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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transforming growth factor, beta 1

TGF-beta, TGF-beta1
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, IL-10, Interleukin-6
Papers on TGF-beta
Proteomic analysis of epithelial to mesenchymal transition reveals crosstalk between SNAIL and HDAC1 in breast cancer cells.
New
Faca et al., São Paulo, Brazil. In Mol Cell Proteomics, Feb 2016
EMT can be triggered by extracellular factors, including TGF-beta, HGF, and EGF.
Loss of alpha-Tubulin Acetylation is Associated with TGF-beta-induced Epithelial-Mesenchymal Transition.
New
Feng et al., China. In J Biol Chem, Feb 2016
UNASSIGNED: The epithelial-to-mesenchymal transition (EMT) is a process by which differentiated epithelial cells reprogram gene expression, lose their junctions and polarity, reorganize their cytoskeleton, increase cell motility and assume a mesenchymal morphology.
Enhanced expression of melanoma progression markers in mouse model of sleep apnea.
New
Fiori et al., Rio Grande, Brazil. In Rev Port Pneumol (barc), Feb 2016
Immunohistochemistry staining for Ki-67, PCNA, S100-beta, HMB-45, Melan-A, TGF-beta, Caspase-1, and HIF-1alpha were quantified using Photoshop.
The barber's pole worm CAP protein superfamily - A basis for fundamental discovery and biotechnology advances.
Review
New
Gasser et al., Melbourne, Australia. In Biotechnol Adv, Dec 2015
We inferred functions for selected Caenorhabditis elegans orthologs (including vap-1, vap-2, scl-5 and lon-1) based on genetic networking and by integrating data and published information, and were able to infer that a subset of orthologs and their interaction partners play pivotal roles in growth and development via the insulin-like and/or the TGF-beta signalling pathways.
[Effect of ASO Blood Stasis Syndrome Serum on Vascular Endothelial Cell Injury and Regulation of Taohong Siwu Decoction on it].
New
Hou et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
Contents of ET, NO, and transforming growth factor beta1 (TGF-beta1) in endothelial cell culture supernatant were detected by ELISA.
[Effect of Flos Daturae Alkaloids on TGF-beta1-induced Epithelial-Mesenchymal Transition of Human Pulmonary Adenocarcinoma A549 Cells].
New
Lv et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
OBJECTIVE: To study the effect of Flos Daturae alkaloids (FDA) on TGF-beta1-1uuuu;U epithelial-mesenchymal transition (EMT) of human pulmonary adenocarcinoma A549 cells.
The Role of EpCAM in physiology and pathology of the epithelium.
Review
New
Untergasser et al., Stockholm, Sweden. In Histol Histopathol, Nov 2015
Recent research pointed to a close interaction of EpCAM with other cell-cell contact molecules like E-cadherin and claudins and an intimate crosstalk with Wnt and TGF-beta signaling in the regulation of cell growth.
Systemic sclerosis: from pathogenesis to targeted therapy.
Review
New
Denton, London, United Kingdom. In Clin Exp Rheumatol, Jul 2015
Other approaches to modulate TGFbeta and other profibrotic pathways also have potential although safety and toxicity remain to be determined.
Immunopathogenesis of psoriasis: a possible role of TGFbeta/Smads pathway.
Review
Vetuschi et al., In Ital J Anat Embryol, 2013
Transforming Growth Factor beta (TGFbeta) is a member of a large family of pleiotropic cytokines with three different isoforms (TGFbeta1,2,3).
Features of intestinal lesions in the clinical course of inflammatory bowel diseases.
Review
Sferra et al., In Ital J Anat Embryol, 2013
Increased evidence indicate that a number of molecules are involved in the development of the disease and a crosstalk between TGFbeta/Smads pathway and alphavbeta6 integrin, mTOR and PPARgamma could play a crucial role in the development of intestinal fibrosis.
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
GeneRIF
Chowdhury et al., Calcutta, India. In Gene, 2012
identified polymorphic markers in TNFalpha, IL10, IL1beta and TGFbeta1 genes to be associated with alcoholic liver disease in the Bengali population
TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy.
Impact
GeneRIF
Laouar et al., Ann Arbor, United States. In Nat Immunol, 2012
These data thus demonstrate an unprecedented role for TGF-beta in ontogeny of natural killer cells
TGF-β-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection.
GeneRIF
Herbert et al., Germany. In Am J Pathol, 2012
TGF-beta effects on myeloid cells suppress helminth immunity as a consequence of restoring lung function after infection.
The haplotype of the TGFβ1 gene associated with cerebral infarction in Chinese.
GeneRIF
Shan et al., Jinhua, China. In Can J Neurol Sci, 2012
The results of this study indicate that polymorphisms and the haplotypes in the TGFbeta1 gene might be genetic markers for CI in the Chinese population.
Role of chymase in diabetic nephropathy.
GeneRIF
Boim et al., São Paulo, Brazil. In Exp Biol Med (maywood), 2012
The results indicate an important role for chymase in inducing fibrosis through TGF-beta1 activation, parallel with Ang II effects.
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment.
Impact
Smith et al., Palo Alto, United States. In Nat Med, 2010
Inhibition of LOXL2 resulted in a marked reduction in activated fibroblasts, desmoplasia and endothelial cells, decreased production of growth factors and cytokines and decreased transforming growth factor-beta (TGF-beta) pathway signaling.
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
Review
Impact
Batra et al., Omaha, United States. In Pharmacol Rev, 2010
Moreover, the pivotal role mediated through the Hh/GLI cascade during cancer progression also implicates the cooperation with other oncogenic products, such as mutated K-RAS and complex cross-talk with different growth factor pathways, including tyrosine kinase receptors, such as epidermal growth factor receptor (EGFR), Wnt/beta-catenin, and transforming growth factor-beta (TGF-beta)/TGF-beta receptors.
The polarization of immune cells in the tumour environment by TGFbeta.
Review
Impact
Licona-Limón et al., New Haven, United States. In Nat Rev Immunol, 2010
Transforming growth factor-beta (TGFbeta) is an immunosuppressive cytokine produced by tumour cells and immune cells that can polarize many components of the immune system.
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Impact
Fagarasan et al., Yokohama, Japan. In Immunity, 2010
We showed here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta1.
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts.
Impact
Pei et al., Guangzhou, China. In Cell Stem Cell, 2010
At the transcriptional level, Sox2/Oct4 suppress the EMT mediator Snail, c-Myc downregulates TGF-beta1 and TGF-beta receptor 2, and Klf4 induces epithelial genes including E-cadherin.
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