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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Pleckstrin homology-like domain, family A, member 1

TDAG51, PHLDA1, T-cell death-associated gene 51
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, cytokeratin, HAD, HAIR, OUT
Papers on TDAG51
Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway.
New
Baek et al., Taegu, South Korea. In J Cell Biochem, Feb 2016
We found that pleckstrin homology-like domain family, member 1 (PHLDA1) is a novel gene up-regulated by TLR2 stimulation and determined the unique signaling pathway for its expression.
Comparative analysis of cytokeratin 15, TDAG51, cytokeratin 20 and androgen receptor in sclerosing adnexal neoplasms and variants of basal cell carcinoma.
New
North et al., San Francisco, United States. In J Cutan Pathol, Nov 2015
We compared cytokeratin 15, (CK15), T-cell death-associated gene 51 (TDAG51), cytokeratin 20 (CK20) and androgen receptor (AR) in differentiating these tumors and assessed their expression in BCC subtypes.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
New
Khanna et al., Bethesda, United States. In Oncotarget, Nov 2015
PHLDA1 (pleckstrin homology-like domain, family A) was identified as one of the genes more highly expressed in the high metastatic compared to low metastatic cells.
Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma).
New
Cribier et al., Poitiers, France. In J Eur Acad Dermatol Venereol, Oct 2015
METHODS: We conducted a retrospective study of 30 cases, 18 MAC, 5 SC and 7 SEDC reviewed and classified by a panel of dermatopathology experts, with immunohistochemical analysis of keratins, including K77, a new keratin specific of eccrine ducts, and PHLDA1 expressed in adnexal structures.
Primitive follicular induction in molluscum contagiosum.
New
Schärer et al., Madrid, Spain. In J Cutan Pathol, Sep 2015
Immunohistochemical expression of BerEP4, PHLDA1 and cytokeratin 20 (CK20) was evaluated in the basaloid germs surrounding the lesions.
Downregulated expression of PHLDA1 protein is associated with a malignant phenotype of cholangiocarcinoma.
New
Liu et al., Beijing, China. In Oncol Lett, Aug 2015
Recent findings suggest that a decrease in pleckstrin homology-like domain family A, member 1 (PHLDA1) expression is significant in the induction of cell migration and tumor invasion.
Cystic trichoblastoma: a report of two cases with an immunohistochemical study.
New
Narisawa et al., Saga, Japan. In J Dermatol, Mar 2015
The follicular germinative cells observed in the papillary projections and in the aggregations of trichoblastoma expressed cytokeratin-15 (clone C8/144B) and PHLDA1, markers of follicular stem cells.
Giant solitary trichoepithelioma.
Review
Rajpurohit et al., India. In South Asian J Cancer, 2015
CD10, CD 34, PHLDA1 but not p75NTR are useful adjunct markers.
Correlation of decreased expression of PHLDA1 protein with malignant phenotype of gastric adenocarcinoma.
Liu et al., Beijing, China. In Int J Clin Exp Pathol, 2014
Recent findings suggest decreasing PHLDA1 (pleckstrin-homologylike domain family A, member1) expression plays a significant role in inhibiting cell migration and tumor invasion.
Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges.
Review
Paus et al., Manchester, United Kingdom. In Bioessays, 2014
We address this by reviewing current concepts on human eHFSC biology, their immediate progeny and their molecular markers, focusing on Keratin 15 and 19, CD200, CD34, PHLDA1, and EpCAM/Ber-EP4.
Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukaemic compound PEP005 in primary AML cells.
Lord et al., Bergen, Norway. In Oncoscience, 2013
Expression microarray analysis of resistant samples following treatment with PEP005 revealed a significant up regulation of the anti-apoptotic genes Bcl-2A1, Mcl-1, and PHLDA1 which was verified using RT-PCR.
Intestinal stem cells - types and markers.
Review
Huang et al., Hangzhou, China. In Cell Biol Int, 2013
We have reviewed several ISCs markers, including Lgr5, PHLDA1, Bmi1 and Lrig1.
TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium.
GeneRIF
Dickhout et al., Hamilton, Canada. In Am J Physiol Renal Physiol, 2012
the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
GeneRIF
Shah et al., West Lafayette, United States. In J Cell Sci, 2011
crucial negative regulator and effector of Aurora A kinase in breast cancer
Stem cell markers can help identify adnexal tumor differentiation when evaluated in the context of morphology: methodology matters.
Review
Sellheyer, Cleveland, United States. In J Cutan Pathol, 2011
The markers critically reviewed in this manuscript include B-lymphocyte-induced maturation protein 1 (Blimp-1), nestin, CD34, p63, cytokeratins 15 and 19 and the most recent ones appearing on the horizon: pleckstrin homology-like domain, family A, member 1 (PHLDA1) (TDAG51) and CD200.
PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.
GeneRIF
Sieber et al., Melbourne, Australia. In Cancer Res, 2011
PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis
Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing cryptorchid-induced apoptosis in rat testes.
GeneRIF
Huang et al., Beijing, China. In Mol Reprod Dev, 2011
The expression of Phlda1 mRNA is significantly elevated 3 days after induction of cryptorchidism.
Transcriptional up-regulation of PHLDA1 by 17beta-estradiol in MCF-7 breast cancer cells.
GeneRIF
Nagai et al., São Paulo, Brazil. In Braz J Med Biol Res, 2008
The anti-estrogen ICI 182,780 (1 microM) inhibited PHLDA1 mRNA expression and completely abolished the effect of 10 nM 17beta-estradiol on PHLDA1 expression (P < 0.05), suggesting that PHLDA1 is regulated by estrogen via ER.
Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction.
Review
Feinberg, Baltimore, United States. In Cancer Res, 1999
identifying six imprinted genes within this domain: (a) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies; (b) H19, an untranslated RNA that is a putative growth suppressor gene regulating IGF-II; (c) p57KIP2, a cyclin-dependent kinase inhibitor that causes G1-S arrest; (d) KvLQT1, a voltage-gated potassium channel; (e) TSSC3, a gene that is homologous to mouse TDAG51, which is implicated in Fas-mediated apoptosis; and (f) TSSC5, a putative transmembrane protein-encoding gene.
A novel gene product that couples TCR signaling to Fas(CD95) expression in activation-induced cell death.
Impact
Choi et al., New York City, United States. In Immunity, 1996
Subsequently, we cloned the gene TDAG51, which restored activation-induced apoptosis when transfected into the mutant cell line, and showed that TDAG51 expression was required for Fas expression.
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