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Tissue factor pathway inhibitor

TFPI
This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, Wnt5a, Plasminogen, CAN, AGE
Papers on TFPI
Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?
New
Araúzo-Bravo et al., San Sebastián, Spain. In Mol Hum Reprod, Feb 2016
STUDY HYPOTHESIS: Does primordial germ cell (PGC) activation start before mouse embryo implantation, and does the possible regulation of the DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l) by transcription factor AP-2, gamma (TCFAP2C) have a role in this activation and in the primitive endoderm (PE)-epiblast (EPI) lineage specification?
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus.
New
Francischetti et al., Bethesda, United States. In Plos Negl Trop Dis, Jan 2016
Furthermore, Boophilin abrogates cathepsin G- and plasmin-induced platelet aggregation and partially affects elastase-mediated cleavage of Tissue Factor Pathway Inhibitor (TFPI).
Tissue Factor Pathway Inhibitor: Multiple Anticoagulant Activities for a Single Protein.
Review
New
Mast, Milwaukee, United States. In Arterioscler Thromb Vasc Biol, Jan 2016
Tissue factor (TF) pathway inhibitor (TFPI) is an anticoagulant protein that inhibits early phases of the procoagulant response.
Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.
New
Shi et al., Shanghai, China. In Thromb Res, Jan 2016
BACKGROUND: Tissue factor pathway inhibitor-2 (TFPI-2) regulates matrix metalloproteinases activation and extracellular matrix degradation.
NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury.
New
Okumura et al., Hirosaki, Japan. In Clin Exp Nephrol, Jan 2016
mRNA expressions of TF and tissue factor pathway inhibitor (TFPI) were analyzed by quantitative RT-PCR.
Association of Serum Sex Hormones with Hemostatic Factors in Women On and Off Hormone Therapy: The Multiethnic Study of Atherosclerosis.
New
Vaidya et al., Seattle, United States. In J Womens Health (larchmt), Jan 2016
A smaller random sample of 491 women also had von Willebrand factor (vWF), plasminogen activator inhibitor (PAI-1), and tissue factor pathway inhibitor (TFPI) levels measured.
A colostrum trypsin inhibitor gene expressed in the Cape fur seal mammary gland during lactation.
New
Arnould et al., Melbourne, Australia. In Gene, Dec 2015
Structural homology modelling of Cape fur seal CTI and Pacific walrus trypsin based on the model of the second Kunitz domain of human tissue factor pathway inhibitor (TFPI) and porcine trypsin (Protein Data Bank: 1TFX) confirmed that CTI inhibits trypsin in a canonical fashion.
Role of exosite binding modulators in the inhibition of fxa by TFPI.
New
Rosing et al., Maastricht, Netherlands. In Thromb Haemost, Dec 2015
UNASSIGNED: Tissue factor pathway inhibitor (TFPI) down-regulates the extrinsic coagulation pathway by inhibiting FXa and FVIIa.
Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer.
New
OSBREAC Study Group et al., Oslo, Norway. In J Thromb Haemost, Dec 2015
Since hypoxic microenvironment is a common feature of solid tumors, we investigated the role of hypoxia in the regulation of tissue factor (TF) pathway inhibitor (TFPI) expression in breast cancer.
Genetic determinants of tissue factor pathway inhibitor plasma levels.
Review
New
Gagnon et al., Toronto, Canada. In Thromb Haemost, Aug 2015
Tissue factor pathway inhibitor (TFPI) impedes early stages of the blood coagulation response, and low TFPI plasma levels increase the risk of thrombosis.
New insights into the biology of tissue factor pathway inhibitor.
Review
New
Mast et al., Milwaukee, United States. In J Thromb Haemost, Jun 2015
Tissue factor pathway inhibitor (TFPI) dampens the initiation of blood coagulation by inhibiting two potent procoagulant complexes, tissue factor-factor VIIa (TF-FVIIa) and early forms of prothrombinase.
Coagulation in patients with severe sepsis.
Review
New
Poll et al., Amsterdam, Netherlands. In Semin Thromb Hemost, Feb 2015
Activation of the coagulation system and ensuing thrombin generation is dependent on expression of tissue factor on activated mononuclear cells and endothelial cells, and is insufficiently counteracted by TFPI.
Enhanced Protective Effect of the Combination of Uncaria and Semen Raphani on Vascular Endothelium in Spontaneously Hypertensive Rats.
Yang et al., Jinan, China. In Evid Based Complement Alternat Med, 2014
The combination of U and R decreased the mRNA level of VCAM-1, Sel-L, TFPI, and Sel-P, while it elevated mRNA expression of FGF-1 and THBD of the thoracic aorta, which may be, at least in part, involved in the mechanism of protective effect on hypertensive endothelial injury.
Tissue factor pathway inhibitor: then and now.
Review
Adams et al., Launceston, Australia. In Semin Thromb Hemost, 2014
Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation.
Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor.
GeneRIF
Sant'Ana Dusse et al., Belo Horizonte, Brazil. In J Thromb Thrombolysis, 2012
Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor.
Exploring the sequence-function relationship in transcriptional regulation by the lac O1 operator.
GeneRIF
Dunbar et al., United States. In Febs J, 2012
Data indicate that in the absence of its inducer, LacI binds to primary operator lac O1 near the transcription start site of the lac operon, and represses its transcription.
The lac repressor displays facilitated diffusion in living cells.
Impact
GeneRIF
Elf et al., Uppsala, Sweden. In Science, 2012
findings show the lac repressor slides 45 +/- 10 base pairs on chromosomal DNA and that sliding can be obstructed by other DNA-bound proteins near the operator; the repressor frequently slides over its natural lacO(1) operator several times before binding
Tissue factor pathway inhibitor, activated protein C resistance, and risk of ischemic stroke due to postmenopausal hormone therapy.
GeneRIF
Lynch et al., Bethesda, United States. In Stroke, 2012
Procoagulant changes in TFPI or nAPCsr do not modify the increased ischemic stroke risk due to postmenopausal hormone therapy.
Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia.
GeneRIF
Mast et al., Milwaukee, United States. In Proc Natl Acad Sci U S A, 2012
Murine models of combined TFPI and factor VIII deficiency were used to examine the impact of TFPI deficiency on bleeding and clotting in hemophilia
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial.
Impact
OPTIMIST Trial Study Group et al., Denver, United States. In Jama, 2003
Tissue factor pathway inhibitor (TFPI) forms a complex with tissue factor and blood protease factors leading to inhibition of thrombin generation and fibrin formation.
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