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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Mar 2015.

T, brachyury homolog

TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: T-bet, BET, CAN, IFN-gamma, CD4
Papers on TFT
Reevluation of the mutagenic response to phosphorothioate nucleotides in human lymphoblastoid TK6 cells.
New
Fellows et al., Macclesfield, United Kingdom. In Toxicol Sci, 20 Mar 2015
Surprisingly, when the colonies from dAMPαS were re-challenged with the selective agent trifluorothymidine (TFT), the TFT-resistant phenotype was lost.
Antiproliferative Activity Of Cobra Venom Cytotoxins.
New
Utkin et al., Moscow, Russia. In Curr Top Med Chem, 16 Mar 2015
UNASSIGNED: Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the three-finger toxin (TFT) family.
Diverse Roles for T-bet in the Effector Responses Required for Resistance to Infection.
New
Hunter et al., Philadelphia, United States. In J Immunol, 01 Mar 2015
The transcription factor T-bet has been most prominently linked to NK and T cell production of IFN-γ, a cytokine required for the control of a diverse array of intracellular pathogens.
Individual T helper cells have a quantitative cytokine memory.
New
Impact
Löhning et al., Berlin, Germany. In Immunity, 20 Feb 2015
Mechanistically, this memory resulted from quantitatively distinct transcription of individual alleles and was controlled by stable expression differences of the Th1 cell lineage-specifying transcription factor T-bet. Functionally, Th1 cells with graded IFN-γ production competence differentially activated Salmonella-infected macrophages for bacterial killing.
[Th2 differentiation features of Mycobacterium tuberculosis heat resistant antigen-activated human γδT cells and the regulation of transcription factor T-bet/GATA-3 on differentiation].
New
Li et al., Bengbu, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Jan 2015
Both transcription factor T-bet and GATA-3 failed to display a fully cross-regulation function in Th2 polarized γδT cells.
A central role for Notch in effector CD8(+) T cell differentiation.
New
Impact
Amsen et al., Amsterdam, Netherlands. In Nat Immunol, Dec 2014
Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet.
A case of thyroid hormone resistance: a rare mutation.
New
Mascarenhas et al., Lisbon, Portugal. In Arq Bras Endocrinol Metabol, Dec 2014
The patient's son underwent thyroid function testing (TFT) and genetic study, both negative, suggesting a sporadic mutation.
CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.
New
Impact
Kaech et al., New Haven, United States. In Immunity, Nov 2014
Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help.
The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.
New
Impact
Tanriver et al., Freiburg, Germany. In Immunity, Sep 2014
Similar to natural killer cells and other innate lymphoid cells, CD8αα(+) IELs constitutively express the T-box transcription factor T-bet.
An overview of the role of innate lymphoid cells in gut infections and inflammation.
Review
Monteleone et al., Roma, Italy. In Mediators Inflamm, 2013
Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ.
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.
Impact
Urdahl et al., Seattle, United States. In Immunity, 2013
These antigen-specific Treg cells peaked in numbers 3 weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet.
Three-finger toxins, a deadly weapon of elapid venom--milestones of discovery.
Review
Utkin, Moscow, Russia. In Toxicon, 2013
The first TFT α-bungarotoxin was isolated almost half a century ago and so far it remains a valuable tool in the study of nicotinic acetylcholine receptors.
The emerging role of T cell cytokines in non-small cell lung cancer.
Review
Finotto et al., Nürnberg, Germany. In Cytokine Growth Factor Rev, 2012
Whereas T helper 1 cells and their master transcription factor T-bet have been identified as important regulators of IFN-gamma driven anti-tumoral immune response, IL-17 producing T helper 17 cells expressing RORA/C transcription factors have been found to augment tumor growth and cell proliferation in NSCLC.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
GeneRIF
Barresi et al., Messina, Italy. In Am J Surg Pathol, 2012
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
GeneRIF
SHARP Investigators et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
T-bet employs diverse regulatory mechanisms to repress transcription.
Review
Weinmann et al., Seattle, United States. In Trends Immunol, 2012
The T-box transcription factor T-bet is required for CD4(+) T helper 1 (Th1) cell differentiation.
P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
GeneRIF
Flanagan et al., In Histopathology, 2011
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.
Mouse T helper 17 phenotype: not so different than in man after all.
Review
Romagnani et al., Florence, Italy. In Cytokine, 2011
Studies performed in human demonstrated apparent species-specific differences, such as the expression by TH17 cells of the TH1-related transcription factor T-bet, the IL-12-inducible plasticity of TH17 cells into TH1 cells, and the dispensability of TGF-β signaling for their development.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Impact
GeneRIF
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
GeneRIF
Elefanty et al., Melbourne, Australia. In Plos One, 2010
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
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