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Methionine adenosyltransferase II, beta

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Renin, Angiotensin II, Ren, HAD, CAN
Papers on TGR
Locus Coeruleus Dysfunction in Transgenic Rats with Low Brain Angiotensinogen.
Bezin et al., Lyon, France. In Cns Neurosci Ther, Feb 2016
AIMS: Transgenic TGR(ASrAOGEN)680 (TGR) rats with specific downregulation of glial angiotensinogen (AOGEN) synthesis develop cardiovascular deficits, anxiety, altered response to stress, and depression.
Moderate additive effects of endothelin receptor a blockade in Ren-2 transgenic rats subjected to various types of RAS blockade.
Zicha et al., Praha, Czech Republic. In Life Sci, Feb 2016
We tested whether the addition of ETA blockade to renin-angiotensin system (RAS) blockade would have further effects on principal vasoactive systems contributing to BP maintenance in Ren-2 transgenic rats (TGR).
Tissue-specific in vivo genetic toxicity of nine polycyclic aromatic hydrocarbons assessed using the Muta™Mouse transgenic rodent assay.
White et al., Ottawa, Canada. In Toxicol Appl Pharmacol, Feb 2016
An OECD test guideline for transgenic rodent (TGR) gene mutation assays was released in 2011, and the TGR assays permit assessment of mutagenicity in any tissue.
NADPH oxidase activity and reactive oxygen species production in brain and kidney of adult male hypertensive Ren-2 transgenic rats.
Zicha et al., Praha, Czech Republic. In Physiol Res, Jan 2016
The aim of our present study was to investigate NADPH oxidase-mediated superoxide (O(2)(-)) production and to search for the signs of lipid peroxidation in hypothalamus and medulla oblongata as well as in renal medulla and cortex of hypertensive male rats transgenic for the murine Ren-2 renin gene (Ren-2 TGR) and their age-matched normotensive controls - Hannover Sprague Dawley rats (HanSD).
Linking Ah receptor mediated effects of sediments and impacts on fish to key pollutants in the Yangtze Three Gorges Reservoir, China - A comprehensive perspective.
Hollert et al., Aachen, Germany. In Sci Total Environ, Jan 2016
The Three Gorges Reservoir (TGR), created in consequence of the Yangtze River's impoundment by the Three Gorges Dam, faces numerous anthropogenic impacts that challenge its unique ecosystem.
Bile acid receptors and nonalcoholic fatty liver disease.
Bambha et al., Los Angeles, United States. In World J Hepatol, Jan 2016
Recent advances in the functional characterization of bile acid receptors, such as farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor (TGR) 5, have provided further insight in the pathophysiology of NASH and have led to the development of potential therapeutic targets for NAFLD and NASH.
Nitrite-dependent anaerobic methane oxidizing bacteria along the water level fluctuation zone of the Three Gorges Reservoir.
Wu et al., Chongqing, China. In Appl Microbiol Biotechnol, Nov 2015
Here, we focused on the population of n-damo bacteria in a fluctuating habitat being the wetland in the water level fluctuation zone (WLFZ) of the Three Gorges Reservoir (TGR) in China.
High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis.
Wang et al., Shanghai, China. In Infect Dis Poverty, 2014
Thioredoxin glutathione reductase (TGR) from S. mansoni (SmTGR) is a well-characterized drug target for schistosomiasis, yet no anti-SmTGR compounds have reached clinical trials, suggesting that therapeutic development against schistosomiasis might benefit from additional scaffolds targeting this enzyme.
Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Salinas et al., Chicago, United States. In Antioxid Redox Signal, 2013
Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).
The significance of the nuclear farnesoid X receptor (FXR) in β cell function.
Drews et al., Tübingen, Germany. In Islets, 2012
The nuclear farnesoid X receptor (FXR) and the G-protein-coupled TGR-5 are the most prominent BA receptors.
Crosstalk in the retinal neurovascular unit - lessons for the diabetic retina.
Hammes et al., Heidelberg, Germany. In Exp Clin Endocrinol Diabetes, 2012
Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2(1/703)HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.
Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection.
Kupatt et al., München, Germany. In Circulation, 2012
Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.
Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases.
Williams et al., Stockholm, Sweden. In Biochim Biophys Acta, 2011
A recently discovered protein, thioredoxin glutathione reductase (TGR) potentially connects these two pathways.
Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics.
Weinshilboum et al., Rochester, United States. In Drug Metab Dispos, 2011
Coexpression of MAT2A and MAT2B in COS-1 cells resulted in significantly increased MAT enzyme activity.
Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria.
Paolocci et al., Baltimore, United States. In J Biol Chem, 2011
Energization of mitochondria increases the antioxidant potential of the TrxR2/Trx2 system and that inhibition of TrxR2 results in increased H(2)O(2) emission.
Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants.
Lu et al., Los Angeles, United States. In J Biol Chem, 2010
Data show MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation.
CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.
Gladyshev et al., Lincoln, United States. In J Biol Chem, 2010
This study pertains to use of non-AUG (CUG) start codon in mouse thioredoxin reductase 3 gene, and conservation of this site in other mammals.
Identification of oxadiazoles as new drug leads for the control of schistosomiasis.
Williams et al., Normal, United States. In Nat Med, 2008
Phosphinic amides and oxadiazole 2-oxides, identified from a quantitative high-throughput screen, were shown to inhibit a parasite enzyme, thioredoxin glutathione reductase (TGR), with activities in the low micromolar to low nanomolar range.
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
Capecchi et al., Salt Lake City, United States. In Cell, 1987
The G418r, 6-TGr cells were all shown to be Hprt- as the result of homologous recombination with the exogenous, neor-containing, Hprt sequences.
High frequency variation in mammary tumor virus expression in cell culture.
Scolnick et al., In Cell, 1976
In somatic cell hybrids between different MMTV TGr clones and mouse or hamster TK- cells, expression of constitutive levels of MMTV and responsiveness to dexamethasone induction is dominant.
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