Bile acid receptors and nonalcoholic fatty liver disease.
Los Angeles, United States. In World J Hepatol, Jan 2016
Recent advances in the functional characterization of bile acid receptors, such as farnesoid X receptor (FXR) and transmembrane G protein-coupled receptor (TGR) 5, have provided further insight in the pathophysiology of NASH and have led to the development of potential therapeutic targets for NAFLD and NASH.
Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites.
Chicago, United States. In Antioxid Redox Signal, 2013
Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).
Crosstalk in the retinal neurovascular unit - lessons for the diabetic retina.
Heidelberg, Germany. In Exp Clin Endocrinol Diabetes, 2012
Studies using adult neurodegenerative animal models such as the transgenic TGR(CMV-PKD2(1/703)HA) rat imply early activation of the innate immunity system and the complement system as well as microglia playing a role in the damage of the retinal neurovascular unit.