YAP/TAZ for cancer therapy: opportunities and challenges (review).
Hangzhou, China. In Int J Oncol, Apr 2015
Conversely, when the Hippo pathway is deactivated, YAP and TAZ will translocate into nucleus and promote transcription of downstream genes by forming complexes with transcription factors, such as transcriptional enhancer factors (TEF; also referred to as TEAD), runt-domain transcription factors (Runx) and others.
Why toxic equivalency factors are not suitable for perfluoroalkyl chemicals.
United States. In Chem Res Toxicol, 2011
Since PPARα has a role in mediating some of these effects, and there is some overlap in the type of toxicities elicited by perfluoroalkyl chemicals, it has been suggested that a scaling system analogous to the toxic equivalency factor (TEF) system used for polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and polychlorinated biphenyls (PCB) could be used for perfluoroalkyl chemicals.
The role of transcription enhancer factors in cardiovascular biology.
Boston, United States. In Trends Cardiovasc Med, 2011
The transcriptional enhancer factor (TEF) multigene family is primarily functional in muscle-specific genes through binding to MCAT elements that activate or repress transcription of many genes in response to physiological and pathological stimuli.
Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences.
Houston, United States. In Nat Biotechnol, 1999
By random assembly of E-box, MEF-2, TEF-1, and SRE sites into synthetic promoter recombinant libraries, and screening of hundreds of individual clones for transcriptional activity in vitro and in vivo, several artificial promoters were isolated whose transcriptional potencies greatly exceed those of natural myogenic and viral gene promoters.