ALK-Rearranged Renal Cell Carcinomas in Children.
Omaha, United States. In Genes Chromosomes Cancer, Feb 2016
In our review of 168 pediatric RCC prospectively registered on Children's Oncology Group AREN03B2 protocol, we identified six RCC (3.5%) that demonstrated a unique epithelioid morphology and a peculiar immunophenotypic profile that includes expression of ALK, TFE3 and retention of INI1.
Alveolar Soft Part Sarcoma.
Iowa City, United States. In Arch Pathol Lab Med, Nov 2015
It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.
Bethesda, United States. In Nat Rev Urol, Oct 2015
Emerging evidence links FLCN with a number of other molecular pathways and cellular processes important for cell homeostasis that are frequently deregulated in cancer, including regulation of TFE3 and/or TFEB transcriptional activity, amino-acid-dependent mTOR activation through Rag GTPases, TGFβ signalling, PGC1α-driven mitochondrial biogenesis, and autophagy.
Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical Neurons.
Ciudad López Mateos, Mexico. In Plos One, 2014
Also, we determined the presence of OCT4, SOX2, NANOG, SSEA3, SSEA4, TRA-1-60, E-cadherin, KLF4, TFE3 as well as the proliferation and epigenetic state by immunocytochemistry of the cells.
Landscape of gene fusions in epithelial cancers: seq and ye shall find.
Ann Arbor, United States. In Genome Med, 2014
Tumor-specific gene fusions can serve as diagnostic biomarkers or help define molecular subtypes of tumors; for example, gene fusions involving oncogenes such as ERG, ETV1, TFE3, NUT, POU5F1, NFIB, PLAG1, and PAX8 are diagnostically useful.