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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T-cell leukemia/lymphoma 1A

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: CAN, Akt, TCL, HAD, BCR
Papers using TCL1 antibodies
The resurgence of platinum-based cancer chemotherapy
Huang Peng et al., In Nature cell biology, 2006
... WL: experimental work, data analysis; HP, JAB, WP: project planning and data interpretation; CMC: provided Tcl-1 transgenic mice; MJK: provided CLL ...
Papers on TCL1
Simvastatin inhibits oxidative stress via the activation of nuclear factor erythroid 2-related factor 2 signaling in trophoblast cells.
Konishi et al., Kyoto, Japan. In J Obstet Gynaecol Res, Jan 2016
Reactive oxygen species levels were analyzed by flow cytometry in immortalized human trophoblast TCL1 cells treated with or without H2 O2 (100 μM) ± simvastatin (50 μM).
Ectopic expression of R3 MYB transcription factor gene OsTCL1 in Arabidopsis, but not rice, affects trichome and root hair formation.
Wang et al., Changchun, China. In Sci Rep, Dec 2015
By BLASTing the rice (Oryza sativa) protein database using the entire amino acid sequence of Arabidopsis R3 MYB transcription factor TRICHOMELESS1 (TCL1), we found that there are two genes in rice genome encoding R3 MYB transcription factors, namely Oryza sativa TRICHOMELESS1 (OsTCL1) and OsTCL2.
BTK inhibition results in impaired CXCR4 chemokine receptor surface expression, signaling and function in chronic lymphocytic leukemia.
Chiorazzi et al., United States. In Leukemia, Dec 2015
Here, we investigated BTK regulation of leukemic B-cell trafficking in a mouse model of aggressive TCL1 CLL-like disease.
The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma.
Perkins et al., Boston, United States. In Oncogene, Dec 2015
c-Rel loss also led to earlier onset of disease in a separate TCL1-Tg-driven lymphoma model.
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex.
Mraz et al., Brno, Czech Republic. In Leukemia, May 2015
We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6).
Molecular basis of chronic lymphocytic leukemia diagnosis and prognosis.
Saki et al., Tehrān, Iran. In Cell Oncol (dordr), Apr 2015
Micro-RNA expression alterations and aberrant methylation patterns in genes that are specifically deregulated in CLL, including the BCL-2, TCL1 and ZAP-70 genes, have also been encountered and linked to distinct clinical parameters.
Cd1d regulates B cell development but not B cell accumulation and IL10 production in mice with pathologic CD5(+) B cell expansion.
Swanson et al., Omaha, United States. In Bmc Immunol, 2014
Interestingly, in the CLL-prone Eμ-TCL1 model, loss of CD1d expression suppressed spontaneous IgG (but not IgM) production, whereas in the dnRAG1xEμ-TCL1 (DTG) model of accelerated CLL, loss of CD1d expression was associated with elevated numbers of splenic CD4(+) and CD8(+) T cells and an inverted CD4(+):CD8(+) T cell ratio.
The long journey of TCL1 transgenic mice: lessons learned in the last 15 years.
Zanesi et al., Columbus, United States. In Gene Expr, 2014
The first transgenic mouse of the TCL1 oncogene was described more than 15 years ago, and since then, the overexpression of the gene in T- and B-cells in vivo has been extensively studied to reveal the molecular details in the pathogenesis of some lymphocytic leukemias.
Regulation of root hair cell differentiation by R3 MYB transcription factors in tomato and Arabidopsis.
Wada et al., Hiroshima, Japan. In Front Plant Sci, 2013
Six additional CPC-like MYB proteins including TRIPTYCHON (TRY), ENHANCER OF TRY AND CPC1 (ETC1), ENHANCER OF TRY AND CPC2 (ETC2), ENHANCER OF TRY AND CPC3/CPC-LIKE MYB3 (ETC3/CPL3), TRICHOMELESS1 (TCL1), and TRICHOMELESS2/CPC-LIKE MYB4 (TCL2/CPL4) also have the ability to regulate root hair and/or trichome cell differentiation in Arabidopsis.
miR deregulation in CLL.
Croce et al., Columbus, United States. In Adv Exp Med Biol, 2012
For example, in indolent CLL, 13q14 deletions targeting miR-15/16 initiate the disease, while in aggressive CLL miR-181 targets the critical TCL1 oncogene and can also be used as a progression marker.Here we discuss the foremost findings about the role of microRNAs in CLL pathogenesis, and how this knowledge can be used to identify new approaches to treat CLL.
TCL1: a shared tumor-associated antigen for immunotherapy against B-cell lymphomas.
Neelapu et al., Houston, United States. In Blood, 2012
TCL1 is hyperexpressed in multiple B-cell lymphomas.
Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.
Hu et al., Tampa, United States. In Blood, 2012
An important role of TCL1 in activating the ER stress response in support for malignant progression of chronic lymphocytic leukemia.
Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia.
Burger et al., Houston, United States. In Leukemia, 2012
These findings demonstrate that the microenvironment has a proactive role in the regulation of the known signaling enhancer and pro-survival molecule TCL1 in CLL.
O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.
Youn et al., Seoul, South Korea. In Cell Stem Cell, 2012
O-GlcNAc modification of threonine 228 in Oct4 regulates Oct4 transcriptional activity and is important for inducing many pluripotency-related genes, including Klf2, Klf5, Nr5a2, Tbx3, and Tcl1.
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary.
Kikkawa et al., Nagoya, Japan. In J Obstet Gynaecol Res, 2012
100% of dysgerminomas were positive for TCL1, but all immature teratomas were negative.
Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).
Pekarsky et al., Columbus, United States. In Proc Natl Acad Sci U S A, 2012
CLL samples with high Tcl1 expression showed a decrease in DNA methylation compared with CLL samples with low Tcl1 expression
Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.
Reik et al., Cambridge, United Kingdom. In Nature, 2011
Knockdown of Tet1 and Tet2 causes downregulation of a group of genes that includes pluripotency-related genes (including Esrrb, Prdm14, Dppa3, Klf2, Tcl1 and Zfp42) and a concomitant increase in methylation of their promoters, together with an increased propensity of ES cells for extraembryonic lineage differentiation.
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
Fujii-Kuriyama et al., Tsukuba, Japan. In Cell Stem Cell, 2008
Our results also suggest that Klf5 regulates ESC proliferation by promoting phosphorylation of Akt1 via induction of Tcl1.
Zfx controls the self-renewal of embryonic and hematopoietic stem cells.
Reizis et al., New York City, United States. In Cell, 2007
Zfx directly activated common target genes in ESC and HSC, as well as ESC-specific target genes including ESC self-renewal regulators Tbx3 and Tcl1.
The TCL1 family of oncoproteins: co-activators of transformation.
Teitell, Los Angeles, United States. In Nat Rev Cancer, 2005
The T-cell leukaemia/lymphoma 1 (TCL1)-family oncoproteins augment AKT signal transduction and enhance cell proliferation and survival.
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