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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lin-9 homolog

TGs, Bara, LIN-9
Top mentioned proteins: CAN, ACID, HDL, HAD, Insulin
Papers on TGs
Association of rs9939609 Polymorphism with Metabolic Parameters and FTO Risk Haplotype Among Tunisian Metabolic Syndrome.
New
Kefi et al., Tunisia. In Metab Syndr Relat Disord, Feb 2016
Among the eight haplotypes in the population, the haplotype GCA was significantly associated with a higher risk of developing the MetS, higher systolic blood pressure, and higher levels of fasting glucose and triglycerides (TGs) in the total sample and females, separately.
Effects of a petunia scaffold/matrix attachment region on copy number dependency and stability of transgene expression in Nicotiana tabacum.
New
Manske et al., Braunschweig, Germany. In Transgenic Res, Feb 2016
Transcriptional gene silencing (TGS) as well as post-transcriptional gene silencing (PTGS) have been shown to occur in transgenic plants depending on integration pattern, copy number and integration site.
Transcriptional regulatory networks in Arabidopsis thaliana during single and combined stresses.
New
Bones et al., Bengaluru, India. In Nucleic Acids Res, Jan 2016
To understand the general and condition-specific activities of the TFs and their regulatory relationships with the target genes (TGs), we have used a homogeneous stress gene expression dataset generated on ten natural ecotypes of the model plant Arabidopsis thaliana, during five single and six combined stress conditions.
The role of TRIB1 in lipid metabolism; from genetics to pathways.
Review
New
Nakayama et al., Tochigi, Japan. In Biochem Soc Trans, Nov 2015
Trib1 deficiency increases plasma cholesterol and TGs in mice and overexpression of TRIB1 in mouse liver reduces these factors.
Post-transcriptional gene silencing, transcriptional gene silencing and human immunodeficiency virus.
Review
New
Kelleher et al., Australia. In World J Virol, Sep 2015
RNAi has the potential to control the turning on/off of specific genes through transcriptional gene silencing (TGS), as well as fine-tuning their expression through post-transcriptional gene silencing (PTGS).
[MicroRNAs in the regulation of brown adipocyte differentiation].
Review
New
Xiangyang et al., Beijing, China. In Yi Chuan, Mar 2015
White adipose tissues store energy in the form of triglycerides (TGs), while brown adipose tissues catabolize TGs to generate energy.
Biochemical Characterization of Medaka (Oryzias latipes) Transglutaminases, OlTGK1 and OlTGK2, as Orthologues of Human Keratinocyte-Type Transglutaminase.
Hitomi et al., Nagoya, Japan. In Plos One, 2014
Calcium-dependent transglutaminases (TGs) are a family of enzymes that catalyze protein cross-linking and/or attachment of primary amines in a variety of organisms.
Biogenesis, Function, and Applications of Virus-Derived Small RNAs in Plants.
Review
Wu et al., Fuzhou, China. In Front Microbiol, 2014
vsiRNAs trigger antiviral defense through post-transcriptional gene silencing (PTGS) or transcriptional gene silencing (TGS) of viral RNA, and they hijack the host RNA silencing system to target complementary host transcripts.
Reconstruction of temporal activity of microRNAs from gene expression data in breast cancer cell line.
Bar et al., Trondheim, Norway. In Bmc Genomics, 2014
Estimation of the temporal activities of the miRNAs is an important step in the way to understand the complex interactions of these important regulatory elements with transcription factors (TFs) and target genes (TGs).
miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis.
Impact
Martienssen et al., New York City, United States. In Nature, 2014
In plants, post-transcriptional gene silencing (PTGS) is mediated by DICER-LIKE 1 (DCL1)-dependent microRNAs (miRNAs), which also trigger 21-nucleotide secondary short interfering RNAs (siRNAs) via RNA-DEPENDENT RNA POLYMERASE 6 (RDR6), DCL4 and ARGONAUTE 1 (AGO1), whereas transcriptional gene silencing (TGS) of transposons is mediated by 24-nucleotide heterochromatic (het)siRNAs, RDR2, DCL3 and AGO4 (ref.
Transglutaminase regulation of cell function.
Review
Impact
Mehta et al., In Physiol Rev, 2014
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease.
Reconstructing de novo silencing of an active plant retrotransposon.
Impact
Voinnet et al., Zürich, Switzerland. In Nat Genet, 2013
In plants, their activity is primarily controlled by transcriptional gene silencing (TGS), usually investigated at steady states, reflecting how long-established silent conditions are maintained, faithfully reiterated or temporarily modified.
Caveolae, lipid droplets, and adipose tissue biology: pathophysiological aspects.
Review
Martin, Brisbane, Australia. In Horm Mol Biol Clin Investig, 2013
Adipocytes are specialized cells that function to store energy in the form of lipids, predominantly triglycerides (TGs), and as a regulatory system contributing to metabolic homoeostasis through the production and secretion of hormones and cytokines.
Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth.
GeneRIF
Gaubatz et al., Würzburg, Germany. In Oncogene, 2012
inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells.
Impact
Bischof et al., Paris, France. In Nat Cell Biol, 2012
Here, we demonstrate that AGO2, RB1 and microRNAs (miRNAs), as exemplified here by let-7, physically and functionally interact to repress RB1/E2F-target genes in senescence, a process that we call senescence-associated transcriptional gene silencing (SA-TGS).
Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression.
GeneRIF
Gaubatz et al., Würzburg, Germany. In Mol Cell Biol, 2010
These experiments provide the first direct genetic evidence for the role of LIN9 in development and mitotic gene regulation and they suggest that it may function as a haploinsufficient tumor suppressor.
ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.
GeneRIF
Colamonici et al., Chicago, United States. In Oncogene, 2010
there is a feedback mechanism between ARF and Mip130/LIN-9 in which either the increase of ARF or the decrease in Mip130/LIN-9
Kinetic target-guided synthesis.
Review
Impact
Manetsch et al., Tampa, United States. In Chem Soc Rev, 2010
In the last decade, various target-guided synthesis (TGS) approaches have been developed in which a target protein is actively engaged in the assembly of its own bidentate ligand from a pool of smaller reactive fragments.
Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex.
GeneRIF
Colamonici et al., Chicago, United States. In Exp Cell Res, 2009
Mip130/LIN-9 contributes to the repression of these E2F-regulated genes in G0/G1 in mice.
A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells.
GeneRIF
Watson et al., London, United Kingdom. In Oncogene, 2009
Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin.
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