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Tenascin XB

tenascin-X, TNX, TNXB
This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tenascin, HAD, CAN, 21-hydroxylase, C4B
Papers on tenascin-X
Rare variants in tenascin genes in a cohort of children with primary vesicoureteric reflux.
New
Gbadegesin et al., Durham, United States. In Pediatr Nephrol, Feb 2016
Recently, we reported mutations in the tenascin XB gene (TNXB) as a cause of PVUR with joint hypermobility.
New insight of some extracellular matrix molecules in beef muscles. Relationships with sensory qualities.
New
Listrat et al., France. In Animal, Dec 2015
UNASSIGNED: The aim of this study was to highlight the relationships between decorin, tenascin-X and type XIV collagen, three minor molecules of extracellular matrix (ECM), with some structural parameters of connective tissue and its content in total collagen, its cross-links (CLs) and its proteoglycans (PGs).
Triple-layer dissection of the lung adenocarcinoma transcriptome: regulation at the gene, transcript, and exon levels.
New
Chen et al., Yü-ching, Taiwan. In Oncotarget, Nov 2015
Genes selected by both detection methods include C16orf59, DAP3, ETV4, GABARAPL1, PPAR, RADIL, RSPO1, SERTM1, SRPK1, ST6GALNAC6, and TNXB.
Host Protein Biomarkers Identify Active Tuberculosis in HIV Uninfected and Co-infected Individuals.
New
Paramithiotis et al., United States. In Ebiomedicine, Sep 2015
Biomarker panels whose composition differed according to HIV status, and consisted of 8 host proteins in HIV(-) individuals (CD14, SEPP1, SELL, TNXB, LUM, PEPD, QSOX1, COMP, APOC1), or 10 host proteins in HIV(+) individuals (CD14, SEPP1, PGLYRP2, PFN1, VASN, CPN2, TAGLN2, IGFBP6), respectively, distinguished TB from ORD with excellent accuracy (AUC = 0.96 for HIV(-) TB, 0.95 for HIV(+) TB).
Broadening the Spectrum of Ehlers Danlos Syndrome in Patients With Congenital Adrenal Hyperplasia.
New
Merke et al., Baltimore, United States. In J Clin Endocrinol Metab, Aug 2015
CONTEXT: The contiguous gene deletion syndrome (CAH-X) was described in a subset (7%) of congenital adrenal hyperplasia (CAH) patients with a TNXA/TNXB chimera, resulting in deletions of CYP21A2, encoding 21-hydroxylase necessary for cortisol biosynthesis, and TNXB, encoding the extracellular matrix glycoprotein tenascin-X (TNX).
[Vascular Calcification - Pathological Mechanism and Clinical Application - . Extracellular matrix tenascin-X in calcific aortic valves].
Review
New
Matsumoto, Japan. In Clin Calcium, May 2015
We previously disclosed a novel extracellular matrix tenascin-X (TNX) , the largest member of the tenascin family.
Secretome Identifies Tenascin-X as a Potent Marker of Ovarian Cancer.
Cohen et al., Genève, Switzerland. In Biomed Res Int, 2014
Tenascin-X secretion was shown to correlate with CA-125 value in the initial case study.
Tenascin-X: beyond the architectural function.
Review
Bartholin et al., Lyon, France. In Cell Adh Migr, 2014
Tenascin-X is the largest member of the tenascin (TN) family of evolutionary conserved extracellular matrix glycoproteins, which also comprises TN-C, TN-R and TN-W.
Transcriptional regulation of tenascin genes.
Review
Chiquet et al., Basel, Switzerland. In Cell Adh Migr, 2014
In contrast, tenascin-X is a constituitive component of connective tissues, and its level is barely affected by external factors.
Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.
Review
Rao et al., Beijing, China. In Arthritis Res Ther, 2014
RESULTS: In total, we extracted 116 potential functional pleiotropic genes for RA and eight other diseases, including five hub pleiotropic genes, BTNL2, HLA-DRA, NOTCH4, TNXB, and C6orf10, where BTNL2, NOTCH4, and C6orf10 are novel pleiotropic genes identified by our analysis.
Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils.
Review
Koch et al., Bern, Switzerland. In Int J Biochem Cell Biol, 2014
Collagen XII binds to collagen I-containing fibrils via its collagenous domain, whereas its large noncollagenous arms interact with other matrix proteins such as tenascin-X.
Early detection of lung cancer by molecular markers in endobronchial epithelial-lining fluid.
GeneRIF
Kuner et al., Heidelberg, Germany. In J Thorac Oncol, 2012
Combined analysis of tenascin-C expression and the nodule size improved the prediction of malignancy in this patient cohort.
Further study of genetic association between the TNXB locus and schizophrenia.
GeneRIF
Wu et al., In Psychiatr Genet, 2011
rs204887 itself or a nearby variant is unlikely to play a major role in the development of schizophrenia although a cumulative contribution of rare variants in the TNXB gene cannot be ruled out.
Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-β1 and peroxisome proliferator-activated receptor γ in alcoholic cardiomyopathy.
GeneRIF
Sang et al., Harbin, China. In Chin Med J (engl), 2011
Tenascin-x is an initiator of myocardial fibrosis and ACM development via upregulation of TGFbeta(1) and downregulation of PPARgamma.
Phenotypic effects of Ehlers-Danlos syndrome-associated mutation on the FnIII domain of tenascin-X.
GeneRIF
Li et al., Vancouver, Canada. In Protein Sci, 2010
Three point mutations in TNX gene were found to be associated with hypermobility type Ehlers-Danlos syndrome (EDS) . The phenotypic effects of V1195M mutation on 7th fibronectin Type III domain (TNXfn7) with regards to EDS were investigated.
Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse.
GeneRIF
Sato et al., Tokyo, Japan. In Eur J Histochem, 2010
Identification of the novel localization of tenascinX in the monkey choroid plexus and comparison with the mouse.
Effect of anti-IgE therapy in patients with peanut allergy.
Impact
Avon Longitudinal Study of Parents and Children Study Team et al., Denver, United States. In N Engl J Med, 2003
TNX-901 is a humanized IgG1 monoclonal antibody against IgE that recognizes and masks an epitope in the CH3 region of IgE responsible for binding to the high-affinity Fc(epsilon) receptor on mast cells and basophils.
Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition.
Impact
GeneRIF
Bristow et al., San Francisco, United States. In Nat Genet, 2002
Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition
A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency.
Impact
Bristow et al., Nijmegen, Netherlands. In N Engl J Med, 2001
METHODS: We screened serum samples from 151 patients with the classic, hypermobility, or vascular types of the Ehlers-Danlos syndrome; 75 patients with psoriasis; 93 patients with rheumatoid arthritis; and 21 healthy persons for the presence of tenascin-X and tenascin-C by enzyme-linked immunosorbent assay.
Tenascin-X deficiency is associated with Ehlers-Danlos syndrome.
Impact
Bristow et al., San Francisco, United States. In Nat Genet, 1997
The tenascins are a family of large extracellular matrix proteins with at least three members: tenascin-X (TNX), tenascin-C (TNC, or cytotactin) and tenascin-R (TN-R, or restrictin).
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