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TEA domain family member 3

TEF-5, DTEF-1, TEAD3, hTEF-5, ETFR-1
This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and thought to play a role in placental gene regulation and development. Alternative splicing, and alternate use of an upstream AUG translation initiation codon, and an in-frame downstream non-AUG (AUA) codon, results in 2 isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TEF, TEF3, ETF, Nkx2.5, GATA4
Papers on TEF-5
Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.
Ma et al., Beijing, China. In Mol Psychiatry, Feb 2016
We observed that rs3744165 × rs8073471 interaction modulated the expression profile of TEAD3 (P=1.87 × 10(-8)), SH3TC2 (P=2.00 × 10(-8)), KCNK9 (P=5.20 × 10(-7)) and PPDPF (P=1.13 × 10(-6)) in postmortem cortex tissue; EFNA1 (P=7.26 × 10(-9)), RNU4ATAC (P=2.32 × 10(-8)) and NUPL2 (P=6.79 × 10(-8)) in cerebellum tissue.
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
Cunningham et al., San Francisco, United States. In Structure, Feb 2016
We show that human TEADs are palmitoylated at a universally conserved cysteine, and report the crystal structures of the human TEAD2 and TEAD3 YAP-binding domains in their palmitoylated forms.
9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.
Stewart et al., Ottawa, Canada. In Circulation, Dec 2015
TEAD3 and TEAD4 overexpression induced p16 in HAoSMCs homozygous for the nonrisk allele, but not for the risk allele.
Stimulation of cardiomyogenesis from mouse embryonic stem cells by nuclear translocation of cardiotrophin-1.
Sauer et al., Gießen, Germany. In Int J Cardiol, Sep 2015
Exogenous CT-1 enhanced cardiomyogenesis, increased the cardiac transcription factors MEF2c, Nkx-2.5, TEAD3 and GATA4, the cardiac proteins α-actinin, MLC2a, MYH7, MLC1a, MLC2v and HCN4 as well as vascular endothelial growth factor (VEGF), platelet-derived growth factor-BB (PDGF-BB), fibroblast growth factor-2 (FGF-2) and atrial natriuretic peptide (ANP).
Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
Wei et al., Nanjing, China. In Int J Cancer, Sep 2015
We used the genotyping data of 1,115 common single nucleotide polymorphisms (SNPs) in the 12 pathway core genes (i.e., MST1, MST2, SAV1, LATS1, LATS2, MOB1A, MOB1B, YAP1, TEAD1, TEAD2, TEAD3 and TEAD4) from the dataset of our previously published CM genome-wide association study and comprehensively analyzed their associations with CM-specific survival (CSS) in 858 CM patients by using the Kaplan-Meier analyses and Cox proportional hazards regression models.
Electron ionization mass spectrum of tellurium hexafluoride.
Ballou et al., Richland, United States. In Inorg Chem, Jun 2015
The eight natural abundance isotopes were observed for each of the set of fragment ions: TeF5(+), TeF4(+) TeF3(+), TeF2(+), TeF1(+), and Te(+), Te2(+).
Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells.
Geng et al., Houston, United States. In Vascul Pharmacol, 2014
In a concentration-dependent manner, simvastatin treatment enhanced expression of several promyogenic nuclear transcription factors, including GATA4, Nkx2.5, DTEF-1 and myocardin A. The statin-treated cells also displayed higher levels of cardiac proteins, including myosin, α-actinin, Ryanodine receptor-2, and atrial natriuretic peptide, and they developed synchronized contraction.
Early onset pre-eclampsia is associated with altered DNA methylation of cortisol-signalling and steroidogenic genes in the placenta.
Robinson et al., Vancouver, Canada. In Plos One, 2012
P<0.00001, and LOPET; -6.88%; P<0.001), TEA domain family member 3 (TEAD3 intron 1; EOPET; -12.56%;
Molecular characterization of the porcine TEAD3 (TEF-5) gene: examination of a promoter mutation as the causal mutation of a quantitative trait loci affecting the androstenone level in boar fat.
Riquet et al., Toulouse, France. In J Anim Breed Genet, 2012
A quantitative trait loci (QTL) for accumulation of androstenone in fat has been identified in an Large White × Meishan cross in a region of SSC7-containing TEAD3.
Expression levels of 25 genes in liver and testis located in a QTL region for androstenone on SSC7q1.2.
Riquet et al., Toulouse, France. In Anim Genet, 2011
In the livers, none of the genes were significantly up- or down-regulated, including TEAD3, which was previously designated as a possible candidate to explain this QTL.
The role of transcription enhancer factors in cardiovascular biology.
Li et al., Boston, United States. In Trends Cardiovasc Med, 2011
Among the TEF family, TEF-1, RTEF-1, and DTEF-1 are critical regulators of cardiac and smooth muscle-specific genes during cardiovascular development and cardiac disorders including cardiac hypertrophy.
Gene silencing of Tead3 abrogates radiation-induced adaptive response in cultured mouse limb bud cells.
Nenoi et al., Chiba, Japan. In J Radiat Res (tokyo), 2010
In this study, we evaluated the role of three candidate genes in the apoptotic AR in a micromass culture of limb bud cells: Csf1, Cacna1a and Tead3.
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma.
Moriyama et al., Ōita, Japan. In Bmc Cancer, 2010
Furthermore, the transcriptional activity of the YAP1 and TEAD3 complex was inhibited in SAV1-transduced 786-O cells.
Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeast.
Ter-Avanesyan et al., Moscow, Russia. In Bmc Mol Biol, 2008
As a result, the genes for gamma (TEF4 and TEF3/CAM1) and alpha (TEF5/EFB1) subunits of the translation elongation factor eEF1B, known to catalyze the exchange of bound GDP for GTP on eEF1A, were revealed.
Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.
Payne et al., Stanford, United States. In Mol Endocrinol, 2004
Transcription enhancer factor-5 and the GATA-like protein act in a coordinate manner to determine the placental-specific expression of the human 3beta-hydroxysteroid dehydrogenase/isomerase I enzyme
Mouse DTEF-1 (ETFR-1, TEF-5) is a transcriptional activator in alpha 1-adrenergic agonist-stimulated cardiac myocytes.
Stewart et al., Pittsburgh, United States. In J Biol Chem, 2002
DTEF-1 is a target for alpha(1)-adrenergic activation of the skeletal muscle alpha-actin gene in cardiac myocytes
Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal.
Li et al., Edmonton, Canada. In Curr Protein Pept Sci, 2001
Transcription factors such as TEF-5, Hand1, HEB, HASH-2 and two genes represented by ESTs may have regulatory roles in placental development.
Human placental TEF-5 transactivates the human chorionic somatomammotropin gene enhancer.
Eberhardt et al., Rochester, United States. In Mol Endocrinol, 1999
The paper described that the translation initiation codon for the TEF-5 protein was a non-AUG (AUA) codon.
Human TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Davidson et al., Illkirch-Graffenstaden, France. In J Biol Chem, 1997
The paper described that the translation initiation codon for the TEF-5 protein was a non-AUG (ATA) codon.
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