Selective anti-herpesvirus agents.
Leuven, Belgium. In Antivir Chem Chemother, 23 Feb 2013
This review article focuses on the anti-herpesvirus agents effective against herpes simplex virus (HSV), varicella-zoster virus (VZV) and cytomegalovirus (CMV), which have either been licensed for clinical use [idoxuridine (IDU), trifluridine (TFT), brivudin (BVDU), acyclovir, valaciclovir, valganciclovir, famciclovir and foscarnet] or are under clinical development [CMX001 (the hexadecyloxypropyl prodrug of cidofovir), the helicase-primase inhibitor BAY 57-1293 (now referred to as AIC316), FV-100 (the valine ester of Cf 1743), and the terminase inhibitor letermovir (AIC246)].
New tricks from an old master.
Saint Louis, United States. In Immunity, Nov 2012
In this issue of Immunity, Zhu et al. (2012) report a mouse reporter strain for the transcription factor T-bet.
Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis.
Hong Kong, Hong Kong. In Chin Med, 2011
A total of 13 differentially expressed proteins including actin, tubulin alpha-1C chain, preprohaptoglobin, hemopexin, galectin-5, glutathione S-transferase alpha-4 (GSTA4), branched chain keto acid dehydrogenase hterotetrameric E1 subunit alpha (BCKDHA), glutathione S-transferase mu (GSTmu); glyceraldehyde-3-phosphate dehydrogenase (GAPDH); thiosulfate sulfurtransferase (TFT); betaine-homocysteine S-methyltransferase 1 (BHMT1); quinoid dihydropteridine reductase (QDPR); ribonuclease UK114 were observed between the TAA and PLP groups.
Mouse T helper 17 phenotype: not so different than in man after all.
Florence, Italy. In Cytokine, 2011
Studies performed in human demonstrated apparent species-specific differences, such as the expression by TH17 cells of the TH1-related transcription factor T-bet, the IL-12-inducible plasticity of TH17 cells into TH1 cells, and the dispensability of TGF-β signaling for their development.
T-bet in disease.
Boston, United States. In Nat Immunol, 2011
At the center of the type 1 inflammatory response is the transcription factor T-bet, a critical regulator of the T(H)1 differentiation program.
Extra-axial soft tissue chordoma of wrist.
Sapporo, Japan. In Pathol Res Pract, 2011
The tumor cells were diffusely positive for brachyury and cytokeratin 19 on immunohistochemistry, suggesting that the tumor was extra-axial soft tissue chordoma.