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Telomerase reverse transcriptase

telomerase reverse transcriptase, TERT
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, POLYMERASE
Papers using telomerase reverse transcriptase antibodies
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Supplier
Frankel Wayne N, In PLoS Genetics, 2000
... Tetracycline-regulated i-TERT transgenic mice were generated as ...
Comparative investigation of proliferation markers and their prognostic relevance in human meningiomas
Supplier
Bettini Giuliano et al., In Journal of Veterinary Science, 2000
... The primary antibody, an anti-human TERT (Clone 44F12, diluted 1 : 50 in PBS; Novocastra, UK), was applied to the slides overnight at 4℃, followed by a streptavidin-biotinperoxidase complex (LSAB Kit; Dako, Netherlands) and diaminobenzidine (0.04% ...
Papers on telomerase reverse transcriptase
A shorter telomere is the key factor in preventing cultured human mesenchymal stem cells from senescence escape.
New
Song et al., In Histochem Cell Biol, 30 Sep 2014
Compared with rMSCs, the hMSCs possessed a much shorter telomere, and lacked both telomerase reverse transcriptase expression and telomerase activity.
Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase--potential role in senescence and aging.
Review
New
Haendeler et al., Düsseldorf, Germany. In Exp Gerontol, Aug 2014
Over the last 40 years it has become clear that telomeres, the end of the chromosomes, and the enzyme telomerase reverse transcriptase (TERT), which is required to counteract their shortening, play a pivotal role in senescence and aging.
Expression of targeted ribozyme against telomerase RNA causes altered expression of several other genes in tumor cells.
New
Yadava et al., New Delhi, India. In Tumour Biol, Jun 2014
The RNA component (TR) serves as template for telomerase reverse transcriptase (TERT) for generating telomere repeats.
CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells.
New
Amundadottir et al., Rochester, United States. In Cancer Res, Jun 2014
that includes the TERT and CLPTM1L genes.
Telomeres, telomerase and colorectal cancer.
Review
New
De Rossi et al., Padova, Italy. In World J Gastroenterol, Mar 2014
The activation of telomerase reverse transcriptase (TERT), the catalytic component of the telomerase complex, allows cancer cells to grow indefinitely by maintaining the length of the telomeres, thus favouring tumour formation/progression.
TERT promoter mutations in cancer development.
Review
New
Kumar et al., Heidelberg, Germany. In Curr Opin Genet Dev, Feb 2014
Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity.
Progress in structural studies of telomerase.
Review
New
Feigon et al., Los Angeles, United States. In Curr Opin Struct Biol, Feb 2014
In addition to new structures of TERT and TER domains, the first structures of telomerase protein domains beyond TERT, and their complexes with TER or telomeric single-stranded DNA, were reported.
Baculovirus vector-mediated transfer of sodium iodide symporter and plasminogen kringle 5 genes for tumor radioiodide therapy.
New
Li et al., Shanghai, China. In Plos One, Dec 2013
METHODS: A recombinant baculovirus containing the NIS gene under control of the human telomerase reverse transcriptase (hTERT) promoter and the K5 gene driven by the early growth response 1 (Egr1) promoter was developed.
Role of 6-shogaol in tert -butyl hydroperoxide-induced apoptosis of HepG2 cells.
New
Park et al., Kyŏngsan, South Korea. In Pharmacology, Dec 2013
The aim of this study was to investigate the protective effects of 6-shogaol on tert-butyl hydroperoxide (tBHP)-induced oxidative stress leading to apoptosis in human hepatoma cell line HepG2.
The somatic genomic landscape of glioblastoma.
New
Impact
TCGA Research Network et al., New York City, United States. In Cell, Nov 2013
TERT promoter mutations are shown to correlate with elevated mRNA expression, supporting a role in telomerase reactivation.
Tight junctions in human pancreatic duct epithelial cells.
Review
New
Sawada et al., Sapporo, Japan. In Tissue Barriers, Nov 2013
We will pay special attention to a novel model of human telomerase reverse transcriptase-transfected human pancreatic ductal epithelial cells and will describe the roles of major signaling molecules such as protein kinase C and c-Jun N-terminal kinase in formation and disassembly of the pancreatic ductal barrier.
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
New
Impact
Turnbull et al., United Kingdom. In Nat Genet, Jun 2013
Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation.
Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.
New
Impact
Tabori et al., Toronto, Canada. In Lancet Oncol, May 2013
We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours.
The architecture of Tetrahymena telomerase holoenzyme.
New
Impact
Feigon et al., Los Angeles, United States. In Nature, May 2013
Telomerase adds telomeric repeats to chromosome ends using an internal RNA template and a specialized telomerase reverse transcriptase (TERT), thereby maintaining genome integrity.
Short telomeres in ESCs lead to unstable differentiation.
New
Impact
Harrington et al., Edinburgh, United Kingdom. In Cell Stem Cell, May 2013
We found that mouse embryonic stem cells (ESCs) with critically short telomeres (Tert(-/-) ESCs) initiated normal differentiation after leukemia inhibitory factor (LIF) withdrawal but, unlike control ESCs, failed to maintain stable differentiation when LIF was reintroduced to the growth medium.
The human CST complex is a terminator of telomerase activity.
Impact
GeneRIF
Lingner et al., Lausanne, Switzerland. In Nature, 2012
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Impact
GeneRIF
Artandi et al., Stanford, United States. In Cell, 2012
Study shows that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.
Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.
GeneRIF
Miyazawa et al., Niigata, Japan. In Febs Lett, 2012
telomerase is upregulated by Amadori-PE in PANC-1 human pancreatic carcinoma cells
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Impact
GeneRIF
Kemler et al., Freiburg, Germany. In Science, 2012
findings show beta-catenin regulates Tert expression through interaction with Klf4, a core component of the pluripotency transcriptional network; beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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