RNA polymerase III transcription control elements: themes and variations.
Parma, Italy. In Gene, 2012
The highly selective, efficient and localized action of Pol III at its minute genomic targets is made possible by a handful of cis-acting regulatory elements, located within the transcribed region (where they are bound by the multisubunit assembly factor TFIIIC) and/or upstream of the transcription start site.
A role for TFIIIC transcription factor complex in genome organization.
Bethesda, United States. In Cell, 2006
We show that inverted repeat (IR) boundary elements flanking the fission yeast mating-type heterochromatin domain contain B-box sequences, which prevent heterochromatin from spreading into neighboring euchromatic regions by recruiting transcription factor TFIIIC complex without RNA polymerase III (Pol III).
TFIIIC boxes in the genome.
Iowa City, United States. In Cell, 2006
In this issue of Cell, Noma et al. (2006) show that B-boxes and TFIIIC limit the spread of heterochromatin at the silent mat region in the fission yeast genome.