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T cell specific GTPase 1

TGTP, Mg21, Irgb6, WDR13
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is widely expressed in various tissues. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: IFN-gamma, HAD, ACID, CAN, POLYMERASE
Papers using TGTP antibodies
Mapping short DNA sequencing reads and calling variants using mapping quality scores.
Supplier
Soldati-Favre Dominique, In PLoS Pathogens, 2007
... A rat monoclonal antibody against HA (3F10, Roche, 1∶500 dilution), a goat polyclonal antibody against mouse TGTP (A-20, Santa Cruz Biotechnology, 1∶100 dilution), a mouse monoclonal ...
Papers on TGTP
DNA polymerase-mediated synthesis of unbiased threose nucleic acid (TNA) polymers requires 7-deazaguanine to suppress G:G mispairing during TNA transcription.
New
Chaput et al., Columbus, United States. In J Am Chem Soc, May 2015
We demonstrate that the unnatural base analogue 7-deazaguanine (7dG) will suppress tGTP misincorporation by inhibiting the formation of Hoogsteen tG:dG base pairs.
Genetic deletion of Wdr13 improves the metabolic phenotype of Lepr (db/db) mice by modulating AP1 and PPARγ target genes.
New
Kumar et al., Hyderābād, India. In Diabetologia, Feb 2015
CONCLUSIONS/INTERPRETATION: This study provides evidence that loss of WD repeat domain 13 (WDR13) protein in the Lepr (db/db) mouse model of diabetes is beneficial.
Role of mouse Wdr13 in placental growth; a genetic evidence for lifetime body weight determination by placenta during development.
Kumar et al., Hyderābād, India. In Sci Rep, 2014
Here using Wdr13 knockout mice, we show that this gene is important for proper placental development.
Temporal gene expression in the hippocampus and peripheral organs to endotoxin-induced systemic inflammatory response in caspase-1-deficient mice.
Wong et al., Canberra, Australia. In Neuroimmunomodulation, 2014
OBJECTIVES: Caspase-1 (casp1), a key protease involved in the systemic inflammatory response syndrome (SIRS), controls the brain expression of a set of eight genes: Nos2 and Ptgs2 (nitric oxide synthase 2 and prostaglandin-endoperoxide synthase 2, two inducible enzymes), Cxcl1 and Cxcl10 (C-X-C motif chemokine ligand 1 and ligand 10), Tgtp and Gbp2 (T cell-specific GTPase 1 and guanylate-binding protein 2, two GTPases), Adamts1 (a disintegrin-like and metallopeptidase with thrombospondin type 1 motif, 1, a metalloprotease) and Il1rn (interleukin-1 receptor antagonist).
Effects of duration of moderate increases in grain feeding on endotoxins in the digestive tract and acute phase proteins in peripheral blood of yearling calves.
Penner et al., Saskatoon, Canada. In J Dairy Sci, 2014
Twenty-five Holstein yearling steer calves received either a forage-based diet containing 92% hay and 8% of a mineral and vitamin pellet on a dry matter basis (CON) or a moderate-grain diet, obtained by replacing 41.5% of the hay in the forage-based diet with barley grain, for 3 (MG3), 7 (MG7), 14 (MG14), or 21 d (MG21) before slaughter.
Role of mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.
Yamamoto et al., Suita, Japan. In J Immunol, 2014
IFN-γ-induced suppression of T. gondii proliferation and recruitment of an IRG Irgb6 and GBPs are profoundly impaired in Atg7- or Atg16L1-deficient cells.
Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs).
Däubener et al., Düsseldorf, Germany. In Med Microbiol Immunol, 2013
Detailed studies with murine IFN-γ-activated MSC indicated an involvement in IRGs like Irga6, Irgb6 and Irgd in the inhibition of N. caninum.
In astrocytes the accumulation of the immunity-related GTPases Irga6 and Irgb6 at the vacuole of Toxoplasma gondii is dependent on the parasite virulence.
Mausberg et al., Düsseldorf, Germany. In Scientificworldjournal, 2012
The two analyzed immunity-related GTPases Irga6 and Irgb6 accumulate at the PV only of avirulent T. gondii strains, whereas in virulent strains this accumulation is only detectable at very low levels.
A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
Impact
Takeda et al., Suita, Japan. In Immunity, 2012
Furthermore, Gbp(chr3)-deleted macrophages were defective in IFN-γ-mediated suppression of T. gondii intracellular growth and recruitment of IFN-γ-inducible p47 GTPase Irgb6 to the parasitophorous vacuole.
Identification and validation of Ifit1 as an important innate immune bottleneck.
Stenzel-Poore et al., Richland, United States. In Plos One, 2011
A small set of putative bottlenecks were identified in each of the data sets investigated including interferon-stimulated genes (Ifit1, Ifi47, Tgtp and Oasl2) as well as genes uncharacterized in immune responses (Axud1 and Ppp1r15a).
Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell proliferation, hyperinsulinemia and mild obesity.
Kumar et al., Hyderābād, India. In Plos One, 2011
WDR13, a member of this family, is conserved from fishes to humans and localizes into the nucleus.
Identification of novel GH-regulated genes in C2C12 cells.
Webb et al., Barcelona, Spain. In Horm Metab Res, 2011
Real-time PCR in biological replicates confirmed the effect of rGH on 15 genes: Cish, Serpina3g, Socs2, Bmp4, Tnfrsf11b, Rgs2, Tgfbr3, Ugdh, Npy1r, Gbp6, Tgfbi, Tgtp, Btc, Clec3b, and Bcl6.
Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.
Taylor et al., Durham, United States. In J Biol Chem, 2011
Similarly, coimmunoprecipitation studies indicated that although Irgm3 did interact directly with Irgb6, it did not interact with Gbp2.
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.
Sibley et al., Saint Louis, United States. In Cell Host Microbe, 2011
Consistent with this, expression of ROP18 was both necessary and sufficient to block recruitment of Irgb6, which was in turn required for parasite destruction.
A mouse gene encoding a novel member of the WD family of proteins is highly conserved and predominantly expressed in the testis (Wdr13).
GeneRIF
Singh et al., Hyderābād, India. In Mol Reprod Dev, 2005
WDR13 is localized to the locus XA1.1 and is predominantly expressed in the testis.
Degradation pathway(s) of chlorophyll: what has gene cloning revealed?
Review
Ohta et al., Yokohama, Japan. In Trends Plant Sci, 2000
After the successive removal of phytol and Mg21 from the chlorophyll molecule by chlorophyllase and 'Mg dechelatase', pheophorbide a is cleaved and reduced to yield a colorless, open tetrapyrrole intermediate.
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