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Telomerase reverse transcriptase

telomerase reverse transcriptase, TERT
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, AGE, POLYMERASE
Papers using telomerase reverse transcriptase antibodies
Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection
Supplier
Frankel Wayne N, In PLoS Genetics, 2000
... Tetracycline-regulated i-TERT transgenic mice were generated as ...
Comparative investigation of proliferation markers and their prognostic relevance in human meningiomas
Supplier
Bettini Giuliano et al., In Journal of Veterinary Science, 2000
... The primary antibody, an anti-human TERT (Clone 44F12, diluted 1 : 50 in PBS; Novocastra, UK), was applied to the slides overnight at 4℃, followed by a streptavidin-biotinperoxidase complex (LSAB Kit; Dako, Netherlands) and diaminobenzidine (0.04% ...
Papers on telomerase reverse transcriptase
A single-nucleotide polymorphism of CCL21 rs951005 T>C is associated with susceptibility of polymyositis and such patients with interstitial lung disease in a Chinese Han population.
New
Li et al., Beijing, China. In Clin Exp Rheumatol, 01 Oct 2015
OBJECTIVES: Our objective was to better understand the roles of single nucleotide polymorphisms (SNPs) in the CCL21, ERBB3, and TERT genes region in the development of idiopathic inflammatory myopathies (IIMs), we explored the associations between SNPs in the mentioned three genes and IIMs susceptibility in a Chinese Han population.
Marek's disease: Genetic regulation of gallid herpesvirus 2 infection and latency.
Review
New
Muylkens et al., Namur, Belgium. In Vet J, 30 Sep 2015
kb mRNA, and also modulates expression of cellular genes, such as Bcl-2 and matrix metalloproteinase 3. GaHV-2 expresses viral telomerase RNA subunit (vTR), which forms a complex with the cellular telomerase reverse transcriptase (TERT), thus contributing to tumorigenesis, while vTR independent of telomerase activity is implicated in metastasis.
Effects of extracellular magnesium extract on the proliferation and differentiation of human osteoblasts and osteoclasts in coculture.
New
Luthringer et al., Geesthacht, Germany. In Acta Biomater, 26 Sep 2015
Human telomerase reverse transcriptase (hTERT) transduced mesenchymal stem cells (SCP-1) were first differentiated into osteoblasts with osteogenic supplements and then further cocultured with peripheral blood mononucleated cells (PBMC) without the addition of osteoclastogenesis promoting factors.
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas.
New
Impact
Zucman-Rossi et al., Paris, France. In Nat Genet, 24 Sep 2015
These AAV2 integrations occurred in known cancer driver genes, namely CCNA2 (cyclin A2; four cases), TERT (telomerase reverse transcriptase; one case), CCNE1 (cyclin E1; three cases), TNFSF10 (tumor necrosis factor superfamily member 10; two cases) and KMT2B (lysine-specific methyltransferase 2B; one case), leading to overexpression of the target genes.
Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer.
New
Park et al., Seoul, South Korea. In World J Gastroenterol, 21 Sep 2015
METHODS: Telomere length and human telomerase reverse transcriptase (hTERT) mRNA expression were measured in 35 gastric cancer tissues and 5 cell lines and correlated to rs2736100 polymorphism.
PGC-1α Modulates Telomere Function and DNA Damage in Protecting against Aging-Related Chronic Diseases.
New
Alexander et al., Atlanta, United States. In Cell Rep, 19 Sep 2015
PGC-1α deletion reduces expression and activity of telomerase reverse transcriptase (TERT) and increases p53 levels.
TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas.
New
Mao et al., Shanghai, China. In Oncotarget, 09 Aug 2015
Recent studies have identified recurrent mutations in the promoter region of telomerase reverse transcriptase (TERT) in gliomas.
Recurrent somatic mutations in regulatory regions of human cancer genomes.
New
Impact
Snyder et al., Stanford, United States. In Nat Genet, Jul 2015
Mutated regulatory sites include known sites in the TERT promoter and many new sites, including a subset in proximity to cancer-related genes.
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
New
Impact
Zhang et al., In N Engl J Med, Jul 2015
Their gliomas harbored mutations in CIC, FUBP1, NOTCH1, and the TERT promoter.
Mitochondrial Dysfunction in Parkinson's Disease.
Review
New
Paek et al., Seoul, South Korea. In Exp Neurobiol, Jun 2015
For the first time, we established human telomerase reverse transcriptase (hTERT)-immortalized wild type, idiopathic and Parkin deficient mesenchymal stromal cells (MSCs) isolated from the adipose tissues of PD patients, which could be used as a good cellular model to evaluate mitochondrial dysfunction for the better understanding of PD pathology and for the development of early diagnostic markers and effective therapy targets of PD.
Cancer. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer.
New
Impact
Costello et al., San Francisco, United States. In Science, Jun 2015
Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental steps in the initiation of human cancer.
Telomere maintenance and the etiology of adult glioma.
Review
New
Wrensch et al., Rochester, United States. In Neuro Oncol, Jun 2015
Common inherited variants near the telomerase-component genes TERC and TERT are associated both with longer telomere length and increased risk of glioma.
Biomarker-driven diagnosis of diffuse gliomas.
Review
New
Brat et al., Atlanta, United States. In Mol Aspects Med, Jun 2015
Oligodendrogliomas are also IDH mutant, but instead are characterized by 1p/19q co-deletion and mutations of CIC, FUBP1, Notch1 and the TERT promoter.
Beyond the World Health Organization grading of infiltrating gliomas: advances in the molecular genetics of glioma classification.
Review
New
Hadjipanayis et al., Atlanta, United States. In Ann Transl Med, May 2015
Glioblastomas (GBMs) previously described as primary or secondary can now be divided based on gene expression into proneural, mesenchymal, and classical subtypes and the identification of mutations in the promoter region of the telomerase reverse transcriptase (TERTp) have been correlated with poor prognosis in GBMs.
Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.
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Impact
Cech et al., Boulder, United States. In Science, Mar 2015
Point mutations in the telomerase reverse transcriptase (TERT) gene promoter occur at high frequency in multiple cancers, including urothelial cancer (UC), but their effect on telomerase function has been unclear.
The human CST complex is a terminator of telomerase activity.
Impact
GeneRIF
Lingner et al., Lausanne, Switzerland. In Nature, 2012
the human CST (CTC1, STN1 and TEN1) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1)-TPP1 telomerase processivity factor
TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
Impact
GeneRIF
Artandi et al., Stanford, United States. In Cell, 2012
Study shows that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT.These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.
Amadori-glycated phosphatidylethanolamine up-regulates telomerase activity in PANC-1 human pancreatic carcinoma cells.
GeneRIF
Miyazawa et al., Niigata, Japan. In Febs Lett, 2012
telomerase is upregulated by Amadori-PE in PANC-1 human pancreatic carcinoma cells
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Impact
GeneRIF
Kemler et al., Freiburg, Germany. In Science, 2012
findings show beta-catenin regulates Tert expression through interaction with Klf4, a core component of the pluripotency transcriptional network; beta-Catenin binds to the Tert promoter in a mouse intestinal tumor model
Bmi-1 siRNA inhibited ovarian cancer cell line growth and decreased telomerase activity.
GeneRIF
Jin et al., Harbin, China. In Br J Biomed Sci, 2011
Bmi-1 siRNA has a role in inhibiting ovarian cancer cell line growth and decreasing telomerase activity
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