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TGFB-induced factor homeobox 2-like, Y-linked

TGIFLY
This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TGIFLX, MEN, POLYMERASE, TGIF2, HAD
Papers on TGIFLY
Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.
GeneRIF
Heidari et al., Tehrān, Iran. In Mol Reprod Dev, 2008
Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.(
Association of TGIFLX/Y mRNA expression with prostate cancer.
GeneRIF
Heidari et al., Tehrān, Iran. In Med Oncol, 2008
most prostate tumors (73.5%) express at least one of these genes (TGIFLX and TGIFLY), although different patterns of mRNA expression were observed. These results suggest an association of TGIFLX/Y expression with the progression of prostate cancer.
The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.
Affara et al., Cambridge, United Kingdom. In Mamm Genome, 2002
Interestingly, a single base pair deletion in the human TGIFLY (as compared with TGIFLX) creates a different reading frame where the C-terminal residues shared by TGIFLX and other TGIF proteins are missing.
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