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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tetraspanin 7

Tetraspanin, UPIb, uroplakin Ib, TM4SF2, A-15
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD151, V1a, CD81, KAI1
Papers on Tetraspanin
Tetraspanin CD37 protects against the development of B cell lymphoma.
van Spriel et al., In J Clin Invest, Feb 2016
Here, we have provided evidence that deficiency of tetraspanin superfamily member CD37, which is important for B cell function, induces the development of B cell lymphoma.
Tetraspanin CD151 and integrin α6β1 mediate platelet-enhanced endothelial colony forming cell angiogenesis.
Li et al., Stockholm, Sweden. In J Thromb Haemost, Feb 2016
CONCLUSION: Platelet-enhanced ECFC angiogenesis requires platelet tetraspanin CD151 and α6β1 integrin, as well as ECFC α6β1 integrin and Src-PI3K signaling.
CD151 knockdown inhibits osteosarcoma metastasis through the GSK-3β/β-catenin/MMP9 pathway.
Sun et al., Shenyang, China. In Oncol Rep, Jan 2016
Tetraspanin CD151 is involved in facilitating tumor metastasis.
Preventive Role of Tetraspanin CD9 in Systemic Inflammation of Chronic Obstructive Pulmonary Disease.
Tachibana et al., Ōsaka, Japan. In Am J Respir Cell Mol Biol, Dec 2015
Tetraspanins, which have a characteristic structure spanning the membrane four times, facilitate lateral organization of molecular complexes and thereby form tetraspanin-enriched microdomains that are distinct from lipid rafts.
Nanoscale Imaging Reveals a Tetraspanin-CD9 Coordinated Elevation of Endothelial ICAM-1 Clusters.
Riethmüller et al., Münster, Germany. In Plos One, Dec 2015
Confocal immunofluorescence microscopy proved them positive for ICAM-1, JAM-A, tetraspanin CD9 and f-actin.
Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin.
Gillette et al., Albuquerque, United States. In Oncogene, Dec 2015
UNASSIGNED: Communication between acute myeloid leukemia (AML) and the bone marrow microenvironment is known to control disease progression.
Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.
Reya et al., San Diego, United States. In Cell Stem Cell, Sep 2015
Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML.
Comprehensive Expression Profiling of Rice Tetraspanin Genes Reveals Diverse Roles During Development and Abiotic Stress.
Katiyar-Agarwal et al., New Delhi, India. In Front Plant Sci, 2014
Tetraspanin family is comprised of evolutionarily conserved integral membrane proteins.
Role of tetraspanin CD9 molecule in fertilization of mammals.
Michalková et al., In Physiol Res, 2014
Tetraspanin CD9 is considered to be a serious candidate molecule participating in these events.
Tetraspanin-enriched microdomains and hepatocellular carcinoma progression.
Carloni et al., Bari, Italy. In Cancer Lett, 2014
The association of certain proteins, including tetraspanins, and lipids in specific location on the plasma membrane constitutes specialized structure called tetraspanin-enriched microdomains (TEMs).
Tetraspanin proteins promote multiple cancer stages.
Hemler, In Nat Rev Cancer, 2014
An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.
Wirth et al., Dresden, Germany. In Int J Cancer, 2012
Loss of TSPAN7 is associated with metastasis in clear-cell renal cell carcinoma.
Tetraspanin genes in plants.
Van Lijsebettens et al., Gent, Belgium. In Plant Sci, 2012
Tetraspanins interact with each other or with other membrane proteins to form tetraspanin-enriched microdomains that play important roles in development, pathogenesis and immune responses via facilitating cell-cell adhesion and fusion, ligand binding and intracellular trafficking.
The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line.
Zhu et al., Nantong, China. In Oncol Rep, 2012
data suggest that the NET-1 gene may play an important role in proliferation, migration and endocytosis in the development and progress of hepatocellular carcinoma
Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.
Byrd et al., Columbus, United States. In Cancer Cell, 2012
We herein demonstrate that upon ligation, CD37, a tetraspanin molecule expressed on mature normal and transformed B cells, becomes tyrosine phosphorylated, associates with proximal signaling molecules, and initiates a cascade of events leading to apoptosis.
The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.
Passafaro et al., Milano, Italy. In Neuron, 2012
This study identified that TSPAN7 as a key molecule for the functional maturation of dendritic spines via PICK1 and ampa receptor trafficking.
Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth.
Zhao et al., Shanghai, China. In Acta Biochim Biophys Sin (shanghai), 2012
TM4SF4/il-TMP has the potential to be biomarker in a hepatocellular carcinoma and plays a crucial role in promotion of cancer cell proliferation
Genomics of hepatitis B virus-related hepatocellular carcinoma and adjacent noncancerous tissues with cDNA microarray.
Wang et al., Changsha, China. In Chin Med J (engl), 2011
Study provided the gene expression profile of HBV-related HCC and presented differential expression patterns of SATB-1, TM4SF-1 and ST-14 between cancerous and noncancerous tissues in patients with HBV-related HCC.
Tetraspanin functions and associated microdomains.
Hemler, Boston, United States. In Nat Rev Mol Cell Biol, 2005
Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall glycoprotein neighbours in the cell membrane.
Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.
Gal et al., Hamburg, Germany. In Nat Genet, 2000
So far, seven X-chromosomal genes mutated in nonspecific mental retardation (MRX) have been identified: FMR2, GDI1, RPS6KA3, IL1RAPL, TM4SF2, OPHN1 and PAK3 (refs 2-9).
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