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Transcription factor B2, mitochondrial

TFB2M, mtTFB2, mitochondrial transcription factor B2, d-mtTFB2
Top mentioned proteins: TFAM, TFB1M, POLYMERASE, CAN, PGC
Papers on TFB2M
Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons.
New
Turnbull et al., Lübeck, Germany. In Ann Neurol, Dec 2015
METHODS: Multiple-label immunofluorescence was applied to postmortem sections of 10 IPD patients and 10 controls to quantify the abundance of CI-IV subunits (NDUFB8 or NDUFA13, SDHA, UQCRC2 and COXI), and mitochondrial transcription factors (TFAM and TFB2M) relative to mitochondrial mass (Porin and GRP75) in dopaminergic neurons.
Structural models of mammalian mitochondrial transcription factor B2.
New
Cameron et al., United States. In Biochim Biophys Acta, Aug 2015
In mammalian systems, the mitochondrial transcription factor B2 (mtTFB2 or TFB2M) is indispensable for transcription initiation.
Cyclophilin-D: a resident regulator of mitochondrial gene expression.
New
Gazmuri et al., North Chicago, United States. In Faseb J, Jul 2015
We demonstrated in HEK 293T cells that transfected Cyp-D interacts with mitochondrial transcription factors B1 and B2 (TFB2M) but not with mitochondrial transcription factor A. We also demonstrated that Cyp-D interacts in vivo with TFB2M.
A model for transcription initiation in human mitochondria.
New
Temiakov et al., United States. In Nucleic Acids Res, May 2015
In this study we mapped the binding sites of the core transcription initiation factors TFAM and TFB2M on human mitochondrial RNA polymerase, and interactions of the latter with promoter DNA.
Suppression of Mic60 compromises mitochondrial transcription and oxidative phosphorylation.
Liu et al., Beijing, China. In Sci Rep, 2014
Here, we report that Mic60 interacts with mitochondrial transcription factors TFAM and TFB2M.
Echinochrome a increases mitochondrial mass and function by modulating mitochondrial biogenesis regulatory genes.
Han et al., Pusan, South Korea. In Mar Drugs, 2014
Furthermore, Ech A treatment up-regulated biogenesis of regulatory transcription genes, including proliferator-activated receptor gamma co-activator (PGC)-1α, estrogen-related receptor (ERR)-α, peroxisome proliferator-activator receptor (PPAR)-γ, and nuclear respiratory factor (NRF)-1 and such mitochondrial transcription regulatory genes as mitochondrial transcriptional factor A (TFAM), mitochondrial transcription factor B2 (TFB2M), mitochondrial DNA direct polymerase (POLMRT), single strand binding protein (SSBP) and Tu translation elongation factor (TUFM).
Accessorizing the human mitochondrial transcription machinery.
Review
Shadel et al., New Haven, United States. In Trends Biochem Sci, 2013
Transcription of human mtDNA is directed by a single-subunit RNA polymerase, POLRMT, which requires two primary transcription factors, TFB2M (transcription factor B2, mitochondrial) and TFAM (transcription factor A, mitochondrial), to achieve basal regulation of the system.
Structure of human mitochondrial RNA polymerase.
Impact
Temiakov et al., München, Germany. In Nature, 2011
Whereas T7 RNAP can initiate transcription by itself, mtRNAP requires the factors TFAM and TFB2M for binding and melting promoter DNA.
Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription.
GeneRIF
Kurabayashi et al., Maebashi, Japan. In Cardiovasc Res, 2011
Mitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription in cardiac myocytes.
Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro.
GeneRIF
Temiakov et al., United States. In J Biol Chem, 2010
only two essential initiation factors, TFAM and TFB2M, and two promoters, LSP and HSP1, are required to drive transcription of the mitochondrial genome
Training response of mitochondrial transcription factors in human skeletal muscle.
GeneRIF
Sundberg et al., Stockholm, Sweden. In Acta Physiol (oxf), 2010
The mRNA levels of TFB1M and TFB2M are influenced by endurance training
DNA conformation-dependent activities of human mitochondrial RNA polymerase.
GeneRIF
Kang et al., Fukuoka, Japan. In Genes Cells, 2009
Promoter-independent DNA conformation-dependent transcription required TFB2M.
Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness.
GeneRIF
Shadel et al., New Haven, United States. In Hum Mol Genet, 2009
rRNA methyltransferase activity is necessary for induction of mitochondrial biogenesis by TFB1M, but not TFB2M.
Something old, something new, something borrowed ...
Impact
Shoubridge, Montréal, Canada. In Cell Metab, 2009
Two mammalian mitochondrial transcription factors (TFB1M and TFB2M) share homology with universally expressed dimethyltransferases that modify conserved adenines in the small ribosomal subunit rRNA.
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome.
Impact
Larsson et al., Stockholm, Sweden. In Cell Metab, 2009
In addition, we present biochemical evidence that TFB1M does not activate or repress transcription in the presence of TFB2M.
Transcriptional paradigms in mammalian mitochondrial biogenesis and function.
Review
Impact
Scarpulla, Chicago, United States. In Physiol Rev, 2008
Transcription of mtDNA requires a small number of nucleus-encoded proteins including a single RNA polymerase (POLRMT), auxiliary factors necessary for promoter recognition (TFB1M, TFB2M) and activation (Tfam), and a termination factor (mTERF).
Mitochondrial transcription and its regulation in mammalian cells.
Review
Gustafsson et al., Stockholm, Sweden. In Trends Biochem Sci, 2007
The mitochondrial genome is transcribed by a specialized machinery that includes a monomeric RNA polymerase, the mitochondrial transcription factor A and one of the two mitochondrial transcription factor B paralogues, TFB1M or TFB2M.
Initiation and beyond: multiple functions of the human mitochondrial transcription machinery.
Review
Shadel et al., New Haven, United States. In Mol Cell, 2007
Recently, the core human mitochondrial transcription machinery has been defined, comprising a bacteriophage-related mtRNA polymerase (POLRMT), an HMG-box transcription factor (h-mtTFA), and two transcription factors (h-mtTFB1 and h-mtTFB2) that also serve as rRNA methyltransferases.
Nuclear control of respiratory gene expression in mammalian cells.
Review
Scarpulla, Chicago, United States. In J Cell Biochem, 2006
Mitochondrial transcription is directed by a small number of nucleus-encoded factors (Tfam, TFB1M, TFB2M, mTERF).
Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.
Impact
GeneRIF
Gustafsson et al., Huddinge, Sweden. In Nat Genet, 2002
This transcription factor activates transcription of human mitochondrial DNA.
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