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Teashirt zinc finger family member 1

Teashirt, tsH1, Tshz1
Top mentioned proteins: CAN, Cho, TSHZ3, FATE, HAD
Papers on Teashirt
Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.
Zhou et al., Nijmegen, Netherlands. In Hum Genet, Jan 2016
Our analyses of these overlapping CNVs identified two genes known to be causative for human OFCs, SATB2 and MEIS2, and 12 genes (DGCR6, FGF2, FRZB, LETM1, MAPK3, SPRY1, THBS1, TSHZ1, TTC28, TULP4, WHSC1, WHSC2) that are associated with OFC or orofacial development.
Tshz1 Regulates Pancreatic β-Cell Maturation.
Stoffers et al., Marseille, France. In Diabetes, Aug 2015
From this, we identified the transcription factor Teashirt zinc finger 1 (Tshz1) as a direct Pdx1 target.
Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.
Eriksson et al., Mountain View, United States. In Hum Mol Genet, Jun 2015
teashirt is required for head-versus-tail regeneration polarity in planarians.
Reddien et al., Cambridge, United States. In Development, Apr 2015
We identified a gene encoding a homolog of the Teashirt family of zinc-finger proteins in the planarian Schmidtea mediterranea to be a target of Wnt signaling in intact animals and at posterior-facing wounds.
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
Tomlinson et al., Brisbane, Australia. In Sci Rep, 2014
Another polymorphism, rs12970291 near gene TSHZ1, was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10(-8)), with the alleles showing opposite effects on the risks of the two cancers.
TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.
Garratt et al., In J Clin Invest, 2014
Using a mouse model, we found that development and maturation of OB interneurons depends on the zinc finger homeodomain factor teashirt zinc finger family member 1 (TSHZ1).
Establishing a reference group for distal 18q-: clinical description and molecular basis.
Hale et al., San Antonio, United States. In Hum Genet, 2014
Published data suggest that 20 are unlikely to cause an abnormal phenotype in the hemizygous state and five are likely to be dosage sensitive: TNX3, NETO1, ZNF407, TSHZ1, and NFATC.
Whole genome sequence and analysis of the Marwari horse breed and its genetic origin.
Bhak et al., In Bmc Genomics, 2013
Additionally, we suggest a potential functional genetic variant in the TSHZ1 gene (p.Ala344>Val) associated with the inward-turning ear tip shape of the Marwari horses.
Mood disorders in individuals with distal 18q deletions.
Cody et al., San Antonio, United States. In Am J Med Genet B Neuropsychiatr Genet, 2013
A critical region was defined in the mood-disordered group that included a hypothetical gene, C18orf62, and two known genes, ZADH2 and TSHZ1.
JAK/STAT signaling is required for hinge growth and patterning in the Drosophila wing disc.
Bach et al., New York City, United States. In Dev Biol, 2013
Within the hinge, Stat92E activity becomes restricted to gap domain cells that lack Nubbin and Teashirt.
Genetic variants associated with disordered eating.
Martin et al., Adelaide, Australia. In Int J Eat Disord, 2013
The current results implicate the following genes: CLEC5A, LOC136242, TSHZ1, and SYTL5 for the AN spectrum phenotype; NT5C1B for the BN spectrum phenotype; and ATP8A2 for the disordered eating behaviors phenotype.
Narrowing the critical region for congenital vertical talus in patients with interstitial 18q deletions.
Haldeman-Englert et al., Grand Rapids, United States. In Am J Med Genet A, 2013
Based on these findings and previous reports in the literature and databases, we narrow the critical region for CVT to a minimum of five genes (ZNF407, ZADH2, TSHZ1, C18orf62, and ZNF516), and propose that TSHZ1 is the likely causative gene for CVT in 18q deletion syndrome.
The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.
Skaer et al., Cambridge, United Kingdom. In Development, 2013
We show that the conserved Teashirt transcription factors are decisive for the differentiation of a subset of secretory cells, stellate cells, in Drosophila melanogaster renal tubules.
A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.
Kumar et al., Bloomington, United States. In Dev Biol, 2012
Tsh contains three zinc finger motifs the second zinc finger is essential to the proper functioning of the protein while the remaining zinc finger domains appear to contribute but are not absolutely required
Ureter myogenesis: putting Teashirt into context.
Woolf et al., London, United Kingdom. In J Am Soc Nephrol, 2010
The Teashirt gene family was first identified in Drosophila where Teashirt (Tsh) protein acts as a transcription factor directing embryonic anterior-posterior patterning and leg and eye development.
Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna.
Kumar et al., Bloomington, United States. In Dev Dyn, 2009
Data demonstrate that ectopic eye formation by teashirt and its paralog tiptop, a potential new eye specification gene, is restricted to the developing antennae.
Zinc-finger paralogues tsh and tio are functionally equivalent during imaginal development in Drosophila and maintain their expression levels through auto- and cross-negative feedback loops.
Casares et al., Sevilla, Spain. In Dev Dyn, 2009
Data show that tio (tiptop) and tsh (teashirt) have coincident expression domains in the imaginal discs, the precursors of the adult body, and that both genes show similar functional properties when expressed ectopically.
Tshz1 is required for axial skeleton, soft palate and middle ear development in mice.
Fasano et al., Marseille, France. In Dev Biol, 2007
In the craniofacial region, loss of Tshz1 function leads to specific malformations of middle ear components, including the malleus and the tympanic ring.
Nubbin and Teashirt mark barriers to clonal growth along the proximal-distal axis of the Drosophila wing.
Mann et al., New York City, United States. In Dev Biol, 2007
Nub and Tsh domains share some of the attributes of classical compartments, but lack their stringent and immobile boundaries.
Regulation and formation of the Drosophila salivary glands.
Andrew, Baltimore, United States. In Ann N Y Acad Sci, 1998
However, other known proteins, including the homeotic protein Abdominal-B, the unusual zinc finger protein Teashirt, and the secreted signaling molecule Decapentaplegic (a TGF-beta family member), limit the recruitment of SCR-expressing cells to salivary glands.
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