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Transglutaminase 7

TGZ, TG(Z), transglutaminase Z, TGM7
Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutaminases, see TGM1 (MIM 190195).[supplied by OMIM, Jul 2002] (from NCBI)
Top mentioned proteins: PPARgamma, PPAR, CAN, HAD, V1a
Papers on TGZ
PPARγ-inactive Δ2-troglitazone independently triggers ER stress and apoptosis in breast cancer cells.
New
Grillier-Vuissoz et al., Vandœuvre-lès-Nancy, France. In Mol Carcinog, May 2015
We focused on Δ2-troglitazone (Δ2-TGZ), a PPARγ inactive TZD that affects breast cancer cell viability.
Hepatocellular exposure of troglitazone metabolites in rat sandwich-cultured hepatocytes lacking Bcrp and Mrp2: interplay between formation and excretion.
Brouwer et al., Chapel Hill, United States. In Drug Metab Dispos, 2014
Inhibition of bile acid transport by troglitazone (TGZ) and its major metabolite, TGZ sulfate (TS), may lead to hepatocellular accumulation of toxic bile acids; TS accumulation and hepatotoxicity may be associated with impaired TS biliary excretion.
Peroxisome proliferator-activated receptor γ ligand troglitazone and TRAIL synergistically induce apoptosis.
Sakai et al., Kyoto, Japan. In Oncol Rep, 2014
In the present study, we showed that co-treatment with troglitazone (TGZ), a synthetic ligand of peroxisome proliferator-activated receptor γ (PPARγ), and TRAIL synergistically induced apoptosis through DR5 upregulation in human colon cancer DLD-1 cells.
Ubiquitination of p53 is involved in troglitazone induced apoptosis in cervical cancer cells.
Zheng et al., Xuzhou, China. In Asian Pac J Cancer Prev, 2013
Cell growth assay, Western blotting, Annexin V and flow cytometry analysis consistently showed that treatment with troglitazone (TGZ, a PPAR-γ agonist) led to dose-dependent inhibition of cervical cancer cell growth through apoptosis, whereas T0070907 (another PPAR-γ antagonist???) had no effect on Hela cell proliferation and apoptosis.
Combinational effect of PPARγ agonist and RXR agonist on the growth of SGC7901 gastric carcinoma cells in vitro.
Pei et al., Xuzhou, China. In Tumour Biol, 2013
In order to investigate the inhibitory effects and mechanisms of troglitazone (TGZ), a peroxisome proliferator-activated receptor γ (PPARγ) agonist, and retinoid X receptor (RXR) agonist (9-cis-retinoic acid (RA)) on gastric carcinoma cells SGC7901, SGC7901 cells were treated with TGZ and 9-cis-RA, respectively, or in combination.
Activation of a retinoic acid receptor pathway by thiazolidinediones induces production of vascular endothelial growth factor/vascular permeability factor in OP9 adipocytes.
Hirasawa et al., Sendai, Japan. In Eur J Pharmacol, 2013
We have confirmed that troglitazone (TGZ), a thiazolidinedione, induced the differentiation of a preadipocyte cell line, OP9, into adipocytes.
Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells.
Appel et al., Bergen, Norway. In Scand J Immunol, 2013
The purpose of this study was to compare four different protocols for generation of tolDC - the antidiabetic drug troglitazone (TGZ DC), NF-κB inhibitor BAY 11-7082 (BAY DC), prostaglandin D2 metabolite 15d-PGJ2 (PGJ DC) and a combination of dexamethasone and 1α,25-dihydroxyvitamin D3 (DexVD3 DC) regarding phenotype, cytokine production and T cell stimulatory capacity.
The effect of troglitazone on lipid accumulation and related gene expression in Hanwoo muscle satellite cell.
Hwang et al., Chŏnju, South Korea. In J Physiol Biochem, 2013
The current study was undertaken to determine the effect of the troglitazone (TGZ) on the expression of peroxisome proliferator-activating receptor (PPARγ), CCAAT/enhancer-binding protein, fatty acid binding protein 4, calpain 1 (CAPN1), and lipid accumulation in the myotube of Hanwoo muscle satellite cells.
Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties.
Ho et al., Singapore, Singapore. In Eur J Pharmacol, 2013
Using pyrrolidinedione analogs of the thiazolidinedione drugs troglitazone (TGZ), rosiglitazone (RGZ), and pioglitazone (PGZ), we evaluated their PPAR(γ) activities, anti-cancer properties as well as toxicological effects.
The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells.
Caraglia et al., Milano, Italy. In Biotechnol Adv, 2012
In addition, since IFN-mediated signalling components STATs are controlled by PPAR gamma we studied the pharmacological interaction between recombinant IFN-β and the PPAR-γ agonist troglitazone (TGZ).
Cytotoxicity of troglitazone through PPARγ-independent pathway and p38 MAPK pathway in renal cell carcinoma.
Okamura et al., Nishinomiya, Japan. In Cancer Lett, 2012
The aim was to investigate the cytotoxicity of troglitazone (TGZ) and its mechanisms in terms of PPARγ dependency and the p38 mitogen-activated protein kinase (MAPK) pathway in three human renal cell carcinoma (RCC) cell lines, 786-O, Caki-2 and ACHN cells.
Role of plastid transglutaminase in LHCII polyamination and thylakoid electron and proton flow.
Kotzabasis et al., Irákleion, Greece. In Plos One, 2011
Furthermore, a plastidial transglutaminase has been cloned from maize and the first plants overexpressing tgz are available (Nicotiana tabacum TGZ OE).
Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
Commandeur et al., Amsterdam, Netherlands. In Chem Res Toxicol, 2011
The applicability of our procedure is demonstrated by the trapping of RMs of acetaminophen (APAP), clozapine (CLOZ), and troglitazone (TGZ) with human glutathione-S-transferase P1-1 (hGST P1-1) as the model target protein.
Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
Lee et al., Pittsburgh, United States. In J Biol Chem, 2011
Although the combination of heregulin and troglitazone (HRG/TGZ) induced both apoptosis and necrosis, the main mode of cell death was caspase-independent and occurred via necrosis.
Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review.
Review
Masubuchi, Chiba, Japan. In Drug Metab Pharmacokinet, 2006
Troglitazone (TGZ), a thiazolidinedione class of antidiabetic agent, causes serious idiosyncratic hepatotoxicity.
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