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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

T, brachyury homolog

TFT, transcription factor T-bet, T-protein
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: T-bet, BET, CAN, IFN-gamma, CD4
Papers on TFT
A central role for Notch in effector CD8(+) T cell differentiation.
New
Impact
Amsen et al., Amsterdam, Netherlands. In Nat Immunol, 31 Dec 2014
Expression of Notch was induced on naive CD8(+) T cells by inflammatory mediators and interleukin 2 (IL-2) via pathways dependent on the metabolic checkpoint kinase mTOR and the transcription factor T-bet.
Large Graphene Quantum Dots Alleviate Immune-Mediated Liver Damage.
New
Trajkovic et al., In Acs Nano, 21 Dec 2014
In the spleen of GQD-exposed mice, mRNA expression of IFN-γ and its transcription factor T-bet was reduced, while that of the IL-33 ligand ST2 was increased.
Early-onset Evans syndrome, immunodeficiency and premature immunosenescence associated with tripeptidyl-peptidase II deficiency.
New
Ehl et al., Jerusalem, Israel. In Blood, 20 Dec 2014
T-cells showed increased expression of the effector molecules perforin and IFN-γ with high expression of the transcription factor T-bet. Age-associated B-cells with a CD21- CD11c+ phenotype expressing T-bet were increased in humans and mice, combined with antinuclear antibodies.
Alterations of T Helper Lymphocyte Subpopulations in Sepsis, Severe Sepsis, and Septic Shock: A Prospective Observational Study.
New
Xie et al., Beijing, China. In Inflammation, 18 Dec 2014
Quantitative real-time polymerase chain reaction (RT-PCR) of Th1, Th2, and Th17; regulatory T (Treg) cell-specific transcription factor T-bet; GATA-3; RORgammat (RORγt); forkhead box P3 (FOXP3); and IL-17 mRNA were performed, and the enzyme-linked immunosorbent assay (ELISA) was used to detect serum interferon (IFN)-γ, IL-4, and IL-10.
Human memory, but not naive, CD4+ T cells expressing transcription factor T-bet might drive rapid cytokine production.
New
Wu et al., Xinhui, China. In J Biol Chem, 05 Dec 2014
UNLABELLED: We found that after stimulation for a few hours, memory but not naive CD4+ T cells produced a large amount of IFN-γ; however, the mechanism of rapid response of memory CD4+ T cells remained undefined.
CD4(+) T Cell Help Guides Formation of CD103(+) Lung-Resident Memory CD8(+) T Cells during Influenza Viral Infection.
New
Impact
Kaech et al., New Haven, United States. In Immunity, 16 Nov 2014
Furthermore, expression of the transcription factor T-bet was increased in "unhelped" lung Trm cells, and a reduction in T-bet rescued CD103 expression in the absence of CD4(+) T cell help.
Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction.
New
Gruener et al., München, Germany. In J Exp Med, 22 Oct 2014
The transcription factor T-bet regulates the production of interferon-γ and cytotoxic molecules in effector CD8 T cells, and its expression correlates with improved control of chronic viral infections.
The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8αα(+) intraepithelial lymphocyte development.
New
Impact
Tanriver et al., Freiburg, Germany. In Immunity, Sep 2014
Similar to natural killer cells and other innate lymphoid cells, CD8αα(+) IELs constitutively express the T-box transcription factor T-bet.
Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.
New
Impact
Urdahl et al., Seattle, United States. In Immunity, Jul 2013
These antigen-specific Treg cells peaked in numbers 3 weeks after infection but subsequently underwent selective elimination driven, in part, by interleukin-12-induced intrinsic expression of the Th1-cell-promoting transcription factor T-bet.
Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.
New
Impact
Howard et al., London, United Kingdom. In Cell Metab, May 2013
We report that mice deficient in the immune cell transcription factor T-bet have lower energy expenditure and increased visceral fat compared with wild-type mice, yet paradoxically are more insulin sensitive.
Three-finger toxins, a deadly weapon of elapid venom--milestones of discovery.
Review
New
Utkin, Moscow, Russia. In Toxicon, Feb 2013
The first TFT α-bungarotoxin was isolated almost half a century ago and so far it remains a valuable tool in the study of nicotinic acetylcholine receptors.
The emerging role of T cell cytokines in non-small cell lung cancer.
Review
Finotto et al., Nürnberg, Germany. In Cytokine Growth Factor Rev, 2012
Whereas T helper 1 cells and their master transcription factor T-bet have been identified as important regulators of IFN-gamma driven anti-tumoral immune response, IL-17 producing T helper 17 cells expressing RORA/C transcription factors have been found to augment tumor growth and cell proliferation in NSCLC.
Expression of brachyury in hemangioblastoma: potential use in differential diagnosis.
GeneRIF
Barresi et al., Messina, Italy. In Am J Surg Pathol, 2012
Propose the use of brachyury as an additional helpful immunohistochemical marker to resolve the differential diagnosis of hemangioblastoma and histologic mimics.
Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
GeneRIF
SHARP Investigators et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Genom-wide association identifies the T gene as a novel asthma pharmacogenetic locus.
T-bet employs diverse regulatory mechanisms to repress transcription.
Review
Weinmann et al., Seattle, United States. In Trends Immunol, 2012
The T-box transcription factor T-bet is required for CD4(+) T helper 1 (Th1) cell differentiation.
P63 does not regulate brachyury expression in human chordomas and osteosarcomas.
GeneRIF
Flanagan et al., In Histopathology, 2011
DeltaNP63 is not expressed and is therefore rarely, if ever, a transcriptional regulator of brachyury in human osteosarcomas and chordomas.
Mouse T helper 17 phenotype: not so different than in man after all.
Review
Romagnani et al., Florence, Italy. In Cytokine, 2011
Studies performed in human demonstrated apparent species-specific differences, such as the expression by TH17 cells of the TH1-related transcription factor T-bet, the IL-12-inducible plasticity of TH17 cells into TH1 cells, and the dispensability of TGF-β signaling for their development.
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.
Impact
GeneRIF
Pedersen et al., Cambridge, United Kingdom. In Cell Stem Cell, 2011
BRA was necessary for and preceded CDX2 expression.
T-bet in disease.
Review
Impact
Glimcher et al., Boston, United States. In Nat Immunol, 2011
At the center of the type 1 inflammatory response is the transcription factor T-bet, a critical regulator of the T(H)1 differentiation program.
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity.
GeneRIF
Elefanty et al., Melbourne, Australia. In Plos One, 2010
Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity
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