Protein phosphatase 1 is a key player in nuclear events.
Aveiro, Portugal. In Cell Signal, Dec 2015
Among them are PNUTS (phosphatase 1 nuclear targeting subunit), NIPP1 (nuclear inhibitor of PP1) and CREB (cAMP-responsive element-binding protein), which have all been associated with transcription.
ARD1 binding to RIP1 mediates doxorubicin-induced NF-κB activation.
Kashiwa, Japan. In Biochem Biophys Res Commun, 2012
These data indicate that the interaction between ARD1 and RIP1 plays an important role in the DNA damage-induced NF-kappaB activation, and that the acetyltransferase activity of ARD1 and its localization in to the nucleus are involved in such stress response.