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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


TE2, ARD1, NIPP1, hARD1, Ard1p
N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, PP1, Arylamine N-Acetyltransferase
Papers using TE2 antibodies
On the role of the second coding exon of the HIV-1 Tat protein in virus replication and MHC class I downregulation
Nekhai Sergei et al., In Retrovirology, 1997
... 293T cells stably expressing NIPP1 (143–224) were generated by transfection of NIPP1-143-224-EGFP, and limited dilution cloning in the presence of geneticin (0.5 mg/ml) (Life Technologies, Rockville, MD) ...
Papers on TE2
The N-terminal acetyltransferase Naa10/ARD1 does not acetylate lysine residues.
Marmorstein et al., United States. In J Biol Chem, Feb 2016
UNASSIGNED: The N-terminal acetyltransferase NatA is a heterodimeric complex consisting of a catalytic subunit (Naa10/ARD1) and an auxiliary subunit (Naa15).
The role of PD-L1 in the radiation response and prognosis for esophageal squamous cell carcinoma related to IL-6 and T-cell immunosuppression.
Lee et al., Taiwan. In Oncotarget, Feb 2016
Furthermore, the human esophageal SCC cell line CE81T and TE2 were selected for cellular experiments to investigate the role of PD-L1 in T cell functions and radiation response.
Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams.
Nomura et al., Chiba, Japan. In Gene Ther, Jan 2016
In vivo therapeutic antitumor efficacy of replication-defective adenovirus (E1 and E3 deleted adenovirus serotype 5) encoding human FIR cDNA (Ad-FIR) was demonstrated in the tumor xenograft model of human esophageal squamous cancer cells, TE-2.
The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth.
Bollen et al., Leuven, Belgium. In J Cell Sci, Jan 2016
Here, we show that the overexpression of nuclear inhibitor of PP1 (NIPP1; also known as PPP1R8) in HeLa cells culminated in a prometaphase arrest, associated with severe spindle-formation and chromosome-congression defects.
Crystal Structure and Substrate Specificity of Human Thioesterase 2: Insights into the Molecular Basis for the Modulation of Fatty Acid Synthase.
Lowther et al., Wake Forest, United States. In J Biol Chem, Jan 2016
In addition, the chain length of fatty acids produced by FASN is controlled by a type II thioesterase called TE2 (E.C.
Protein phosphatase 1 is a key player in nuclear events.
da Cruz E Silva et al., Aveiro, Portugal. In Cell Signal, Dec 2015
Among them are PNUTS (phosphatase 1 nuclear targeting subunit), NIPP1 (nuclear inhibitor of PP1) and CREB (cAMP-responsive element-binding protein), which have all been associated with transcription.
Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Single-Center Experience.
Kudo et al., Sayama, Japan. In Oncology, Nov 2015
RESULTS: In the countable HCC group, contrast-enhanced CT demonstrated RECICL TE4 in 43.8% (14/32), TE3 in 12.5% (4/32), TE2 in 37.5% (12/32), and TE1 in 6.3% (2/32) of patients.
Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits.
Bollen et al., Leuven, Belgium. In Nucleic Acids Res, Aug 2015
RepoMan, NIPP1 and PNUTS.
Protein N-terminal acetyltransferases in cancer.
Arnesen et al., Bergen, Norway. In Oncogene, 2013
The human N-terminal acetyltransferases (NATs) catalyze the transfer of acetyl moieties to the N-termini of 80-90% of all human proteins.
ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation.
Miyamoto et al., Kashiwa, Japan. In Biochem Biophys Res Commun, 2012
These data indicate that the interaction between ARD1 and RIP1 plays an important role in the DNA damage-induced NF-kappaB activation, and that the acetyltransferase activity of ARD1 and its localization in to the nucleus are involved in such stress response.
N-α-acetyltransferase 10 protein inhibits apoptosis through RelA/p65-regulated MCL1 expression.
Shou et al., Beijing, China. In Carcinogenesis, 2012
study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription
Combined phenotype of 4 markers improves prognostic value of patients with colon cancer.
Shou et al., Beijing, China. In Am J Med Sci, 2012
Arrest-defective protein 1 homolog A (ARD1) in combination with SNCG/Hiwi/PRL-3 may lead to a poor outcome in patients with or without lymph node metastatic colon cancer.
Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis.
Liu et al., New Orleans, United States. In Proc Natl Acad Sci U S A, 2012
ARD1 functions as a unique AR regulator in prostate cancer cells.
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency.
Lyon et al., Salt Lake City, United States. In Am J Hum Genet, 2011
A reduction in acetylation by hNaa10p causes lethal X-linked disorder of infancy.
The protein acetyltransferase ARD1: a novel cancer drug target?
Lillehaug et al., Bergen, Norway. In Curr Cancer Drug Targets, 2008
This review focuses on the enzymatic and biological activities of human ARD1, the reduction of which negatively affects cell growth and may be a potential cancer drug target.
HIF-1: master and commander of the hypoxic world. A pharmacological approach to its regulation by siRNAs.
Pouysségur et al., Nice, France. In Biochem Pharmacol, 2004
The alpha subunit of HIF-1 is the principal actor while the supporting actors (PHDs, FIH-1, ARD1, CITED2, p300...) all contribute to the complexity of the grand finale.
Composition and function of the eukaryotic N-terminal acetyltransferase subunits.
Sherman et al., Rochester, United States. In Biochem Biophys Res Commun, 2003
Saccharomyces cerevisiae contains three N-terminal acetyltransferases (NATs), NatA, NatB, and NatC, composed of the following catalytic and auxiliary subunits: Ard1p and Nat1p (NatA); Nat3p and Mdm20p (NatB); and Mak3p, Mak10, and Mak31p (NatC).
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.
Kim et al., Seoul, South Korea. In Cell, 2002
ARD1-mediated acetylation regulates and destabilizes HIF-1 alpha by directly binding to it.
Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae.
Gottschling et al., Chicago, United States. In Cell, 1991
SIR2, SIR3, SIR4, NAT1, ARD1, and HHF2 (histone H4) were identified as modifiers of the position effect at telomeres, since transcriptional repression near telomeres was no longer observed when any of the modifier genes were mutated.
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways.
Szostak et al., In Cell, 1985
Mutations in the yeast gene ARD1 lead to inability to respond to alpha-factor, inability to enter stationary phase, and inability to sporulate, suggesting an important role for the ARD1 gene product in controlling the switch between the mitotic cell cycle and alternative cell fates.
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