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Deoxynucleotidyltransferase, terminal

TdT, terminal deoxynucleotidyl transferase, DNA Nucleotidylexotransferase, terminal transferase
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, caspase-3, bcl-2, V1a, Bax
Papers using TdT antibodies
Genetic ablation of Rac1 in cartilage results in chondrodysplasia
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Beier Frank et al., In BMC Developmental Biology, 2006
... LY294002, PI3-K α inhibitor IV, and the TdT-FragEL™ DNA Fragmentation Detection Kit were purchased from Calbiochem, Antibodies for immunohistochemistry were purchased from Sigma (monoclonal anti-collagen type X-C7974), Cell Signaling Technology ...
Requirements for DNA unpairing during displacement synthesis by HIV-1 reverse transcriptase.
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Romesberg Floyd, In PLoS ONE, 2003
... P]ddATP and terminal transferase (New England Biolabs, Inc.) as described by ...
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
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Gautier Jean et al., In The Journal of Cell Biology, 2002
... PflMI and terminal transferase were obtained from New England Biolabs, Inc ...
A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2; 5 translocation
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Marx Alexander et al., In Diagnostic Pathology, 1996
... monoclonal antibodies: CD2, CD7, CD20, CD30, CD31, CD79, CD99, CD117, Alk-1, Desmin, D2-40, EMA, Ki67, TdT (all Dako Cytomation, Glostrup; Denmark), CD3, ...
2-5A-dependent RNase molecules dimerize during activation by 2-5A
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Youle Richard J. et al., In The Journal of Experimental Medicine, 1994
... ) or TdT (14) (Trevigen, Gaithersburg, MD), then counterstained ...
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Papers on TdT
Actively targeting d-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactic acid) nanoparticles as vesicles for chemo-photodynamic combination therapy of doxorubicin-resistant breast cancer.
New
Chen et al., Shanghai, China. In Nanoscale, Feb 2016
The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and the hematoxylin and eosin staining of the treated tumors further demonstrated the anti-tumor efficacy of tLyp-1-NP in the presence of a laser.
Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma.
New
Afify et al., Salt Lake City, United States. In Pediatr Blood Cancer, Feb 2016
This case report documents a 5-year-old female who presented with B-cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL.
Recent progress in therapeutic strategy for ischemic stroke.
New
Abe et al., In Cell Transplant, Feb 2016
GDNF and HGF significantly reduced infarct size, the number of microtubule-associated protein 1 light chain3 (LC3)-positive cells, and the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end labeling (TUNEL)-positive cells, indicating that GDNF and HGF were greatly associated with not only the antiapoptotic effect but also the antiautophagic effects.
Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord ischemia/reperfusion injury.
New
Ma et al., Shenyang, China. In Mol Med Report, Feb 2016
The role of hypoxic preconditioning in the promotion of the protective effect of BMSCs on SCIRI was investigated using neurological function scores, Evans blue staining, hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling.
When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults.
Review
New
Impact
Advani et al., Cleveland, United States. In J Clin Oncol, Jan 2016
The lymphoblasts were examined by flow cytometry and immunohistochemistry and expressed the T-cell markers CD2, CD3, CD4, and terminal deoxynucleotidyl transferase.
Geldanamycin induces apoptosis in human gastric carcinomas by affecting multiple oncogenic kinases that have synergic effects with TNF-related apoptosis-inducing ligand.
New
Pan et al., Fuzhou, China. In Oncol Lett, Dec 2015
The expression of target proteins at the mRNA level was determined using reverse transcription-polymerase chain reaction (RT-PCR), and apoptosis was evaluated with the terminal deoxynucleotidyl transferase mediated digoxigenin-dUTP nick-end labeling and Annexin V/propidium iodide (PI) staining methods.
Preventive effects of fermented brown rice and rice bran against N-nitrosobis (2-oxopropyl) amine-induced pancreatic tumorigenesis in male hamsters.
New
Mori et al., Nagoya, Japan. In Oncol Lett, Dec 2015
Using terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling, augmentation of apoptosis by FBRA exposure in the non-lesional ductal epithelium and proliferative lesions was not evident.
Composite primary breast diffuse large B-cell lymphoma and T lymphoblastic leukemia/lymphoma: report of a case and review of literature.
Review
Chen et al., Nanjing, China. In Int J Clin Exp Pathol, 2014
The aberrant terminal deoxynucleotidyl transferase (TDT) and cCD3 positive T-cell population that lack surface CD10 and CD19 were identified by flow cytometric immunophenotyping.
Merkel cell carcinoma: is this a true carcinoma?
Review
Czajkowski et al., Bydgoszcz, Poland. In Exp Dermatol, 2014
MCC commonly expresses terminal deoxynucleotidyl transferase and PAX5.
Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus.
Review
Zhang et al., Nanning, China. In Neural Regen Res, 2014
Results from the electrical stimulation group revealed that rats exhibited a reduction in brain infarct size, a significant increase in the expression of Ku70 in cerebral ischemia/reperfusion regions, and a decreased number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive cells.
Assays for human telomerase activity: progress and prospects.
Review
Impact
Xing et al., Guangzhou, China. In Chem Soc Rev, 2012
Human telomerase is a ribonucleoprotein complex that functions as a telomere terminal transferase by adding multiple TTAGGG hexamer repeats using its integral RNA as the template.
Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies.
Impact
de Bono et al., United Kingdom. In J Clin Oncol, 2011
ARQ 197 decreased phosphorylated c-MET, total c-MET, and phosphorylated focal adhesion kinase and increased terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick-end labeling (TUNEL) staining in tumor biopsies (n = 15).
Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide α-1,3 dextran.
GeneRIF
Kearney et al., Birmingham, United States. In J Immunol, 2010
TdT is essential for the generation of the predominant higher-affinity DEX-responsive J558 clone
Activating mutations in ALK provide a therapeutic target in neuroblastoma.
Impact
Look et al., Boston, United States. In Nature, 2008
Cytotoxicity was associated with increased amounts of apoptosis as measured by TdT-mediated dUTP nick end labelling (TUNEL).
Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses.
GeneRIF
La Gruta et al., Melbourne, Australia. In J Immunol, 2008
The role of TdT ensures enhanced diversity and selection of private T cell receptor repertoires and promotes optimal CD8-positive T cell immunity, both within individuals and across the species as a whole.
Terminal deoxynucleotidyl transferase establishes and broadens antiviral CD8+ T cell immunodominance hierarchies.
GeneRIF
Yewdell et al., Bethesda, United States. In J Immunol, 2008
TdT plays a critical role in the magnitude and breadth of anti-viral T(CD8+) responses toward individual determinants
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
Impact
Rajewsky et al., Boston, United States. In Cell, 2008
We found intact Ig gene rearrangements in immunoglobulin heavy (IgH) and kappa chain loci, but increased sterile transcription and usage of D(H) elements of the DSP family in IgH, and increased N sequence addition in Igkappa due to deregulated transcription of the terminal deoxynucleotidyl transferase gene.
Identification of functional domains in TdIF1 and its inhibitory mechanism for TdT activity.
GeneRIF
Koiwai et al., Noda, Japan. In Genes Cells, 2007
The TdT binding, DNA binding and dimerization regions, and nuclear localization signal (NLS) in TdIF1, were identified.
Terminal deoxynucleotidyl transferase-positive cells in spleen, appendix and branchial cleft cysts in pediatric patients.
GeneRIF
Orazi et al., In Haematologica, 2006
In spleen, appendix and branchial cleft cysts the range of TdT-positivity was 0-13, 0-96 and 0-6 TdT+ cells per high-power field.
Review
Viprakasit et al., Nicosia, Cyprus. In Unknown Journal, 0001
The need for management guidelines for Transfusion Dependent Thalassaemias (TDT) is clear.
More papers using TdT antibodies
A functionally active retrovirus vector for gene therapy in Fanconi anemia group C.
Supplier
Marinus Martin G., In PLoS ONE, 1993
... P]-ATP (3,000 Ci/mmol-1) (PerkinElmer), or 3′-end labelled by terminal deoxynucleotidyl transferase (New England Biolabs) in the presence of ...
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