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Methionine adenosyltransferase II, beta

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on TGR
Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.
Kupatt et al., M√ľnchen, Germany. In Circulation, 2012
Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.
Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.
Weinshilboum et al., Rochester, United States. In Drug Metab Dispos, 2011
Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity.
Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria.
Paolocci et al., Baltimore, United States. In J Biol Chem, 2011
Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 system and that inhibition of TrxR2 results in increased H(2)O(2) emission.
Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants.
Lu et al., Los Angeles, United States. In J Biol Chem, 2010
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation.
CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.
Gladyshev et al., Lincoln, United States. In J Biol Chem, 2010
This study pertains to use of non-AUG (CUG) start codon in mouse thioredoxin reductase 3 gene, and conservation of this site in other mammals.
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