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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Trefoil factor 3

TFF3, intestinal trefoil factor, trefoil factor 3
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: pS2, TFF2, HAD, CAN, ACID
Papers on TFF3
Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study.
New
Girkontaitė et al., Vilnius, Lithuania. In Int Arch Allergy Immunol, Feb 2016
RESULTS: Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls.
Clinical and Emergent Biomarkers and Their Relationship to the Prognosis of Ovarian Cancer.
New
Goode et al., Rochester, United States. In Oncology, Feb 2016
In univariate analyses, overexpression of TFF3, MDM2, and p53 were associated with improved recurrence-free survival.
CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.
New
Paulsen et al., Erlangen, Germany. In Invest Ophthalmol Vis Sci, Feb 2016
PURPOSE: Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing.
Nestin: A biomarker of aggressive uterine cancers.
New
Syed et al., Bethesda, United States. In Gynecol Oncol, Jan 2016
Nestin was inversely correlated with ER, PR and TFF3, and correlated with p53 and IMP3.
Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review.
Review
New
Reis et al., Brasília, Brazil. In J Adv Nurs, Jan 2016
Interventions of zinc sulphate, amifostine, chewing gum, sucralfate, recombination human intestinal trefoil factor, kefir and vitamin E were evaluated by one article each.
Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer.
Review
New
Yang et al., Hengyang, China. In Clin Chim Acta, Nov 2015
Trefoil factor family (TFF), composed of TFF1, TFF2, and TFF3, is a cluster of secreted peptides characterized by trefoil domain (s) and C-terminal dimerization domain.
Trefoils: An unexplored natural protective shield of oral cavity.
Review
New
Suresh et al., Ambāla, India. In J Oral Biol Craniofac Res, Sep 2015
The predominant secretion of trefoil factor (TFF) occurs from gastric mucosal lining, small and large intestine, oral mucosal cells, and salivary glands.
Diagnosis and management of high risk group for gastric cancer.
Review
Kim et al., Seoul, South Korea. In Gut Liver, 2015
Although endoscopic evaluation using enhanced technologies such as narrow band imaging-magnification, the serum pepsinogen test, Helicobacter pylori serology, and trefoil factor 3 have been evaluated, a gold standard method to accurately select individuals with AG and IM has not emerged.
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.
Review
Hansson et al., Göteborg, Sweden. In Immunol Rev, 2014
The intestinal goblet cells secrete not only the MUC2 mucin but also a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.
In Vitro Investigation of the Immunomodulatory Potential of Probiotic Lactobacillus casei.
Lakshmi et al., Chennai, India. In Probiotics Antimicrob Proteins, 2013
To evaluate the downstream target of STAT3 upregulation, expression of the intestinal trefoil factor TFF3 which is a NF-κB regulator and STAT3 downstream target was studied.
Trefoil factor family peptides in normal and diseased human pancreas.
GeneRIF
Alison et al., London, United Kingdom. In Pancreas, 2012
Report TFF3 expression in normal/diseased pancreas.
Increased trefoil factor 3 levels in the serum of patients with three major histological subtypes of lung cancer.
GeneRIF
Xiao et al., Jinan, China. In Oncol Rep, 2012
results show increased TFF3 levels in serum and lung tissues, suggesting that TFF3 may serve as a promising, easily detected biomarker of lung cancer.
TFF3 is a normal breast epithelial protein and is associated with differentiated phenotype in early breast cancer but predisposes to invasion and metastasis in advanced disease.
GeneRIF
May et al., Newcastle upon Tyne, United Kingdom. In Am J Pathol, 2012
TFF3 is expressed in both the normal and diseased breast and although associated with features of good prognosis, its profile of expression in invasive cancer is consistent with a role in breast tumor progression and tumor cell dissemination.
Differential expression of gastric MUC5AC in colonic epithelial cells: TFF3-wired IL1 β/Akt crosstalk-induced mucosal immune response against Shigella dysenteriae infection.
GeneRIF
Devaraj et al., Chennai, India. In J Cell Sci, 2012
Differential expression of MUC5AC involves crosstalk between interleukin-1beta and Akt, whereby the trefoil factor family peptide TFF3 activates Akt by phosphorylation of EGFR.
Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) study.
GeneRIF
Coresh et al., Baltimore, United States. In Am J Nephrol, 2010
Trefoil factor 3 predicts incident chronic kidney disease
Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury.
Impact
Gerhold et al., United States. In Nat Biotechnol, 2010
The capacities of urinary trefoil factor 3 (TFF3) and urinary albumin to detect acute renal tubular injury have never been evaluated with sufficient statistical rigor to permit their use in regulated drug development instead of the current preclinical biomarkers serum creatinine (SCr) and blood urea nitrogen (BUN).
Phase II, randomized, double-blind, placebo-controlled study of recombinant human intestinal trefoil factor oral spray for prevention of oral mucositis in patients with colorectal cancer who are receiving fluorouracil-based chemotherapy.
Impact
Woon et al., Farmington, United States. In J Clin Oncol, 2009
PURPOSE: This study evaluated the safety and efficacy of recombinant human intestinal trefoil factor (rhITF) administered as topical oral spray for prevention and treatment of chemotherapy-induced oral mucositis (OM).
Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers.
Review
Impact
Wiseman et al., Vancouver, Canada. In J Clin Oncol, 2006
A review of the top 12 candidates revealed well known thyroid cancer markers such as MET, TFF3, SERPINA1, TIMP1, FN1, and TPO as well as relatively novel or uncharacterized genes such as TGFA, QPCT, CRABP1, FCGBP, EPS8 and PROS1.
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice.
Impact
GeneRIF
Ernst et al., Melbourne, Australia. In Nat Med, 2002
gene activation mediated by SHP2 and STAT pathways in gp130 mutant mice
Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor.
Impact
Fishman et al., Boston, United States. In Science, 1996
The gene encoding intestinal trefoil factor (ITF), a protein secreted throughout the small intestine and colon, was rendered nonfunctional in mice by targeted disruption.
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