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Telomerase reverse transcriptase

telomerase reverse transcriptase, TERT
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, p53
Papers using telomerase reverse transcriptase antibodies
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Supplier
Frankel Wayne N, In PLoS Genetics, 2000
... Tetracycline-regulated i-TERT transgenic mice were generated as ...
Comparative investigation of proliferation markers and their prognostic relevance in human meningiomas
Supplier
Bettini Giuliano et al., In Journal of Veterinary Science, 2000
... The primary antibody, an anti-human TERT (Clone 44F12, diluted 1 : 50 in PBS; Novocastra, UK), was applied to the slides overnight at 4℃, followed by a streptavidin-biotinperoxidase complex (LSAB Kit; Dako, Netherlands) and diaminobenzidine (0.04% ...
Papers on telomerase reverse transcriptase
Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types.
New
Impact
Larsson et al., Göteborg, Sweden. In Nat Genet, 31 Dec 2014
Somatic mutations in noncoding sequences are poorly explored in cancer, a rare exception being the recent identification of activating mutations in TERT regulatory DNA.
Development and Characterization of Six New Human Papillary Thyroid Carcinoma Cell Lines.
New
Clayman et al., Seoul, South Korea. In J Clin Endocrinol Metab, 26 Dec 2014
Five of the six cell lines had a mutation in the promoter of the human telomerase reverse transcriptase gene.
Glial fibrillary acidic protein promoters direct adenovirus early 1A gene and human telomerase reverse transcriptase promoters direct sodium iodide symporter expression for malignant glioma radioiodine therapy.
New
Li et al., Tianjin, China. In Mol Cell Biochem, 20 Dec 2014
Ad-Tp-E1A-Gp-NIS is engineered with human telomerase reverse transcriptase (hTERT) and glial fibrillary acidic protein (GFAP) promoters to express early region 1A (E1A) and hNIS genes, which may be useful in targeted gene therapy.
Genome-wide analysis of noncoding regulatory mutations in cancer.
New
Impact
Lee et al., New York City, United States. In Nat Genet, 30 Nov 2014
These methods identify recurrent mutations in regulatory elements upstream of PLEKHS1, WDR74 and SDHD, as well as previously identified mutations in the TERT promoter.
The somatic genomic landscape of chromophobe renal cell carcinoma.
New
Impact
Creighton et al., Houston, United States. In Cancer Cell, 08 Oct 2014
Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.
Telomerase promoter mutations in cancer: an emerging molecular biomarker?
Review
New
Soares et al., Porto, Portugal. In Virchows Arch, Aug 2014
Recently, mutations in telomerase (TERT) gene promoter were found in sporadic and familial melanoma and subsequently in several cancer models, notably in gliomas, thyroid cancer and bladder cancer.
[Construction of a general piggyBac transposon inducible cell immortalization vector and verification of its basic properties].
New
Zhang et al., In Sheng Wu Gong Cheng Xue Bao, Aug 2014
The modified vector contained the necessary transposon elements, a PB transposase expression cassette, a co-expression selectable element and a human telomerase reverse transcriptase (hTERT) expression cassette.
The Mitochondrial Genome in Aging and Senescence.
Review
New
Capogrossi et al., Milano, Italy. In Ageing Res Rev, Aug 2014
Specifically, we address how p53 and Telomerase Reverse Transcriptase (TERT) activity switch their roles from cytoprotective to detrimental and also examine the role of microRNAs in cell aging.
Umbilical cord blood mesenchymal stem cells co-modified by TERT and BDNF: a novel neuroprotective therapy for neonatal hypoxic-ischemic brain damage.
Review
New
Mu et al., Chengdu, China. In Int J Dev Neurosci, Aug 2014
Telomerase reverse transcriptase (TERT), which promotes cell proliferation and survival, plays a protective role in hypoxic-ischemic (HI) brain injury.
Integrated genomic characterization of adrenocortical carcinoma.
New
Impact
Bertherat et al., Paris, France. In Nat Genet, Jun 2014
We performed exome sequencing and SNP array analysis of 45 ACCs and identified recurrent alterations in known driver genes (CTNNB1, TP53, CDKN2A, RB1 and MEN1) and in genes not previously reported in ACC (ZNRF3, DAXX, TERT and MED12), which we validated in an independent cohort of 77 ACCs.
Telomeres and telomerase in T cells of tumor immunity.
Review
New
Cao et al., Tianjin, China. In Cell Immunol, May 2014
However, studies have demonstrated that human telomerase reverse transcriptase (hTERT), thought to be the major component regulating telomerase activity, can enhance the proliferation of T cells when overexpressed.
"Ins" and "Outs" of mesenchymal stem cell osteogenesis in regenerative medicine.
Review
New
Yamaguchi, Los Angeles, United States. In World J Stem Cells, May 2014
While propagating hMSCs under hypoxic conditions may maintain their ability to self-renew, the strategy of using human telomerase reverse transcriptase (hTERT) to allow for hMSCs to prolong their replicative lifespan is an attractive means of ensuring a critical mass of cells with the potential to differentiate into various mesodermal structural tissues including bone.
Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation.
New
Impact
Zucman-Rossi et al., Paris, France. In Cancer Cell, May 2014
Finally, integrative analysis of HCAs transformed to hepatocellular carcinoma revealed β-catenin mutation as an early alteration and TERT promoter mutations as associated with the last step of the adenoma-carcinoma transition.
Synthesis and discovery of 18α-GAMG as anticancer agent in vitro and in vivo via down expression of protein p65.
New
Liu et al., Hefei, China. In Sci Rep, Dec 2013
Western blot and immunofluorescence results indicated that the expression of p65-telomerase reverse transcriptase (TERT) was clearly down-regulated treated with it.
Promoter trapping method: transcription factor purification using human telomerase reverse transcriptase promoter.
New
Jarrett et al., San Antonio, United States. In Proteome Sci, Dec 2013
BACKGROUND: Transcription factors bind to response elements on the promoter regions of genes to regulate transcriptional activity.
The human CST complex is a terminator of telomerase activity.
Impact
GeneRIF
Lingner et al., Lausanne, Switzerland. In Nature, 2012
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Impact
GeneRIF
Artandi et al., Stanford, United States. In Cell, 2012
Study shows that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.
Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.
GeneRIF
Miyazawa et al., Niigata, Japan. In Febs Lett, 2012
telomerase is upregulated by Amadori-PE in PANC-1 human pancreatic carcinoma cells
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Impact
GeneRIF
Kemler et al., Freiburg, Germany. In Science, 2012
findings show beta-catenin regulates Tert expression through interaction with Klf4, a core component of the pluripotency transcriptional network; beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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