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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ets variant 6

TEL, ETV6
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: ETV6, AML1, HAD, CAN, BCR
Papers on TEL
High-resolution antibody array analysis of childhood acute leukemia cells.
New
Kalina et al., Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
In addition, OPAL1 overexpression corresponded to ETV6-RUNX1 chromosomal translocation.
Concurrent detection of targeted copy number variants and mutations using a myeloid malignancy next generation sequencing panel allows comprehensive genetic analysis using a single testing strategy.
New
Kelley et al., Salt Lake City, United States. In Br J Haematol, Feb 2016
The most frequent CNVs were 7q deletion including LUC7L2 and EZH2, TP53 deletion, ETV6 deletion, gain of RAD21 on 8q, and 5q deletion, including NSD1 and NPM1.
Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.
New
Vázquez-Laslop et al., Chicago, United States. In Nat Chem Biol, Feb 2016
Cladinose-containing macrolides such as erythromycin (ERY), but not ketolides such as telithromycin (TEL), arrest translation of ermCL, whereas either ERY or TEL stall ermBL translation.
Myelodysplastic syndromes: Contemporary review and how we treat.
Review
New
Tefferi et al., Rochester, United States. In Am J Hematol, Jan 2016
With the advent of next generation sequencing, recurrent somatic mutations in genes involved in epigenetic regulation (TET2, ASXL1, EZH2, DNMT3A, IDH1/2), RNA splicing (SF3B1, SRSF2, U2AF1, ZRSR2), DNA damage response (TP53), transcriptional regulation (RUNX1, BCOR, ETV6) and signal transduction (CBL, NRAS, JAK2) have been identified in MDS.
[Detection of copy number variations in pediatric ETV6/RUNX1-positive acute lymphoblastic leukemia with multiplex ligation-dependent probe amplification].
New
Zhu et al., Tianjin, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
OBJECTIVE: To investigate the application of multiplex ligation-dependent probe amplification (MLPA) in the detection of copy number variations (CNVs) in pediatric ETV6/RUNX1-positive acute lymphoblastic leukemia (ALL), to compare this method with conventional karyotype analysis and fluorescence in situ hybridization (FISH), and to evaluate the value of MLPA.
Determination of ETV6-RUNX1 genomic breakpoint by next-generation sequencing.
New
Chai et al., China. In Cancer Med, Jan 2016
UNASSIGNED: The t(12;21)(p13;q22) ETV6-RUNX1 gene fusion is one of the most common chromosomal translocation in childhood acute lymphoblastic leukemia (ALL).
Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study.
New
Impact
Yang et al., Memphis, United States. In Lancet Oncol, Dec 2015
Recent reports of germline ETV6 variations associated with substantial familial clustering of haematological malignancies indicated that this gene is a potentially important genetic determinant for ALL susceptibility.
Mediator kinase inhibition further activates super-enhancer-associated genes in AML.
New
Impact
Shair et al., Cambridge, United States. In Nature, Nov 2015
In AML cells, CA upregulated SE-associated genes with tumour suppressor and lineage-controlling functions, including the transcription factors CEBPA, IRF8, IRF1 and ETV6 (refs 6-8).
Prognostification of ALL by Cytogenetics.
Review
New
Lone et al., Srīnagar, India. In Indian J Hematol Blood Transfus, Sep 2015
Some chromosomal abnormalities are associated with more favorable outcomes, such as high hyperdiploidy (51-65 chromosomes) and the ETV6-RUNX1 fusion.
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Review
New
Vargas et al., Piracicaba, Brazil. In J Oral Pathol Med, Jun 2015
Finally, the identification of ETV6-NTRK3 in cases previously diagnosed as uncommon acinic cell carcinomas, cystadenocarcinomas, and adenocarcinomas not otherwise specified led to the characterization of a completely new and now widely accepted entity, including, therefore, mammary analogue secretory carcinoma in the list of well-recognized salivary gland carcinomas.
Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.
New
Impact
Di Paola et al., Aurora, United States. In Nat Genet, May 2015
Whole-exome sequencing identified a heterozygous single-nucleotide change in ETV6 (ets variant 6), c.641C>T, encoding a p.Pro214Leu substitution in the central domain, segregating with thrombocytopenia and elevated MCV.
The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes.
Review
New
Tandon et al., Saint Louis, United States. In Int J Lab Hematol, May 2015
DNA-level mutations in several of these genes including NPM1, FLT3, and CEBPA in AML and ASXL1, ETV6, EZH2, RUNX1, and TP53 in MDS are associated with changes in patient outcomes and are now tested for in clinical laboratories.
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
New
Impact
Shimamura et al., Seattle, United States. In Nat Genet, Feb 2015
We report germline missense mutations in ETV6 segregating with the dominant transmission of thrombocytopenia and hematologic malignancy in three unrelated kindreds, defining a new hereditary syndrome featuring thrombocytopenia with susceptibility to diverse hematologic neoplasms.
Secretory breast carcinoma in a 41-year-old man with long-term follow-up: a special report.
Review
Yang et al., Haikou, China. In Future Oncol, 2014
ETV6-NTRK3 fusion gene is a specific genetic alteration in SBC.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Impact
Mullighan et al., Memphis, United States. In N Engl J Med, 2014
Cell lines and human leukemic cells expressing ABL1, ABL2, CSF1R, and PDGFRB fusions were sensitive in vitro to dasatinib, EPOR and JAK2 rearrangements were sensitive to ruxolitinib, and the ETV6-NTRK3 fusion was sensitive to crizotinib.
Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain.
GeneRIF
McIntosh et al., Vancouver, Canada. In J Mol Biol, 2012
the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS domain
Detection of ETV6 gene rearrangements in adult acute lymphoblastic leukemia.
GeneRIF
Yu et al., Beijing, China. In Ann Hematol, 2012
Multiplex-nested RT-PCR is an effective and accurate tool to identify ETV6 rearrangements in adult ALL (acute lymphoblastic leukemia), which provides some clues into the diagnosis and prognosis of ALL and detection of minimal residual disease.
ETV6 fusion genes in hematological malignancies: a review.
Review
GeneRIF
De Braekeleer et al., Brest, France. In Leuk Res, 2012
ETV6 is frequently involved in leukemogenesis because of the large number of partners with which it can rearrange and the several pathogenic mechanisms by which it can lead to cell transformation.
Genome-wide analysis of cytogenetic aberrations in ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia.
GeneRIF
Schmiegelow et al., Copenhagen, Denmark. In Br J Haematol, 2012
The present study sheds further light on the genetic diversity of ETV6/RUNX1-positive childhood ALL, which may be important for understanding poor responses among this otherwise highly curable subset of ALL and lead to novel targeted treatment strategies.
The leukemia-associated fusion protein Tel-platelet-derived growth factor receptor β (Tel-PdgfRβ) inhibits transcriptional repression of PTPN13 gene by interferon consensus sequence binding protein (Icsbp).
GeneRIF
Eklund et al., Chicago, United States. In J Biol Chem, 2012
interaction between Tel and Tel-PdgfRbeta decreases Tel/Icsbp/Hdac3 binding to the PTPN13 cis element, resulting in increased transcription.
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