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Trans-golgi network protein

TGN38
resident integral membrane proteins of the trans-Golgi network (TGN), cycles constitutively between the TGN and the plasma membrane [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, Transferrin, CAN, ACID, HAD
Papers using TGN38 antibodies
Cell biology of acid secretion by the parietal cell
Supplier
Gleeson Paul A. et al., In Biology of the Cell, 2002
... Mouse mAbs against GM130 and TGN38 were purchased from BD Biosciences (v) (NSW, Australia) ...
CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis
Supplier
Ghosh Sankar et al., In The Journal of Cell Biology, 1999
... Cruz Biotechnology, Inc; H552), anti-Smad2 (Cell Signaling Technology), anti-M6PR (Affinity BioReagents, Inc.), anti-EEA1 (BD Biosciences), anti-TGN38 (BD Biosciences), anti–mouse transferrin receptor (BD ...
Papers on TGN38
PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner.
New
Dominguez et al., Philadelphia, United States. In Mol Biol Cell, May 2015
Consistently, full-length PICK1 shows diffuse cytoplasmic localization, but it clusters on vesicle-like structures that colocalize with the trans-Golgi network marker TGN38 upon deletion of either the ACT or PDZ domain.
Human T cell activation induces synaptic translocation and alters expression of the serine protease inhibitor neuroserpin and its target protease.
New
Birch et al., Auckland, New Zealand. In J Leukoc Biol, Apr 2015
Neuroserpin partially colocalized with a TGN38/LFA-1-positive vesicle population in T cells and translocates to the immunological synapse upon activation with TCR antibodies or antigen-pulsed APCs.
A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling.
New
Grant et al., United States. In Proc Natl Acad Sci U S A, Apr 2015
Here we provide evidence that the F-BAR domain proteins TOCA-1 and TOCA-2 (Transducer of Cdc42 dependent actin assembly), the small GTPase CDC-42 (Cell division control protein 42), associated polarity proteins PAR-6 (Partitioning defective 6) and PKC-3/atypical protein kinase C, and the WAVE actin nucleation complex mediate the transport of MIG-14/Wls and TGN-38/TGN38 cargo proteins from the recycling endosome to the TGN in Caenorhabditis elegans.
The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor.
McGlade et al., Toronto, Canada. In Exp Cell Res, 2014
Furthermore, the stable knockdown of RNF126 leads to the lysosomal degradation of CI-MPR and missorting of cathepsin D. RNF126 specifically regulates the sorting of the CI-MPR as other cargo that follow the retrograde sorting route including the cholera toxin, furin and TGN38 are unaffected in the absence of RNF126.
TGN38 is required for the metaphase I/anaphase I transition and asymmetric cell division during mouse oocyte meiotic maturation.
Sun et al., Zhengzhou, China. In Cell Cycle, 2013
The cellular functions of the trans-Golgi network protein TGN38 remain unknown.
Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.
Gleeson et al., Melbourne, Australia. In Traffic, 2013
To explore the relevance of the itinerary of BACE1 on APP processing, we generated a BACE1 chimera containing the cytoplasmic tail of TGN38 (BACE/TGN38), which cycles between the cell surface and TGN in an AP2-dependent manner.
ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.
Shin et al., Kyoto, Japan. In Mol Biol Cell, 2013
Moreover, the depletion of ARF1 and ARF4 inhibits retrograde transport of TGN38 and mannose-6-phosphate receptor from early/recycling endosomes to the trans-Golgi network (TGN) but does not affect the endocytic/recycling pathway of transferrin receptor or inhibit retrograde transport of CD4-furin from late endosomes to the TGN.
Structural basis for the recognition of tyrosine-based sorting signals by the μ3A subunit of the AP-3 adaptor complex.
Bonifacino et al., Valdivia, Chile. In J Biol Chem, 2013
To elucidate the mode of recognition of YXXØ signals by other members of the μ family, we solved the crystal structure at 1.85 Å resolution of the C-terminal domain of the μ3 subunit of AP-3 (isoform A) in complex with a peptide encoding a YXXØ signal (SDYQRL) from the trans-Golgi network protein TGN38.
Amino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function.
Heximer et al., Toronto, Canada. In J Biol Chem, 2012
Comparison of the endosomal distribution pattern of wild type and mutant RGS4 proteins with TGN38 indicated that palmitoylation of these two cysteines contributes differentially to the intracellular trafficking of RGS4.
Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis.
Arai et al., Tokyo, Japan. In Genes Cells, 2012
In PSA-3 cells, the Golgi localization of TGN38, a protein that circulates between the Golgi and the PM through endosomes by retrograde traffic, was abolished, whereas the localizations of other organelle markers remained unchanged.
Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.
Maxfield et al., New York City, United States. In Plos One, 2011
In this study, we used Chinese hamster ovary (CHO) cell lines that express chimeric constructs of CD25, the Tac antigen, attached to the cytoplasmic domain of the TGN-targeted transmembrane proteins, TGN38 and furin.
ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.
Shin et al., Kyoto, Japan. In Cell Struct Funct, 2011
Moreover, the simultaneous depletion of ARF1 and ARF3 suppresses recycling of transferrin but does not affect either its endocytosis or the retrograde transport of TGN38 from early/recycling endosomes to the TGN.
Case-control association study of TGOLN2 in attempted suicide.
GeneRIF
Willour et al., Baltimore, United States. In Am J Med Genet B Neuropsychiatr Genet, 2010
These analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders.
Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.
GeneRIF
Gleeson et al., Melbourne, Australia. In Eur J Cell Biol, 2010
These data have identified different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos.
Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.
GeneRIF
Grant et al., Leeds, United Kingdom. In Blood, 2010
FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport.
Multiple routes of protein transport from endosomes to the trans Golgi network.
Review
Pfeffer, Stanford, United States. In Febs Lett, 2010
Shiga and cholera toxins and TGN38/46 are routed from early and recycling endosomes, while mannose 6-phosphate receptors are routed from late endosomes.
Rapid dendritic transport of TGN38, a putative cargo receptor.
GeneRIF
VanDongen et al., Durham, United States. In Brain Res Mol Brain Res, 2004
The results of this study suggest a role for TGN38 in facilitating rapid changes in the protein composition of postsynaptic membranes.
Rme-1 regulates the distribution and function of the endocytic recycling compartment in mammalian cells.
Impact
Maxfield et al., New York City, United States. In Nat Cell Biol, 2001
The delivery of a TGN38 chimaeric protein to the trans-Golgi network is also slowed down.
A structural explanation for the recognition of tyrosine-based endocytotic signals.
Impact
Evans et al., Cambridge, United Kingdom. In Science, 1998
Crystal structures of the internalization signal binding domain of mu2 complexed with the internalization signal peptides of epidermal growth factor receptor and the trans-Golgi network protein TGN38 have been determined at 2.7 angstrom resolution.
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