelial cells in response to microbial stimulation or airway injury and promote local TH2 inflammation.