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proteins. Page last changed on 14 Mar 2013.
Telomerase reverse transcriptase
telomerase reverse transcriptase, TERT
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
telomerase reverse transcriptase
antibodies
Comparative investigation of proliferation markers and their prognostic relevance in human meningiomas
Supplier
In Journal of Veterinary Science, 2000
... The primary antibody, an anti-human TERT (Clone 44F12, diluted 1 : 50 in PBS; Novocastra, UK), was applied to the slides overnight at 4℃, followed by a streptavidin-biotinperoxidase complex (LSAB Kit; Dako, Netherlands) and diaminobenzidine (0.04% ...
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Supplier
In PLoS Genetics, 2000
... Tetracycline-regulated i-TERT transgenic mice were generated as ...
Papers on
telomerase reverse transcriptase
Structure of active dimeric human telomerase.
New
Cambridge, United Kingdom. In Nat Struct Mol Biol, 10 Apr 2013
Telomerase contains a large RNA subunit, TER, and a protein catalytic subunit, TERT.
Amplification of the human epidermal growth factor receptor 2 gene in differentiated thyroid cancer correlates with telomere shortening.
New
Tokyo, Japan. In Int J Oncol, 05 Apr 2013
We investigated 69 cases of differentiated thyroid cancers with reference to: i) telomere length as measured using tissue quantitative fluorescence in situ hybridization (Q-FISH), ii) expression of human telomerase reverse transcriptase (hTERT) as determined by immunohistochemistry (IHC), and iii) overexpression of the HER2 protein as determined by IHC and amplification of the HER2 gene as determined by fluorescence in situ hybridization (FISH).
Recurrent Noncoding Mutations in TERT May Promote Melanoma.
New
In Cancer Discov, 31 Mar 2013
TERT promoter mutations are frequent in melanoma and create ETS/TCF binding motifs.
The TERT MNS16A polymorphism contributes to cancer susceptibility: Meta-analysis of the current studies.
New
Nanjing, China. In Gene, 22 Mar 2013
The MNS16A polymorphism in the telomerase reverse transcriptase (TERT) gene has been implicated in cancer risk in multiple populations and various types of cancers; however, the results of previous studies exploring this association were inconclusive.
Highly recurrent TERT promoter mutations in human melanoma.
New
Impact
Cambridge, United States. In Science, 22 Mar 2013
Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 (71%) melanomas examined.
TERT promoter mutations in familial and sporadic melanoma.
New
Impact
Heidelberg, Germany. In Science, 22 Mar 2013
We investigated a melanoma-prone family through linkage analysis and high-throughput sequencing and identified a disease-segregating germline mutation in the promoter of the telomerase reverse transcriptase (TERT) gene, which encodes the catalytic subunit of telomerase.
hTERT Extends the Life of Human Fibroblasts without Compromising Type I Interferon Signaling.
New
Lawrence, United States. In Plos One, Dec 2012
It has been previously shown that expression of the telomerase reverse transcriptase () gene extends the life of certain cell types.
Biogenesis of telomerase ribonucleoproteins.
Review
New
Berkeley, United States. In Rna, Oct 2012
Catalytic activity for repeat synthesis results from the cooperation of the telomerase reverse transcriptase protein (TERT) and the template-containing telomerase RNA (TER).
Targeting claudin-4 in human pancreatic cancer.
Review
New
Sapporo, Japan. In Expert Opin Ther Targets, Sep 2012
hTERT-HPDE cells, in which the human telomerase reverse transcriptase (hTERT) gene is introduced into normal HPDE cells, may be a useful model of normal HPDE cells not only for physiological regulation of claudin-4 expression but also for developing safer and more effective therapeutic methods targeting claudin-4 in pancreatic cancer.
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
New
Impact
Stanford, United States. In Cell, Sep 2012
Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma.
New
Impact
Hong Kong, Hong Kong. In Nat Genet, Jul 2012
We also identified recurrent HBV integration events (in ≥ 4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue.
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
New
Impact
Freiburg, Germany. In Science, Jul 2012
Here, we report a molecular link between Wnt/β-catenin signaling and the expression of the telomerase subunit Tert.
Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis.
Review
New
Padova, Italy. In J Natl Cancer Inst, Jul 2012
BACKGROUND: Several recent studies have provided evidence that polymorphisms in the telomerase reverse transcriptase (TERT) gene sequence are associated with cancer development, but a comprehensive synopsis is not available.
Separation of telomerase functions by reverse genetics.
GeneRIF
Seattle, United States. In Proc Natl Acad Sci U S A, 2012
Enhanced cell proliferation is an independent function of hTERT that could provide a new target for the development of anti-telomerase cancer therapeutic agents.
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.
Impact
GeneRIF
Los Angeles, United States. In Nat Genet, 2011
We identified a common risk variant for estrogen receptor-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15: rs10069690
InTERTesting association between telomerase, mTOR and phytochemicals.
Review
Norfolk, United States. In Expert Rev Mol Med, 2011
Human TERT (telomerase reverse transcriptase - the rate-limiting component of telomerase), heat shock protein 90, Akt, p70 S6 kinase (S6K) and mammalian target of rapamycin (mTOR) form a physical and functional complex with one another.
Expression of telomerase & its significance in the diagnosis of pancreatic cancer.
Review
Shanghai, China. In Indian J Med Res, 2011
Telomerase is made up of three major parts namely, human telomerase reverse transcriptase, human telomerase and telomerase -associated protein.
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate.
GeneRIF
Chapel Hill, United States. In Biochemistry, 2011
A new biologically relevant mechanism for telomerase down regulation is revealed through caspase-mediated cleavage of TERT
Change of telomerase activity in peripheral whole blood of head and neck squamous cell carcinoma patients before and after surgery: a pilot study.
GeneRIF
Seoul, South Korea. In Clin Transl Oncol, 2011
High TERT is associated with recurrence in head and neck squamous cell carcinoma.
Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.
GeneRIF
Brisbane, Australia. In Plos One, 2010
Polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.
