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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transcription factor EB

TFEB, Alpha-TFEB, transcription factor EB
Top mentioned proteins: TFE3, CAN, Microphthalmia-Associated Transcription Factor, V1a, mTORC1
Papers on TFEB
TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
New
Wang et al., Suzhou, China. In Embo J, Feb 2016
In this study, we found that loss of TDP-43 strongly induced a nuclear translocation of TFEB, the master regulator of lysosomal biogenesis and autophagy, through targeting the mTORC1 key component raptor.
Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection.
New
Kehrl et al., Bethesda, United States. In J Immunol, Feb 2016
This triggered the nuclear translocation of transcription factor EB, a known activator of lysosomal gene transcription.
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
New
Botas et al., Houston, United States. In Autophagy, Feb 2016
In mammals, TFEB and other members of the MiTF-TFE family of transcription factors control this network.
Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster.
New
Vaccari et al., Milano, Italy. In Autophagy, Feb 2016
UNASSIGNED: In vertebrates, TFEB (transcription factor EB) and MITF (microphthalmia-associated transcription factor) family of basic Helix-Loop-Helix (bHLH) transcription factors regulates both lysosomal function and organ development.
The regulation of autophagy during exercise in skeletal muscle.
Review
New
Hood et al., York, United Kingdom. In J Appl Physiol, Jan 2016
A longer-term transcriptional program involving FoxO, TFEB, p53 and PGC-1α transcriptional regulators is also induced to fuel sustained increases in autophagic capacity.
MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.
Review
New
Mehra et al., Ann Arbor, United States. In Arch Pathol Lab Med, Oct 2015
Translocation-associated renal cell carcinoma (t-RCC) is a relatively uncommon subtype of renal cell carcinoma characterized by recurrent gene rearrangements involving the TFE3 or TFEB loci.
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.
Review
New
Linehan et al., Bethesda, United States. In Nat Rev Urol, Oct 2015
Emerging evidence links FLCN with a number of other molecular pathways and cellular processes important for cell homeostasis that are frequently deregulated in cancer, including regulation of TFE3 and/or TFEB transcriptional activity, amino-acid-dependent mTOR activation through Rag GTPases, TGFβ signalling, PGC1α-driven mitochondrial biogenesis, and autophagy.
Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis.
Review
New
Razani et al., Saint Louis, United States. In Curr Opin Lipidol, Oct 2015
Finally, the discovery of the transcription factor transcription factor EB as a mechanism of inducing lysosomal biogenesis can have therapeutic value by reversing lysosomal dysfunction in macrophages.
The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis.
Review
New
De Robertis et al., Los Angeles, United States. In Pharmacol Res, Sep 2015
Other MiT members, TFEB and TFE3, are known to play important roles in cellular clearance pathways by transcriptionally regulating the biogenesis of lysosomes and autophagosomes via activation of CLEAR elements in gene promoters of target genes.
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
New
Impact
Bardeesy et al., Boston, United States. In Nature, Sep 2015
In human PDA cells, the MiT/TFE proteins--MITF, TFE3 and TFEB--are decoupled from regulatory mechanisms that control their cytoplasmic retention.
The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways.
New
Impact
Cresswell et al., New Haven, United States. In Nat Immunol, Jul 2015
The transcription factor TFEB regulates lysosomal function by inducing lysosomal activation.
[Clear cell papillary renal cell carcinoma: a distinct low-grade renal tumour].
New
Wang et al., Shanghai, China. In Zhonghua Bing Li Xue Za Zhi, Jun 2015
The staining for CD10, P504S, CD117, TFE3 and TFEB was negative.
Transcriptional regulation of autophagy by an FXR-CREB axis.
Impact
Kemper et al., Urbana, United States. In Nature, 2015
Mechanistically, CREB upregulated autophagy genes, including Atg7, Ulk1 and Tfeb, by recruiting the coactivator CRTC2.
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
Impact
Irazoqui et al., Boston, United States. In Immunity, 2014
By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense.
Of worms and men: HLH-30 and TFEB regulate tolerance to infection.
Impact
Garsin et al., Houston, United States. In Immunity, 2014
The finding inspires study of the mammalian ortholog TFEB, in which a similar role in immune response is ascertained.
PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
GeneRIF
La Spada et al., San Diego, United States. In Sci Transl Med, 2012
TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease.
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
GeneRIF
Ferguson et al., New Haven, United States. In Sci Signal, 2012
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
Translocation renal cell carcinomas in adults: a single-institution experience.
GeneRIF
Cai et al., New York City, United States. In Am J Surg Pathol, 2012
Describes the clinical and histopathologic features of TFE3 and TFEB translocation renal cell carcinoma.
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
GeneRIF
Ballabio et al., Napoli, Italy. In Embo J, 2012
When nutrients are present, phosphorylation of TFEB by mTORC1 inhibits TFEB activity.
TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy.
GeneRIF
Brugarolas et al., In Cell Cycle, 2012
mTORC1 regulates the nuclear localization of TFEB by promoting phosphorylation in the serine-rich motif.
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