telomerase reverse transcriptase
telomerase reverse transcriptase
PinX1 inhibits cell proliferation, migration and invasion in glioma cells.
Xuzhou, China. In Med Oncol, 31 Mar 2015
In this study, we found that PinX1 obviously reduced the gliomas cell proliferation through regulating the expressions of cell cycle-relative molecules to arrest cell at G1 phase and down-regulating the expression of component telomerase reverse transcriptase (hTERT in human), which is the hardcore of telomerase.
Telomere dynamics in the lower plant Physcomitrella patens.
Brno, Czech Republic. In Plant Mol Biol, 21 Mar 2015
To follow telomerase expression, we first characterize the gene coding for the telomerase reverse transcriptase subunit PpTERT in P. patens, for which only incomplete prediction has been available so far.
Treatment of anaplastic glioma.
Heidelberg, Germany. In Cancer Treat Res, Dec 2014
Anaplastic gliomas are classified using single biomarkers, namely isocitrate dehydrogenase (IDH) or the related CpG island methylator phenotype (CIMP), alpha-thalassemia/mental retardation syndrome X-linked (ATRX), telomerase reverse transcriptase (TERT), p53, 1p/19q, and O(6)-methylguanine DNA-methyltransferase (MGMT).
Dietary intake alters behavioral recovery and gene expression profiles in the brain of juvenile rats that have experienced a concussion.
Calgary, Canada. In Front Behav Neurosci, Dec 2014
Gene expression changes in BDNF, CREB, DNMT1, FGF-2, IGF1, LEP, PGC-1α, SIRT1, Tau, and TERT were analyzed with respect to injury and diet.
Familial pulmonary fibrosis.
Paris, France. In Rev Mal Respir, Dec 2014
Mutations of TERT, the coding gene for the telomerase reverse transcriptase, are the most frequently identified mutations and are present in 15% of cases of familial pulmonary fibrosis.
Telomere-regulating Genes and the Telomere Interactome in Familial Cancers.
Sanger, United States. In Mol Cancer Res, Oct 2014
Telomeres need to be replicated each cell cycle and protected from DNA-processing enzymes, tasks that cells execute using specialized protein complexes such as telomerase (TERT), which aids in telomere maintenance and replication, and the shelterin complex, which protects chromosome ends.
The somatic genomic landscape of chromophobe renal cell carcinoma.
Houston, United States. In Cancer Cell, Oct 2014
Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
Integrated genomic characterization of adrenocortical carcinoma.
Paris, France. In Nat Genet, Jun 2014
We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs.
The human CST complex is a terminator of telomerase activity.
Lausanne, Switzerland. In Nature, 2012
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Stanford, United States. In Cell, 2012
Study shows that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.