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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TRK-fused gene

TFG, TRK-fused gene
There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: TGF-beta, CAN, trkA, HAD, POLYMERASE
Papers on TFG
Programming A Molecular Relay for Ultrasensitive Biodetection through (129) Xe NMR.
Dmochowski et al., Philadelphia, United States. In Angew Chem Int Ed Engl, Jan 2016
A cucurbit[6]uril (CB[6])-based molecular relay was programmed for three sequential equilibrium conditions by designing a two-faced guest (TFG) that initially binds CB[6] and blocks the CB[6]-Xe interaction.
ALK, ROS1 and NTRK3 gene rearrangements in inflammatory myofibroblastic tumors.
Oda et al., Fukuoka, Japan. In Histopathology, Jan 2016
One case with ROS1 positivity showed cytoplasmic and dot-like ROS1 expression by IHC and the TFG-ROS1 fusion transcript by RT-PCR.
The c.*229C > T gene polymorphism in 3'UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma.
Bryś et al., Łódź, Poland. In Tumour Biol, Nov 2015
The incidence of LOH in BRCA1/BRCA2 was significantly related to higher tumor grade and TFG (p < 0.05).
Reduced dentin matrix protein expression in Camurati-Engelmann disease transgenic mouse model.
MacDougall et al., Shihezi, China. In J Cell Physiol, Nov 2015
CONCLUSIONS: Our results provide in vivo evidence suggesting that TFG-β1 mediates expression of important dentin extracellular matrix components secreted by dental pulp, and when unbalanced, may contribute to abnormal dentin disorders.
Interaction potential of Trigonella foenum graceum through cytochrome P450 mediated inhibition.
Bandyopadhyay et al., Calcutta, India. In Indian J Pharmacol, Sep 2015
OBJECTIVE: The seeds of Trigonella foenum-graecum (TFG) (family: Leguminosae) are widely consumed both as a spice in food and Traditional Medicine in India.
[Review of the recent literature on hereditary neuropathies].
Birouk, Rabat, Morocco. In Rev Neurol (paris), 2014
The gene TFG on chromosome 3 has been recently identified to be responsible for this form.
Expression of Th17 cell population regulatory cytokines in laryngeal carcinoma - Preliminary study.
Starska et al., Kraków, Poland. In Contemp Oncol (pozn), 2014
The clinicomorphological criteria included pTNM, stage, G, and the total tumour front grading (TFG) score.
Novel approaches in anaplastic thyroid cancer therapy.
Chen et al., Madison, United States. In Oncologist, 2014
Lastly, novel approaches and agents involving the Notch1 pathway, nuclear factor κB, Trk-fused gene, cancer stem-like cells, mitochondrial mutation, and tumor immune microenvironment are discussed.
Recent advances in Charcot-Marie-Tooth disease.
Timmerman et al., Antwerp, Belgium. In Curr Opin Neurol, 2014
RECENT FINDINGS: Several new Charcot-Marie-Tooth disease-causing genes have been recently identified, further enlarging the genetic diversity and phenotypic variability, including: SBF1, DHTKD1, TFG, MARS, HARS, HINT1, TRIM1, AIFM1, PDK3 and GNB4.
Targeting tropomyosin-receptor kinase fused gene in cancer.
Tseng et al., Taipei, Taiwan. In Anticancer Res, 2014
Tropomyosin-receptor kinase fused gene (TRK-fused gene, TFG) encodes a protein which is a conserved regulator of protein secretion that localizes in the endoplasmic reticulum exit sites and controls the export of materials from the endoplasmic reticulum.
Development and remodeling of the vertebrate blood-gas barrier.
Djonov et al., Bern, Switzerland. In Biomed Res Int, 2012
GATA, HNF-3, and WNT5a; signaling molecules including FGF, BMP-4, Shh, and TFG- β and extracellular proteins and their receptors have been implicated.
The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.
Tsuji et al., Tokyo, Japan. In Am J Hum Genet, 2012
The TRK-fused gene is mutated in hereditary motor and sensory neuropathy with proximal dominant involvement.
The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.
Kim et al., Seoul, South Korea. In Carcinogenesis, 2012
results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC chimeric protein and that fusion of the TFG (NTD) to the TEC protein produces a gain-of-function chimeric product
Identification of TFG (TRK-fused gene) as a putative metastatic melanoma tumor suppressor gene.
Hayward et al., Brisbane, Australia. In Genes Chromosomes Cancer, 2012
Mutations in TFG may have important clinical relevance for current therapeutic strategies to treat metastatic melanoma.
Transforming ER exit: protein secretion meets oncogenesis.
Miller et al., In Nat Cell Biol, 2011
TFG is now defined as a factor that modulates recruitment of the coat and links ER sequestration of kinases to oncogenesis.
TFG-1 function in protein secretion and oncogenesis.
Audhya et al., Madison, United States. In Nat Cell Biol, 2011
We identify TFG-1, a new conserved regulator of protein secretion that interacts directly with SEC-16 and controls the export of cargoes from the endoplasmic reticulum in Caenorhabditis elegans.
TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals.
Cross et al., Salisbury, United Kingdom. In Haematologica, 2010
A polymorphic gene fusion consisting of TRK-fused gene and G-protein-coupled receptor 128 is identified in healthy individuals and in patients with lymphoma and soft tissue neoplasms.
The TFG protein, involved in oncogenic rearrangements, interacts with TANK and NEMO, two proteins involved in the NF-kappaB pathway.
Greco et al., Milano, Italy. In J Cell Physiol, 2006
TFG enhances the effect of TNF-alpha, TANK, TNF receptor-associated factor (TRAF)2, and TRAF6 in inducing NF-kappaB activity; it is suggested that TFG is a novel member of the NF-kappaB pathway
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Constam et al., China. In Nat Cell Biol, 2002
This process is triggered by Nodal, a protein related to transforming growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal.
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15.
Massagué et al., New York City, United States. In Nature, 1997
Repression of Cdc25A and induction of p15 are independent effects mediating the inhibition of Cdk4/6 by TFG-beta.
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