Genetic and epigenetic regulation of Tcrb gene assembly.
Raleigh, United States. In Curr Top Microbiol Immunol, 2011
This chapter describes our current understanding of the cross-talk between key genetic elements and epigenetic programs during recombination of the Tcrb locus in developing T cells, how each contributes to the regulation of chromatin accessibility at individual DNA targets for recombination, and potential mechanisms that coordinate their actions.
CXCR4 acts as a costimulator during thymic beta-selection.
Charlottesville, United States. In Nat Immunol, 2010
Passage through the beta-selection developmental checkpoint requires productive rearrangement of segments of the T cell antigen receptor-beta gene (Tcrb) and formation of a pre-TCR on the surface of CD4(-)CD8(-) thymocytes.