ALK-Rearranged Renal Cell Carcinomas in Children.
Omaha, United States. In Genes Chromosomes Cancer, Feb 2016
In our review of 168 pediatric RCC prospectively registered on Children's Oncology Group AREN03B2 protocol, we identified six RCC (3.5%) that demonstrated a unique epithelioid morphology and a peculiar immunophenotypic profile that includes expression of ALK, TFE3 and retention of INI1.
Alveolar Soft Part Sarcoma.
Iowa City, United States. In Arch Pathol Lab Med, Nov 2015
It is characterized by a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in fusion of the transcription factor E3 (TFE3) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25.
Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.
Bethesda, United States. In Nat Rev Urol, Oct 2015
Emerging evidence links FLCN with a number of other molecular pathways and cellular processes important for cell homeostasis that are frequently deregulated in cancer, including regulation of TFE3 and/or TFEB transcriptional activity, amino-acid-dependent mTOR activation through Rag GTPases, TGFβ signalling, PGC1α-driven mitochondrial biogenesis, and autophagy.
PEComa: morphology and genetics of a complex tumor family.
London, United Kingdom. In Ann Diagn Pathol, Oct 2015
PEComas constitute a genetically diverse group that includes neoplasms harboring TFE3 gene rearrangements and those with TSC2 mutations, indicating alternative tumorigenic pathways.
[Alveolar soft part sarcoma in pediatric patients].
Strasbourg, France. In Bull Cancer, Sep 2015
ASPS is characterized by an almost specific translocation t(X, 17)(p11;25) which creates a fusion protein, APSL-TFE3, acting as an aberrant transcription factor.
Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical Neurons.
Ciudad López Mateos, Mexico. In Plos One, 2014
Also, we determined the presence of OCT4, SOX2, NANOG, SSEA3, SSEA4, TRA-1-60, E-cadherin, KLF4, TFE3 as well as the proliferation and epigenetic state by immunocytochemistry of the cells.