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Thyrotrophic embryonic factor

TEF, thyrotroph embryonic factor
This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, POLYMERASE, Actin
Papers on TEF
Effect of theanine and polyphenols enriched fractions from decaffeinated tea dust on the formation of Maillard reaction products and sensory attributes of breads.
New
Andlauer et al., Sion, Switzerland. In Food Chem, May 2016
The antiglycoxidative properties of theanine (TEF) and polyphenols enriched fractions (PEF) prepared from tea dust were tested in a model system composed of bovine serum albumin (BSA) and methylglyoxal (MGO).
Immunosuppressive evidence of Tityus serrulatus toxins Ts6 and Ts15: insights of a novel K(+) channel pattern in T cells.
New
Arantes et al., Ribeirão Preto, Brazil. In Immunology, Feb 2016
In this study, the Ts6 and Ts15 toxins isolated from Tityus serrulatus (Ts) were investigated for their immunosuppressant roles on CD4(+) cell subsets: naive, effector (TEF ), central memory (TCM ) and effector memory (TEM ).
Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR-Cas9-Mediated Genome Editing in Yarrowia lipolytica.
New
Wheeldon et al., Riverside, United States. In Acs Synth Biol, Feb 2016
The highest efficiencies were achieved with a SCR1'-tRNA(Gly) promoter and Y. lipolytica codon-optimized Cas9 expressed from a UAS1B8-TEF promoter.
YAP/TAZ for cancer therapy: opportunities and challenges (review).
Review
New
Teng et al., Hangzhou, China. In Int J Oncol, Apr 2015
Conversely, when the Hippo pathway is deactivated, YAP and TAZ will translocate into nucleus and promote transcription of downstream genes by forming complexes with transcription factors, such as transcriptional enhancer factors (TEF; also referred to as TEAD), runt-domain transcription factors (Runx) and others.
Xerotolerant Cladosporium sphaerospermum Are Predominant on Indoor Surfaces Compared to Other Cladosporium Species.
Dijksterhuis et al., Utrecht, Netherlands. In Plos One, 2014
A total of 123 Cladosporium isolates originating from indoor air and indoor surfaces of archives, industrial factories, laboratories, and other buildings from four continents were identified by sequencing the internal transcribed spacer (ITS), and a part of the translation elongation factor 1α gene (TEF) and actin gene (ACT).
ESOPHAGEAL ATRESIA WITH RECURRENT TRACHEOESOPHAGEAL FISTULAS AND MICRODUPLICATION 22q11.23.
Mehta et al., In Genet Couns, 2014
Esophageal atresia/tracheoesophageal fistula (EA/TEF) has recently been linked with the Tbx1 gene mutation located on the long arm of chromosome 22(22q11.21).
Clinical and etiological heterogeneity in patients with tracheo-esophageal malformations and associated anomalies.
Review
de Klein et al., Rotterdam, Netherlands. In Eur J Med Genet, 2014
Esophageal Atresia (EA) is a severe developmental defect of the foregut that presents with or without a Tracheo-Esophageal Fistula (TEF).
Genetic and cellular mechanisms regulating anterior foregut and esophageal development.
Review
Que et al., Rochester, United States. In Dev Biol, 2012
Disruption of regulatory networks inevitably leads to defective separation and malformation of the trachea and esophagus and results in the formation of a relatively common birth defect, esophageal atresia with or without tracheoesophageal fistula (EA/TEF).
Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
GeneRIF
Gimeno et al., Boston, United States. In Endocrinology, 2012
In Ccdc80(-/-) mice, expression of the core clock member Arntl/Bmal1 was reduced whereas that of the oscillating transcription factors Dbp and Tef was increased in all tissues examined.
Tef polymorphism is associated with sleep disturbances in patients with Parkinson's disease.
GeneRIF
Xiao et al., Nanjing, China. In Sleep Med, 2012
the TT genotype in Tef rs738499 is associated with sleep disturbances in Parkinson disease.
Why toxic equivalency factors are not suitable for perfluoroalkyl chemicals.
Review
Gonzalez et al., United States. In Chem Res Toxicol, 2011
Since PPARα has a role in mediating some of these effects, and there is some overlap in the type of toxicities elicited by perfluoroalkyl chemicals, it has been suggested that a scaling system analogous to the toxic equivalency factor (TEF) system used for polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and polychlorinated biphenyls (PCB) could be used for perfluoroalkyl chemicals.
The role of transcription enhancer factors in cardiovascular biology.
Review
Li et al., Boston, United States. In Trends Cardiovasc Med, 2011
The transcriptional enhancer factor (TEF) multigene family is primarily functional in muscle-specific genes through binding to MCAT elements that activate or repress transcription of many genes in response to physiological and pathological stimuli.
A novel pathway of TEF regulation mediated by microRNA-125b contributes to the control of actin distribution and cell shape in fibroblasts.
GeneRIF
Fernandez-Luna et al., Santander, Spain. In Plos One, 2010
evidence of TEF regulation through a miR-125b-mediated pathway
Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
GeneRIF
Fang et al., Shanghai, China. In Plos One, 2010
Data show that S100a9, Mmp10 and Ang2 were among the most downregulated genes, whereas Per3, Tef and Prdx6 were significantly upregulated in the DMH + Calcium group.
Cardiac hypertrophy, low blood pressure, and low aldosterone levels in mice devoid of the three circadian PAR bZip transcription factors DBP, HLF, and TEF.
GeneRIF
Gachon et al., Lausanne, Switzerland. In Am J Physiol Regul Integr Comp Physiol, 2010
we demonstrate that D site albumin promoter binding protein/thyrotroph embryonic factor/hepatic leukemia factor triple knockout mice develop cardiac hypertrophy and left ventricular dysfunction associated with a low blood pressure
The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification.
Impact
GeneRIF
Schibler et al., Genève, Switzerland. In Cell Metab, 2006
The Tef protein control the expression of many enzymes and regulators involved in detoxification and drug metabolism, such as cytochrome P450 enzymes, carboxylesterases, and constitutive androstane receptor (CAR).
Xenobiotic metabolism in the fourth dimension: PARtners in time.
Review
Impact
Takahashi et al., Charlottesville, United States. In Cell Metab, 2006
A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control.
Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences.
Impact
Draghia-Akli et al., Houston, United States. In Nat Biotechnol, 1999
By random assembly of E-box, MEF-2, TEF-1, and SRE sites into synthetic promoter recombinant libraries, and screening of hundreds of individual clones for transcriptional activity in vitro and in vivo, several artificial promoters were isolated whose transcriptional potencies greatly exceed those of natural myogenic and viral gene promoters.
A serum shock induces circadian gene expression in mammalian tissue culture cells.
Impact
Schibler et al., Genève, Switzerland. In Cell, 1998
Oscillating genes include rper1 and rper2 (rat homologs of the Drosophila clock gene period), and the genes encoding the transcription factors Rev-Erb alpha, DBP, and TEF.
The HeLa cell protein TEF-1 binds specifically and cooperatively to two SV40 enhancer motifs of unrelated sequence.
Impact
Chambon et al., Strasbourg, France. In Cell, 1988
We have purified a protein (TEF-1) that specifically binds to two sequence unrelated motifs (GT-IIC and Sph) of the simian virus 40 (SV40) enhancer.
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