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Tenascin R

tenascin-R, TNR
Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993 [PubMed 7694605]). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Tenascin, CD45, CAN, SPINK5, fibronectin
Papers on tenascin-R
The neuronal extracellular matrix restricts distribution and internalization of aggregated Tau-protein.
New
Arendt et al., Leipzig, Germany. In Neuroscience, Feb 2016
PNs are composed of large aggregating chondroitin sulfate proteoglycans connected to a hyaluronan backbone, stabilized by link proteins and cross-linked via tenascin-R.
Extracellular matrix protein expression is brain region dependent.
New
Parker et al., Cambridge, United States. In J Comp Neurol, Feb 2016
To test our hypothesis, we quantitatively analyzed the distribution, co-localization, and protein expression of aggrecan, brevican, and tenascin-R throughout the rat brain utilizing immunohistochemistry and mass spectrometry analysis and assessed the effect of aggrecan, brevican, and/or tenascin-R on neurite outgrowth in vitro.
Short CCG repeat in huntingtin gene is an obstacle for replicative DNA polymerases, potentially hampering progression of replication fork.
New
Maki et al., Ikoma, Japan. In Genes Cells, Oct 2015
DNA replication is reported to be involved in TNR instability, but the current models are insufficient in explaining TNR expansion is induced during replication.
Sphingomonas fonticola sp. nov., isolated from spring water.
New
Chen et al., Kao-hsiung, Taiwan. In Int J Syst Evol Microbiol, Oct 2015
UNASSIGNED: A bacterial strain designated TNR-2T was isolated from spring water in Taiwan and characterized using the polyphasic taxonomy approach.
Modification of tenascin-R expression following unilateral labyrinthectomy in rats indicates its possible role in neural plasticity of the vestibular neural circuit.
New
Matesz et al., Debrecen, Hungary. In Neural Regen Res, Sep 2015
The tenascin-R has repelling effect on pathfinding during axonal growth/regrowth, and thus inhibits neural circuit repair.
Transcriptional regulation of tenascin genes.
Review
Chiquet et al., Basel, Switzerland. In Cell Adh Migr, 2014
Tenascin-R is specific to the central nervous system.
Tenascin-X: beyond the architectural function.
Review
Bartholin et al., Lyon, France. In Cell Adh Migr, 2014
Tenascin-X is the largest member of the tenascin (TN) family of evolutionary conserved extracellular matrix glycoproteins, which also comprises TN-C, TN-R and TN-W.
Mutation analysis of 6 spinocerebellar ataxia (SCA) types in patients from southern Turkey.
ErkoƧ et al., In Turk J Med Sci, 2014
The clinical data of patients were also evaluated to correlate with the increased TNR numbers.
Perineuronal net, CSPG receptor and their regulation of neural plasticity.
Review
Zhang et al., Shanghai, China. In Sheng Li Xue Bao, 2014
The main components of PNNs are hyaluronan (HA), chondroitin sulfate proteoglycans (CSPGs) of the lectican family, link proteins and tenascin-R.
Neural ECM and epilepsy.
Review
Powell et al., Kuopio, Finland. In Prog Brain Res, 2013
Here, we review the role of urokinase-type plasminogen activator receptor interactome, matrix metalloproteinases, tenascin-R, and LGI1 in epileptogenesis and ictogenesis.
Novel host genetic variations associated with spontaneous clearance of a single-source outbreak of HCV1b infections.
Jia et al., Beijing, China. In Bmj Open Gastroenterol, 2013
Two SNPs in the tenascin receptor (TNR), five in the transmembrane protease serine 11A (TMPRSS11A), and one in the serine peptidase inhibitor kunitz type 2 (SPINT2) showed the closest associations (p<10(-5)).
Epigenetic modifications in trinucleotide repeat diseases.
Review
Saffery et al., Australia. In Trends Mol Med, 2013
Several conditions, including fragile X syndrome and Huntington's disease are caused by trinucleotide repeat (TNR) expansions in or near specific genes.
Spatiotemporal distribution of tenascin-R in the developing human cerebral cortex parallels neuronal migration.
GeneRIF
Figarella-Branger et al., Marseille, France. In J Comp Neurol, 2011
results show that tenascin-R expression is tightly regulated in a spatiotemporal manner during brain development, especially cortical plate formation; its pattern of expression suggests a role for tenascin-R in corticogenesis
Improved reversal learning and working memory and enhanced reactivity to novelty in mice with enhanced GABAergic innervation in the dentate gyrus.
GeneRIF
Schachner et al., Hamburg, Germany. In Cereb Cortex, 2010
Ablation of TNR modifies the extracellular matrix and leads to reorganization of the dentate gyrus with enhanced GABAergic innervation and altered plasticity, promoting working memory and reversal learning.
KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas.
GeneRIF
Figarella-Branger et al., Marseille, France. In Neuropathol Appl Neurobiol, 2010
KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
Impact
Rafii et al., New York City, United States. In Cell Stem Cell, 2010
In transgenic notch-reporter (TNR.Gfp) mice, regenerating TNR.Gfp(+) LT-HSCs were detected in cellular contact with sinusoidal ECs.
Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway.
GeneRIF
Faissner et al., Bochum, Germany. In Glia, 2009
Compared tenascin C and tenascin R in oligodendrocyte differentiation. Tnc and Tnr play antagonistic roles for differentiation and comparably inhibit morphologic maturation. conclude that independent molecular pathways regulate these processes.
Parallel genotyping of 10,204 single nucleotide polymorphisms to screen for susceptible genes for IgA nephropathy.
GeneRIF
Chan et al., Singapore, Singapore. In Ann Acad Med Singapore, 2009
The researchers found evidence that the tenascin R gene is a potential susceptiblity or marker gene for IgA nephropathy.
Tenascin-X deficiency is associated with Ehlers-Danlos syndrome.
Impact
Bristow et al., San Francisco, United States. In Nat Genet, 1997
The tenascins are a family of large extracellular matrix proteins with at least three members: tenascin-X (TNX), tenascin-C (TNC, or cytotactin) and tenascin-R (TN-R, or restrictin).
Cultivation of the Drosophila sex-ratio spiroplasma.
Impact
Whitcomb et al., In Science, 1986
Uncultivable for more than 25 years, the sex-ratio spiroplasma of Drosophila willistoni grew in a tissue culture medium (H-2) containing an embryo-derived lepidopteran cell line (IPLB-TN-R(2)).
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