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Transforming growth factor, beta 3

TGF-beta3
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: TGF-beta, beta2, CAN, HAD, POLYMERASE
Papers on TGF-beta3
Incorporation of TGF-beta 3 within collagen-hyaluronic acid scaffolds improves their chondrogenic potential.
New
O'Brien et al., Dublin, Ireland. In Adv Healthc Mater, Jul 2015
Incorporation of therapeutics in the form of growth factors within biomaterials can enhance their biofunctionality.
Role of uterine contraction in regeneration of the murine postpartum endometrium.
Ezaki et al., Tokyo, Japan. In Biol Reprod, 2014
In particular, the antifibrotic factor TGFbeta3 was released during the endometrial healing process.
[Analysis between transforming growth factor beta3 gene sfaNI polymorphism variant and non-syndromic cleft lip with or without cleft palate in people of Uygur's nationality and Han's in Xinjiang].
Hong et al., In Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2014
TGFbeta3 gene fragment including SfaNI was amplified and purified as the template of the primer extension reaction thenafter.
[Chondrogenesis of bone marrow mesenchymal stem cells induced by transforming growth factor beta3 gene in Diannan small-ear pigs].
Cao et al., In Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 2014
OBJECTIVE: To observe transforming growth factor beta3 (TGF-beta3) gene expression and the chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) after TGF-beta3 gene is transfected into BMSCs of Diannan small-ear pig.
Regional divergence of palate medial edge epithelium along the anterior to posterior axis.
Ding et al., Louisville, United States. In Int J Dev Biol, 2013
Previous studies demonstrated that medial edge epithelium expression of Mmp13 was regulated by TGF-beta3.
Interleukin-1 beta and transforming growth factor-beta 3 cooperate to activate matrix metalloproteinase expression and invasiveness in A549 lung adenocarcinoma cells.
GeneRIF
Vincenti et al., United States. In Cancer Lett, 2013
IL-1B & TGFB3 synergistically activated MMP)-1, MMP-3,& MMP-10 gene expression in NSCLC cells via MAPK-dependent pathways.
SOX9 gene plus heparinized TGF-β 3 coated dexamethasone loaded PLGA microspheres for inducement of chondrogenesis of hMSCs.
GeneRIF
Park et al., South Korea. In Biomaterials, 2012
SOX9 gene plus heparinized TGF-beta 3 coated dexamethasone loaded PLGA microspheres induce chondrogenesis of hMSCs
TGF-β mediates proinflammatory seminal fluid signaling in human cervical epithelial cells.
GeneRIF
Robertson et al., Adelaide, Australia. In J Immunol, 2012
TGF-beta3 isoform is a key agent in seminal plasma that signals induction of proinflammatory cytokine synthesis in cervical cells.
Changes in biomechanical strain and morphology of rat calvarial sutures and bone after Tgf-β3 inhibition of posterior interfrontal suture fusion.
GeneRIF
Opperman et al., Dallas, United States. In Anat Rec (hoboken), 2012
Tgf-beta3 treated sutures showed less fusion over time than control groups, and strain patterns in the skulls of the Tgf-beta3-treated group were different from that of the control group.
Posttraumatic temporal TGF-β mRNA expression in lens epithelial cells of paediatric patients.
GeneRIF
Kimsa et al., Katowice, Poland. In Folia Biol (praha), 2011
The aim of the study was to determine temporal TGFB1, TGFB2 and TGFB3 gene expression profiles in the anterior lens capsule of paediatric patients with posttraumatic cataract.
Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study.
Impact
Mao et al., New York City, United States. In Lancet, 2010
The entire articular surface of unilateral proximal humeral condyles of skeletally mature rabbits was surgically excised and replaced with bioscaffolds spatially infused with transforming growth factor beta3 (TGFbeta3)-adsorbed or TGFbeta3-free collagen hydrogel.
Role of transforming growth factor Beta in corneal function, biology and pathology.
Review
Mohan et al., Columbia, United States. In Curr Mol Med, 2010
TGFbeta1 has been shown to play a central role in scar formation in adult corneas whereas TGFbeta2 and TGFbeta3 have been implicated to play a critical role in corneal development and scarless wound healing during embryogenesis.
Role of TGF-betas in normal human endometrium and endometriosis.
Review
Tinneberg et al., Nairobi, Kenya. In Hum Reprod, 2010
Furthermore, because of high postmenstrual TGF-beta3 levels, we suppose that it might participate in scarless postmenstrual regeneration of endometrium.
Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia--a step forward but not the definitive answer.
Review
Lorquet et al., Liège, Belgium. In J Reprod Immunol, 2009
These soluble receptors may bind VEGF, PLGF and TGFbeta1 and TGFbeta3 in the maternal circulation, causing endothelial dysfunction in many maternal tissues.
Transforming growth factor-beta isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery.
Review
Blann et al., Johannesburg, South Africa. In J Craniofac Surg, 2009
The addition of minced fragments of autogenous rectus abdominis muscle partially restores the osteoinductive activity of the human TGF-beta3 isoform resulting in the induction of bone formation in the treated calvarial defects.
TGF-beta3 and cancer: a review.
Review
GeneRIF
Ferguson et al., Manchester, United Kingdom. In Cytokine Growth Factor Rev, 2009
Studies indicated that TGF-beta3 may actually play a protective role against tumourigenesis in a range of tissues including the skin, breast, oral and gastric mucosa.
Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies.
Impact
O'Kane et al., Manchester, United Kingdom. In Lancet, 2009
BACKGROUND: Research into mechanisms of skin scarring identified transforming growth factor beta3 (TGFbeta3) as a potential antiscarring therapy.
Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches.
Impact
Lako et al., Newcastle upon Tyne, United Kingdom. In Cell Stem Cell, 2008
Transcriptional and functional analysis identified TGF-beta1 and TGF-beta3 as positive enhancers of hESC hematopoietic differentiation that can further stimulate this process when added to the culture.
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice.
Impact
Akhurst et al., Glasgow, United Kingdom. In Cell, 1996
There was also a higher incidence of spindle cell carcinomas, which expressed high levels of endogenous TGFbeta3, suggesting that TGFbeta1 elicits an epithelial-mesenchymal transition in vivo and that TGFbeta3 might be involved in maintenance of the spindle cell phenotype.
Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction.
Impact
Groffen et al., Los Angeles, United States. In Nat Genet, 1995
A broad spectrum of biological activities has been proposed for transforming growth factor-beta 3 (TGF-beta 3).
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