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Testis expressed gene 14

TEX14, testis expressed gene 14
The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] (from NCBI)
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Top mentioned proteins: CAN, ACID, Cep55, SCP3, MSY2
Papers on TEX14
Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells.
New
Lee et al., Seoul, South Korea. In Proc Natl Acad Sci U S A, Nov 2015
The TEX14 (testis-expressed gene 14) protein is recruited to the midbody and plays a key role in the inactivation of germ cell abscission.
Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.
Review
New
Looijenga et al., Rotterdam, Netherlands. In Asian J Androl, May 2015
Since 2009, several genome wide association studies (GWAS) have been published, reporting on single-nucleotide polymorphisms (SNPs) with significant associations in or near the genes KITLG, SPRY4, BAK1, DMRT1, TERT, ATF7IP, HPGDS, MAD1L1, RFWD3, TEX14, and PPM1E, likely to be related to TGCT development.
The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.
Westbrook et al., Houston, United States. In Cell Rep, 2014
SCYL1, TEX14, and PLK1 ("STP axis") cooperatively trigger degradation of the REST tumor suppressor protein, a frequent event in human TNBC.
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
Whitfield et al., Brisbane, Australia. In Nat Commun, 2013
We find 11 genome-wide-significant (P<5 × 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14).
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Impact
Nathanson et al., Bethesda, United States. In Nat Genet, 2013
P = 4.04 × 10(-9)), a locus that includes TEX14, RAD51C and PPM1E.
Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint.
GeneRIF
Couch et al., Rochester, United States. In Mol Cell, 2012
Tex14 is an important mediator of kinetochore structure and function and the fidelity of chromosome separation.
Distribution of GFRA1-expressing spermatogonia in adult mouse testis.
Vicini et al., Roma, Italy. In Reproduction, 2012
Using qRT-PCR analysis, we found that GDNF regulates the expression of genes such as Tex14, Sohlh1 and Kit (c-Kit) known to be involved in spermatogonial differentiation.
Mouse germ cell clusters form by aggregation as well as clonal divisions.
Capel et al., Durham, United States. In Mech Dev, 2012
Several molecular components of intercellular bridges in mammalian cells have been identified, including TEX14, a protein required for the stabilization of intercellular bridges, and several associated proteins that are components of the cytokinesis complex.
Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells.
Matzuk et al., Houston, United States. In Plos One, 2011
Here, we show not only the characteristics of testis-expressed gene 14 (TEX14) null spermatogonial stem cells lacking intercellular bridges but also a trial application of genetic correction of a mutation in spermatogonial stem cells as a model for future gene therapy.
Germ cell intercellular bridges.
Review
Matzuk et al., Houston, United States. In Cold Spring Harb Perspect Biol, 2011
Mammalian germ cell intercellular bridges are composed of general cytokinesis components with additional germ cell-specific factors including TEX14.
[Spontaneous differentiation potency of induced pluripotent stem cells into male germ cells in vitro].
Huang et al., Shanghai, China. In Zhonghua Nan Ke Xue, 2011
Each of the 9 genes analyzed exhibited one of the four temporal expression patterns: wavelike increase of Oct4, progressive decrease of Dppa3 and Stra8, wavelike decrease of Dazl, and decrease following initial increase of Tex14, Msy2, Scp1, Scp3 and Akap3.
An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs.
Vilkki et al., Finland. In Bmc Genomics, 2010
Sequencing of a candidate gene Tex14 revealed a 51 bp insertion within exon 27, which caused differential splicing of the exon and created a premature translation stop codon.
Identification and characterization of RBM44 as a novel intercellular bridge protein.
GeneRIF
Matzuk et al., Houston, United States. In Plos One, 2010
RBM44 interacts with itself and TEX14 using yeast two-hybrid, mammalian two-hybrid, and immunoprecipitation.
TEX14 interacts with CEP55 to block cell abscission.
GeneRIF
Matzuk et al., Houston, United States. In Mol Cell Biol, 2010
TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge.
Presumptive germ cells derived from mouse pluripotent somatic cell hybrids.
Kerkis et al., São Paulo, Brazil. In Differentiation, 2009
Presumptive GC obtained reacted positively with anti-EMA, Vasa, Fragilis and Dazl antibodies and expressed GC-specific genes, such as Vasa, Stella, Dazl, Piwil 2, Tex14, Bmp8b, Tdrd1 and Rnf17.
Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.
GeneRIF
Matzuk et al., Houston, United States. In Biol Reprod, 2009
Despite the absence of embryonic intercellular bridges in the Tex14-null mice, male mice initiate spermatogenesis, and female mice are fertile. But fewer oocytes were present in Tex14-null neonatal ovaries.
TEX14 is essential for intercellular bridges and fertility in male mice.
GeneRIF
Matzuk et al., Houston, United States. In Proc Natl Acad Sci U S A, 2006
TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility
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