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Telomerase reverse transcriptase

telomerase reverse transcriptase, TERT
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, AGE, V1a, POLYMERASE
Papers using telomerase reverse transcriptase antibodies
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Supplier
Frankel Wayne N, In PLoS Genetics, 2000
... Tetracycline-regulated i-TERT transgenic mice were generated as ...
Comparative investigation of proliferation markers and their prognostic relevance in human meningiomas
Supplier
Bettini Giuliano et al., In Journal of Veterinary Science, 2000
... The primary antibody, an anti-human TERT (Clone 44F12, diluted 1 : 50 in PBS; Novocastra, UK), was applied to the slides overnight at 4℃, followed by a streptavidin-biotinperoxidase complex (LSAB Kit; Dako, Netherlands) and diaminobenzidine (0.04% ...
Papers on telomerase reverse transcriptase
An intact putative mouse telomerase essential N-terminal (TEN) domain is necessary for proper telomere maintenance.
New
Autexier et al., Montréal, Canada. In Biol Cell, Feb 2016
BACKGROUND INFORMATION: Naturally occurring telomerase reverse transcriptase (TERT) isoforms may regulate telomerase activity, and possibly function independently of telomeres to modulate embryonic stem cell self-renewal and differentiation.
TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
New
Mishra et al., In J Clin Invest, Feb 2016
Moreover, tumorigenesis-associated genes IGF2 and telomerase reverse transcriptase (TERT) were overexpressed in fibroblasts from BWS patients and TGF-β-defective mice.
Genome-wide methylation profiling identifies novel methylated genes in neuroblastoma tumors.
New
Carén et al., Göteborg, Sweden. In Epigenetics, Feb 2016
The genes with the highest number of hypermethylated CpG sites in INRG M tumors are TERT, PCDHGA4, DLX5, and DLX6-AS1.
The Role of Telomeres and Telomerase Reverse Transcriptase Isoforms in Pluripotency Induction and Maintenance.
New
Betts et al., London, Canada. In Rna Biol, Feb 2016
Telomeric DNA is synthesized by way of the ribonucleoprotein called telomerase containing a reverse transcriptase (TERT) subunit and RNA component (TERC).
TERT promoter mutations in thyroid cancer.
Review
New
Xing et al., Baltimore, United States. In Endocr Relat Cancer, Feb 2016
UNASSIGNED: The 2013 discovery of TERT promoter mutations chr5, 1,295,228 C>T (C228T) and 1,295,250 C>T (C250T) in thyroid cancer represents an important event in the thyroid cancer field and much progress has occurred since then.
New surprises from an old favourite: The emergence of telomerase as a key player in the regulation of cancer stemness.
Review
New
Yilmazer et al., Nicosia, Cyprus. In Biochimie, Jan 2016
It is striking that there is a positive feedback loop between a number of gene products targeting telomerase's reverse transcriptase subunit (TERT) and TERT expression itself.
The Anti-inflammatory Effect of GV1001 Mediated by the Downregulation of ENO1-induced Pro-inflammatory Cytokine Production.
New
Lee et al., Seoul, South Korea. In Immune Netw, Dec 2015
GV1001 is a peptide derived from the human telomerase reverse transcriptase (hTERT) sequence that is reported to have anti-cancer and anti-inflammatory effects.
TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.
New
Impact
Versteeg et al., Amsterdam, Netherlands. In Nat Genet, Dec 2015
Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage neuroblastomas, with five cases resulting from chromothripsis.
The Genetic Evolution of Melanoma from Precursor Lesions.
New
Impact
Bastian et al., Australia. In N Engl J Med, Dec 2015
A total of 77% of areas of intermediate lesions and melanomas in situ harbored TERT promoter mutations, a finding that indicates that these mutations are selected at an unexpectedly early stage of the neoplastic progression.
Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions.
New
Impact
Feigon et al., Los Angeles, United States. In Science, Nov 2015
Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3'-ends, using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT).
Telomerase activation by genomic rearrangements in high-risk neuroblastoma.
New
Impact
Fischer et al., Köln, Germany. In Nature, Nov 2015
Here we have performed whole-genome sequencing of 56 neuroblastomas (high-risk, n = 39; low-risk, n = 17) and discovered recurrent genomic rearrangements affecting a chromosomal region at 5p15.33 proximal of the telomerase reverse transcriptase gene (TERT).
Genetic Polymorphism, Telomere Biology and Non-Small Lung Cancer Risk.
Review
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Liu et al., West Lafayette, United States. In J Genet Genomics, Nov 2015
Of these regions, single-nucleotide polymorphisms (SNPs), especially rs2736100 located in the telomerase reverse transcriptase (TERT) gene show unique and significant association with non-small cell lung cancer (NSCLC) in a few subpopulations including women, nonsmokers, East Asians and those with adenocarcinoma.
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation.
New
Impact
Tergaonkar et al., Singapore, Singapore. In Nat Cell Biol, Oct 2015
Transcriptional reactivation of TERT, the catalytic subunit of telomerase, is necessary for cancer progression in about 90% of human cancers.
Update in genetic susceptibility in melanoma.
Review
New
Puig et al., Barcelona, Spain. In Ann Transl Med, Sep 2015
The technologic advances have allowed the identification of new genes involved in melanoma susceptibility: Breast cancer 1 (BRCA1) associated protein 1 (BAP1), CXC genes, telomerase reverse transcriptase (TERT), protection of telomeres 1 (POT1), ACD and TERF2IP, the latter four being involved in telomere maintenance.
Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis.
Review
Raschellà et al., Roma, Italy. In Cell Death Dis, 2014
High-risk NB frequently displays MYCN amplification, mutations in ALK and ATRX, and genomic rearrangements in TERT genes.
The human CST complex is a terminator of telomerase activity.
Impact
GeneRIF
Lingner et al., Lausanne, Switzerland. In Nature, 2012
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Impact
GeneRIF
Artandi et al., Stanford, United States. In Cell, 2012
Study shows that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.
Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.
GeneRIF
Miyazawa et al., Niigata, Japan. In Febs Lett, 2012
telomerase is upregulated by Amadori-PE in PANC-1 human pancreatic carcinoma cells
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Impact
GeneRIF
Kemler et al., Freiburg, Germany. In Science, 2012
findings show beta-catenin regulates Tert expression through interaction with Klf4, a core component of the pluripotency transcriptional network; beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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