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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan

testican-3, SPOCK3
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: CD166, MT3-MMP, MT1, osteonectin, OUT
Papers on testican-3
A systematic review on the association between inflammatory genes and cognitive decline in non-demented elderly individuals.
Baune et al., Adelaide, Australia. In Eur Neuropsychopharmacol, Jan 2016
Genome-wide association studies have implicated less direct and less obvious regulators of inflammatory processes (i.e., PDE7A, HS3ST4, SPOCK3), indicating that a shift away from the major cytokine-encoding genes in future studies will be important.
Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.
Wu et al., Taipei, Taiwan. In Osteoarthritis Cartilage, Apr 2015
Up-regulated expression of IL11, POSTN, TNFAIP6, and down-regulated expression of CHRDL2, MATN4, SPOCK3, VIT, PDE3B were significantly associated with OA progression and validated in both medial and lateral compartment dominant OA samples.
SPOCK3, a risk gene for adult ADHD and personality disorders.
Reif et al., Würzburg, Germany. In Eur Arch Psychiatry Clin Neurosci, 2014
SPOCK3, a poorly characterized, putatively Ca(2+)-binding extracellular heparan/chondroitin sulfate proteoglycan gene encoded by the human chromosomal region 4q32.3, was found to be associated with polymorphisms among the top ranks in a genome-wide association study (GWAS) on ADHD and a pooled GWAS on personality disorder (PD).
TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms.
Chiquet-Ehrismann et al., Basel, Switzerland. In J Cell Sci, 2014
We identified a functional N-terminal motif in MKL1_S that allows specific induction of a group of genes including the extracellular matrix (ECM) modifiers MMP16 and SPOCK3/testican-3.
Detection of genome-wide copy number variations in two chicken lines divergently selected for abdominal fat content.
Li et al., Harbin, China. In Bmc Genomics, 2013
Integrating the results of CNVRs, known quantitative trait loci (QTL) and selective sweeps for abdominal fat content suggested that some genes (including SLC9A3, GNAL, SPOCK3, ANXA10, HELIOS, MYLK, CCDC14, SPAG9, SOX5, VSNL1, SMC6, GEN1, MSGN1 and ZPAX) may be important for abdominal fat deposition in the chicken.
Testican-3: a brain-specific proteoglycan member of the BM-40/SPARC/osteonectin family.
Paulsson et al., Köln, Germany. In J Neurochem, 2013
Here, we describe the biochemical characterization and tissue distribution of mouse testican-3 as well as the inactivation of the corresponding gene.
Over-expression of miR-145 enhances the effectiveness of HSVtk gene therapy for malignant glioma.
Kim et al., South Korea. In Cancer Lett, 2012
The second observation is that the over-expression of a small noncoding RNA, miR-145, causes down-regulation of metastasis-related genes, such as PLAUR, SPOCK3, ADAM22, SLC7A5 and FASCN1.
Differential expression patterns of OCC1-related, extracellular matrix proteins in the lateral geniculate nucleus of macaque monkeys.
Yamamori et al., Okazaki, Japan. In J Chem Neuroanat, 2010
We have found that expression of OCC1, testican-1, testican-2, testican-3, SPARC and SC1 mRNAs, which encode members of the OCC1-related family of ECM proteins, exhibits distinct activity-dependent expression patterns in the adult macaque visual cortex.
A homozygous deletion of 8q24.3 including the NIBP gene associated with severe developmental delay, dysgenesis of the corpus callosum, and dysmorphic facial features.
Chitayat et al., Toronto, Canada. In Am J Med Genet A, 2010
In addition, the child inherited a 781-kb deletion on 4q32.2 from the mother that contains the SPOCK3 gene.
Differential expression patterns of occ1-related genes in adult monkey visual cortex.
Yamamori et al., Okazaki, Japan. In Cereb Cortex, 2009
Neither SC1 nor testican-3 mRNA expression is selective to particular areas, but SC1 mRNA is abundantly observed in blobs.
Testican 3 expression in adult T-cell leukemia.
Sugiura et al., Kōchi, Japan. In Leuk Res, 2009
High expression of testican 3 is associated with adult T-cell leukemia.
Comprehensive gene expression analysis in human periodontal ligaments of the mandibular third molars performing vertical movement and the maxillary second premolars with occlusal contact.
Suda, Tokyo, Japan. In Orthod Craniofac Res, 2008
The expression of CALB1 (encoding calbindin 1), CYP26A1 (encoding cytochrome P450, family 26, subfamily A, polypeptide 1), SPOCK3 (encoding testican-3), CCK (encoding cholecystokinin) and SCRG1 (encoding scrapie responsive protein 1) was more than 30-fold higher in PDLs of the third molars than the second premolars.
Evaluation of the 4q32-34 locus in European familial pancreatic cancer.
German National Case Collection for Familial Pancreatic Cancer et al., Liverpool, United Kingdom. In Cancer Epidemiol Biomarkers Prev, 2006
These were HMGB2, PPID, MORF4, and SPOCK3.
Testican-1 is dispensable for mouse development.
Hartmann et al., Köln, Germany. In Matrix Biol, 2006
Despite the fact that neither of the testican-1 homologues expressed in the brain, testican-2, testican-3 and SC1/hevin, showed an increased expression in Ticn1 null mice, these results, together with those from other gene targetings, indicate extensive functional redundancy among brain proteoglycans.
Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.
Sato et al., Kanazawa, Japan. In Cancer Res, 2003
We identified recently N-Tes, which is a product of testican 3 splicing variant gene, as an inhibitor of membrane-type matrix metalloproteinases (MT-MMPs).
Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes.
Sato et al., Kanazawa, Japan. In Cancer Res, 2002
It encodes the NH(2)-terminal 313-amino acid region of a calcium-binding proteoglycan, testican 3, with a 3-amino acid substitution at the COOH terminus and thus was named N-Tes.
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