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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Nov 2015.

T, brachyury homolog

TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: BET, T-bet, CAN, IFN-gamma, CD4
Papers on TFT
Ex vivo lymphocyte phenotyping during Plasmodium falciparum sporozoite immunization in humans.
Scholzen et al., Nijmegen, Netherlands. In Parasite Immunol, 30 Nov 2015
Transient induction of the transcription factor T-bet and the cytotoxic molecule granzyme B indicated a role of Th1 responses and cytotoxic T cells in CPS-induced immunity.
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection.
Kaech et al., New Haven, United States. In J Exp Med, 26 Nov 2015
UNASSIGNED: The transcription factor T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the formation of both terminal effector and memory precursor cells during viral infection.
Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling.
Zhang et al., Tianjin, China. In Mol Neurobiol, 06 Nov 2015
In addition, the Th1 cytokine IFN-γ and transcription factor T-bet, as well as the Th17 cytokines IL-17A, IL-17F, and transcription factor ROR-γt are significantly suppressed upon arctigenin treatment in vitro and in vivo.
The Trojan Female Technique for pest control: a candidate mitochondrial mutation confers low male fertility across diverse nuclear backgrounds in Drosophila melanogaster.
Gemmell et al., Australia. In Evol Appl, 31 Oct 2015
The Trojan Female Technique (TFT) was recently proposed as a prospective approach to biological pest control.
Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.
Marrack et al., Aurora, United States. In J Immunol, Oct 2015
A newly discovered B cell subset, age-associated B cells, expresses the transcription factor T-bet, has a unique surface phenotype, and accumulates progressively with age.
The transcriptional programs of iNKT cells.
Brenner et al., Boston, United States. In Semin Immunol, Feb 2015
As in MHC-restricted T cells, specific transcription factors are characteristic of functional subsets of iNKT cells, such as the transcription factor T-bet in the NKT1 subset.
Individual T helper cells have a quantitative cytokine memory.
Löhning et al., Berlin, Germany. In Immunity, Feb 2015
Mechanistically, this memory resulted from quantitatively distinct transcription of individual alleles and was controlled by stable expression differences of the Th1 cell lineage-specifying transcription factor T-bet. Functionally, Th1 cells with graded IFN-γ production competence differentially activated Salmonella-infected macrophages for bacterial killing.
A central role for Notch in effector CD8(+) T cell differentiation.
Amsen et al., Amsterdam, Netherlands. In Nat Immunol, Dec 2014
Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet.
Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation.
Owens et al., Odense, Denmark. In Front Immunol, Dec 2014
Moreover, in contrast to BMDM/DC, both subsets of microglia express protective interferon-beta (IFNβ), high levels of colony-stimulating factor-1 receptor, and do not express the Th1-associated transcription factor T-bet.
CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.
Kaech et al., New Haven, United States. In Immunity, Nov 2014
Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help.
The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.
Tanriver et al., Freiburg, Germany. In Immunity, Sep 2014
Similar to natural killer cells and other innate lymphoid cells, CD8αα(+) IELs constitutively express the T-box transcription factor T-bet.
Is T-bet a potential therapeutic target in multiple sclerosis?
Lovett-Racke et al., Columbus, United States. In J Interferon Cytokine Res, Aug 2014
Work over the past several years suggests that the transcription factor T-bet appears to be an important factor in T cell encephalitogenicity; however, recent data suggest that it is also dispensable in certain situations, particularly for Th17 cells.
Roles for helper T cell lineage-specifying transcription factors in cellular specialization.
Weinmann, Seattle, United States. In Adv Immunol, 2013
In this review, we will explore our evolving views on these topics, often times using the Th1-lineage-specifying transcription factor T-bet as an example.
An overview of the role of innate lymphoid cells in gut infections and inflammation.
Monteleone et al., Roma, Italy. In Mediators Inflamm, 2013
Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ.
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.
Urdahl et al., Seattle, United States. In Immunity, 2013
These antigen-specific Treg cells peaked in numbers 3 weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
Barresi et al., Messina, Italy. In Am J Surg Pathol, 2012
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
SHARP Investigators et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
Flanagan et al., In Histopathology, 2011
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
Elefanty et al., Melbourne, Australia. In Plos One, 2010
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
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