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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Mar 2014.

T, brachyury homolog

TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: T-bet, BET, CAN, IFN-gamma, CD4
Papers on TFT
T-bet Regulates Immunity to Francisella tularensis Live Vaccine Strain Infection, Particularly in Lungs.
New
Elkins et al., Rockville, United States. In Infect Immun, 30 Apr 2014
Upregulation of the transcription factor T-bet is correlated with the strength of protection against secondary challenge with the live vaccine strain (LVS) of Francisella tularensis.
Therapeutic effects of nonerythropoietic erythropoietin analog ARA290 in experimental autoimmune encephalomyelitis rat.
New
Zhang et al., Chongqing, China. In J Neuroimmunol, 15 Apr 2014
Therapeutic (from Day 7 to Day 18 or from Day 9 to Day 19) administration of ARA290 (35, 70μg/kg, intra-peritoneal) to EAE rats once daily significantly reduced the severity and shortened the duration of clinical score, reduced the accumulation of inflammatory cells in EAE spinal cords and suppressed mRNA levels of interleukin-1β (IL-1β), IL-17, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), inducible nitric oxide synthase (iNOS), matrix metalloproteinase 9 (MMP9) and transcription factor T-bet in spinal cords of EAE rats.
The immune cell transcription factor T-bet: A novel metabolic regulator.
New
Howard et al., London, United Kingdom. In Adipocyte, Feb 2014
T-bet (Tbx21) is an immune cell transcription factor originally described as the master regulator of Th1 cell development, although is now recognized to have a role in both the adaptive and innate immune systems.
Softenin, a novel protein that softens the connective tissue of sea cucumbers through inhibiting interaction between collagen fibrils.
New
Motokawa et al., Tokyo, Japan. In Plos One, Dec 2013
The Triton-treated dermis was subjected to repetitive freeze-and-thawing to make Triton-Freeze-Thaw (TFT) dermis that was softer than the Triton-treated dermis, implying that some force-bearing structure had been disrupted by this treatment.
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.
New
Impact
Urdahl et al., Seattle, United States. In Immunity, Jul 2013
These antigen-specific Treg cells peaked in numbers 3 weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet.
Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.
New
Impact
Howard et al., London, United Kingdom. In Cell Metab, May 2013
We report that mice deficient in the immune cell transcription factor T-bet have lower energy expenditure and increased visceral fat compared with wild-type mice, yet paradoxically are more insulin sensitive.
The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway.
New
Impact
Belz et al., Melbourne, Australia. In Nat Immunol, Apr 2013
We report here that the transcription factor T-bet (encoded by Tbx21) was essential for the development of NKp46+ ILCs but not of LTi cells or nuocytes.
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues.
New
Impact
Spits et al., Amsterdam, Netherlands. In Nat Immunol, Mar 2013
ILC1 cells expressed the transcription factor T-bet and responded to interleukin 12 (IL-12) by producing interferon-γ (IFN-γ).
A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells.
New
Impact
Diefenbach et al., Freiburg, Germany. In Nature, Mar 2013
Here we provide evidence that the transcription factor T-bet determines the fate of a distinct lineage of CCR6(-)RORγt(+) ILCs.
Three-finger toxins, a deadly weapon of elapid venom--milestones of discovery.
Review
New
Utkin, Moscow, Russia. In Toxicon, Feb 2013
The first TFT α-bungarotoxin was isolated almost half a century ago and so far it remains a valuable tool in the study of nicotinic acetylcholine receptors.
The emerging role of T cell cytokines in non-small cell lung cancer.
Review
Finotto et al., Nürnberg, Germany. In Cytokine Growth Factor Rev, 2012
Whereas T helper 1 cells and their master transcription factor T-bet have been identified as important regulators of IFN-gamma driven anti-tumoral immune response, IL-17 producing T helper 17 cells expressing RORA/C transcription factors have been found to augment tumor growth and cell proliferation in NSCLC.
Multivariable model consisting of clinical and biological markers for time to first treatment in CLL patients: Preliminary results from single centre experience.
Panovska-Stavridis et al., Скопје, Macedonia. In Prilozi, 2012
This multivariable model was used to develop a nomogram-a weighted tool to calculate 5- and 10-year survival probability and estimate median time to first treatment (TFT).
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
GeneRIF
Barresi et al., Messina, Italy. In Am J Surg Pathol, 2012
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
GeneRIF
SHARP Investigators et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
T-bet employs diverse regulatory mechanisms to repress transcription.
Review
Weinmann et al., Seattle, United States. In Trends Immunol, 2012
The T-box transcription factor T-bet is required for CD4(+) T helper 1 (Th1) cell differentiation.
P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
GeneRIF
Flanagan et al., In Histopathology, 2011
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.
Mouse T helper 17 phenotype: not so different than in man after all.
Review
Romagnani et al., Florence, Italy. In Cytokine, 2011
Studies performed in human demonstrated apparent species-specific differences, such as the expression by TH17 cells of the TH1-related transcription factor T-bet, the IL-12-inducible plasticity of TH17 cells into TH1 cells, and the dispensability of TGF-β signaling for their development.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Impact
GeneRIF
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
T-bet in disease.
Review
Impact
Glimcher et al., Boston, United States. In Nat Immunol, 2011
At the center of the type 1 inflammatory response is the transcription factor T-bet, a critical regulator of the T(H)1 differentiation program.
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
GeneRIF
Elefanty et al., Melbourne, Australia. In Plos One, 2010
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
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