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Testis-specific kinase 2

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TESK1, ACID, RFX4, Inactive, TOE1
Papers on TESK2
Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence.
Liu et al., Johnson City, United States. In J Mol Neurosci, 2012
Interestingly, several genes (TESK2, TIPARP, THEMIS, ABLIM1, RFX4, STON2 and LILRA1) are associated with three personality traits with p < 10(-3) using single trait analysis and AD.
Comparative analysis of an unusual gene arrangement in the human chromosome 1.
Makałowska, Poznań, Poland. In Gene, 2008
MUTYH, TOE1, TESK2, LOC126661, MMACHC, and PRDX1, in vertebrates, insects, sea urchin, and Arabidopsis genomes and performed detailed analysis of their genomic arrangements.
Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells.
Mizuno et al., Sendai, Japan. In J Biol Chem, 2001
We now report identification and characterization of another member of a TESK family, testicular protein kinase 2 (TESK2), with 48% amino acid identity with TESK1.
Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis.
Aasheim et al., Oslo, Norway. In Genomics, 1999
In this study we present the cDNA sequence of a novel putative protein kinase, denoted TESK2.
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