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Thymine-DNA glycosylase

TDG, thymine-DNA glycosylase
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using TDG antibodies
Statistics of the Comet assay: a key to discriminate between genotoxic effects
Supplier
Haber James E, In PLoS Biology, 2002
... Tdg expression constructs.Chemicals and reagents were purchased from Sigma, Complete protease inhibitor from Roche, RNase from Qiagen and UGI from New ...
Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice
Supplier
Fugmann Sebastian D., In PLoS ONE, 2001
... mismatch glycosylase; also known as thermostable TDG from Trevigen, USA catalog No 4070–500-EB) ...
Papers on TDG
A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype.
GeneRIF
Alberg et al., Baltimore, United States. In Carcinogenesis, 2012
genetic variants in TDG, important not only in base excision repair but also in regulating the epigenome and gene expression, which may contribute to the non-melanoma skin cancer associated increase in overall cancer risk.
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA.
GeneRIF
Drohat et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2012
We solved a crystal structure of TDG (catalytic domain) bound to a substrate analog and characterized active-site residues by mutagenesis, kinetics, and molecular dynamics simulations.
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
GeneRIF
He et al., Chicago, United States. In Nat Chem Biol, 2012
5-carboxylcytosine is specifically recognized in the active site of thymine DNA glycosylase
Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline.
GeneRIF
Uehara et al., Sendai, Japan. In Tohoku J Exp Med, 2011
Embryonic lethality in Tdg (-/-) embryos is due, in part, to the reduction of noradrenaline levels.
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.
GeneRIF
Drohat et al., Baltimore, United States. In J Biol Chem, 2011
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.
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