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Telomerase reverse transcriptase

telomerase reverse transcriptase, TERT
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, POLYMERASE
Papers using telomerase reverse transcriptase antibodies
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Supplier
Frankel Wayne N, In PLoS Genetics, 2000
... Tetracycline-regulated i-TERT transgenic mice were generated as ...
Comparative investigation of proliferation markers and their prognostic relevance in human meningiomas
Supplier
Bettini Giuliano et al., In Journal of Veterinary Science, 2000
... The primary antibody, an anti-human TERT (Clone 44F12, diluted 1 : 50 in PBS; Novocastra, UK), was applied to the slides overnight at 4℃, followed by a streptavidin-biotinperoxidase complex (LSAB Kit; Dako, Netherlands) and diaminobenzidine (0.04% ...
Papers on telomerase reverse transcriptase
Buffalo (Bubalus bubalis) term amniotic-membrane-derived cells exhibited mesenchymal stem cells characteristics in vitro.
New
Yadav et al., Hisār, India. In In Vitro Cell Dev Biol Anim, 28 Jun 2015
These cells were shown the positive expression of pluripotency markers (OCT-4, SOX-2, NANOG, TERT), mesenchymal stem cell markers (CD29, CD44, CD105) and negative for haematopoietic marker (CD34) genes at different passages.
Pro-apoptotic and anti-proliferative effects of 3,3'-diindolylmethane in nasopharyngeal carcinoma cells via downregulation of telomerase activity.
New
Tao et al., Wuhan, China. In Mol Med Report, 25 Jun 2015
Reverse transcription polymerase chain reaction was used to detect the mRNA expression levels of human telomerase reverse transcriptase (hTERT) and human telomerase RNA (hTR), and western blot analysis was used to detect the protein expression of hTERT.
Telomere maintenance and the etiology of adult glioma.
Review
New
Wrensch et al., Rochester, United States. In Neuro Oncol, 25 Jun 2015
Common inherited variants near the telomerase-component genes TERC and TERT are associated both with longer telomere length and increased risk of glioma.
Biomarker-driven diagnosis of diffuse gliomas.
Review
New
Brat et al., Atlanta, United States. In Mol Aspects Med, 21 Jun 2015
Oligodendrogliomas are also IDH mutant, but instead are characterized by 1p/19q co-deletion and mutations of CIC, FUBP1, Notch1 and the TERT promoter.
The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
New
Impact
Costello et al., San Francisco, United States. In Science, 14 Jun 2015
UNASSIGNED: Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, fundamental steps in the initiation of human cancer.
Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification.
Review
New
Hadjipanayis et al., Atlanta, United States. In Ann Transl Med, 31 May 2015
Glioblastomas (GBMs) previously described as primary or secondary can now be divided based on gene expression into proneural, mesenchymal, and classical subtypes and the identification of mutations in the promoter region of the telomerase reverse transcriptase (TERTp) have been correlated with poor prognosis in GBMs.
Aggressive periodontitis: An appraisal of systemic effects on its etiology-genetic aspect.
New
Satadal et al., Calcutta, India. In J Indian Soc Periodontol, Mar 2015
The m-RNA expression of human telomerase reverse transcriptase (hTERT) was undetectable in the gingival tissue of the control group.
Emerging Interplay of Genetics and Epigenetics in Gliomas: A New Hope for Targeted Therapy.
Review
New
Tsankova et al., New York City, United States. In Semin Pediatr Neurol, Mar 2015
We highlight the genetic aberrations recently discovered in isocitrate dehydrogenase, alpha thalassemia/mental retardation syndrome X-linked, death-domain-associated protein, histone H3.3, and telomerase reverse transcriptase and discuss how these mutations lead to unexpected changes in the epigenetic landscape in gliomas.
Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.
New
Impact
Cech et al., Boulder, United States. In Science, Mar 2015
Point mutations in the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancers, including urothelial cancer (UC), but their effect on telomerase function has been unclear.
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types.
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Impact
Larsson et al., Göteborg, Sweden. In Nat Genet, Dec 2014
Somatic mutations in noncoding sequences are poorly explored in cancer, a rare exception being the recent identification of activating mutations in TERT regulatory DNA.
Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies.
Review
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Creighton et al., Chapel Hill, United States. In Oncoscience, Dec 2014
Analysis of WGS data led to the discovery of recurrent genomic rearrangements involving TERT promoter region, which were associated with very high expression levels of TERT, pointing to a potential mechanism for TERT deregulation that might be found in other cancers.
Association of TERT Polymorphisms with Clinical Outcome of Non-Small Cell Lung Cancer Patients.
New
Lu et al., Shanghai, China. In Plos One, Dec 2014
UNASSIGNED: TERT is of great importance in cancer initiation and progression.
Tobacco smoking is associated with methylation of genes related to coronary artery disease.
New
Dehghan et al., Rotterdam, Netherlands. In Clin Epigenetics, Dec 2014
These sites were located in the genes TERT, SARS, GNGT2, SMG6, SKI, TOM1L2, SIPA1, MRAS, CDKN1A, LRRC2, FES and RPH3A.
Genome-wide analysis of noncoding regulatory mutations in cancer.
New
Impact
Lee et al., New York City, United States. In Nat Genet, Nov 2014
These methods identify recurrent mutations in regulatory elements upstream of PLEKHS1, WDR74 and SDHD, as well as previously identified mutations in the TERT promoter.
The somatic genomic landscape of chromophobe renal cell carcinoma.
New
Impact
Creighton et al., Houston, United States. In Cancer Cell, Oct 2014
Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
The human CST complex is a terminator of telomerase activity.
Impact
GeneRIF
Lingner et al., Lausanne, Switzerland. In Nature, 2012
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Impact
GeneRIF
Artandi et al., Stanford, United States. In Cell, 2012
Study shows that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.
Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.
GeneRIF
Miyazawa et al., Niigata, Japan. In Febs Lett, 2012
telomerase is upregulated by Amadori-PE in PANC-1 human pancreatic carcinoma cells
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Impact
GeneRIF
Kemler et al., Freiburg, Germany. In Science, 2012
findings show beta-catenin regulates Tert expression through interaction with Klf4, a core component of the pluripotency transcriptional network; beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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