[Metabolism enzyme controls cancer stemness].
In Nihon Rinsho, May 2015
TGIF2 was identified which interacted with PKM2 in nucleus in response to EMT induction, which was considered to have a key role in controlling EMT induction.
Role of TG-interacting factor (Tgif) in lipid metabolism.
Huddinge, Sweden. In Biochim Biophys Acta, 2015
As these proteins can interact with the ligand binding domain of retinoid X receptor α, a common heterodimeric partner of several nuclear receptors [e.g., liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs)], Tgif1 and Tgif2 might repress other transcriptional pathways activated by lipids.
A multi-resource data integration approach: identification of candidate genes regulating cell proliferation during neocortical development.
Tallahassee, United States. In Front Neurosci, 2013
We used a mouse in situ hybridization dataset (The Allen Institute for Brain Science) to identify 13 genes (Cdon, Celsr1, Dbi, E2f5, Eomes, Hmgn2, Neurog2, Notch1, Pcnt, Sox3, Ssrp1, Tead2, Tgif2) with high correlation of expression in the proliferating cells of the VZ of the neocortex at early stages of development (E15.5).
The Tgif2 gene contains a retained intron within the coding sequence.
Charlottesville, United States. In Bmc Mol Biol, 2005
The Tgif2 gene contains a retained intron, within the second coding exon. One splice variant encodes the full length 237 amino acid Tgif2, whereas the shorter form results in the removal of 39 codons from the centre of the coding region.