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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Jul 2015.

T, brachyury homolog

TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: T-bet, BET, CAN, IFN-gamma, CD4
Papers on TFT
Type 1 innate lymphoid cells contribute to the pathogenesis of chronic hepatitis B.
New
Tian et al., Chongqing, China. In Innate Immun, 31 Aug 2015
In this study, we found the markedly elevated levels of the ILC1 transcription factor T-bet, the effector cytokine IFN-γ and the IL/receptor signaling molecules IL-12/IL-12R, which are indispensable for ILC1 differentiation, in the helper ILCs of chronic hepatitis B (CHB) patients.
Induction of a Th1 immune response and suppression of IgE via immunotherapy with a recombinant hybrid molecule encapsulated in liposome-protamine-DNA nanoparticles in a model of experimental allergy.
New
Sankian et al., Bābol, Iran. In Immunol Res, 31 Jul 2015
The LPD-rHM induced allergen-specific responses with relatively high interferon-gamma production, as well as expression of the transcription factor T-bet in stimulated splenocytes.
Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse.
New
Chiba et al., Tsukuba, Japan. In Cancer Chemother Pharmacol, 18 Jul 2015
PURPOSE: Trifluridine (TFT) is an antitumor component of a novel nucleoside antitumor agent, TAS-102, which consists of TFT and tipiracil hydrochloride (thymidine phosphorylase inhibitor).
Hypogammaglobulinemia in newly diagnosed chronic lymphocytic leukemia: Natural history, clinical correlates, and outcomes.
New
Shanafelt et al., Rochester, United States. In Cancer, May 2015
The relation between hypogammaglobulinemia at diagnosis and the novel prognostic parameters time to first treatment (TFT) and overall survival (OS) were evaluated.
The transcriptional programs of iNKT cells.
Review
New
Brenner et al., Boston, United States. In Semin Immunol, Feb 2015
As in MHC-restricted T cells, specific transcription factors are characteristic of functional subsets of iNKT cells, such as the transcription factor T-bet in the NKT1 subset.
Individual T helper cells have a quantitative cytokine memory.
New
Impact
Löhning et al., Berlin, Germany. In Immunity, Feb 2015
Mechanistically, this memory resulted from quantitatively distinct transcription of individual alleles and was controlled by stable expression differences of the Th1 cell lineage-specifying transcription factor T-bet. Functionally, Th1 cells with graded IFN-γ production competence differentially activated Salmonella-infected macrophages for bacterial killing.
A central role for Notch in effector CD8(+) T cell differentiation.
New
Impact
Amsen et al., Amsterdam, Netherlands. In Nat Immunol, Dec 2014
Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet.
ANP/NPRA signaling preferentially mediates Th2 responses in favor of pathological processes during the course of acute allergic asthma.
New
Wang et al., Guilin, China. In Int J Clin Exp Med, Dec 2014
Mechanistic studies revealed that ANP repressed the expression of Th1 transcription factor T-bet, but enhanced Th2 transcription GATA3 expression.
CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection.
New
Impact
Kaech et al., New Haven, United States. In Immunity, Nov 2014
Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help.
The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.
New
Impact
Tanriver et al., Freiburg, Germany. In Immunity, Sep 2014
Similar to natural killer cells and other innate lymphoid cells, CD8αα(+) IELs constitutively express the T-box transcription factor T-bet.
Is T-bet a potential therapeutic target in multiple sclerosis?
Review
New
Lovett-Racke et al., Columbus, United States. In J Interferon Cytokine Res, Aug 2014
Work over the past several years suggests that the transcription factor T-bet appears to be an important factor in T cell encephalitogenicity; however, recent data suggest that it is also dispensable in certain situations, particularly for Th17 cells.
Roles for helper T cell lineage-specifying transcription factors in cellular specialization.
Review
Weinmann, Seattle, United States. In Adv Immunol, 2013
In this review, we will explore our evolving views on these topics, often times using the Th1-lineage-specifying transcription factor T-bet as an example.
An overview of the role of innate lymphoid cells in gut infections and inflammation.
Review
Monteleone et al., Roma, Italy. In Mediators Inflamm, 2013
Specifically, ILCs1 express the transcription factor T-bet and secrete T helper type-1- (Th1-) related cytokines, ILCs2 are dependent on the transcription factor RORα and express Gata-3 and the chemokine receptor homologous molecule (CRTH2) and produce Th2-related cytokines, and ILCs3 express the transcription factor RORγt and synthesize interleukin- (IL-) 17, IL-22, and, under specific stimuli, interferon-γ.
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.
Impact
Urdahl et al., Seattle, United States. In Immunity, 2013
These antigen-specific Treg cells peaked in numbers 3 weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet.
The emerging role of T cell cytokines in non-small cell lung cancer.
Review
Finotto et al., Nürnberg, Germany. In Cytokine Growth Factor Rev, 2012
Whereas T helper 1 cells and their master transcription factor T-bet have been identified as important regulators of IFN-gamma driven anti-tumoral immune response, IL-17 producing T helper 17 cells expressing RORA/C transcription factors have been found to augment tumor growth and cell proliferation in NSCLC.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
GeneRIF
Barresi et al., Messina, Italy. In Am J Surg Pathol, 2012
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
GeneRIF
SHARP Investigators et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
GeneRIF
Flanagan et al., In Histopathology, 2011
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Impact
GeneRIF
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
GeneRIF
Elefanty et al., Melbourne, Australia. In Plos One, 2010
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
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