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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

T, brachyury homolog

TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: BET, T-bet, CAN, CD4, IFN-gamma
Papers on TFT
Complementarity and redundancy of IL-22-producing innate lymphoid cells.
New
Impact
Vivier et al., Melbourne, Australia. In Nat Immunol, Feb 2016
We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells.
INTERFERON-γ IS INCREASED IN THE GUT OF PATIENTS WITH IRRITABLE BOWEL SYNDROME AND MODULATES SEROTONIN METABOLISM.
New
Barbara et al., Bologna, Italy. In Am J Physiol Gastrointest Liver Physiol, Feb 2016
Compared to asymptomatic control (AC), the expression of IFN-γ gene and its transcription factor T-bet were markedly increased in the colonic mucosa of IBS patients.
An aza-anthrapyrazole negatively regulates Th1 activity and suppresses experimental autoimmune encephalomyelitis.
New
Quinn et al., Toledo, United States. In Int Immunopharmacol, Jan 2016
IFN-γ is known to be regulated by the transcription factor T-bet.
Improvement in the Electrical Performance of Ge-Doped InZnO Thin-Film Transistor.
New
Yi et al., In J Nanosci Nanotechnol, Oct 2015
In order to optimize the electrical properties of Ge-IZO TFTs, we tried to adjust the processing parameters and the best Ge-IZO TFT was obtained at a co-sputtering oxygen partial pressure of 2% and GeO2 target power of 10 W. The fabricated Ge-IZO TFT exhibited an on/off ratio of 3.0 x 10(7), a saturation mobility of 13.05 cm2/V·s, a subthreshold swing of 0.95 V/dec, and a threshold voltage of 0 V. XPS and XRD analyses of Ge-IZO films were performed to investigate the binding energies of atoms in Ge-IZO films and the crystallinity of the films.
Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.
Review
New
Marrack et al., Aurora, United States. In J Immunol, Oct 2015
A newly discovered B cell subset, age-associated B cells, expresses the transcription factor T-bet, has a unique surface phenotype, and accumulates progressively with age.
A Comparison of Photo-Induced Hysteresis Between Hydrogenated Amorphous Silicon and Amorphous IGZO Thin-Film Transistors.
New
Koo et al., In J Nanosci Nanotechnol, Sep 2015
An a-IGZO TFT exhibits a large hysteresis window in the illuminated measuring condition but no hysteresis window in the dark condition.
The transcriptional programs of iNKT cells.
Review
New
Brenner et al., Boston, United States. In Semin Immunol, Feb 2015
As in MHC-restricted T cells, specific transcription factors are characteristic of functional subsets of iNKT cells, such as the transcription factor T-bet in the NKT1 subset.
Individual T helper cells have a quantitative cytokine memory.
New
Impact
Löhning et al., Berlin, Germany. In Immunity, Feb 2015
Mechanistically, this memory resulted from quantitatively distinct transcription of individual alleles and was controlled by stable expression differences of the Th1 cell lineage-specifying transcription factor T-bet. Functionally, Th1 cells with graded IFN-γ production competence differentially activated Salmonella-infected macrophages for bacterial killing.
Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription Factor T-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis.
Kriegova et al., Olomouc, Czech Republic. In Mediators Inflamm, 2014
We therefore investigated gene expression of 25 inflammation-related miRNAs, 27 cytokines/chemokines/receptors, and a Th1-transcription factor T-bet in unseparated BAL cells obtained from 48 sarcoidosis patients and 14 control subjects using quantitative RT-PCR.
A central role for Notch in effector CD8(+) T cell differentiation.
Impact
Amsen et al., Amsterdam, Netherlands. In Nat Immunol, 2014
Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet.
Antiproliferative activity of cobra venom cytotoxins.
Review
Utkin et al., Moscow, Russia. In Curr Top Med Chem, 2014
Cytotoxins (or cardiotoxins, CTs) are small rigid membrane-active proteins of the three-finger toxin (TFT) family.
CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.
Impact
Kaech et al., New Haven, United States. In Immunity, 2014
Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help.
The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.
Impact
Tanriver et al., Freiburg, Germany. In Immunity, 2014
Similar to natural killer cells and other innate lymphoid cells, CD8αα(+) IELs constitutively express the T-box transcription factor T-bet.
Is T-bet a potential therapeutic target in multiple sclerosis?
Review
Lovett-Racke et al., Columbus, United States. In J Interferon Cytokine Res, 2014
Work over the past several years suggests that the transcription factor T-bet appears to be an important factor in T cell encephalitogenicity; however, recent data suggest that it is also dispensable in certain situations, particularly for Th17 cells.
Roles for helper T cell lineage-specifying transcription factors in cellular specialization.
Review
Weinmann, Seattle, United States. In Adv Immunol, 2013
In this review, we will explore our evolving views on these topics, often times using the Th1-lineage-specifying transcription factor T-bet as an example.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
GeneRIF
Barresi et al., Messina, Italy. In Am J Surg Pathol, 2012
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
GeneRIF
SHARP Investigators et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
GeneRIF
Flanagan et al., In Histopathology, 2011
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Impact
GeneRIF
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
GeneRIF
Elefanty et al., Melbourne, Australia. In Plos One, 2010
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
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