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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

G protein-coupled receptor 65

TDAG8, T cell death-associated gene 8, GPR65
Top mentioned proteins: OGR1, GPR4, ACID, G2A, GPCR
Papers on TDAG8
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.
Regev et al., Cambridge, United States. In Cell, Jan 2016
Using knockout mice, we validate four new genes: Gpr65, Plzp, Toso, and Cd5l (in a companion paper).
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
Roth et al., Chapel Hill, United States. In Nature, Dec 2015
The same approach led to the discovery of allosteric agonists and negative allosteric modulators for GPR65.
Increased expression of the proton-sensing G protein-coupled receptor Gpr65 during retinal degeneration.
Grimm et al., Zürich, Switzerland. In Neuroscience, Sep 2015
GPR4, GPR65 and GPR68 are G protein-coupled receptors that aid cells to sense and survive conditions of acidic pH and inflammatory cells express Gpr65 enhancing their viability.
Psychosine inhibits osteoclastogenesis and bone resorption via G protein-coupled receptor 65.
Koh et al., Seoul, South Korea. In J Endocrinol Invest, Aug 2015
BACKGROUND: It was recently reported that G protein-coupled receptor 65 (GPR65) suppresses ovariectomy-induced bone loss.
Acid sensitivity of the spinal dorsal root ganglia C-fiber nociceptors innervating the guinea pig esophagus.
Kollarik et al., Baltimore, United States. In Neurogastroenterol Motil, Jun 2015
Other evaluated targets (PKD2L1, TRPV4, TASK3, TALK1, G2A, GPR4, and TDAG8) were expressed rarely.
G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.
Rogler et al., Zürich, Switzerland. In Inflamm Bowel Dis, Jun 2015
BACKGROUND: A novel family of proton-sensing G protein-coupled receptors, including OGR1, GPR4, and TDAG8, was identified to be important for physiological pH homeostasis and inflammation.
Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury.
Okajima et al., Maebashi, Japan. In Int J Mol Sci, 2014
Here we explored the role of TDAG8 in lung injury induced by lipopolysaccharide (LPS) administrated intratracheally.
Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses.
Okajima et al., Maebashi, Japan. In Plos One, 2014
In the cells that express proton-sensing GPCRs, including GPR4, OGR1, TDAG8, and G2A, extracellular acidification stimulates serum responsive element (SRE)-driven transcriptional activity, which has been shown to reflect Rho activity, with different proton sensitivities.
Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL Microenvironment.
Distelhorst et al., Cleveland, United States. In J Leuk (los Angel), 2014
Here we are the first to report that the extracellular acid sensing G-protein coupled receptor, GPR65, is expressed in primary CLL cells where its level correlate strongly with anti-apoptotic Bcl-2 family member levels.
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Aronstam et al., Rolla, United States. In Plos One, 2014
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibition of forskolin stimulated expression (GPR4, GPR26, GPR61, GPR62, GPR78, GPR101, GPR119); 3) elevation of baseline signaling coupled with inhibition of forskolin stimulated expression (GPR6, GPR12); 4) elevation of baseline signaling without inhibition of forskolin stimulated expression (GPR3, GPR21, GPR52, GPR65); and 5) no effect on expression (GPR1, GPR19, GPR22, GPR34, GPR35, GPR39, GPR63, GPR82, GPR85, GPR87).
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors.
Yang et al., Greenville, United States. In Front Physiol, 2012
Recent studies show that the pH-sensing GPCRs, including GPR4, GPR65 (TDAG8), GPR68 (OGR1), and GPR132 (G2A), regulate cancer cell metastasis and proliferation, immune cell function, inflammation, and blood vessel formation.
pH sensing and regulation in cancer.
Gillies et al., Tampa, United States. In Front Physiol, 2012
However, there is evidence that expression of proton-sensing GPCRs such as GPR4, TDAG8, and OGR1 can regulate aspects of tumorigenesis and invasion, including cofilin and talin regulated actin (de-)polymerization.
Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.
Distelhorst et al., Cleveland, United States. In J Biol Chem, 2012
Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.
Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro.
Oda et al., Tokyo, Japan. In Eur J Pharmacol, 2012
Data suggest that one physiological function of TDAG8 is negative regulation of inflammation by inhibiting production of pro-inflammatory cytokines in T-lymphocytes, macrophages, and splenocytes.
Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages.
Okajima et al., Maebashi, Japan. In Biochem Biophys Res Commun, 2012
TDAG8 is involved in the GC-induced anti-inflammatory actions in macrophages.
Activation of T cell death-associated gene 8 attenuates inflammation by negatively regulating the function of inflammatory cells.
Oda et al., Tokyo, Japan. In Eur J Pharmacol, 2011
TDAG8 acts as a negative regulator of inflammation
The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor.
Ishii et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2010
These results support the hypothesis that TDAG8 enhances tumor development by promoting adaptation to the acidic environment to enhance cell survival/proliferation.
Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism.
Jakobs et al., Essen, Germany. In Biochim Biophys Acta, 2007
Receptors of the endothelial differentiation gene family are activated by S1P (S1P(1-5)) or LPA (LPA(1-3)); two more distantly related receptors are activated by LPA (LPA(4/5)); the GPR(3/6/12) receptors have a high constitutive activity but are further activated by S1P and/or SPC; and receptors of the OGR1 cluster (OGR1, GPR4, G2A, TDAG8) appear to be activated by SPC, LPC, psychosine and/or protons.
Receptors for protons or lipid messengers or both?
Wolf et al., Basel, Switzerland. In J Recept Signal Transduct Res, 2005
The subfamily of G protein-coupled receptors comprising GPR4, OGR1, TDAG8, and G2A was originally characterized as a group of proteins mediating biological responses to the lipid messengers sphingosylphosphorylcholine (SPC), lysophosphatidylcholine (LPC), and psychosine.
Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: a novel type of multi-functional receptors.
Okajima et al., Maebashi, Japan. In Cell Signal, 2005
OGR1, GPR4, G2A, and TDAG8 share 40% to 50% homology with each other and seem to form a family of GPCRs.
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