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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Transforming growth factor, beta receptor 1

TGF-beta type I receptor, ALK5, TbetaRI, TGFBR1
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Papers using TGF-beta type I receptor antibodies
The Heidelberg classification of renal cell tumours.
Supplier
Yeudall Andrew, In PLoS ONE, 1996
... Cells were treated with 2 µM TGFBR1 inhibitor (SB431542, Sigma Aldrich, Munich, Germany), 10 µM ...
Papers on TGF-beta type I receptor
An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy.
GeneRIF
Sunada et al., Okayama, Japan. In Lab Invest, 2012
We show that a TbetaRI kinase inhibitor, Ki26894, restores impaired myoblast differentiation in vitro caused by activin, myostatin, and TGF-beta1, as well as CAV3(P104L).
Post-translational regulation of TGF-β receptor and Smad signaling.
GeneRIF
Derynck et al., San Francisco, United States. In Febs Lett, 2012
TGF-beta family signaling through Smads is conceptually a simple and linear signaling pathway, driven by sequential phosphorylation, with type II receptors activating type I receptors, which in turn activate R-Smads [review]
Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily.
GeneRIF
Hinck, San Antonio, United States. In Febs Lett, 2012
analysis of evolution of the TGF-beta superfamily and how they signal through a single pair of receptors, known as TbetaR-I and TbetaR-II [review]
USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.
Impact
GeneRIF
ten Dijke et al., Leiden, Netherlands. In Nat Cell Biol, 2012
Results uncover USP4 as an important determinant for crosstalk between TGF-beta/TGF-beta type I receptor and AKT signalling pathways.
Involvement of transforming growth factor β and its type 1 receptor in the development of breast cancer.
GeneRIF
Bereschanskaya et al., Moscow, Russia. In Bull Exp Biol Med, 2011
several polymorphisms detected in the TGFbeta1 gene and its receptor associated with benign and malignant breast tumors
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