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TGFB-induced factor homeobox 1

TGIF, TG-interacting factor
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TGF-beta, CAN, ACID, Shh, Smad2
Papers on TGIF
Hyperbaric oxygen effects on neuronal apoptosis associations in a traumatic brain injury rat model.
New
Kuo et al., Tainan City, Taiwan. In J Surg Res, 31 Aug 2015
BACKGROUND: The neuroprotective mechanisms of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) remain unclear, especially neuronal apoptosis associations such as the expression of tumor necrosis factor alpha (TNF-α), transforming growth-interacting factor (TGIF), and TGF-β1 after TBI.
Transforming growth factor β-interacting factor-induced malignant progression of hepatocellular carcinoma cells depends on superoxide production from Nox4.
New
Huang et al., Tainan City, Taiwan. In Free Radic Biol Med, 31 Jul 2015
Previously, we showed that transforming growth factor β-interacting factor (TGIF) antagonizes arsenic trioxide-induced apoptosis of HepG2 cells and is associated with poor prognosis and progression of urothelial carcinoma in patients after radical nephroureterectomy.
Elevated expression of TGIF is involved in lung carcinogenesis.
New
Zhang et al., Zhengzhou, China. In Tumour Biol, 20 Jul 2015
UNASSIGNED: The purpose of this study was to explore the expression of TG-interacting factor (TGIF) in lung carcinogenesis.
TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis.
New
Huang et al., Tainan City, Taiwan. In Toxicol Appl Pharmacol, 15 Jun 2015
Previously, we demonstrated that the JNK-induced complex formation of phosphorylated c-Jun and TG-interacting factor (TGIF) antagonizes ERK-induced cyclin-dependent kinase inhibitor CDKN1A (p21(WAF1/CIP1)) expression and resultant apoptosis in response to ATO in A431 cells.
TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.
New
Impact
Atfi et al., Boston, United States. In Cancer Cell, 13 May 2015
Moreover, genetic experiments revealed that Tgif1 ablation impeded mammary tumor development in MMTV-Wnt1 mice, further underscoring a requirement of TGIF for oncogenic Wnt signaling.
Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis.
New
Atfi et al., Paris, France. In Cell Rep, Mar 2015
UNASSIGNED: PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain repressor factor TGIF.
Role of TG-interacting factor (Tgif) in lipid metabolism.
Review
New
Parini et al., Huddinge, Sweden. In Biochim Biophys Acta, Jan 2015
Mutations in TGIF1 have been linked to holoprosencephaly, which is a human genetic disease that affects craniofacial development.
TG-interacting factor mediates arsenic-induced malignant transformation of keratinocytes via c-Src/EGFR/AKT/FOXO3A and redox signalings.
New
Huang et al., Tainan City, Taiwan. In Arch Toxicol, Jan 2015
Surprisingly, low-dose arsenic could also transcriptionally increase TG-interacting factor (TGIF) expression via c-Src/EGFR/AKT/FOXO3A signaling involving superoxide production from NADPH oxidase.
PHRF1 promotes genome integrity by modulating non-homologous end-joining.
New
Chang et al., Taipei, Taiwan. In Cell Death Dis, Dec 2014
A recent study reveals that PHRF1 is a tumor suppressor that promotes TGF-β cytostatic signaling through TGIF ubiquitination.
Overexpression of TG-interacting factor is associated with worse prognosis in upper urinary tract urothelial carcinoma.
GeneRIF
Huang et al., Tainan City, Taiwan. In Am J Pathol, 2012
TGIF contributes to the progression of urothelial carcinoma via the phosphatidylinositol 3-kinase-AKT pathway.
Premature senescence and increased TGFβ signaling in the absence of Tgif1.
GeneRIF
Wotton et al., Charlottesville, United States. In Plos One, 2011
Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs.
The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway.
GeneRIF
Milliat et al., Fontenay-aux-Roses, France. In Plos One, 2011
TGF-beta/Smad co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad-independent mechanism.
New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.
GeneRIF
Odent et al., Rennes, France. In J Med Genet, 2011
There was a positive correlation between the severity of the brain malformation and facial features for SHH, SIX3, and TGIF, but no such correlation was found for ZIC2 mutations.
Etiopathogenetic advances and management of holoprosencephaly: from bench to bedside.
Review
Bona et al., Novara, Italy. In Panminerva Med, 2010
Genetic causes are responsible for about 20% of cases: they are chromosomal abnormalities and gene mutations: up to date, nine genes (SHH, ZIC2, SIX3, TGIF, PATCHED1, TDGF1/CRIPTO, FAST1, GLI2 and DHCR) are definitely associated with HPE, but many others candidate gene are under investigation.
PCTA: a new player in TGF-beta signaling.
Review
Liu, United States. In Sci Signal, 2007
cPML is sequestered in the nucleus by the homeodomain protein TGIF (TG-interacting factor), a negative regulator of TGF-beta signaling.
Functional analysis of mutations in TGIF associated with holoprosencephaly.
Review
GeneRIF
Muenke et al., Bethesda, United States. In Mol Genet Metab, 2007
Of the eleven sequence variations in TGIF, all but four can be demonstrated to be functionally abnormal, associated with holoprosencephaly.
Holoprosencephaly.
Review
David et al., Rennes, France. In Orphanet J Rare Dis, 2006
To date, seven genes have been positively implicated in HPE: Sonic hedgehog (SHH), ZIC2, SIX3, TGIF, PTCH, GLI2 and TDGF1.
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
Impact
Elledge et al., Philadelphia, United States. In Nat Genet, 2000
Here we describe the involvement of the TG-interacting factor (TGIF), a homeodomain protein, in human HPE.
A Smad transcriptional corepressor.
Impact
Massagué et al., New York City, United States. In Cell, 1999
We identified the homeodomain protein TGIF as a Smad2-binding protein and a repressor of transcription.
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