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Trefoil factor 2

TFF2, trefoil factor 2
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: pS2, TFF3, HAD, CAN, POLYMERASE
Papers on TFF2
CXCR4 and CXCR7 Mediate TFF3-Induced Cell Migration Independently From the ERK1/2 Signaling Pathway.
New
Paulsen et al., Erlangen, Germany. In Invest Ophthalmol Vis Sci, Feb 2016
However, the chemokine receptor CXCR4 has been described as a low affinity receptor for TFF2.
Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer.
Review
New
Yang et al., Hengyang, China. In Clin Chim Acta, Nov 2015
Trefoil factor family (TFF), composed of TFF1, TFF2, and TFF3, is a cluster of secreted peptides characterized by trefoil domain (s) and C-terminal dimerization domain.
TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more (Review).
Review
New
Hoffmann, Magdeburg, Germany. In Int J Oncol, Sep 2015
The peptide TFF2 (formerly 'spasmolytic polypeptide'), a member of the trefoil factor family (TFF) containing two TFF domains, is mainly expressed together with the mucin MUC6 in the gastric epithelium and duodenal Brunner's glands.
Trefoils: An unexplored natural protective shield of oral cavity.
Review
New
Suresh et al., Ambāla, India. In J Oral Biol Craniofac Res, Sep 2015
The new mammalian growth factor peptide family consists of three peptides, TFF1, TFF2, and TFF3, which are secreted mainly from mucous epithelia with mucus gel.
Involvement of trefoil factor family 2 in the enlargement of intestinal tumors in Apc(Min/+) mice.
New
Wada et al., Sasebo, Japan. In Biochem Biophys Res Commun, Sep 2015
Unexpectedly, microarray analysis identified trefoil factor family 2 (Tff2) rather than growth related genes and/or oncogenes as a most variable gene.
Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.
New
Hong et al., Taejŏn, South Korea. In J Korean Med Sci, Aug 2015
The aims of this study were to evaluate the association between polymorphisms in TFF gene family, TFF1, TFF2, and TFF3 and the risk of gastric cancer (GC) and GC subgroups in a Korean population via a case-control study.
Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis.
New
Kohgo et al., Asahikawa, Japan. In Inflamm Bowel Dis, Jul 2015
According to the microarray analysis, trefoil factor 2 (TFF2) was identified as a candidate molecule targeted by hnRNP A1 in the anti-CD3 antibody-induced enteritis group.
TFF2-CXCR4 Axis Is Associated with BRAF V600E Colon Cancer.
New
Chan et al., Boston, United States. In Cancer Prev Res (phila), Jul 2015
We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 with BRAF V600E-mutant colon cancer (P = 3.0 × 10(-3) and 0.077, respectively for TCGA; P = 3.0 × 10(-8) and 5.1 × 10(-7) for CIT).
Trefoil Factor 3 (TFF3) Is Regulated by Food Intake, Improves Glucose Tolerance and Induces Mucinous Metaplasia.
Baribault et al., Thousand Oaks, United States. In Plos One, 2014
Here we show that in contrast to other trefoil factor family members, TFF1 and TFF2, TFF3 is highly expressed in mouse duodenum, jejunum and ileum and that its expression is regulated by food intake.
Bile acids but not acidic acids induce Barrett's esophagus.
Tian et al., Jinan, China. In Int J Clin Exp Pathol, 2014
Furthermore, elevated levels of Cdx2, Muc2, Bmp4, Kit19, and Tff2 (differentiation genes in BE) were found in BA-treated rats.
Transient changes of enzyme activities and expression of stress proteins in the small intestine of piglets after weaning.
Men et al., Hangzhou, China. In Arch Anim Nutr, 2014
Similarly, the mRNA expressions of TFF1 and TFF2 were significantly increased on Day 7 compared with those on Day 0. Expression of TFF3 was not affected by time after weaning.
Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome.
Lee et al., Hong Kong, Hong Kong. In Plos One, 2014
In addition, Regulator Effects network analysis suggested that TASP1, TOB1, C1orf61, AIF1, ROCK1, TFF2 and miR503-5p may be acting on the cardiomyocytes in 13-day-old mouse hearts to inhibit cardiomyocyte proliferation and G1/S phase transition.
Quantitative measurements of trefoil factor family peptides: possibilities and pitfalls.
Review
Samson, Århus, Denmark. In Scand J Clin Lab Invest, 2013
The trefoil factor family (TFF) peptides TFF1, TFF2, and TFF3 are produced and secreted by mucous membranes throughout the body.
Self-renewal of the gastric epithelium from stem and progenitor cells.
Review
Hoffmann, Magdeburg, Germany. In Front Biosci (schol Ed), 2012
For example, the TFF2/spasmolytic polypeptide expressing metaplasia (SPEM) is the result of a dysregulated trans-differentiation of the mucous neck-zymogenic cell lineage and SPEM can even evolve to intestinal metaplasia.
Trefoil factor family peptides in normal and diseased human pancreas.
GeneRIF
Alison et al., London, United Kingdom. In Pancreas, 2012
Report TFF2 expression in normal/diseased pancreas and suggest role in tumor cell migration.
A novel TFF2 splice variant (∆EX2TFF2) correlates with longer overall survival time in cholangiocarcinoma.
GeneRIF
Limpaiboon et al., Khon Kaen, Thailand. In Oncol Rep, 2012
Report a novel TFF2 splice variant (EX2TFF2) which correlates with longer overall survival time in cholangiocarcinoma.
Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection.
GeneRIF
Herbert et al., Cincinnati, United States. In J Exp Med, 2012
TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection.
Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia.
Impact
Wang et al., New York City, United States. In Cancer Cell, 2012
Histopathology and gene signatures closely resembled human BE, with upregulation of TFF2, Bmp4, Cdx2, Notch1, and IL-6.
Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.
GeneRIF
Montrose et al., Cincinnati, United States. In J Biol Chem, 2011
functional NHE2, but not NHE1, is essential for mouse gastric epithelial restitution and TFFs activate epithelial repair via NHE2
Trefoil factor 2 regulates airway remodeling in animal models of asthma.
GeneRIF
Tang et al., Australia. In J Asthma, 2011
Trefoil factor 2 plays a role in the pathogeneasis of airway remodeling in airway disease in the mouse model.
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