GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
T, brachyury homolog
TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
TFT
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway.
New
Impact
Melbourne, Australia. In Nat Immunol, 03 Apr 2013
We report here that the transcription factor T-bet (encoded by Tbx21) was essential for the development of NKp46+ ILCs but not of LTi cells or nuocytes.
IL-2 Produced by CD8+ Immune T Cells Can Augment Their IFN-γ Production Independently from Their Proliferation in the Secondary Response to an Intracellular Pathogen.
New
Lexington, United States. In J Immunol, 01 Apr 2013
Inhibition of cell proliferation by mitomycin C did not affect the enhancing effect of IL-2 on the IFN-γ production, and significant increases in transcription factor T-bet expression were associated with the IL-2-mediated IFN-γ amplification.
Triggering of specific Toll-like receptors and proinflammatory cytokines breaks allergen-specific T-cell tolerance in human tonsils and peripheral blood.
New
Zürich, Switzerland. In J Allergy Clin Immunol, 31 Mar 2013
RESULTS: In allergic patients the immune profile of the tonsils represents the atopic status of patients, with low expression of the T1 cell-specific transcription factor T-bet and the cytokine IFN-γ, as well as IL-10.
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
New
Impact
Amsterdam, Netherlands. In Nat Immunol, 31 Mar 2013
ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ).
A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells.
New
Impact
Freiburg, Germany. In Nature, 14 Mar 2013
Here we provide evidence that the transcription factor T-bet determines the fate of a distinct lineage of CCR6(-)RORγt(+) ILCs.
Covalently functionalized double-walled carbon nanotubes combine high sensitivity and selectivity in the electrical detection of small molecules.
New
College Park, United States. In J Am Chem Soc, 13 Mar 2013
The devices displayed an NH(3) sensitivity of 60 nM (or ∼1 ppb), which is comparable to small molecule aqueous solution detection using state-of-the-art SWCNT TFT sensors while concomitantly achieving 6000 times higher chemical selectivity toward a variety of amine-containing analyte molecules over that of other small molecules.
Selective anti-herpesvirus agents.
New
Leuven, Belgium. In Antivir Chem Chemother, 23 Feb 2013
This review article focuses on the anti-herpesvirus agents effective against herpes simplex virus (HSV), varicella-zoster virus (VZV) and cytomegalovirus (CMV), which have either been licensed for clinical use [idoxuridine (IDU), trifluridine (TFT), brivudin (BVDU), acyclovir, valaciclovir, valganciclovir, famciclovir and foscarnet] or are under clinical development [CMX001 (the hexadecyloxypropyl prodrug of cidofovir), the helicase-primase inhibitor BAY 57-1293 (now referred to as AIC316), FV-100 (the valine ester of Cf 1743), and the terminase inhibitor letermovir (AIC246)].
The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.
New
Impact
London, United Kingdom. In Immunity, Nov 2012
Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis.
New tricks from an old master.
New
Impact
Saint Louis, United States. In Immunity, Nov 2012
In this issue of Immunity, Zhu et al. (2012) report a mouse reporter strain for the transcription factor T-bet.
T-bet employs diverse regulatory mechanisms to repress transcription.
Review
New
Seattle, United States. In Trends Immunol, Feb 2012
The T-box transcription factor T-bet is required for CD4(+) T helper 1 (Th1) cell differentiation.
Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis.
Hong Kong, Hong Kong. In Chin Med, 2011
A total of 13 differentially expressed proteins including actin, tubulin alpha-1C chain, preprohaptoglobin, hemopexin, galectin-5, glutathione S-transferase alpha-4 (GSTA4), branched chain keto acid dehydrogenase hterotetrameric E1 subunit alpha (BCKDHA), glutathione S-transferase mu (GSTmu); glyceraldehyde-3-phosphate dehydrogenase (GAPDH); thiosulfate sulfurtransferase (TFT); betaine-homocysteine S-methyltransferase 1 (BHMT1); quinoid dihydropteridine reductase (QDPR); ribonuclease UK114 were observed between the TAA and PLP groups.
Mouse T helper 17 phenotype: not so different than in man after all.
Review
Florence, Italy. In Cytokine, 2011
Studies performed in human demonstrated apparent species-specific differences, such as the expression by TH17 cells of the TH1-related transcription factor T-bet, the IL-12-inducible plasticity of TH17 cells into TH1 cells, and the dispensability of TGF-β signaling for their development.
T-bet in disease.
Review
Impact
Boston, United States. In Nat Immunol, 2011
At the center of the type 1 inflammatory response is the transcription factor T-bet, a critical regulator of the T(H)1 differentiation program.
Extra-axial soft tissue chordoma of wrist.
GeneRIF
Sapporo, Japan. In Pathol Res Pract, 2011
The tumor cells were diffusely positive for brachyury and cytokeratin 19 on immunohistochemistry, suggesting that the tumor was extra-axial soft tissue chordoma.
Brachyury expression predicts poor prognosis at early stages of colorectal cancer.
GeneRIF
Hamburg, Germany. In Eur J Cancer, 2011
Brachyury expression predicts poor prognosis at early stages of colorectal cancer
Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases.
GeneRIF
Stanford, United States. In Mod Pathol, 2011
This study confirms the specificity of brachyury for chordoma in the differential diagnostic distinction from the potential genitourinary mimics, germ cell tumors and metastatic clear cell renal cell carcinoma.
Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.
GeneRIF
London, United Kingdom. In J Pathol, 2011
findings show chromosomal aberrations resulting in gain of the T locus are common in sporadic chordomas and expression of this gene is critical for proliferation of chordoma cells in vitro
Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3.
GeneRIF
Suzhou, China. In J Clin Neurosci, 2011
brachyury expressed in chordoma tumor cells, but not in benign notochoral cell rests that were coexistent.
Molecular mechanisms by which T-bet regulates T-helper cell commitment.
Review
Seattle, United States. In Immunol Rev, 2010
Studies examining the developmental T-box transcription factor T-bet demonstrate the powerful information that is gained from combining in vivo analysis with basic biochemical and molecular mechanism approaches.
Effects of stress on the immune response to Theiler's virus--implications for virus-induced autoimmunity.
Review
College Station, United States. In Neuroimmunomodulation, 2009
Expression of mRNA for the Th1 transcription factor T-bet and the Th2 transcription factor GATA-3 were decreased in spleen cells isolated from stressed mice.
