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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carboxylesterase 1D

TGH, carboxylesterase 3
Top mentioned proteins: ACID, Carboxylesterase, HAD, ES-31, fibrillin-1
Papers on TGH
Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes and Erk1/2 signalling pathway.
New
Yang et al., China. In Cell Biol Int, May 2015
Meanwhile the levels of adipogenic markers, including peroxisome proliferator activated receptor γ (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), CCAAT/enhancer-binding protein β (C/EBPβ) and adipocyte fatty acid-binding protein 4 (aP2), were decreased after treatment with anti-CTRP6 siRNA, whereas the expression of adipose triglyceride lipase (ATGL) and triacylglycerol hydrolase (TGH) were increased.
The rolB gene activates the expression of genes encoding microRNA processing machinery.
New
Shkryl et al., Vladivostok, Russia. In Biotechnol Lett, Apr 2015
In rolB-transformed Arabidopsis thaliana cells, we detected a 2.2 to 7-fold increase in the expression of genes encoding core and accessory proteins (DCL1, SE, HYL1, AGO1, TGH, DDL, HEN1, AGO4 and RDR2) of the microRNA processing machinery.
Overexpression of miR-155 in the liver of transgenic mice alters the expression profiling of hepatic genes associated with lipid metabolism.
Xiao et al., Guangzhou, China. In Plos One, 2014
Additionally, carboxylesterase 3/triacylglycerol hydrolase (Ces3/TGH) was identified as a direct miR-155 target gene that is potentially responsible for the partial liver phenotypes observed in Rm155LG/Alb-Cre mice.
Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet.
Gonzalez et al., Bethesda, United States. In Biochim Biophys Acta, 2014
These increases were correlated with reduced body weight and white adipose tissue (WAT) mass, increased phosphorylation of hormone-sensitive lipase, and up-regulation of genes encoding carboxylesterase 3 and β2-adrenergic receptor in WAT, indicating accelerated lipolysis in adipocytes.
Critical role of neutral cholesteryl ester hydrolase 1 in cholesteryl ester hydrolysis in murine macrophages.
Ishibashi et al., Tochigi, Japan. In J Lipid Res, 2014
In mouse peritoneal macrophages (MPMs), this process is thought to involve several enzymes: hormone-sensitive lipase (Lipe), carboxylesterase 3 (Ces3), neutral CE hydrolase 1 (Nceh1).
[Influences of high-fat diet and methanogens inhibitor on the cecal microbiota and fat metabolism in C57BL/6J mice].
Zhu et al., In Wei Sheng Wu Xue Bao, 2014
High-fat diet up-regulated the expression of TGH gene (P < 0.05).
Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes.
Saez et al., Los Angeles, United States. In Nat Chem Biol, 2014
Using this approach, we identify carboxylesterase 3 (Ces3, also known as Ces1d) as a primary molecular target of bioactive compounds that promote lipid storage in adipocytes.
Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat.
Ichihara et al., Tsu, Japan. In Diabetol Metab Syndr, 2013
Further analysis using the 2D-DIGE connected with MALDI-TOF/TOF analysis, the expression of monoglyceride lipase (MGLL) was significantly up-regulated and that of carboxylesterase 3 (CES3) was significantly down-regulated in 6- and 25-week-old CP compared with age-matched control (WKY and Lean rats).
Day to Day Variability and Reliability of Blood Oxidative Stress Markers within a Four-Week Period in Healthy Young Men.
Labban et al., Greensboro, United States. In J Biomark, 2013
The ICC's for GSH, GSSG, and the GSSG/TGH ratio ICC were 0.600, 0.573, and 0.570, respectively, with Cronbach's α being 0.913, 0.904, and 0.903, respectively.
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis.
Impact
Gonzalez et al., Bethesda, United States. In Cell Metab, 2012
Serum metabolomics identified azelaic acid monoesters as significantly increased metabolites after TCDD treatment, due to downregulation of hepatic carboxylesterase 3 (CES3, also known as triglyceride hydrolase) expression in an arylhydrocarbon receptor (AhR)-dependent manner in mice.
Regulation of miRNA abundance by RNA binding protein TOUGH in Arabidopsis.
GeneRIF
Yu et al., Lincoln, United States. In Proc Natl Acad Sci U S A, 2012
TGH might regulate abundance of miRNAs through promoting DCL1 cleavage efficiency and/or recruitment of pri-miRNAs.
Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression.
GeneRIF
Lehner et al., Edmonton, Canada. In Mol Biol Cell, 2010
TGH-mediated changes in cytosolic lipid droplet dynamics, were investigated.
Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure.
Impact
GeneRIF
Lehner et al., Edmonton, Canada. In Cell Metab, 2010
Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure.
Racialized genetics and the study of complex diseases: the thrifty genotype revisited.
Review
Fullerton et al., Darwin, Australia. In Perspect Biol Med, 2006
Nor is it clear why such genetic differences would be expected, given the original pan-species orientation of the TGH.
The evolutionarily conserved TOUGH protein is required for proper development of Arabidopsis thaliana.
GeneRIF
Schwechheimer et al., Tübingen, Germany. In Plant Cell, 2005
The evolutionarily conserved TOUGH (TGH) protein is a novel regulator required for Arabidopsis thaliana development. It plays a role in RNA binding or processing. [TOUGH] [TGH]
C/EBPalpha activates the transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes.
GeneRIF
Vance et al., Edmonton, Canada. In Biochem J, 2005
C/EBPalpha participates directly in the regulation of TGH, an enzyme associated with lipolysis
Triacylglycerol hydrolase: role in intracellular lipid metabolism.
Review
Lehner et al., Edmonton, Canada. In Cell Mol Life Sci, 2004
An enzyme that hydrolyzes stored triacylglycerol (TG), triacylglycerol hydrolase (TGH), was purified from porcine, human and murine liver microsomes.
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes.
Impact
Cravatt et al., Los Angeles, United States. In Nat Biotechnol, 2003
We show that competitive profiling of a library of candidate serine hydrolase inhibitors in complex proteomes with activity-based chemical probes identifies nanomolar reversible inhibitors of several enzymes simultaneously, including the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH), triacylglycerol hydrolase (TGH) and an uncharacterized membrane-associated hydrolase that lacks known substrates.
Immune evasion genes from filarial nematodes.
Review
Zang et al., Edinburgh, United Kingdom. In Int J Parasitol, 2001
We have identified two TGF-beta homologues in B. malayi, and shown that one form (Bm-TGH-2) is both secreted by adult parasites in vitro and able to bind to host TGF-beta receptors.
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